Nick Lane: Origin of the eukaryotic cell

Sdílet
Vložit
  • čas přidán 26. 06. 2017
  • Dr Nick Lane's lecture at the Molecular Frontiers Symposium at the Royal Swedish Academy of Sciences, Sweden, May 2017. The topic of the symposium was "Tailored Biology". Check our CZcams channel for more exciting science videos! For more information, visit www.molecularfrontiers.org
  • Věda a technologie

Komentáře • 231

  • @goobah01
    @goobah01 Před 5 lety +34

    Nick Lane is pretty good speaker. This is a really well organised and informative lecture.
    But read his books. The books are absolutely stunning.

    • @Elephantine999
      @Elephantine999 Před 10 měsíci +1

      The advantage of reading his books is that you can take it all in at an easier pace than he is going in this lecture! He has so many ideas and stories. Fascinating guy talking about fascinating stuff.

  • @robbie_
    @robbie_ Před 6 lety +4

    Very good. Thanks for sharing.

  • @travellingonuptozion5658
    @travellingonuptozion5658 Před 3 lety +2

    Thanks for sharing the details

  • @PhilipSalen
    @PhilipSalen Před 4 měsíci

    Nick Lane is one of the best lecturers about cell and molecular biology that I have ever heard. This is no surprise because all of his books are uniformly fascinating; Life Ascending is my favorite.

    • @rl7012
      @rl7012 Před 4 měsíci

      They are uniformly full of word salads, avoidance, stating the obvious and avoiding any real information as to the origin of life.

    • @mcmanustony
      @mcmanustony Před 4 měsíci

      @@rl7012 feel free to fill in the gaps with your own research

  • @neerajlivesinindia
    @neerajlivesinindia Před rokem

    Amazing lecture

  • @marc-andrebrunet5386
    @marc-andrebrunet5386 Před 5 lety +4

    I really love this lecture because👉 Rocks and Chemistry Makes Good Biology !! 📊 Bravo Nick your lecture is the Best, that's my fourth time viewing in 4 different place, Bravo again👍

  • @maxdoubt5219
    @maxdoubt5219 Před 6 lety +8

    We're closing in on LUCA. Very exciting!

  • @robertdavenport7802
    @robertdavenport7802 Před rokem +1

    It is different to say complex cells arose only once and only one lineage of complex cells survived. It may be that once in a great while these symbiotic events occurred, but once it successfully occurred once, that all subsequent attempts failed because the created ecological niches were filled. In any event, these must be extremely rare but non-zero chance events, and we are lucky to be here at all...

  • @lastchance8142
    @lastchance8142 Před 3 lety +3

    Nick Lane is brilliant, articulate and an interesting speaker. He, like all other OOL scientists is doing his best to explain the unexplainable. Nobody was there, no fossils exist, and no similar process is happening now. But since mitochondria have the same size, shape and membrane construction as bacteria...It's as good a theory as any. Unless one invokes special creation at this point in evolution, there may be no other option.

    • @Nagy50Magyar
      @Nagy50Magyar Před 3 lety

      Oh, absolutely no option at all, except for the far more absurd idea of nothing needed to create that creator.

    • @lastchance8142
      @lastchance8142 Před 2 lety

      @@Nagy50Magyar The idea of a First Cause is eminently scientific! Ascribing religious myths and dogmas to the idea is another story. But everything we know from science and physics demands causality. No physical process, including quantum effects, proceeds from a state of nothingness.

    • @Nagy50Magyar
      @Nagy50Magyar Před 2 lety

      @@lastchance8142 First cause is not only unscientific, it is illogical. The argument is self contradictory.
      1. Everything had to have a cause.
      2. Causes cannot regress to infinity, so there had to be an ultimate (first cause).
      The contradiction you cannot see is that you must create an arbitrary exception to your first statement. You are a spectacular idiot.

    • @lastchance8142
      @lastchance8142 Před 2 lety

      @@Nagy50Magyar Ha! I hadn't considered the possibility that I am a spectacular idiot! That may be the end of the matter. However, your argument against a first cause presumes that causes MUST regress to infinity. Have you contemplated the implications of that assertion?

    • @emmashalliker6862
      @emmashalliker6862 Před 2 lety

      Spectacular misrepresention of the first cause arguement. If you read some Thomist thinkers perhaps they could help you get a better understanding.

