The MS Severity Gene Explained by Neurologist
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- čas přidán 22. 08. 2023
- Genes are known to affect the risk of multiple sclerosis but were not thought to affect the severity of MS…until now. This genome wide association study reports that the rs10191329 allele in the DYSF-ZNF638 locus is linked to worse MS Severity (shorter median time to walking with a cane by 3.7 years along with increased brainstem and cortex pathology). This video reviews the article and implications for people with MS.
Selected Sources:
The article I am discussing: If you need a link, ask me on twitter (I do not have permission to post it publicly)
Multiple Sclerosis Risk Variant HLA-DRB1*1501 Associates with High Expression of DRB1 Gene in Different Human Populations: www.ncbi.nlm.nih.gov/pmc/arti....
Is multiple sclerosis progression associated with the HLA-DR15 haplotype?: www.ncbi.nlm.nih.gov/pmc/arti...
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information. - Věda a technologie
Well, *I* have 14 years of education behind me, but I lost you here, bro, and it should be noted that I listened twice: All these genes still read out like something you have to type in to prove that you're not a robot!! 🤖😅 All I understand is that Dad OBM had a bad case of Parkinson's in his last 8 years, and that I checked in in 2018 at age 55, already with EDDS 6.5! 😝 Thanks, though, for thinking so highly of us, and trying to raise our intellects rather than just assuming that everything is going to fall through the holes in our brains! 🤗 Wishing you a Shana Tova from Jerusalem! ⚖️✒ 📙 🍯 🍎
Haha. I know this is a somewhat esoteric topic. Sometimes I just make videos which are interesting to me without necessarily thinking of the intending audience. I may make some simpler more general videos about MS soon.
@@DrBrandonBeaber Please don't dumb things down too much, my wife and I are so thankful for all the information and look up what we need to completely understand.
@@MRMIKE276 acknowledged
@@DrBrandonBeaberthanks for the info. I have benign ms. My prolactin levels are always high so I have to take medicine for that. Have found internet about Asian type of ms(benign and high prolactine). have you heard about that type?
@@arr2820 I am not aware of any known association between elevated prolactin and MS. Sometimes elevated prolactin is related to a pituitary adenoma and is treated with dostinex
Wow! Great research, and thanks for making us aware.
Thanks. Dr. Brandon on another awesome video didn't understand all of it but I got a couple things out of it so I guess that's better than nothing haha. I find myself watching some of your videos two or three times to get a handle on things but I will say this theyare always very interesting. Thanks again for keeping us in the loop, have a great day sir
You will never know how much you are appreciated for your work on this outside your work. Thank you.
If I was to ask for a deeper dive (please let me know if you've already done one), I'm curious about progression when I have many brain lesions. To name a few spots I know that I have medulla, pons, corpus collosum, white matter? Periventricular, subcortical, juxtacortical, etc.. (this is all from what I can remember my neuro telling me). I'm in my mid 30's and I seem completely fine from any onlookers, but with this much damage it's worrisome to think I'll be fine in ten years. I'm very into math and statistics, how would someone's outlook for someone with my lesions? I don not yet have any spinal or optic lesions.
progression has more to do with brain atrophy than lesions...
What a pleasure to watch your videos Dr!
Thanks
Very interesting. Thanks for presenting this study for us. I have a suggestion for another topic if I may. I'm interested if there is a connection between MS and Parkinson's genetically. I have MS. On my mother's side, all adults had either MS or Parkinson's, except my mother's mother.
Yes...myself had father w/Parkinsons...and seen three or four others post same. Parkinsons has aspects of AI disease so no wonder.
Thank a lot for sharing us latest researches.
So would it necessary to have a gene test for newly diagnosed with MS patients after this research?
As explained near the end of the video, I don't think the association of this gene with prognosis is significant. Also, it is really not actionable information.
i had a panic attack, sensory overload, screamed at my wife, beat my dog and tried heroin for the first time all trying to figure out what you were saying 🤯
Hey Doc, can you please either blow up your charts to momentary full screen (so i can pause it and see/follow/ grasp what you're saying) or give a link in your blurb? Thanks! Also, this topic was fascinating, thanks for interpreting it.
