Making Adrenaline
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- čas přidán 7. 08. 2023
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In this video I'm making Adrenaline!
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best vpn add tbh lol
Can you synthesize melanin🎉
Got an adrenaline rush from watching with great synth. :)
I was wondering how to select between 1alpha and 2alpha methyl 4,5a- dihydrotestosterone? And would it be possible to add a 17B- undec-10 enoate ? I just don't know how selectivity on positional placement
Love how so many Chemistry YT channels embraced the chaotic nature of the subject.
I think the right word is "consumed". They've been consumed by the chaos. Lol
Im glad there is now always some chemistry content being made, whether it is from you, NileRed, CodysLab, E&F or others I can never get bored
Thanks to NileRed creating mainstream media we have this kind of channels
nurd rage started it off
It was actually much better a few years ago, many active chemistry channels either got banned or left when CZcams started cracking down on certain chemistry subjects
At 4:25 M*thylamine ha-ha Wowza :D
@@semesabrown8203Going after drug adjacent chemistry videos is like banning the use of 2x4 brick in lego sets.
I've an adrenal tumour and produce waaaaaaaay too much, if you need adrenaline, all you have to do is ask dude!
What does that feel like?
Do you age fast because of it?
Bill Gates entered the chat
@@jamesbrown99991 adrenaline isn't adrenochrome
@@taiiiz3969 if you get an EpiPen and inject yourself you can find out lmfao they're just adrenaline, or sudaphed is almost the same chemical and reacts very similarly in your body so that would probably be easier to get an idea from, it probably won't be exactly the same but it's like Adderall and meth, people who have done both usually say they're basically identical feeling
It's crazy how human bodies can make such complicated chemicals without breaking a sweat or accidentally killing ourselves
The power of enzymes
@@giuseppedelcuratolo1589Exactly. Once our department head (a pure chemist) said: "come on if that enzyme can do that reduction in 99% ee, we can do it in the lab too". I was just standing there like: "No, just no"
Enzymes can achieve precision that is unmatched. It's crazy how evolution turned amino acids into peptides and then proteins and enzymes which perform their task in crazy precision. Take Candida mediated terminal oxidation of alkane chains to carboxylic acids. Even when labile functional groups are present. We need multistep reactions and harsh conditions to do the same thing and need to protect all labile groups.
Evolution.
You’ve bullied the Australian thesis guy too much already..
Too
It's ok. Have you ever seen a video of gazelles giving birth? That baby has to hit the ground running or it gets eaten by the first predator that sees it. That's similar to how Australians are raised. A hostile environment is what they thrive in.
@@xWonderxBreadx 🤣
I‘m not sure it is bullying unless there‘s more beef going on in subrabbits etc.
😂😂😂
I love that you actually go through the theory and not just the lab procedure. a lot of chemists these days follow the procedures without understanding the mechanistic steps. you obviously do and you share your knowledge
Love the reaction theory instead of just mindless mixing chemicals.
me at 3 AM making an absolute abomination of a snack
i start a degree apprenticeship as a laboratory scientist next week and your channel was a huge inspo in keeping me into chemistry through the slog of uk education aha, hope youre doing well!
Keep us updated on what impossible hunts the chemistry people send their apprentices as pranks.
@@Kenionatusshes gonna make YELLOW chemistry
Is this the same as a laboratory technician?
You're now probably flagged for making something more illegal with that catechol and methylamine lol. Keep up the good work!
Adrenoreceptor activators come in many tasty shapes!
I had never looked into adrenochrome at all before. I never knew that the synthesis was so reasonable and straightforward. This really shows how stupid all the adrenochrome conspiracy theories really are.
Which is easier for a conspiracy to do without getting caught: traumatize hundreds of children and purify adrenochrome from their body fluids, or suborn one single chemist to buy it for them off Sigma? I mean, I'd think natural products extraction is enough of a pain in the ass without hundreds of traumatized children screaming and attracting police attention.