  • @A3Kr0n
    @A3Kr0n Před 4 lety +2

    "This isn't working". If I had a nickle for every time I heard that during a lecture...

    • @worfoz
      @worfoz Před 3 lety

      the pay-out system isn´t working either.

  • @petermiesler9452
    @petermiesler9452 Před 4 lety +1

    28:00

  • @user-cn2sr6nv7n
    @user-cn2sr6nv7n Před 6 lety +5

    Oxygen:the molecule that made the world ⭐️⭐️⭐️⭐️⭐️

    • @b.griffin317
      @b.griffin317 Před 4 lety +2

      and nearly destroyed it a couple of times

    • @FdaApprvd
      @FdaApprvd Před 2 lety +1

      Oxygen is not a molecule. It’s an atom

    • @HotelPapa100
      @HotelPapa100 Před 11 měsíci

      @@FdaApprvd So you don't respire oxygen from the air?

  • @jesslyn4919
    @jesslyn4919 Před 3 lety

    #AwarenessConsciousness

  • @myopenmind527
    @myopenmind527 Před 4 lety +1

    In the transition from low entropy universe to a high entropy universe, life is an efficient adventure probably inevitable #catalyst which accelerates that process. (Speaking metaphorically).

    • @johnschlottman619
      @johnschlottman619 Před rokem

      That's doubtful / dependent on scale. Evolution takes place in an environment of inconsistent pressure 'to use less energy', in effect 'stating' outright 'Okay, here's a ton of extra energy: use it, waste it, let's see what you can do with it'. My God every presentation ever on the subject always includes mentioning gobs and gobs of ways that 'organisms' of all kinds come about, various coming up with 'their own' means of making a living, that survive - meaning essentially each strain is another quasi-experiment: and most definitely not all masters at 'energy savings', not by any means... so by default 'evolving in' something else. 'Energy-expensive pseudo-experimentation plus alpha' is going on. That 'plus alpha' led to us multi-cellulars.
      The 'reduction in genes' need have little to do with 'become more energy efficient'; I get the feeling the real pressure on the genes is more like 'if the useless data crap goes away, I get by just fine', and I suspect something else in there - maybe the interactions between the 'mitochondria' and the original host? In any case it all just had to happen in ONE lineage, in ONE eukaryote - to explain ALL CURRENT eukaryote - i.e. eukayotes themselves all tracing back to one bottleneck / common ancestor. Maybe the 'large host' somehow 'predated out / leached out / starved out' all the superfluous genes.... I wonder. It's arrarent to me that it's NOT an 'energy use' issue, perhaps a 'data + alpha' issue, or something else.
      What do you think?
      All this 'life evolves to save energy' hot wind seems to me no more than a long-time, popular fad of lazy thinking among science students; mostly NOT a logic-based explanation of evolution reality.
      I have spoken 😁

    • @myopenmind527
      @myopenmind527 Před rokem

      @@johnschlottman619 life exists to use energy and increase entropy.

  • @philsmith7398
    @philsmith7398 Před rokem +1

    Wait, has this guy got just the one talk?!

    • @mcmanustony
      @mcmanustony Před rokem +1

      No. You're thinking of creationist Stephen Meyer...... "inside the cell we find digital code with nano technology inside the cell with characters in a machine code digital information inside the cell with digital information find digital code with nano the cell miniature miniature machines inside the cell digital information miniature machines inside the cell in a machine code digital information find digital code with nano the cell miniature miniature machines inside the cell digital information miniature machines.......blah blah....in Jesus name, Amen"

    • @rl7012
      @rl7012 Před 4 měsíci

      @@mcmanustony No he isn't, Nick Lane has only one line of bs to push.

    • @mcmanustony
      @mcmanustony Před 4 měsíci

      @@rl7012 and you expect a grown adult to believe a howling moron such as yourself is in a position to evaluate the research of a distinguished biochemistry professor.....
      He has published 5 books (and dozens of papers, none of which you've actually read). Can you rate the 5 in order of weakness?
      Do you do kids parties?

  • @derrickbonsell
    @derrickbonsell Před 3 lety +7

    At least British schools teach evolution...

