267 ‒ The latest in cancer therapeutics, diagnostics, and early detection | Keith Flaherty, M.D.
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- čas přidán 31. 05. 2024
- Watch the full episode and view show notes here: bit.ly/3YBy1ti
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Keith Flaherty is the director of clinical research at the Massachusetts General Hospital Cancer Center and a previous guest on The Drive. In this episode, Keith first delves into the statistics on cancer's prevalence as we age, underscoring the significance of finding effective treatments and early detection methodologies. He touches on the history of cancer therapeutics and illuminates the notable enhancements in cancer therapy within the last decade that are setting the stage for a promising future. He goes into detail on the potential of immunotherapy and therapies that can combat cancer’s evasive tactics while explaining some of the existing challenges around specificity, cost, and scalability. Additionally, Keith highlights the significant leap in early detection methodologies, namely liquid biopsies, which have the potential not only to determine if a cancer is present in an early stage, but also identify the possible tissue of origin.
We discuss:
0:00:00 - Intro
0:00:40 - Keith’s interest and expertise in cancer
0:04:55 - Cancer deaths by decade of life, and how cancer compares to other top causes of death
0:10:33 - The relationship between hormones and cancer
0:18:42 - The link between obesity and cancer
0:23:40 - Current state of treatments for metastatic cancer and reasons for the lack of progress over the decades
0:35:19 - The interplay between the immune system and cancer cells
0:44:29 - Different ways cancer can suppress the immune response, and how immunotherapy can combat cancer’s evasive tactics
0:59:30 - Elimination of a substantial portion of cancers through immune cell engineering faces challenges of specificity, cost, and scalability
1:10:15 - Why TIL therapy isn’t always effective, and the necessity for multimodal therapy to address various aspects of the cancer microenvironment
1:31:49 - The challenge of treating metastatic cancer underscores the importance of early detection to improve survivability
1:38:36 - Liquid biopsies for early detection of cancer and determining the possible tissue of origin
1:49:21 - Commercially available cancer screening tests
1:57:21 - How to address the disparity in cancer care, and the exciting pace of progress for cancer detection and treatment
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Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
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In this episode, we discuss:
0:00:40 - Keith’s interest and expertise in cancer
0:04:55 - Cancer deaths by decade of life, and how cancer compares to other top causes of death
0:10:33 - The relationship between hormones and cancer
0:18:42 - The link between obesity and cancer
0:23:40 - Current state of treatments for metastatic cancer and reasons for the lack of progress over the decades
0:35:19 - The interplay between the immune system and cancer cells
0:44:29 - Different ways cancer can suppress the immune response, and how immunotherapy can combat cancer’s evasive tactics
0:59:30 - Elimination of a substantial portion of cancers through immune cell engineering faces challenges of specificity, cost, and scalability
1:10:15 - Why TIL therapy isn’t always effective, and the necessity for multimodal therapy to address various aspects of the cancer microenvironment
1:31:49 - The challenge of treating metastatic cancer underscores the importance of early detection to improve survivability
1:38:36 - Liquid biopsies for early detection of cancer and determining the possible tissue of origin
1:49:21 - Commercially available cancer screening tests
1:57:21 - How to address the disparity in cancer care, and the exciting pace of progress for cancer detection and treatment
Peter Attia is a modern-day superhero. His superpower is a combination of intense passion, incredible intelligence, and an unstoppable drive. He is a force of nature in the world of medicine and is doing so much good. I'm reading his book now and it's phenomenal. He really gives me hope for the future of health care. Medicine 3.0 is on the way!
On my way to my yearly cystoscopy. Six years clear since bladder cancer treatment! Yea, fingers crossed.
Hope good news again 😊
Congratulations! I am 23 years clear of bladder cancer. My warning to everyone is: blood in urine with no pus or pain equals cancer. My doctor wasted time treating me for an infection because he couldn't wrap his head around the idea of bladder cancer in a patient 48 years old. He was a good doctor though. It's hard to be a urologist and have to deliver bad news to patients all day long. I had a customer who procrastinated while peeing out lots of blood clots and ended up losing his bladder.
Ah! Thank you!! I thoroughly enjoy your podcasts. I find myself going from re-reading a chapter in your book Longevity to rewatching an episode. Absolutely insightful and inspiring ❤
Speaking as a clinical Hematopathologist practicing at a national laboratory, this was a great interview that highlighted the importance of further developing and focusing on diagnostics at this juncture in the saga of cancer therapeutics. Having incorporated next-generation sequencing (DNA and more recently RNA) into our diagnostic hematopathology reports over the last 5+ years has done a great deal to allow us to not only more specifically diagnose leukemia or myeloid/ lymphoid neoplasms, but also to provide prognostic information in those patients on whom neither leukemia nor a myeloid/ lymphoid neoplasm has arisen yet. I am excited to see how we can further incorporate advancements in this field to even better prognosticate (and accordingly, prescribe guidance on the frequency/ closeness of follow-up) for those patients in whom leukemia/ lymphoma or its precursors have not yet arisen. Great interview.
"Men have the highest rate of prostate cancer when their testosterone and DHT levels are at their lowest, in old age." - Yeah, but you're not taking into consideration that the old man had decades of his prostate cells being under oncogenic stimulation from those same hormones, while the young man has only a decade or so of that. HUGE difference. I don't understand why it's so difficult for people to understand the concept of damage accumulating over long spans of time, that you cannot establish a cause-and-effect link between things without taking into consideration time elapsed. It's like when people say that telomere shortening is the cause of ageing because young people have long telomeres and old people short telomeres, when they forget that young people have been around for a lot less long time so they have accumulated a loss less DNA damage, a lot less misfolded proteins, and have undergone a lot less epigenetic drift from having to constantly repair DNA damage(and telomerase actually accelerates the methylation clock). Correlation and causality are two different things. This is logic 101, but who even studies the branch of philosophy and mathematics known as logic nowadays?