Of all the things to take from a hunter s Thompson book..
What's also funny is even if it were a super complicated compound only available biologically, the first thing we would do is splice the genes for it into yeast and brew it by the hubdreds of gallons in giant vats like beer.
Many of these conspiracy theorists are mentally ill genuinely. I say this because my father is borderline psychotic and he expresses it with his world view. When he went on a tangent about adrenochrome, I let him say his piece. I didn’t interrupt, I listened, I tried to understand. Then I asked him calmly if I can provide another piece of data.
That data was a link to a complete synth of adrenochrome and a link to a site to BUY adrenochrome from a chemical company for the measly price of like $40/g.
This changed nothing in his mind. No shift in perspective. No reconsideration of the “facts” as he sees them. (Bear in mind my dad has a successful career and supports his family with an honest career. He is “normal” to society)
That was when I realized his world view is unreasonable. Not unreasonable in the sense that he’s difficult to reason with.
Unreasonable in the sense that he is “not comfortable to reason” which is the dictionary definition for unreasonable.
Rather than reevaluate his personal view and consider concrete data, he just…doubled down.
It’s one thing to believe child’s blood has special powers. It’s another to have your theory disproven and instead of find a new explanation or new theory, you just double down on the same one despite evidence??
That’s a deficit in critical thinking and reasoning capacity. Years later, I understand my father is mentally Ill and growing old. I wouldn’t be surprised if he is unable to care for himself 10 years from now.
It’s sad, but also scary that so many “normal” people especially of old age are clearly mentally compromised and their higher thinking is at a deficit or compromised. 10 years from now I doubt my father will be “normal” like he is today.
Thanks for your comment. Hope this made sense
@@rileymerson8781 That made a lot of sense-- well, as much sense as a discussion of conspiracy theory ever can. I'm sorry you're going through that with your father. It must be distressing to watch someone you are close to lose grasp on logical thought processes.
I've started to think about different types of falsifiable theory recently. Normally, we criticize a scientific theory as "unfalsifiable" if it doesn't make any testable predictions.
But I've noticed that many conspiracy theories are unfalsifiable in another manner: they make testable predictions, but their adherents refuse to consider falsification as a possibility. I don't understand the psychology of it. Perhaps it's the rush of knowing a secret truth, the pleasure of being part of a tight-knit community (of conspiracy theorists); combined with a disinterest in self-criticism and the dysphoric feeling of being proven wrong.
There are some really really obviously wrong conspiracy theories out there, and some people who believe them no matter the evidence.
But again--I don't really understand it.
I wonder how the Heisenberg guy who comments on every video feels about censoring that one compound that's essential for making that other compound that also makes you faster.
Wonder what happens when you drink it do you get a adrenaline rush or what?
Now you need to give yourself an anaphylactic shock and try it
Man I love your videos. These chemistry channels got me brushing up on basic math and general chemistry. I think ima go back to college for organic chem.
It’s all so interesting and all ties to or can be applied to things I’ve spent years reading about for fun. Thank you chemistry CZcamsrs!
Go for it my guy.
@@breakinglegsandbreakinghea3167 thanks man! Math never made sense to me but this time I can see the rhyme reason & beauty.
I’ll update this comment when I take the placement test in a couple months and let y’all know how it went
@@toomanycactus3138huge W, commenting so youtube (hopefully) notifies me
I love home many different colours this synthesis goes through.
I once worked on photoswitchable diazo PROTACS and I kid you not, I went through a complete rainbow during the multistep synthesis. From white to blue, to violet, yellow fluorescent then green and in the end after diazo coupling a pure red. This was really nice.
How does activated charcoal always know which molecules are impurities and which are the desired product? Literally black magic.
Actually, it does not know and absorbs things in a non-specific way. But as long as your sample is relatively pure, you'll get a higher purity sample at a cost of small yield loss
But why ?
I do understand why crystallization does improve purity thanks to the equilibrium of every species : X(solution) - X(s) and that considering the composition of the solution doesn’t change the solubility of the species that much.