  • @AndreyBogoslowskyNewYorkCity

    If the individual cell “makes a decision” to run away from hot environment or polluted environment my willful decisions a.k.a. consciousness is also a chemical reaction plus micro electricity.
    It seems that consciousness is a …complex machine #Bogoslowsky

  • @longcastle4863
    @longcastle4863 Před rokem

    So right off the bat, the very first scandal was _sex._

  • @RonJohn63
    @RonJohn63 Před 5 lety +4

    14:44 I don't know, therefore God. Or space aliens.

    • @b.griffin317
      @b.griffin317 Před 4 lety +1

      or....give me more money. the other god.

    • @lastchance8142
      @lastchance8142 Před 3 lety

      The problem with special creation and/or intelligent design arguments is that no mortal can know when, or by what methods the higher being intervened in creation. Making dogmatic assumptions is silly and counterproductive to knowledge. I myself believe there must be a First Cause, but that is all I am dogmatic about.

    • @edenrosest
      @edenrosest Před 2 lety

      ​@@lastchance8142It is kind of hypocritical because
      the "First Cause" is the most critical part that will be all about the life.

    • @lastchance8142
      @lastchance8142 Před 2 lety

      @@edenrosest not sure I understand what u mean..?

    • @simplejack2136
      @simplejack2136 Před 2 lety

      Let me fix it a little bit for you "i don't know, therefore I can't exclude god. Or space aliens".

  • @esrefcelikcelik8789
    @esrefcelikcelik8789 Před rokem +1

    There are also millions maybe billions of holes or gaps to be filled with ideology and (dis)belief.
    My body is my life carrier, but it is not the whole of me.

    • @mcmanustony
      @mcmanustony Před rokem

      Is this supposed to mean something? It just reads like vacuous drivel.

  • @davidwilkie9551
    @davidwilkie9551 Před 2 lety

    The life of meaning, (might be Vogon Poetry), could start with bio-logical clocking recombinant Superposition-point Singularity Superspin re-evolution cause-effect of e-Pi-i omnidirectional-dimensional logarithmic interference positioning that is i-reflection containment time-timing.
    And under the circumstances, the Holographic Principle Modulation Mechanism Image condensation is self-defining in/of complete explanation.., here-now-forever.
    It has to be self-consistent with WYSIWYG QM-TIME resonance floating in flat-space ground-state No-thing-defined eternally, and so is just about the most "unsatisfying" answer intellectually, because it's constant condensation circulation sequences of divergence-convergence perspectives, Quantum-fields Chemistry and "dumd luck" of pseudo random cycles of Uncertainty. It's always NOW.., and that is that.

    • @SMHman666
      @SMHman666 Před 2 lety

      David Wilkes Don't take offence but what a pile of f**king drivel.

    • @ansfridaeyowulfsdottir8095
      @ansfridaeyowulfsdottir8095 Před 2 lety

      You'd need an Infinite Improbability Drive for that.
      {:-:-:}

  • @johnm.6975
    @johnm.6975 Před 3 lety +1

    Lmfao

  • @TheSdzfr
    @TheSdzfr Před 2 lety +1

    Alright, but why didn't photosynthesis evolve multiple times.
    All chloroplasts are descendants of ancient Cyanobacteria, why didn't Thylakoids evolve in Eukaryotes?

  • @thomashess6211
    @thomashess6211 Před 3 lety

    We all know things get more complex over time.

    • @mcmanustony
      @mcmanustony Před 2 lety

      who is "we"?

    • @johnschlottman619
      @johnschlottman619 Před rokem +1

      Not so, Thomo: think about scale; parasites; cave-dweller descendants; and other myriad ways in which genomes shrink.
      There's no reason even tax codes might undergo (have undergone, somewhere) simplification. Both increases and decreases happen, 'exclusive catagorical statements' cannot be made.
      I have spoken. 😁😁

  • @SolaceEasy
    @SolaceEasy Před 3 lety +1

    Develop morality in preparation for the coming AI singularity.

  • @ardd.c.8113
    @ardd.c.8113 Před 2 lety +3

    on the question why bacteria only formed eukaryotes once is simple: competition. microbal eukaryotes exist and bacteria can't compete with them on a multicellar level in the ecosystem; the roles in microbal societies have become fixed. further more there's probably a high level of co-operations among them; symbiosis. When society works together they can conquer the world

    • @rl7012
      @rl7012 Před 2 lety +2

      That does not answer the question at all. How did eukaryotes first form is the question. Saying 'competition' caused them to exist is a ridiculous answer. If eukaryotes don't exist, then how can completion bring them into existence? Can competition bring dragons into existence too then? Wake up will you.

