NMN Resveratrol Trial: Why We Follow David Sinclair Taking Alpha Lipoic Acid (ALA)
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- čas přidán 23. 08. 2020
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In our NMN and resveratrol trial we follow David Sinclair in taking Alpha Lipoic Acid.
We take ALA for its many benefits, and in this we are following people like Dr. David Sinclair, Dr. Mark Hyman, Ben Greenfield and Dave Asprey. Not to mention Dr. Denham Harmen one of the earliest pioneers in aging research.
In this video we discuss why we choose to take the supplement and what the benefits are. We look at some of these benefits and the scientific papers behind them.
. Recovery of a sense of smell after upper respiratory trct infection
. Improvement in lipid profile and glucose levels in blood
. Reducing inflammatory markers
. Combat neuropathy in diabetic patients
. Helps weight loss
. Potent anti-oxidant
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Supplements that we are taking:
Here are the links to the two Alpha Lipoic Acid products mentioned in the video.
The first is the mixed form and the second is the R form.
1. Doctor's Best, Alpha-Lipoic Acid, 600 mg, 180 Veggie Caps iherb.co/tLzKWiyV
TMG Powder 50g amzn.to/3hhtiGB
2. Doctor's Best, Stabilized R-Lipoic Acid with BioEnhanced Na-RALA, 100 mg, 60 Veggie Caps iherb.co/7VdAZ4ZE
References
Lipoic Acid in the Treatment of Smell Dysfunction Following Viral Infection of the Upper Respiratory Tract
www.researchgate.net/publicat...
The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials
pubmed.ncbi.nlm.nih.gov/29990...
The effects of alpha-lipoic acid supplementation on inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials
nutritionandmetabolism.biomed...
Effects of alpha-lipoic acid supplementation on C-reactive protein level: A systematic review and meta-analysis of randomized controlled clinical trials
www.sciencedirect.com/science...
pubmed.ncbi.nlm.nih.gov/17065...
Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial
Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials
pubmed.ncbi.nlm.nih.gov/28295...
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential
www.ncbi.nlm.nih.gov/pmc/arti...
Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex
pubmed.ncbi.nlm.nih.gov/15829...
Bioavailability of ALA
lpi.oregonstate.edu/mic/dieta... - Věda a technologie
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R is the best form!
Detailed and most importantly no rambling which is very common on CZcams. Well done again.
Hi Andreas, thank you for your supportive comment. It is very encouraging.
Thank you! R is the way to go
I'd like to see some more research on R vs S as I have seen other vidoes saying that taking the combination S and R is pointless.
I had with great difficulty convincing my mother to take ALA she is 70 has diabetes and the related neuropathy and also another condition called transverse myelitus which has caused tearing in her spinal nerves and since then she has had chronic neuropathy. The Dr has put her on pregabalin/Lyrica for the last 7 years and although it helps with the pain greatly it comes with severe side effects including memory loss confusion excessive sleeping for hours on end. I convinced her to go on ALA for the last 1 month and she seems much better less confusion more energy and although she isnt the kind of person to admit it im quite sure it is helping with er neuropathy. she takes a 600mg capsule in the morning.
I found your info on alpha lipoid acid very helpful! Thank you for doing this research! I was taking it for years for a neuroma in my foot and it greatly helped. For some reason, I stopped taking it but after seeing the info you presented in this video, I plan to add it back to my protocol!
Thank you, that was amazing information including ones in comments! New sub
Great series.
I watch and continue to watch more thankfully.
End piano is louder than probably desired.
Will follow you are good in explaining
I love your channel; clear, crisp and concise with supporting data. I follow many of the Doctors you reference but their shows are too long for a working person.
Excellent video. You backed up everything with video and studies
Hi Hihdhhsu, thank you for your kind comments
Blessings to you 🙏🏼💕
Great Video! Very detail, thank you. Interesting to know Dr. Sinclair is taking ALA.
Hi Gary, thank you for your supportive comments. It is true he does not mention it in his book.