With carbon, you could write a similar equilibrium but I would have say that having a concentrated solution of A would favor A(adsorbed) over B(adsorbed) (with B an impurity, in smaller concentration), because the carbon would saturate itself with A ? So as a result you would loss as much of A than B and conserve the ratio ? Idk… I can’t think it right I guess but if you have an explanation it would be welcome !
@@Tom-to7dy I have found some claims that activated charcoal preferably absorbs conjugated molecules with high MW (which are usually colored), which makes sense considering that activated charcoal mostly used for decolorization. So not 100% "non-specific" I guess...
@@Tom-to7dy It is just a gamble, sometimes the only thing charcoal does is steal some of your yield. It can absolutely happen that it binds much more strongly to your desired product, there is no easy way to predict it. You just have to try it, and note down the results so that the next person doing the same reaction is better informed.
In the video's Friedel-Crafts reaction, the byproducts are likely oligomeric conjugated molecules resulting from the oxidation of catechol, so activated carbon appears to have worked in the favor
Takes many of the organic synthesis techniques we learned in class and shows a real life application beyond what we could do in lab. Great video!
No joke, I take noradrenaline reuptake inhibitor, because unless I am in fight/flight I am couch/potato.
I actually wouldn't mind like a slow-release adrenaline xD
you're trying to say you do meth??
adderall
SNRI?
venlafaxine ftw
yup, atomoxetine
Chemiolis with the consistent uploads i love it 💪🏻
Next up: Making adrenochrome because I want to be able to see hell.
Adrenochrome is just oxidised adrenaline
/tinfoil hat just get traffic children for the elites you will get some
It's kinda scary/funny how easily convinced an entire group of conspiracy theorists were that it *only* comes from sacrificing children and that politicians use it to stay young. I know perfectly intelligent people that would normally be smart enough to look into it and see how easily it could be synthesized by a decent lab that would totally avoid using their brain just to believe their echo chamber. Sad state of politics right now :X
@@friedrichvonsnatch3501 Yes. Exactly. It is in the body in low amounts but usually people have many pathways so that it does not stay stable in the bloodstream. It's a hypothesis of
Abram Hoffer showing that it has psychotomimetic properties like LSD or mescaline. It's a theory but he has many studies showing that psychotic symptoms can be reversed by high dose niacin (B3) and vitamin C as an over-methylation and oxidation happens in these people from chronic stress and malnourishment.
He did ingest some and gave him paranoid depression for a week.
The science community ignores it. Call me crazy but this guy has cured dozens upon dozens of psychiatric patients and got "debunked" by the usual fact-checkers.
@friedrichvonsnatch3501 is it true that it gets you high if you take it?
The visualizations are very nice, my chemistry studies only start in a month yet i could understand most ofehat was going on
I'm definitely sure there are some fancy metal catalysts out there (from the Noyori group specifically) that can enantioselectively reduce adrenalone to the desired enantiomer. Splice in a Mitsunobu reaction/hydrolysis to flip the isomer if necessary.
Also, shouldn't the yield in the previous steps be better if the product was purified by chromatography instead of recrystallization?
Always great high quality content!
Nice job ! I suggest dissolve adrenaline in DCM and then carefully dropwise add conc. sulfuric acid until no more solid is formed, filter and then alcohol washing of the formed salt.
Very nice video man! Guess I need to join the neurotransmitter club now...
@@peepeepoopoo5932 I was working on my own dopamine synth long before Pyrotechnical scooped me, and I ain't stopping progress until I HAVE PURE FREEBASE DOPAMINE
it feels nice watching this kind of videos knowing what those cryptic symbols meant after taking a chemistry class
To think that our bodies do this every single time we get jumpscared in a movie...