    • @noelcruz6226
      @noelcruz6226 Před 2 lety

      "If it could be proved that any part of the structure of any one species had been formed for the exclusive good of another species, it would annihilate my theory, for such could not have been produced through natural selection" (The Origin of Species, 1859, Masterpieces of Science edition, 1958, p. 164). Symbiosis... The last nail on the coffin... The annihilation of The Theory of Evolution... More like The Hypothesis of Evolution... The tittle of the video is misleading, he picked a well thought bait... He used the word... Origin... You see, the study of the Origin of Life (Ool) is another field by itself, he mixed adaptation with origins, and that's misleading, you can't adapt a language to another one if first you don't have the building blocks in the first place and some basic rules, like developing an alphabet, then some grammar rules for sintax to create sense an order, then you can translate into another language, etc. Some degree of adaptation among intraspecies is a whole different universe than saying transpeciation by natural selection.

  • @andreybogoslowsky
    @andreybogoslowsky Před 10 měsíci

    читал недавно ученых которые предсказывают статистику на 2023-й год и по-моему они правы что единственная программа которая приносит новых учеников/клиентов это TikTok.
    Всё остальное это наддуваловка💰обман 🙀

  • @johnschlottman619
    @johnschlottman619 Před rokem

    OK, BUT: Reaching 'a culmination/climax point' in your presentation was OK; but that isn't the most effective 'ending'.
    Summarizing / repeating back once the main points you accumulated over the course of your speech, would have been better: as that would be a most excellent way of reaffirming and accenting the points made, and cementing it in the minds of your student-listeners (i.e. all of us listener/recipients). Still, indeed, thanks fo the video 😄😄😄, and I want to encourage you further.

  • @hainetkorea
    @hainetkorea Před 2 lety

    The Origin of Life is Chemical Synthesis.Marine algae(green seaweed):Cellulose is a cell

    • @rl7012
      @rl7012 Před 2 lety +1

      Totally and utterly wrong. Learn some basic chemistry and maths and you will discover the chances of something like that happening are zilch. Where did the information in the cell come from then? Have you any idea just how complex even the simplest cell is? The best scientists in the world in the best labs in the world still cannot create a cell from scratch. And that is with all the knowledge and equipment. Science has no idea how life first came to exist.

  • @noelcruz6226
    @noelcruz6226 Před 2 lety +3

    And... After 44 min... We are still waiting for the explanation OF THE ORIGINS, not "adaptive" or "evolutionary must have" remarks and opinions, and other "not working" stufff...

    • @mcmanustony
      @mcmanustony Před 2 lety

      Sober up ad try watching again.

    • @rl7012
      @rl7012 Před 2 lety +1

      @@mcmanustony You can watch it how many times. you like and the guy still does nothing except muddy the waters, answer no questions, and just provides a word salad of nothing that he thinks sounds clever.

    • @mcmanustony
      @mcmanustony Před 2 lety

      @@rl7012 Word salad? I guess everything sounds like word salad if you try to learn science from the backs of cereal packets.

    • @noelcruz6226
      @noelcruz6226 Před 2 lety +1

      @mcmanustony, since you opened up your a** and said sh*t... Why don't you help your friend Nick and pinpoint the EXACT minute where he supposedely addressed the transition between non-living matter and living matter. Since you are such a good brown noser with Nick and "have a good knowledge" about Origin Of Life scientific advancement, why don't you help him by trying to "explain" all the non sense he talked, since all that he did was deflecting from explaining the REAL hook, bait and sinker that he used in the title to lure some of the serious Origin Of Life (Ool) debaters out there... By the way, I don't do Alcohol, Tobacco or any illicit drugs, perhaps you are an expert user on those toxins and poisons, but not every body is that uneducated... Before even thinking to reply, consider this: I hold over 120 credits in Civil Engineering, over 50 credits in Humanities and Philosophy, a BBA in Financial Accounting and a MPH in BIOSTATISTICS from a Medical Sciences Campus... If you have anything INTELLIGENT, EDUCATED & RESPECTFUL to say and have THE PROPER QUALIFICATIONS to engage on this kind of debate, I MIGHT consider having a Friendly Discussion with you. I you fall short, then, this is it.