Thank you sir. Been a student of my own health for the last three years. And yet, your video taught me two things I was unaware of. Hoping Hong Kong returns to democratic rule. Best regards...
Thank you as always :)
Hi Kimberly, thank you very much for your comment and support.
Very interesting presentation. Perhaps there are two other important reasons why ALA is important. The laboratory of Wayne Alexander (Emory University) published a comprehensive study of ALA able to induce PGC-1a which in-turn activates hTERT (enzyme that can add telomere length) in mouse arterial endothelial cells (published in Cell Reports). PGC1a is a known to induce mitrochondriogenesis. The abstract is given below. Also there was a publication of a study by Li Zi et al in high-fat fed rats that it inhibits mTOR-C1 which is critical in the aging pathway (rapamycin induces its antiaging effects through inhibiting mTOR-C1. I started taking ALA after reading these papers not because of its antioxidant effects, which even David Sinclair says is overrated,
Cellular senescence and organismal aging predispose age-related chronic diseases, such as neurodegenerative, metabolic, and cardiovascular disorders. These diseases emerge coincidently from elevated oxidative/electrophilic stress, inflammation, mitochondrial dysfunction, DNA damage, and telomere dysfunction and shortening. Mechanistic linkages
are incompletely understood. Here, we show that ablation of peroxisome proliferator-activated receptor g coactivator-1a (PGC-1a) accelerates vascular aging and atherosclerosis, coinciding with telomere dysfunction and shortening and DNA damage. PGC-1a deletion reduces expression and activity of telomerase reverse transcriptase (TERT) and increases
p53 levels. Ectopic expression of PGC-1a coactivates TERT transcription and reverses telomere malfunction and DNA damage. Furthermore, alpha lipoic acid (ALA), a non-dispensablemitochondrial cofactor, upregulates PGC-1a-dependent TERT and the cytoprotective Nrf-2-mediated antioxidant/ electrophile-responsive element (ARE/ERE) signaling
cascades, and counteracts high-fat-dietinduced, age-dependent arteriopathy. These results illustrate the pivotal importance of PGC-1a in ameliorating senescence, aging, and associated chronic diseases, and may inform novel therapeutic approaches involving electrophilic specificity.
After I read a similar industry paid for study, with all that interesting biology it concluded ALA was worthless! (Not mentioning what type was used in the so-called survey! Needed to promote corrupt / evil Big Pharma's $2,300 Syfovre.
I had covid and I still couldn't smell even strong fragrance. I was taking R&S ALA before, during and after covid. 600 mg per day. It made no difference.. still big problem with my sense of smell
As someone who took the plunge with the L variant in the not so recent past, owing to pretty much all the favourable characteristics you rightly highlighted, I feel modestly validated in my decision.
Factor that in with so many of the products sold on CZcams adverts that are just a vehicle for parting people from their money, without living up to any of their lofty claims, this production shows that not all mainstream media claims are wholly fanciful.
Because if Germans have been using it favourably for so long, it's more likely than not to have that all important word - ethicasy. On that score, this vid scores highly.
Thank you for all your researches. I'm taking ALA a few years now, other than anti-oxidant, didn't know there are so many benefits. I'm only taking 300mg, surprise to know Asprey taking 2g a day.
Hi Mark, thanks for your supportive comments. Yes it does seem to have many benefits in different areas.
Doctor said no point to take more that 800mg per day
@@angelsandocean2853 But what kind? S, or RS, mix or 10 times more expensive more effective R-ALA! One Doctor's CZcams video claims RS mix is not good? But what do I know?
I am using Alfaton 600 mg + 2 tablets of Neurorubine Forte every day for Diabetic Neuropathy.
It increases telomerase and lengthens telomeres for lifespan. Look up the research.
Thanks Richard. This is an excellent video. You mentioned that you are taking the mixed form of ALA and you showed two Doctor's Best brand of ALA. Are they both mixed form and which one are you taking?