Lol I think we synthesise it from amino acids instead
@@vicesimum_phi8123 Levodopa
"The product isnt supposed to be a barbie add so I will oppenheimer it" got me cackling
Okay someone please explain the omniscient activated carbon. So many chemistry channels that have said the exact same line "add some activated carbon to get rid of some impurities". Never the same compound and I'm guessing never the same impurities. But still the carbon seem to know what to absorb. Is activated carbon the chemist equivalent to alternative medicine peoples colloidal silver? That it "knows" what you want to remove and removes it?
Can someone please explain how the activated carbon always removes unknown impurities but never the actual chemical you are striving to purify?
Activated carbon is good at binding with colored impurities. Can't tell you the exact mechanism as I don't know that level of chemistry, but yeah, it is quite promiscuous with its adsorption. Binds to a lot of stuff, especially stuff wit visible light color and ions, and if it doesn't bind to your product, it will pull a bunch of extra random stuff off.
Really, solvent washing is not much different from that. Chemical reactions are a random process, you just try to select for the one compound you need.
Were you to make the chemical that activated carbon would adsorb, you would simply not use activated carbon to purify it. Among those that you've seen on youtube using activated carbon, none were of that type because people generally know what they're doing.
P.S. Maybe you should do at least a cursory internet read before assuming that a widely industrially and chemically used purification method is snake oil.
Thanks for the tutorial
This is such an underrated channel, lol
Great Vid, keep up the good work,
I make adrenalin for free every time I have a panic attack
For the fiedl and crats wont you get a mot of isomers? You have to ortho and oara directing groups which both direct to other positions.
Just out of curiosity, why did you censor methylamene?
The m*thylamine censor had me dead. Love your videos man
*implies he's going to inject the adrenaline*
"... But I'm not doing that."
M*thylamine 💀
You know YT's anti-profanity has gone too far when you have to censor ordinary molecules.
Not exactly anti-profanity I'd guess but yeah.
It’s to prevent any chance of the video being flagged 💀
Crazy right, fucklyamine is a common and useful chemical. So sad.
@Chemiolis can you please share the paper for this, i am curious as go how they have chirally resolved the molecule
I’m wondering if it would’ve been easier to just start from phenylephrine. It has everything except the 4-OH group. Idk how hard it would be to add that.
So distillation separation/filtering is a preferred separatory technique technique, because heat sources are cheap...
But wouldn't solvent separation + freezing be another good one in some cases?
higher temps = increased reaction rates, but dissociation in a solution a reaction; so I'd think if you want to halt reactions + separate, if you can be selective enough in freeze temp, then that would be a way to go.
Just a thought.
Well, it seems that you have become quite the chemist!
I know that McMurry makes good books on chemistry (regular and organic chemistry). Which books did you use?
Zubrick organic chemistry lab manual is also handy when you are new to real chemistry. But which books did you use?
Thanks!
Greetings,
Jeff
Damn Nile red catching strays 😭💀💀
my man just calling out Tom and Nigel like this!
Love your videos dude keep up the fantastic work
Tom and Joey, according to the video
@@NebulonRangerNilered is called Nigel
How do you search this whole procedure? I tried to search it on the internet but I didn't find any papers. Can you give it tutorial how to find papers and how to to proceed reactions. It will be really helpful.
I really like the improved video quality
Which protocol did you follow to make adrenaline?
I subscribed when this channel had about 10 subscribers, thinkng it would grow to be huge. Foresight at its best
8:00 why didnt you use NaBH4? was it to eqpansive or to hard to get? would seem like a simpler version to me
This guy is just flexing with being the best chemist on CZcams
Bruh created a speed boost potion
4:28 The m*thyl group is the simplest organyl group, represented by the formula -CH3.
Why did u censor the word methyl?
@@kingmewto7148 To poke fun at the censorship. Methyl has the letters meth in it - the narcotic drug methamphetamine is also shortened to meth.
Given that adrenaline is the same thing as epinephrine, I wonder how hard it would be to create black market epipens like this.
LMFAO , all I could think about was Cartman's Vchip .
Its that simple of a molecule? Cool
When something turns from red into orange, it's one step closer to yellow. I don't trust this - it's already half-evil!
