Chemiolis
Chemiolis
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Making a Red Bull Patented Stimulant (and trying it)
Support my channel with patreon: www.patreon.com/chemiolis
Correction: Cumene hydroperoxide structure is wrong (Chemdraw name to structure conversion issue), it should have the hydroperoxide attached to the alkyl.
Synthesis:
pubs.acs.org/doi/10.1021/acsomega.3c09348
Patent:
patentimages.storage.googleapis.com/7d/13/5e/fad1cb9db91e6a/EP3553053A1.pdf
Sharpless literature:
www.thieme-connect.de/products/ejournals/abstract/10.1055/s-1986-31489
pubs.acs.org/doi/10.1021/cr040698p
www.sciencedirect.com/science/article/abs/pii/B9780080523491001967?via%3Dihub
link.springer.com/chapter/10.1007/3-540-56252-4_25
zhlédnutí: 122 851

Video

Making Tryptamines for Enlightenment
zhlédnutí 108KPřed měsícem
Head to squarespace.com/chemiolis to save 10% off your first purchase of a website or domain using code CHEMIOLIS Support my channel with patreon: www.patreon.com/chemiolis In this video I make the common medication scaffold tryptamine from the essential amino-acid L-Tryptophan, found in all foods and available OTC as a supplement. I then use it to make a Tryptoline derivative, which are intere...
Making Truth Serum
zhlédnutí 182KPřed měsícem
Support my channel with patreon: www.patreon.com/chemiolis In this video I explain some background about barbiturates and truth serum, and synthesize the barbiturate thiamylal. Intro largely written by Damian (Discord: tangramexcerpt)
Making Experimental Parkinson's Medication
zhlédnutí 25KPřed 2 měsíci
Support my channel with patreon: www.patreon.com/chemiolis In this video I tell the basics behind Parkinson's disease and the currently used classes of medications. I synthesize a new medication of the MAO-B Inhibitor class, with a different structure compared to medication in the same class, that has recently been developed. This new inhibitor, KDS2010, can reversibly bind to the receptor and ...
Making Hydrosilatrane: A New and Better Reductant?
zhlédnutí 28KPřed 2 měsíci
Join the patreon! www.patreon.com/chemiolis Procedures followed: Boratrane sci-hub.se/10.1016/0022-328X(85)80362-4 sci-hub.se/doi.org/10.1002/zaac.19522680305 Aluminum ethoxide sci-hub.se/doi.org/10.1016/0022-1902(62)80106-7 Triethoxysilane sci-hub.se/doi.org/10.1021/jo01160a017 Hydrosilatrane orgsyn.org/demo.aspx?prep=v98p0227 sci-hub.se/doi.org/10.1002/ejoc.201501599
Making and Tasting the COLDEST Substance Known - Icilin
zhlédnutí 111KPřed 3 měsíci
Head to squarespace.com/chemiolis to save 10% off your first purchase of a website or domain using code CHEMIOLIS In this video I am making one of the coldest/iciest/mintiest substances known, Icilin. It is a super-agonist of the TRMP8 ion-channel which is a receptor on our mucous membranes that gives us the cold feeling from temperature and food such as mint. The compound is not found in natur...
Making Cursed Oxygen Benzene - Pyrylium
zhlédnutí 52KPřed 3 měsíci
Head to squarespace.com/chemiolis to save 10% off your first purchase of a website or domain using code CHEMIOLIS In this video I am making Pyrylium Tetrafluoroborate, a unique oxonium containing heterocycle that is very useful for the transformation of heterocyclic amines. It's currently used quite little due to its price, availability and knowledge about what it can be used for. The introduct...
Making Arsenic-based Antibiotics (Arsinothricin)
zhlédnutí 40KPřed 3 měsíci
In this video I'm making the recently discovered broad-spectrum antibiotic Arsinothricin. An arsenic-based non-proteinogenic amino acid analog of glutamic acid. It is an inhibitor of the glutamine synthethase enzyme. Some researchers are working on developing a more convenient synthetic route to Arsinothricin, which would be useful in larger scale production and for tests in trials. It has been...
