Parkinson's Disease Part-1 , pathophysiology, basal ganglia (nuclei)
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- čas přidán 30. 12. 2018
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/ cology009
Good effort sir
Thanks, glad it helped!!!
Sir plzz plzz upload on pathophysiology
No words to appreciate u....
Ur videos clear my concept thoroughly.....
Thank you. Will restart soon......
You can connect directly with me on Instagram at cology9
great sir
Your way of teaching is marvelous MashaALLAH even i didn't get complete it ..
Thank you, I am happy my videos could help you.
Very informative and interactive video. Your way of simplification of the topics is just marvelous. Please keep posting more such educational videos.
Thank you so much for your words.
Keep feeding the motivation.
Thank you sir...
Very nice explanation . Thank you sir ❤️❤️
Very nice and helpful.. Thnks sir
Thank you. Subscribe and ask your friends to subscribe too....🤗
Sir please make video for antipsychotic drugs classification
The point that contradicts herr is earlier the final glutaminergic neuron of indirect pathway .was inhibited so that the signals to antagonist muscle decreses,but after dopaminergic action ..this glutaminergic neuron is excited .so how this dopaminergic signal is caliberating both the pathways .. please explain this sir
good lecture sir it is very useful and i have a small doubt. Actually GABA is inhibitory.in the direct pathway 12:42 why GABA is stimulated and next Gaba neuron why inhibited and next glutamate why stimulated ...and (13:05) how to form ipsp(GABA) to epsp(GLU)…pls explain it sir
Now Waiting for the Pharmacological management section
Tomorrow morning at 9 am
Sir you are best
Its my request to upload the video lecture of general pharmacology
Thank you Ashish. What exactly are you expecting from General Pharmacology?
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This is wrong isn't it? Dompamine ibh bits the indirect pathway through D2 receptor and " weakens" the relaxation. At 24.50 you make it sound like DA potentiates both the contraction and the relaxation.
D2 is inhibitory and it releases the inhibitory neurons from inhibition (excitation), and you rightly mentioned that indirect pathway causes relaxation and D2 potentiates this relaxation process. Which can be understood as dopamine potentiating both the pathways (direct and indirect).
Since dopamine potentiates both the pathways we get better contractions. I hope this has answered your question, else I am open for discussion on this.
I can see that we agree on the function. I just feel like wording it as dopamine potentiating the indirect pathway is counter intuitive, as it sound like you are potentiating the inhibitory effect. English is not my first language so maybe it is just me ☺️
@@trinerasmussen7099 my bad. English is not my first language. May be my poor selection of the words.
Dopamine at last increases motor activity that is contractility of both agonist and antagonist muscle increases because it activates the direct pathway which normal increase motor activity and inhibits indirect pathway which normal decrease Morton activity
You add copious number of adds and thats irritating
from which book?? to read this ...
Made this from research papers and several books. Not a single source of information.
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@@cology9
Thanks for your revert.
I m not having an insta account.
Is it necesary to do this topic in huge detail???
I m a pharmacy student
@@mayankmehendiratta999 it is important to study this, I would say you study it in detail