Thanks for the suggestion. I do have sources in the notes below the video.
Thanks for the video Dr. I was just reading an article that said that early treatment may slow disability progression.
Awesome analysis as always! I have a rather mild MS, 17 years and minor invisible symptoms. Would like to know if it's a higher chance for me to stay in the mild zone in the future if I take care of myself physically, nutritionally and mentally.
Thank you for this detailed information. I was diagnosed 7 yrs ago at the age of 49 and my 2nd child was diagnosed 3 yrs after I was at the age of 32. Our symptoms are so very similar that we knew there had to be a genetic link to this even though one of our neurologist says no and the other said possibly. This explained alot for us. I think that genetic testing for these genes while undergoing diagnosis should be something as important as the MRI'S and other tests are. We could possibly continue to learn even more by doing this.
Maybe an environmental risk as you lived together for some time?
@@hw7029 maybe. Just very odd. Would love to know if genetics could be playing a role in it though.
Thank you so much dear dr beaber you are an awesome person ❤
Really interesting! Thanks for sharing.
:)
Personally, I have HLA-DRB1*1501, APOE4, Vitamin D deficiency and increased risk of elevated homocysteine. These factors have helped educate my diet, supplements and lifestyle(OMS covers it pretty well). MS runs through my family so there is definitely a large genetic factor, it would be exacerbated by gene expression and lifestyle. Personal genome sequencing is a great educator, when it is spread over a large sample size maybe not.
Hi dr what are your views on the hydroxychloroquine studies for PPMS ? Thank you for everything you do 👍
Video on Neuriva placebo study please
Thanks so much! I like videos this detailed. I thought you explained it well!
Interesting research! Question - is the structure and composition of myelin the same throughout the nervous system or can it differ in different parts of the brain, spinal cord …?
Dr. Please tell something about citicoline in a video please.
May I ask you dr. Brandon this question. Why other autoimmune diseases don't have extensive researches like what we see with MS? Is it because other AIDs don't put alot of pressure on the medical authorities compared to MS?
another really interesting video. if there were a severity gene, I've got it, that's for sure! waiting to see if a BTK inhibitor can slow progression of disability. i really hope so, or something comes along. atm i seem to be on the fast track to EDSS 9.5 🙁
Do a news google search on “MS progression genetic breakthrough”
Is there a male vs female or when first DXd, I'm EDSS 6.0-6.5 and am 64 male. was DXd 16 years ago and was told then that late onset males generally did more poorly. Wondering if I have this, Probably not, but unless there's a treatment, then its just academic info that someday might help in new treatments.
How do we screen for these genes?
Hi from Israel thanks for the interesting data gives a hope...god bless you
how do i know if have MS Severity Gene or not? i am 32 years old male, and I have had MS for 15 years now and I don't have any kind of disability.
There isn't a severity gene, that was the point of the video.
@@christinefarmer5938 Yes exactly Christine. Also, this test would not be commercially available right now.
@@christinefarmer5938 I judged the video by its title I didn't watch it completely. how about we just jump to the conclusion next time? MS made me allergic to waiting.
As an armchair scientist from a family packed with various autoimmune diseases, I’ve always thought that you suffer from “autoimmune disease “ generically that secondarily has found your personal vulnerability. The switch-flipping genes being in the immune system with the “severity” genes being in the CNS comes as no surprise.
there may be some validity to this.
Thanks for the info. Can you do a video on the stem cell therapy being done in Panama City, Panama at the Stem Cell Institute. Thanks.
Can you modify genes to mitigate the effect?
Unfortunately we cannot.
You are on the right path to eliminate the devil(s).
Thank you Dr. Beaber! Can one reques from their neurologist to be tested if they're a carrier? I'm so concerned I was dx in 2021 and keep a journal of my day to symptomalogy. I have steadily progressed in the past two years. I'm not on a cane. However, went from working full-time as an RN and contract work on the side. To seven shifts a payperiod. That is all my legs 🦵 can manage. One example.
My personal opinion is that it would not be helpful to test for this gene, and it wouldn't be readily personally available.