    • @mcmanustony
      @mcmanustony Před 2 lety

      @@noelcruz6226 "a** and said sh*t.."- you mean "ass and shit"- and you're wrong.

  • @Itsuser_1234
    @Itsuser_1234 Před 3 lety

    All these scientists don’t know how to speak plainly.

  • @bobdobbs943
    @bobdobbs943 Před 2 lety +2

    he thinks this is all some happy accident.

    • @mcmanustony
      @mcmanustony Před rokem

      No he doesn't.

    • @bobdobbs943
      @bobdobbs943 Před rokem +1

      @@mcmanustony Then someone designed everything. Thats good to know.

    • @mcmanustony
      @mcmanustony Před rokem

      @@bobdobbs943 that doesn’t follow. Your comment is absurd.

    • @bobdobbs943
      @bobdobbs943 Před rokem +1

      @@mcmanustony If its not a happy accident, then it was on purpose. You must be an evo person. They have trouble defending the impossible.

    • @mcmanustony
      @mcmanustony Před rokem

      @@bobdobbs943 "Accident" suggests there was some legitimate reality from which life is a deviation- as if there was some way things were supposed to be. What is that? How do you know?
      Defending the impossible is....ummm....impossible. Evolution does not need defending as it has been observed repeatedly in real time.
      You seem a bit stupid. Do you know how books work?

  • @ansfridaeyowulfsdottir8095

    I wanted science, not a stand up comedian.
    {;-;-;}

    • @rl7012
      @rl7012 Před 2 lety +1

      It is not even funny though, just drivel and waffle and 'look at me trying to sound clever'. He just spouts a word salad but does not give the answers he claims to.

    • @ansfridaeyowulfsdottir8095
      @ansfridaeyowulfsdottir8095 Před 2 lety +1

      @@rl7012
      Ain't it the truth?
      {:-:-:}

  •  Před 4 lety +13

    I used to believe all this, until I watched a few lectures of James Tour. Then it became very clear to me, that we know absolutely nothing about the origin of life, or of the eukariotic cell for the matter.

    • @jomen112
      @jomen112 Před 4 lety +20

      Rather James Tour knows nothing, or want us to believe this to be the case. Imo he is full of bs, misrepresentations and pretend we know nothing when we do know something. The fact is that there are many suggestion on how to life came to be, the problem is that biologist does not know how to exclude one suggestion from another and this is something James Tour carefully avoids mentioning to his ignorant audience which he wants to misslead with his nonsense.

    • @Thethinker1124
      @Thethinker1124 Před 4 lety

      What if the photon and Earth magnetic field is the key to cell division.

    •  Před 3 lety +3

      @Victorious Yankee Tour has arguments. You have none. Diffamation is not an argument.

    • @rl7012
      @rl7012 Před 3 lety +4

      @@jomen112 So the basis of you disrmissing what Tour says is that are 'many suggestions' to how life formed??? How on Earth is that any kind of scientific refute? You dismiss actual science for the 'many suggestions' and then you act like this is enough to act superior on the subject? James Tour is light years ahead of the no brain faith based conventional theories of something from nothing explanation.. Tour deals in science, but it seems like you deal in wishful thinking.

    • @jomen112
      @jomen112 Před 3 lety +5

      @@rl7012 That is not is not my claim. My claim is that there exists knowledge that James Tour dines exists. To say we know "nothing" is nothing less than misinformation. Hence my statement that James knows nothing or lies.

  • @pkrpdl7325
    @pkrpdl7325 Před 2 lety

    Can please anyone answer me on 1 question?
    How did human as a mammal shift in diet preference? Are human really an omnivorous or is it just a societal construct in view of survival of fittest? How mammals had been differentiated into carnivores and also as herbivores in natural selection process? This doesn't make sense. Unlike today world where cows are fed with meats. Lets kill all vertebrates and invertebrates below us for survival. Dietary preferences for survival doesn't make any sense in evolution. Just a fossil and observational findings in eukaryotes doesn't confirm evolution. Evolution theory need modification

    • @rl7012
      @rl7012 Před 2 lety

      Human diet has always been animal based. This plant based diet pushed today is fairly new and not natural to our bodies. How do you think humans survived the ice ages with no plants etc. They ate animals and animal produce. That is what our bodies crave most and thrives on. Veganism is the most unnatural diet known to man and very unhealthy too.

