ASCO2022 DESTINY BREAST 04 - How can we interpret a trial without pre or post treatment information?
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- čas přidán 9. 07. 2024
- Vinay Prasad, MD MPH; Physician & Associate Professor
Google Scholar: scholar.google.com/citations?...
Substack: vinayprasadmdmph.substack.com/
Podcast: podcasts.apple.com/us/podcast...
Personal Website: www.vinayakkprasad.com
Laboratory Website: www.vkprasadlab.com
Podcast Website: www.plenarysessionpodcast.com
Academic Publications: www.vinayakkprasad.com/papers
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Twitter @vprasadmdmph
I’m not a doctor, I’m a breast cancer survivor…I tried to keep up with this but obviously, I’m not your target audience! I love your podcasts and believe you are very knowledgeable and forthcoming in your opinions. Have you ever stumbled across any studies linking breast cancer to oxalates in diets? Some people posted them on integrative support groups along with links to studies. I couldn’t be more confused because almost 80-90% of my anti-cancer diet (recommended by other cancer survivors because my oncologist doesn’t think diet matters too much and the Director of Oncology generally suggests a Mediterranean diet)! If high oxalate diets cause microcalcifications and tumor growth in mammory glands of mice, then I have been boosting my risk not reducing it! I’m the reason I’m asking you is because you are so intelligent in reviewing what studies actually prove. Help!
Why did TNBC pts receive prior endocrine tx? My immediate thought is that they were likely previously ER+ , rebiopsied in metastatic setting which demonstrated TNBC. e.g. Perhaps they had endocrine/CDK4/6i as 1L metastatic then had biopsy showing TNBC?
With no background in the medical field of course I didn't understand 99.9% of your presentation. BUT I did understand your concern about missing info. Keep probing, keep holding toes to the fire. I hope med professionals get a chance to view this & the other Plenary Session videos.
He does not hold toes to line. Look at his early vaccine videos. He likes CZcams cash so hit that like and subscribe button!
Thank You!!! It’s always easier to manipulate then to do proper science.
I'm a onco fellow and my journal club was about destiny breast 0.4, you really helped me to understand a little bit more about the trial and also have a critical review. Thank you very much
Vinay:
1. At 12:30 you asked how else 7% of patients could have received only one prior line. It is technically possible that some people received a combination of endocrine therapy and chemotherapy as their only prior line. This would seem to satisfy the protocol criteria. Granted, that would be strange, but it is certainly possible.
2. I had the same question as you when they brought up the bystander effect, although with a bit of a different flavor. Do we know that this drug (with or without the antibody) doesn't also work in HER2 0+ breast cancer?
Hi! I can't figure out why the investigators chose to look at PFS in HR+ HER2low as primary outcome? vs PFS in all patients? Would be thankful if you could shed some light on that! thank you!
Could some patients have changed receptor profile from early breast cancer to metastatic breast cancer transition? Could they have had endocrine therapy earlier due to that?
What about ER low cancers? Are they counted as ER-ve?
Can we give Irinotecan by itself for breast cancer? It is cheap.
Excellent as always! Just bought your 2 books.
22:38 next tweet, "aw im the only who liked it" then I realized only one person liked my tweet at that time and it wasn't even him!! hahaha!!
Could you become TNBC over time, if you initially started something else?
Do you know the technical definition of HER2-0. Isn’t there some level of expression?
Thanks :)
Just subscribed !! amazing analysis , true the reader is blinded
Please do dostarlimab!
If the antibody conjugation actually delivers the drug preferentially to Her2 expressing cells, then that is kinda hard to reconcile with the observed toxicity profile 🤔
Could you comment PALOMA-2? The questions and answer was sad...Huge fan of your work
regarding TNBC + palbociclib... could have been a clinical trial ?
Vinay, can you do a video debunking Christian Parenti's Covid piece in the Grayzone.
no sound, again!!!
5:12 I almost fell off my chair from laughter
Hello doctor, love your channel, would you discuss any recent papers or ongoing clinical trials on thymic carcinoma?
Athena mono in 1L advanced ovarian cancer
Invest in it and the haze will clear.
Clap for the $$.
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Oh wow that's impressive
Count me in because I'm placing my trades with Expert Armando, This is the kind of information that we don't get from most CZcamsrs I will get in touch with him right now.
Would you ever say what you did in substack today about Jha and Covid vaccine on CZcams? Wouldn’t want to give up you tube cash?
I read that substack and I think Dr Prasad has stated on CZcams in prior videos how he feels about the Covid vax in regard to healthy children. He's been one of the few outspoken doctors on this particular age group. Why the rub?
@@ideo4430 kind of. His opinion has evolved a bit. Initially he said things like maybe they need just one dose of the safe and effective. Also suggested maybe just needed lower dose and that more studies needed. Kids absolutely do not need any of the “vaccine”. He knew it from beginning. I like dr pressed. He is incredibly bright. It’s my opinion he should use his knowledge and platform to denounce this mass vaccination program. It’s not working and should only be given to our high risk population. I’m a physician and I’ve taken care of 2 pts with strokes after 2nd dose Pfizer. In an avid cyclist and my coach has athlete with bilateral pe after 2nd dose. national pro cyclist myocarditis. This week my group had 4 people out because of Covid. As is the policy they are compliant with current protocol of having deltoids as medical indication for 2 shots and a boost of the good stuff. Trust me if vinay was honest about vaccine he would be taken off CZcams. I could go on about people with adverse events.He is weak on the matter. Many physicians are now. They are bloody scared sheep. I do not give him a break.
@@patrickhaarhues2870 your response has been shadow banned fyi . I had to go click newest vs top comments then appear .. anyway you are being kind to him. The stance he had didn’t weigh as much as the personal attacks on peep that didn’t agree. Making fun of names, peep bodies, John Campbell being a nurse, idea of no aspiration maybe sign as completely ignorant no wonder a nurse or PhD instead md laugh laugh laugh .. he was on ZDogg podcast a few times and when you couldn’t see his face just hear his giggle while ZDogg was saying really cruel things to do to the xx … banned if use the word but the pack mentality and you can tell he has no interest in reading or helping comments .. he 100% about the cash..
No sound
Doesn't seem to be a problem now, I van hear him loud and clear.
Yes sound.
It would be helpful to show graphs for viewing not “you”
And it’s Down ….. hahah
Physical scientist perspective:
Unusual group selection, no comparative inclusive V exclusive type control, no detailed data…
Smells like it’s in the neighborhood of P sampling, an all too common problem. It might not be and this may happen by accident so nothing against authors. I don’t have time to review the article today sry!
When given enough data and parameters something will have an overlapping significance or increased significance just by random chance.
I know this is old, perhaps it will help interested readers uncertain on research.
Thanks for your vids!