Turning my own pee into medicine
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- čas přidán 17. 05. 2018
- Note: Reuploaded due to multiple diagram errors.
This is a video that I've been wanting to do for a while. I really think that is cool that I can build an entire medication from almond oil and urine.
References:
1) Benzoine - goo.gl/BwWdzT
2) Benzil - Chemplayer - goo.gl/VVgwX5
3) Phenytoin - goo.gl/ZaWLaK
Sorry the Bonfire t-shirt campaign has ended :(
Urea from Urine: • Extracting urea from m...
Procedure adapted from: • Extracting urea from m...
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Nile talks about lab safety: • Chemistry is dangerous.
Music in credits (Walker by SORRYSINES): / walker - Věda a technologie
Reuploaded to add warning and to fix multiple diagram errors
NileRed Better safe than sorry, after all
Show how to make some thc things
Thanks! Sucks that youtube removed annotations so these things _require_ a reupload now...
Good man
I just stare at the diagrams and just go, "Yup! Them's are chemistry!" :P
This gives a whole new meaning to “Getting a taste of your own medicine”
“TASTE SE PEE PUNK”
NOOOO
BAHAHA WHY
@Warning Sirens of Colorado NO CLUE
@Zombified MX5 YOU HAVE COMMITTED SIN. CHANGE YOUR LETTER-CASE.
the "(mine)" on the bottle of Urea is the funniest thing I've seen today - thanks.
*_( M I N E )_*
I seem to remember him getting a diabetic friend to give him her urine to experiment with, so maybe he doesn’t want to get the pee products mixed up xD
Kelsey Mixer he has a different video where he bought some pure urea that’s why it’s labeled mine
2ECOND ohhh I see, that makes more sense haha
Everyone:
CZcams Chemist: *Here is my urea*
Nilered: "I'm not very patient"
Also nilered: *dissolves then precipitates overnight 15 times in a row*
His view, of what impatience is, is beyond our comprehension.
Crystalize you mean? 👀 but yeah it's different type of patience.
Crystallize and precipitate are synonymous in this context I believe
The fact that people have figured out so much about chemistry is sort of amazing to me.
It also amazes me!
Unlocked
Thank physicists for the advances we've made then. Without their work and the development of instruments such as NMR, IR, GC-MS, LC-MS, etc we wouldn't be able to qualitatively confirm that these compounds are indeed what we intend them to be. Also the development of a standardized nomenclature allowed for a lot of the advancements given that before a universal naming system people were never able to convey what exactly they were looking at
Thank the the glassblowers, and the glass technicians because without them we would eventually run out of glassware due to accidents and shit.
its easy to blow glass. a lot easier than basic chemistry.. essentially.
Gone Lucid
Making calibrated and precision glassware is not easy, its why every piece of glassware in a lab is so expensive
Lets all get NileRed a pH-Meter ... its hard to watch you with these rough pH-papers :D
🤣🤣🤣🤣
That is why you should go to his patreon and.....
If zombie apocalypse were to ever happen, I want this guy in my group.
fax
Nuclear war, Zombie apocalypse, he will be the doc
@@BotulinSpikedMarzipan nah he would be the one who started it
Watching your videos makes me feel like I chose the right degree (Chemistry of course). Thank you for showing how practical chem can be, which professors attempt to do but gets lost by all the theories and concepts.
Because its not their job, their job is to give you the basics you need to pursue chemistry.
Erik Perez i am also earning my degree in Chemistry! Woot! Nice to see other people who have a love for the topic.
True that
When is the meth video coming out
Let's not do a meth video! Stick to practical use chemicals
Umm...
@Anonymous Anonymous Iodine isnt really red.... So by searching "red" with "iodine" you force google to give you the most likely answer, which is reduction using HI/red P, which is usually going to be in context of Meth more than other chemistry.
@Anonymous Anonymous oh wait, you literally searched for "I ans r. phosph." So the amswer you got was accurate, and the related question was awkward.
Maybe the internet is guiding you towards your destiny? You know what they say....
In the places you go, you'll see the place where you're from.
And in the faces you meet, you'll see the place where you'll die.
And on the day that you die, you'll see the people you'd met.