    • @rl7012
      @rl7012 Před 2 lety +1

      @@TheAlmostFunnyGuy If Veganism were healthy and natural then there would be no need for them to require so many supplements. Like it or not human beings are natural carnivores and we would not have survived or evolved as we have if our ancestors ate a vegan diet.
      You can still be healthy as a vegetarian if you include animal produce like eggs and cheese and if you can include fish even better. But the king of nutrition is meat. Especially red meat.

    • @johnschlottman619
      @johnschlottman619 Před rokem

      Lotsa primates are omnivorous; so are humans. That we can digest all that stuff (and only 'very dgestible' plant matter (fructose, etc, not cellulose) is the biggest clue.
      As for 'diet preference shift': well, humans are certainly the sensei-masters there; but even primates (and I imagine very many mammals; I have no time to check) even do pretty well with that when environment circmustances change.
      As for our comparative 'sensei-level diet mastery': the house-mouse bookshelf of diet books is quite light.

  • @blulagoon21
    @blulagoon21 Před 3 lety +1

    Where do they get these "Billions of years" from. Can they prove it ?? No, they can't !!

  • @FXNorm
    @FXNorm Před 4 lety +2

    Sorry, evilution is dead.

    • @mcmanustony
      @mcmanustony Před 3 lety +4

      Given that new research on evolution in a dozen or more branches of science is continuing you would appear to talking out of your arse.

    • @johnbrinsmead3316
      @johnbrinsmead3316 Před 3 lety +1

      because the frequency of heritable changes within a biological population doesn't change over time?

  • @simplejack2136
    @simplejack2136 Před 2 lety +1

    Why is he allowing only the possibility of evolution? Why not intelligent design for example?

    • @mcmanustony
      @mcmanustony Před 2 lety

      Because its religious dogma crudely disguised as science. There's not a shred of evidence for it.

    • @rl7012
      @rl7012 Před 2 lety +2

      Because he is a brainwashed leftie puppet who dare not question the orthodox religion of so called 'science'.

    • @mcmanustony
      @mcmanustony Před 2 lety

      @@rl7012 " leftie puppet"-can you give a timestamp where he identified his politics? Were you tripping?

    • @spatrk6634
      @spatrk6634 Před 2 lety

      because evolution is real. intelligent design is pseudoscience.

    • @rl7012
      @rl7012 Před 2 lety

      @@spatrk6634 There is no evidence whatsoever for macro evolution. Micro evolution there is. Man has known for centuries, probably thousands of years that evolution exists. They may not have called it evolution, but they knew it existed or they would not have been able to breed different wheats and plants and farm animals etc. But macro evolution has zero going for it. What is pseudoscience is that a bacteria magically appeared billions of years ago and then eventually turned into a fish that eventually waddled out of a murky swamp, magically grew legs and lungs, became a dinosaur and then a bird. That is complete and utter bs.

  • @rl7012
    @rl7012 Před 3 lety +1

    What a load of bollocks and wishful thinking. And he still doesn't answer the origin of eukaryotic cells, he just muddies the water instead.

    • @worfoz
      @worfoz Před 3 lety +5

      It is a talk about the origins, not The Answer to Life and Everything.
      The answer you are looking for is 42.
      Enjoy.

    • @rl7012
      @rl7012 Před 3 lety +1

      @@worfoz 'The answer to life'?? WTF are you about? I commented on, the lack of any real answer to the origins of eukaryotic cells. Learn to read properly will you?

    • @worfoz
      @worfoz Před 3 lety +3

      @@rl7012 what a loaf of bollocks, again
      42
      not shut up

    • @rl7012
      @rl7012 Před 3 lety +1

      @@worfoz
      You have no rational argument so you resort to insults and tired old Douglas Adam quotes. And you can't even insult me properly you use the words I use to you, back at me.
      Grow a brain cell little sheep and use your own material. You have answered zilch. We still don't know where eukaryote cells come from and you refuse to see that your utter blind faith in non sensical explanations keep you ignorant..

    • @spatrk6634
      @spatrk6634 Před 3 lety +1

      @@rl7012 we dont know where eukaryotic cells come from. we are pretty sure they come from endosymbiosis