"they use chiral resolution but I'm not doing that BYE" 💀💀💀💀
If you're in the US, you can just buy adrenaline and save yourself the effort. It's the active ingredient in Primatene Mist inhalers, which are sold OTC.
@2:30 aren´t there other byproducts forming, like double, triple, quadruple acylations or ether formations ?
and when comes the injection part?
What happens if you eat it?
"hn oh oh oh" yep, it's adrenaline all right
İt is wonderful that you passed many many steps to make adrenaline, but our body makes it like usual work. Human body is amazing....
Bro wanted to make adrenochrome
The chem diagram says it all. Hn- oh- oh- oh 😂
Youre videos are truly awesome…
Next video - resolution via chiral tartarate salt ;)
We want a video about coverting Epinephrine molecule into N - Methyl Amphetamine.
por qué no usaste un agente reductor como NaBH4 o LiAlH4 para la reducción del grupo carbonilo?
Methylamine is an organic compound with a formula of CH3NH2. This colorless gas is a derivative of ammonia, but with one hydrogen atom being replaced by a methyl group. It is the simplest primary amine.
Why did you use dichloroethan in the first reaction as solvent? It isnt a classic solvent in organic chemistry, so why you thought it was a good idea to use it?
I also wonder why it didnt do a fridel crafts alkylation with the solvent.
I find it amusing that the final intermediate is adrenochrome. No terrified kids required. 👍
Great Video!
The catechol too easy to be oxidized, why not protect it ?
What happens when a dutch guy gets acces to all chemicals lol
Nice chemistry behind the ephedrine chemical. PdH2 is super expensive online.
Could you provide the procedure you used ?
i might be missing a point, but wouldn't the amount of the product of one of the hydroxy group addition on the acyl chloride be considerably high ?
@@uncleal thank you, it seems i didn't even try...
4:28 what's the bleep for? Don't tell me CZcams doesn't like the word "meth"
Shots fired at e&f. How dare you. You monster!
I assume you track the reactions by TLC?
You could show it from time to time for the people that are either not familiar with typical laboratory work or are young and simply interested in how everything works.
You could also do a video on NMR interpretation or GC/HPLC-MS interpretation. It is not as entertaining as synthesis but some might be interested. I think Mestrenova has a free version which could allow viewers to follow your steps on a predicted NMR spectrum since MNova has that feature.
Showing Nilered as the lazy youtuber is gold 😂 I wish he would upload a lot more
Oh so we can do the adrenaline boost thing from kickass. Cool
I find it interesting that compounds such as adrenaline, dopamine, l-DOPA, phenylalanine, tyrosine, etc are found naturally within the human system yet, under the law, can be considered as _analog_ drugs or precursors.
Would love to see a pure dopamine or histamine synthesis too!
Why is methyl amine censored?
idk why it felt like forever to get to 1:19 where the chemistry starts but i'm glad i waited
Why doesnt the reaction of the halogenated structure with the methylamine run to the second or third degree to an ammonium salt? Very nice synth tho, keep it up!
Small scale synthesis
Would be interesting to see if you could make Adrenaline from Levodopa, itself extracted from Velvet beans.
Make sure to store it under an inert gas as the chemical oxidizes redily.
You should have done the chiral resolution I wanted to see that
make fentanyl next
Please show how Chiral Resolution is done, it's so interesting 🤩
thanks!! now i can get a calamity speedrun wr
What's the bleep for
Walter fight or Walter flight
Funny enough Hn Oh Oh OH! Is the sound you make while taking it
Phenethylamines are so intetesting. Adrenaline is Tyramine with 2 extra hydroxyl groups. All these things are near to amphetamine and the amino acids tryptophan and phenylalanine. Barium hydroxide is your friend if you have those amino acids. Phenethylamines have a wide spectrum of chemistry across plants and animals.
is this the method pharmaceutical companies use at a larger scale?
Some would say harder, better, faster, stronger.