And in the faces you see, you'll see just who you've been.
I watch your videos before sleep.
Your channel and approach are unique. Love it!
Still the best chem channel lol
thanks! :)
Dman You're right
If youtube has its way it may be one of the last chem channels
I've chem channel but Nilered is something way more better
I'm old school youtube. I watched NurdRage.
"The gayest person on patreon" whoever that is made me laugh when I read his name at the end.
Kyle H I think it’s a chemistry channel too? Not sure, thought it was someone trolling at first
Kyle H found em czcams.com/video/LsdesMWC37g/video.html
Sunny Hill Woah I didn't believe you 😂
I love these chemistry videos so much. Watching different chemicals turn into something else with different properties is quite amazing IMO. Unfortunately, High School chemistry didn't interest me since it's almost completely paperwork, but at least it's laid out the groundwork.
Nincadalop I'm a Highschool drop out yet have more chemistry knowledge then those who graduated. I don't need years of listing to talking heads, I can teach my self ;)
Nobody said you can't learn without school bro
Patient: This medicine saved my life what's it made of?
Doctor: ...
lol
Arsenic Trioxide: I work at a cancer research facility in a non scientific capacity, arsenic trioxide is used as a chemotherapeutic drug. It sounds impressive and could allow you to give a brief explanation of chemotherapy. Just a suggestion. Your content is always top notch! 👍🤘
there's a tom Scott video on how their freezing tons of that inside a mountain because it's so toxic
@@Pseud0nymTXT It's toxic because there's 237,000 metric tons of the stuff. In small doses, Arsenic Trioxide looks to be a pretty widespread and promising Chemotherapy drug, at least from a quick google search.
www.ncbi.nlm.nih.gov/pmc/articles/PMC2918685/
Very poisonous shit is always a good candidate for chemo, providing that a proper delivery method is used
For instance I heard about Ricin being investigated for chemo
I always worry about this channel, and more so Codyslab, about lawsuits. I worry about some idiot trying something, getting hurt, and then suing. Extra warning labels are always a good idea
It's the nature of the internet, always pissed me off that it's possible. Mostly in the states it seems... same place some lady spilled coffee on herself and was able to sue mcdonald's because it was hot and burned her: www.caoc.org/?pg=facts
Reminds me also of the occult book called The Picatrix - full of dubious magical recipes, some which involved things like smoking hemlock. The idea was to weed out the unworthy because they would be gullible enough to try it without doing any research.
See also: 4chan /b/ DIY crystals www.geekinsider.com/toxic-homemade-crystal-recipe-sweeps-internet-geek-insider-fyi/
Not even that, but the fact that he's showing HOW to make a medication which possibly has a huge markup (I haven't looked up the price). He could attract the attention of some major companies.
Wolfin did you even read that page about the McDonald's coffee case? That was not an example of a frivolous lawsuit; people only believe so because McDonald's created a huge PR campaign and paid off journalists. Lookup the images of the Stella Liebeck burns case. Even according to that page that you posted:
"McDonald’s operations manual required the franchisee to hold its coffee at 180 to 190 degrees Fahrenheit."
"Coffee at that temperature, if spilled, causes third-degree burns in three to seven seconds."
"McDonald’s admitted it had known about the risk of serious burns from its scalding hot coffee for more than 10 years. The risk had repeatedly been brought to its attention through numerous other claims and suits."
Hot coffee is hot. And it would have been still hot 40*F cooler where most companies provided it at. McDonalds also provided false testimony that they'd cranked it up to let commuters keep it hotter over time driving, when they had done research into just that and found that even commuters preferred to drink coffee purchased immediately upon purchasing. They'd also had many lawsuits before this point, as he pointed out, and had never resolved the issue. Stella's case went as it did because they had shown gross negligence over multiple years.
Additionally, she only initially wanted $20,000 for medical expenses. McDonald's offered $800. In the end they settled for less than $600,000. This amount was less than 0.05% of the revenue McDonald's received for all of 1992.
the real definition of self medicating 🧍♀️
Love your work man! You really got me interested by chemistry and have introduced me to a whole world of wonder. Thanks!