Making 1,3-Dioxolane
zhlédnutí 30KPřed 4 měsíci
In this video I am making the solvent 1,3-dioxolane because there was no video on CZcams about it yet! In general you should add a tiny bit of BHT or HQ as stabilizer against peroxide formation if stored. Support my channel with patreon: www.patreon.com/chemiolis
Making and Testing The ANTI-SPICY Molecule (Capsazepine)
zhlédnutí 138KPřed 4 měsíci
Subscribe to Curiosity Stream and start exploring the world around you! bit.ly/CuriosityStreamChemiolis1223 In this video I am making and self-testing the molecule Capsazepine (albeit crude), a molecule that blocks access to the receptor activated by the spicy-molecule capsaicin, thus removing its ability to cause you the spicy feeling. There is no known literature on its use on humans, it is u...
Will This Revolutionize Chemistry? (Organic Electrochemistry)
zhlédnutí 108KPřed 5 měsíci
Check out the IKA Electrasyn 2.0 via: www.ika.com/en #electrasyn (sponsored) In this video I am showing a typical procedure for how to conduct synthetic organic electrochemistry, using the Electrasyn. It shows that it is a lot easier, safer and more convenient than regular organic chemistry where dangerous and more expensive reagents are required. It is also more atom-economic and reduces the a...
Making and Tasting Government Banned Sweeteners
zhlédnutí 203KPřed 7 měsíci
In this video I am making and then tasting 3 banned sweeteners: 5-nitro-2-propoxyaniline (P4000), Sodium cyclamate and Dulcin. Support my channel with patreon: www.patreon.com/chemiolis
Can You Trust NileRed?
zhlédnutí 525KPřed 7 měsíci
This video is just for fun to see if I can recreate his experiments. *I did generalize the (optimal) meaning of peer review, often it is not necessarily reproduced (replicated). Unless the paper is purely calculations etc like we more often see in physics. A lot of papers are not reproducible even if they are peer reviewed, which is why replication is the ultimate test of truth for an experimen...
Making [2.2.2]Cryptand: A Chemical Prison
zhlédnutí 43KPřed 7 měsíci
Potassium has been naughty and deserves to be locked up. Support my channel with patreon: www.patreon.com/chemiolis
Making Tetraphenyl Uranocene (Air stable Uranocene)
zhlédnutí 62KPřed 8 měsíci
Making Tetraphenyl Uranocene (Air stable Uranocene)
Making Adrenaline
zhlédnutí 181KPřed 8 měsíci
Making Adrenaline
Making Chemical Hair Remover
zhlédnutí 44KPřed 9 měsíci
Making Chemical Hair Remover
Extracting Thorium Oxide from Ore
zhlédnutí 81KPřed 9 měsíci
Extracting Thorium Oxide from Ore
Making Chemotherapy from Platinum Metal
zhlédnutí 78KPřed 10 měsíci
Making Chemotherapy from Platinum Metal
Making Cubane (without handles)
zhlédnutí 90KPřed 11 měsíci
Making Cubane (without handles)
I Made Cubane First
zhlédnutí 297KPřed 11 měsíci
I Made Cubane First
Making [1.1.1]Propellane
zhlédnutí 69KPřed rokem
Making [1.1.1]Propellane
Making Uranium Tetrachloride out of my Rock
zhlédnutí 238KPřed rokem
Making Uranium Tetrachloride out of my Rock
Making Oxetane
zhlédnutí 60KPřed rokem
Making Oxetane
Making Cat Attractant (Nepetalactone)
zhlédnutí 166KPřed rokem
Making Cat Attractant (Nepetalactone)
Making an Azodye from Acetone
zhlédnutí 70KPřed rokem
Making an Azodye from Acetone
Making the Smell of Rain
zhlédnutí 517KPřed rokem
Making the Smell of Rain
Making the Pinkest Chemical: Thiobenzoyl Chloride
zhlédnutí 72KPřed rokem
Making the Pinkest Chemical: Thiobenzoyl Chloride
Making ABNO: A New Stable Radical
zhlédnutí 65KPřed rokem
Making ABNO: A New Stable Radical
New Molecules for Chemistry with LEDs
zhlédnutí 43KPřed rokem
New Molecules for Chemistry with LEDs