Hi David, thanks for your kind comments. We are taking the mixed form, which is the first one in the description (I swapped them around to match the slide). The second link is to the R-Form.
Thanks ...for the lessons ..
Thanks for your kind comments
Hi, what’s your advice on taking ALA if you have a hyperactive thyroid?
Do you have a preference as to where you purchase ALA?
What is proper dosage?
This is interesting. My 78 year old mother had a mysterious virus last September that almost killed her. Her symptoms were very similar to Covid 19. She lost her sense of taste and smell and has yet to gain it back. It has had a negative impact on her life since she gets pleasure out of cooking and can’t taste anything she prepares. I’ll suggest she looks into this supplement.
Hi Nick, thank you for sharing your experience. The paper showed 61% of the trial participants showed an improvement. I hope that it works for your mother.
Nick, just wondering if your Mom took it and how she's doing
@@elisabethseaton6521 I suggested it to her but she wasn't open to the idea. She still doesn't have her smell back but occasionally gets a hint of smell from extreme scents like gasoline.
I took ALA over decade now, it enhance my mood and keep my blood glucose in a good level. When I am not taking it, I feel the difference...
Hi Kona, thanks for sharing your experience. It is good to hear you have a positive effect.
Tell me please which brand do u take and the dose
Only R-ALA has any benefits. S-ALA is synthetic, I took some made no difference for my trigeminal nerve pain. Only R-ALA is ok to take
👏🏾👏🏾
Will taking flaxseed oil provide the same benefits as ALA or R-ALA?
I take r-ALA in a stabilized form. Sinclair DID mention that this molecule binds itself onto heavy, toxic metals (mercury) sitting in the body and is then filtered out by the kidneys. Great, right? but what about the OTHER metals (iron, zinc, Mg, copper etc.) we need. Are these removed as well before they get to where the body needs them? At any rate, I've postponed my intake about 4 hours after taking any supplements or after eating anything so as not to disturb the metals getting to the bodily parts. What do you think? Thank you for the video and for your response.
What competes with absorption of ALA in digestion? Is it all foods and supplements or just some?
I'm trying to figure out what I can/cannot take it with.
Also: do any vitamins/nutrients enhance the effects of ALA?
Thanks for all the helpful info!
What have you found out about these questions?
Alpha Lipoic acid should be taken on an empty stomach because food decreases absorption. L carnitine and vitamin E work synergistically with ALA
can you take ala and mnm together at the same time？
Thanks. Great channel sir.
Hi Sway, thank you for your comment and glad to know you like our channel.
Blood pressure patient also take it?
Brilliant update..quick question...I do not plan to take nmn and all the other ones till I hit 40 but seems that ALA is something I can start. Is it good to take in your research ALA as is without any combination of supplements? Thanks
Hi Ankur, thanks for your kind comments and question. None of the research articles that I looked at were studying ALA in combination with NMN, they were stand alone. Please make your own choice if you see benefits in the effects that the papers describe.
@@ModernHealthspan thanks for the response, which ALA do you take Doctor's Best regular one or Stabilized R-Lipoic Acid with BioEnhanced one? Thanks
@Ankur Agrawal We take the regular one. As well as the link in the description there is also a 150 mg capsule. Doctor's Best, Alpha-Lipoic Acid, 150 mg, 120 Veggie Caps iherb.co/pNBQzcGd
@@ModernHealthspan I ordered the 150mg one and will start taking in the morning on empty stomach and will move up to 300mg and post that to 600mg over 6 months
Hi there ,
Are you taking Alpha Lipoic acid or R-Alpha lipoic acid 600g , which one is the best in bioavailability thank you very much for your reply in advance 🙏
R-ALA is best and read is the only form that should be taken because it's natural and S-ALA is synthetic.
When I take ala I get muscle cramps big time. I have taken biotin with ala I still get cramps. Any suggestions would be appreciated.
I have read that biotin uses up magnesium. You may need to either start taking magnesium if you aren’t taking it or look into increasing the dosage of magnesium
Ty
Hi Danielle, thanks
So are you now taking both ALA and TMG?