If you have already done this, someone else can read this tutorial:
If you haven't already, try making some Sodium Acetate (hot ice) [Vinegar + baking soda]. It's probably the easiest chemical you can create that is neat to make and look at. As for the ratio of Vinegar to baking soda, All you do is start with baking soda and keep adding vinegar until the baking soda stops dissolving. Then heat it up and add more baking soda until it stops dissolving again, then add enough vinegar to dissolve the last bit of baking soda.
Everyone seems to talk about measuring things out, but if you have to correct the ratio, then measuring was a waste of time, unless you need a specific yield.
If you add too much baking soda, just add more vinegar. If you added too much vinegar, then just add more baking soda. If you cook it down too much and the whole thing is crystallizing on the stove, just add water back to it. Just make sure you do it outside or near a window or have a strong fan blowing the air outside, because the acid fumes are strong while making it in large batches.
You can start on the highest heat setting and as you cook it down, lower the temperature. Technically this can be done at room temperature, using normal evaporation and should give you a higher quality result, but that would take forever. So just gradually start reducing the heat, once most of the water is boiled off.
All you need is a metal pot and a glass or ceramic container (something that won't warp from boiled water), baking soda and vinegar.
Optional:
paper coffee filters or a vacuum filter,
91% Rubbing alcohol or 95% ethanol,
Activated charcoal or normal charcoal (although I don't know if this would mess it up, I never tried).
You can make a test batch with a VERY small amount, that would probably be very quick, or you can do a huge batch, which will take a lot longer to boil off the water.
I don't recommend tasting it or eating it, because it's a home-made chemical.
@@FusionDeveloper when you use a CZcams comment as a tutorial.
no one:
nilered: so i've been saving my pee in jars
I recall a line from south park "I tested the ph this morning, it was all pee, no h" 🤦🏻
Love your channel and videos! I hope the warnings and disclaimers you put up will let you keep making videos and your fans keep enjoying fascinating experiments.
Thanks!
Man I love your videos!
I've always loved chemistry but in school they made it seem like such a bore. You are actually making science seem fun. Keep up the good work!
I am now picturing Chemistry Students bottling up their Urine for future use.
This is still a Nilered video that I needed to see today 😂 I appreciate the reupload, the integrity for quality is 👌♡
Wow, this is the first useful Pinacol rearrangement I have seen! So cool to see what I learned in the book be valuable.
wow, I just realized chemistry might not be as confusing as I thought it was. I'm seeing a lot of reoccurring stuff in a lot of your videos.
I'm a chemistry student and i feel so thankful for this channel. Organic chemistry is a pain in the ass but damn it is useful! Keep it up pal
Like I said in the previous video's comments I love how you do these demonstrations so we don't have to. Thanks!
WOW. . . I used to take Dilantin capsules. It's side-effects, are all the things described here and some.
But it worked.
So I found this video extremely interesting.
Trileptal was a godsend for me when it came to market. Nice work. Great videos NileRed! ;)
I would love a Cody's lab and NileRed collaboration please
NileRed is slowly turning into the Bear Grylls of chemistry.
i cant stop watching your videos! so interesting! you make me actually interested in chem!
The Benzil production was one of our first practical experiments in my Organic Chem 1 class at uni... Great memories
This video brought back memories of when I made Phenytoin in university. Back then, I found the most interesting part of the synthesis to be the benzilic acid rearrangement and wondered why you didn't mention it at all.
Using a paper clip for stirring the hot bath is fucking genius! Thanks for this great idea.
"...and I only recovered several grams from my urine, anyways"
Very cool. A product that matters. Chemistry that demonstrates principle or generates interesting effects is great; but I think we need more like this that gets us all the way to a useful product.
yooo Nile congrats on 400k less than a hundred away. and please put the hoodies for sale again I would love one. BTW I love ur videos keep up the great work !!!
Is there a reason why you don't use an electric pH meter?
They're not really that expensive.
Look I know you've been getting a lot of messages for me but I just got to say I'm at like 3 minutes and 51 seconds into this video and I noticed your lap etiquette, highly professional. I love it.