Explains why cancer has flourished after the COVID shots - immune suppression.
Hi Peter I found you on Andrew and Tim’s channel. Absolutely love your knowledge and how you explain things. Thank you for sharing so much valuable information to general people who don’t otherwise have access to these resources
Great discussion
Delfi was the most interesting thing I saw at AACR this year
Is there a modern version of the book "The transformed cell" by Rosenberg and Barry?
What about the Differential Stress Resistance Hypothesis and cancer treatment?
Great lecture on the basics of immunotherapy - thanks for having Dr Flaherty on. I find few podcasts which really get into the path/phys of cancer - thank you!
Have I heard correctly that immune therapy overall didn't pay the investment and now metabolic paths are in the focus? Even idea of pulse therapy was mentioned?
That sound more what Dr Seyfried is saying for years...
The people who have followed Dr Seyfried and colleagues research need to be listened to! Results are visible and give better quality of life and in a lot of cases, longevity! Not Early death!
Thanks docs. Grateful.
Can someone help? Three oncologists denied that the Warburg Effect is happening in my wife’s breast cancer. Is there a new study?
Have you listened to Thomas Seyfried talks on metabolic therapies? I don’t understand why more doctors don’t talk about it. Oh yeah! There’s no money in it
So basically every time the US Presidential Primaries are starting to come into view, I'll be looking out for another one of these updates. lol Thank you guys for sharing!
What about incurable cancer like mutiple myeloma mantle cell lymphoma .
Why is there never mention about prevention. If early screening is so go why are the deaths so high ?? Screening = profits
because in a huge percent of cancer cases, the patients have no risk factors
How many are living healthily? Whole Foods, sleep, movement, social and physical environment etc etc drinking? obese? Stressed? Unhappy?
And I acknowledge that “healthy” people get cancer
What is going wrong?
I'm new here, just wondering, is chemotherapy ever used as a preventative treatment in healthy patients? Would an every 5 year regiment of chemo starting at age 50 help weed out some of these microscopic-metastatic cases that are currently very difficult to detect?
Worst case scenario here would be a patient who would hypothetically never get cancer in their life. Would this hypothetical treatment shorten their life and shorten their life enjoyment? if so by how much? would it be worth it?
listening further along here and it sounds like a robust immune system may do a good job already at preventing cancer... and chemo would hurt that system... so may hurt the overall goal of preventing cancer.
Chemo is poisonous...we sign a waiver should chemo give us a new cancer....all the side effects from chemo are early stages of bone cancer, brain cancer, lung cancer etc... these are new cancers because the chemo destroys all your good cells. My oncologist didn't explain what I learnt after chemo...they gloss over it. Chemo is a catch 22.
Are mammograms very effective in early detection? I’ve heard about a better machine for detection.
Ultrasound, for dense breast tissue
Does moderate to heavy alcohol consumption contribute as an independent risk factor in cancer?
Yes, Ethanol is considered a probable carcinogen. While light drinking might not significantly increase the risk for development of various cancers, heavy and possibly moderate drinking can increase said risk.
X cures as a platform can scale expertise
If you will
Listening to Flaherty was like listening and watching Michael J Fox. He was all over the place with what he had to say and was so animated, I could hardly follow him. His hands were waving, he talked as if he had drunk 40 cups of coffee, thus, unfortunately a lot of what he had to say was lost. He was very difficult to understand.
You talk about using standard chemo drugs when cells are still at the microscopic level. But is there any evidence this would work? Chemo only works on fast growing cells. Are they fast-enough growing at the microscopic level? And chemo doesn't kill cancer stem cells, so is there even a benefit to killing the daughter cells if you aren't treating the stem cells? It makes me crazy that there are numerous papers and conferences on how what is needed is a way to kill the cancer stem cells, yet you doctors never talk about them. Ever.
Just give us a protocol please 😢 Long covid is going to escalate cancer in the next decade dramatically
Long civid aged me. Weight gain. Muscle wasting. Lung weakness. Serious fatigue. Exercise a 'no way'. Price gouging delivery charges. Depression. Lonliness. No medical care. Gov't agencies shutdown. Check dont come. Id theft. Records tampering. Familial breaķown. Trans agenda escalating endangerment and harassment. Street mobbings. Home insurance tripled. Can't get affordable help cuz no one wants to work. Hustlers like carpetbaggers everywhere. Racism and sexism back in vogue. Dumbed down kids. Everyone is scared.
You mean vaccines?
Not long covid - long vaccine!
Sit down@@Thomas-wz2nu
“Why not both?”
I found your speaker very wishy washy and not specific
I don't think you appreciate what medicine is then.
@@bhylton86 I have cancer and it is stage 4 do not give me your wasted comment
blah blah.. reductionist blither blather. nothing useful said here unfortunately.
please find an expert speak a full sentence without pause of Uh, like, or break a sentence into 10 phrases
I have been very interested in training as an oncologist since high school, but my friend in medical school dissuaded me saying it is very depressing and has very low job sanctification. Is this true?
How much time has been spent looking for a cure? While the cancer death rates go up? Go figure