Hi Albert, thanks for your question. Yes, as they serve different purposes in the body, we are taking both. 600mg of ALA and 2.5g of TMG per day.
S-ALA vs. R-Alpha Lipoic Acid -- is the "R" worth the higher price over S-ALA?
I can only give you my personal experience on this - I have a mild form of neuropathy in my feet and legs and tried, by pure chance, the R form of ALA. Had results within a very few days. Then I bought the 'normal' kind (the other version was no longer on Amazon.it) and it didn't work at all. Sent it back and got the R form again.
How effective is Lipoic Acid for improving symptoms of nerve compression symptoms such as carpal tunnel?
Is there a difference in effectiveness between the R and S forms?
Hi thanks for your question. Unfortunately I don't know the answer to the first part. But on the second, yes, R is the form that the body uses and is at least twice as effective as the S form.
Am getting severe mouth ulcers while taking ALA. I am taking 600mg morning and 600mg evening on empty stomach. Can someone suggest how to take ALA with out getting mouth ulcers
I am not a Doctor but if I were you I would go down on the dosage. It is my understanding that we should not take more than 600 mg / day. Good luck!
So confusing 😭
You need to seriously work on your poor sound quality. Invest in a lavalier mic or other external microphone source. Watch most other videos on CZcams from various experts and listen to how much better their sound quality is than yours.
Wouldn't Alpha ketoglutarate just serve better the same purpose ?
Can you recommend a company selling ALA please?
hi Richard, get a better mic. it's difficult to listen to you.
haha, he didn't reply
ALA is well known autophagy inhibitor. Same time autophagy degrades damaged organelles, cell membranes and proteins, and electing against autophagy is thought to be one of the main reasons for the accumulation of damaged cells and aging. All modern Anti age protocols linked with autophagy activating example by rapamycin. Seems taking ALA is not good idea for longevity
Hi, thanks for your comment. Would you be able to share a reference for ALA as a inhibitor of autophagy? The papers I found seemed to say the opposite. www.embopress.org/doi/10.15252/embr.201949583
www.ncbi.nlm.nih.gov/pmc/articles/PMC6615199/
Modern Healthy HK Hi, yes. sure
"Alpha-lipoic acid inhibits lung cancer growth via mTOR-mediated autophagy inhibition" www.ncbi.nlm.nih.gov/pubmed/32090494
"Alpha-lipoic acid alleviated 6-OHDA-induced cell damage by inhibiting AMPK/mTOR mediated autophagy"
www.ncbi.nlm.nih.gov/pubmed/30986422
@@mymail3187 - It seems mixed. Other studies point to ALA promoting autophagy. From what I can tell, ALA regulates autophagy which means it can both increase and decrease it, depending on context.
"Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats"
www.ncbi.nlm.nih.gov/pmc/articles/PMC6615199/
"Alpha-Lipoic Acid Protects Cardiomyocytes against Heat Stroke-Induced Apoptosis and Inflammatory Responses Associated with the Induction of Hsp70 and Activation of Autophagy"
www.hindawi.com/journals/mi/2019/8187529/
Ben Steele 🤦♂️
Ben Steele would be nice if you check data how mTor impact on cell cycle. ALA stimulate wounds healing. if you check manual for rapamune you ll see that this medicine inhibit wounds healing. Guess why ? Ala can not block and stimulate mTor in the same time. All data should be checked for quality of evidence. I don’t have any questions about quality of data in the studies which I mentioned before
Are you looking younger though?
You mean L?
Studies done outside Sinclair’s lab have shown that Resveratrol doesn’t do anything. Dr Sinclair was even an author of one of the papers. Yet he keeps promoting Resveratrol because he is making millions off of selling his parents. He has lost his credibility.
I read that it's the effect of fluorescent light shining on the yeast. Maybe one should sleep with the fluorescent light on instead...
Dave Asprey is mega maniac
I suspect in Dr. Sinclair's attic is a portrait getting uglier and uglier.