You're an incredibly funny dude for this , good for you brother
Haha NileRed saw that there was a paper clip, also I am almost 15 years old and you and the channel nerd rage gave me new ideas for expirements. Also thought it was funny that you could make this medication in that manner, love your videos.
Im not really into chemistry as like a hobby or a study but I do find it very interesting. So I guess I have a general interest lol. Great videos man you really know a lot about chemistry
Love the videos man, keep it up ☺
It’s amazing, how we can increase yield, by chosing the right and perfect solvent
"Hey nile, i feel dizzy, about to vomit and shit."
Nile: I have Pee
Awesome video as always!
Thanks!
I take anti seizure medication so this video hits home for me.
Cool synth man! One thing that’s totally unnecessary but works pretty well for huge crystals. When you recryst leave the solution on the hot plate and let the beaker come down to rt at the same rate as the hot plate cools. This takes much longer but you’ll get huge crystals! Again totally unnecessary but big crystals are pretty awesome.
Also taking a few TLCs might help you figure out when the rxn is done and give you better yields (or at least save you some time), literature timing is almost never correct.
Anyway, great video man!
Congratulations on reaching 1M subs!!!
I've literally taken this med before. Good to know I was taking pics mixed with almond juice.
Those are some fluffy crystals. Very nice synthesis!
NileRed: So today I decided to use my pee to like make some medicine, are you interested?
433k people: Yes, obviously.
Would love to see a similar video on Valproic Acid/Sodium Valproate. Should be easy to continue on from an extraction of Valerian or its roots.
FYI, Urea is used in wine and beer making as a yeast nutrient. You can get it for much cheaper than using ice packs.
I really love your channel
this. this is the type of quality content we want, nay we need on youtube!
ive done this exact reaction, save for the last step, i remember that the mechanism for the first step is fascinating especially the N-heterocyclic carbene ftom the thiamine and how it replaces cyanide as tge conventional reactant, id hoped you would mention that
Is there any reason why you don't smooth the surface of the substance layer in the frit while letting it sit to dry? In my experience the drying is much faster if you squeeze the substance gently with a flat bottomed glass stopper due to the liquid manually squeezed out and to minimize the distance between the liquid molecules so that cohesiveness helps you suck out the rest . :)
Greez from Germany.
Next video: Making Boredom Medication with Ergotamine Tartrate and Diethlymine.
i like the paperclip in place of the stir bar in the water bath
Love the shirts brother!♡ "anyway"... lol
Good video. Very intresting and well done as always. Thanks nile
Huge fan of yours; saw some of your glassware on Cody's Lab today. Awesome :)
I saw it too! Cool stuff
nice video nile. this is a very good video. thank you so much. thank you so much for this video. thank you.
Very cool, phenytoin was the drug that my second ever paper was published on, brings back good memories
Can you make a lot more of your edible chemistry series? It'll be interesting to see how some of the gelatinizers and things like that are created
The message in the ending blew my mind.
On a side note, the potassium phenytoin is a great example of NH acidity. If there is an atom with a hydrogen on it right next to a carbonyl group, it can form a resonance stabilized anion by cleaving the N-H or C-H bond and giving off a proton. Thus these compounds tend to act as acids, just like carboxylic acids do with O-H. This is why some nitrogen containing compounds like amides, or imides like phenytoin, are acidic or pH neutral in solution, in contrast to amines which are strong bases.
I went to respond to a comment and I thought YT had pulled a NurdRage on your video. Good to see that's not what happened.
I like how he titles it with “pee” and not “urine” lol
You might want to look into diesel exhaust fluid as a viable source of urea; it's supposed to be 32.5% high purity urea dissolved in purified water. I can find a 2.5 gallon container on amazon for a little over USD 21, which works out to about 23 lb of urea.
On the topic of urea, it's thiol derivative can react with cadmium ions in water to produce urea and cadmium sulfide crystals.
Please make a video on toxic waste disposal/neutralization of dangerous compounds e.g. manganese heptoxide
🎮 ms_swag 🎮 I would love to see that as well, either reprocessing them into harmless molecules or destroying them safely
I don't think he's addressed magnesium hepoxide directly, but a number of his videos which feature really nasty products also have a note on disposal at the end. His video on chromyl chloride comes to mind.
Thanks you!
Good try because you learned how to make it better from your mistakes... Excellent educational point you made....!
Hey NileRed,
I just discovered your channel an hour ago and Iove it! I am a high school chemist teacher in austria and I think i can use a lot of your experements for my classes - thank you! Where do you get your experiment-instrucions? Are you a Chemist-Student?
“Proper ventilation”… which we now know was his fan aiming at the open garage door. 😆
Nile is very proud of his pee chemicals
NileRed: "I made dilantin out of my own piss."
DEA: "Uhhh... okay."
Bear Gryles: "Did you take some of it?"
Thiamine hydrochloride is sensitive not just to pH but to light. Once I made benzoin, had to do it in a dark place 'cause I got the same yields you had.
I'm going to watch it only because I've watched dr. stone and I think it's cool
Is the nitric acid concentrated to a 68% azeotrope, or are you using fume grade? Also, could the nitric acid be substituted with another oxidizer like 30% peroxide? As always, excellent video, great content, and thank you for posting.
I came for Urine video. Damn the redirect.
Thank you for so interesting theme! Very exiting video.
Why don’t you talk about pinacol rearrangement in the last stage of phenytoin obtaining ?
I love those videos about chemicals and medications made from urea. That's a bit weird. :D
I love your channel. More medications please!
Next up, Codeine!
If NileRed offers you a medicine for something that ails you and he swears that it's not his pee extract then BEWARE chances are that the previous two vowels had already been changed into two big Os.
You say you don't exactly trust the pH paper, so why not just quickly make a buffer?
I didn't see the magnetic stir bar at first and it took me a minute to realize that the paper clip wasn't actually stuck to the beaker with pure magic lmao.
Hey mate, your yield for the benzoin condensation is probably due to the NaOH not being fantastic at deprotonating your thiazolium salt (pKa roughly 13) and the fact that the free carbene you generate is likely somewhat oxygen sensitive.
Your merch is awesome by the way
When you say "concentrated Nitric acid", what exact percentage are we talking about? Trace metal grade (67-70%)? or fuming Nitric?
Nice work ! Beautiful white crystals there.
Do you have a hundred fritts or are you just really good at cleaning 'em ?
Imagine being the poor sap who had to stir stuff constantly for the chemists in the days before magnetic stir bars 😂
So how long before this video is taken down by a pharma company?
And you have to clean it up a lot. You need precursers with a very low level of heavy metals like mercury. Sometime you have to seperate chiral compounds. It's a mess. :D
Peeps love to demonize pharma. No doubt there are many pharma assholes but you have to keep in mind that the process NileRed is using was probably pioneered by someone working for pharma. R&D costs money. Once you have a compound that you think might work you have to take it through animal and human trials. That's money. You have to come up with an industrial-scale process that does the same thing as the bench-scale one. That costs money. You have to make sure your product is pure enough for human consumption. That costs money. Sure, if it's a matter of life and death I'd totally go for homemade meds, but otherwise, not really
I doubt this would happen as this specific medicine has no current copyrights on it. For generic drugs like say lidocaine there's nothing really stopping you from releasing information on how to produce it, provided it's not a controlled substance. Nurofen on the other hand would come under copyright infringement- that's when the strikes start coming.
I too, love to demonise companies that are literally able to make a huge profit off of selling CF drugs they've already developed to the NHS for literally dying children but are so greedy that they won't because they actually want even more money.
Alex Medina and then to recover your costs you gouge the American markets but sell it for a tenth of the cost in Mexico.
Stayed for the science, subbed for the outro track ~
I'm always amazed how complex medication chemicals are and how they came up with them ... I suppose they just mix everything and then try to understand for what it could be useful ... and when they find something, they call it "research". 😄
I was on Dilantin and it can to have a sedative effect! It sedated me and made me feel weird and they had to take me off of it due to negative side effects. I was on it because I had a head injury which caused me to start having granmal seizures about once week.
Nile Video on Basic chemistry please? :)
A lot of work condensed into 12 minutes! Benzaldehyde looks fine
You could make your own pharmaceuticals. This is absolutely insane.