Komentáře

  • @seilgu
    @seilgu Před 2 hodinami

    Can you make Picaridin(Icaridin) the mosquito repellent? I'm wondering how cheap it actually is compared to what we can buy commercially.

  • @BrandonHobson-mr2hm
    @BrandonHobson-mr2hm Před 6 hodinami

    Tryptipmenes got me off opiods and opiates

  • @geroldbendix1651
    @geroldbendix1651 Před 8 hodinami

    Informative, but not very entertaining. To much 0815, somehow theme relevant sequences pasted together and somebody talking without stoppage. I've seen to much of that.

  • @TheSmartestManonEarth
    @TheSmartestManonEarth Před 13 hodinami

    Found it. Thanks

  • @Reggiebossman4
    @Reggiebossman4 Před 15 hodinami

    Cut up a line bossman

  • @ro.zyipitoe5226
    @ro.zyipitoe5226 Před dnem

    not to flex but i can make this myself

  • @watermelon.mp4
    @watermelon.mp4 Před dnem

    thanks

  • @DaveNorthWest
    @DaveNorthWest Před 2 dny

    When it first came out there was ephedrine in it

  • @douro20
    @douro20 Před 2 dny

    How about bupropion? Or are the precursors too expensive?

  • @boxfabio
    @boxfabio Před 2 dny

    after buying every sweetner in my area i only buy the one from aldi , that is sodium cyclamate (i live in Portugal) i have been drinking 10 coffee's a day with 3 pills or more on my coffee ( if is expresso or "american" sized ) this is for almost 20 years now so if it was bad i would be already dead.

  • @andrewferreira1261
    @andrewferreira1261 Před 2 dny

    Guy finds patent for niche stimulant and decides to not only make it but to consume it as well. Holy based...

  • @danf7411
    @danf7411 Před 2 dny

    Make one of the analogs of pyravelone and smoke it on camerq

  • @Mysucculentchinesemeal

    Love how it jumped out of the flask.

  • @davidemelia6296
    @davidemelia6296 Před 2 dny

    Look, if you want your channel to take off, there's no need to keep dick riding other, better YTers. Just stop being so boring. Otherwise, your videos are good!

  • @Jason-fd4vp
    @Jason-fd4vp Před 2 dny

    I learned how to make DMT from a kid on CZcams with a Bronx accent said he was in Peru 😂 I thought about making some videos of it but I don't think it's a safe thing for people to be doing on there own it's far to dangerous and luckily I didn't have any serious issues but I hope it becomes legal someday because it's life changing for the better

  • @vanyaagrigorashchenko

    Mu ch better

  • @microponics2695
    @microponics2695 Před 2 dny

    Worked in a Goodyear hose factory years ago and EVERYONE there even old geezers had amazing looking skin. Benzene wasn't even banned from use in cosmetics until the mid 80's. I wish someone was smart enough to make it not carcinogenic because that stuff makes your skin feel and look so so so so SO very amazing.. Like you're a super model.. it's so nice.. but toxic.

  • @declaimant
    @declaimant Před 3 dny

    Sorry folks, there's no such thing as a Nootropic. If you get a cognitive boost from taking this it's likely cause you're chronically sleep deprived and/or have undiagnosed ADHD (modafinil, it's analogs, and armodafinil all increase dopamine in the brain: www.ncbi.nlm.nih.gov/pmc/articles/PMC2696807/). The good news? It's much safer than the other prescription stimulants (as long as you still get enough sleep of course)

  • @john-michaelrobinson3994

    Where specifically did you get the small container of lignosulfonate?

  • @user-fs3mx2nx4d
    @user-fs3mx2nx4d Před 3 dny

    P3eeeee

  • @dyscotopia
    @dyscotopia Před 3 dny

    I used to have a prescription for modafinil for ADHD and chronic fatigue. As I also suffer anxiety, Ritalin and Dexedrine were a no go for me, but modafinil was relatively smoother

  • @kibnob
    @kibnob Před 3 dny

    2:25 This effect is pretty overblown. It doesn't apply at all to reversible inhibitors like beta-carbolines because as concentrations of other amines (e.g. tyramine) rise, they displace the inhibitor. (This is also why reversibles are poor antidepressants.) With respect to irreversible inhibitors (e.g. tranylcypromine, phenelzine), which react covalently to destroy the enzyme, the human body still retains (diminished) capacity to metabolize dietary monoamines, both from residual MAO as well as other enzymes (e.g. hepatic cytochrome oxidases). As a result, there is a threshold dose for tyramine-induced hypertension, which varies by person and food source, but in the absolute worst case is still approximately a quarter pound (0.1 kg) of cheese. Probably not the best dietary practice in any case. Like anything else, the effect beyond that point scales with dosage. The symptoms can be uncomfortable but are very rarely medically problematic, as it is very difficult for tyramine alone to raise blood pressure above the levels seen during intense exercise, and the body is capable of clearing systemic tyramine in 1-2 hours. Ironically, fear of this effect has led to inappropriate overtreatment, where powerful antihypertensives are used and cause dangerously low blood pressure since the tyramine is shortly cleared. For context, millions of people were prescribed irreversible MAOIs during the early 60s (when tyramine levels in food were much higher), with no knowledge or warning of this possibility, and there were only a handful of cases of death occurring, which were due to cerebral hemorrhage. Any time your blood pressure rises a lot, even during intense exercise, there is a risk of this happening, but fundamentally it is because of a pre-existing weakness in the cerebral vasculature. This is something that people on MAOIs have to be aware of, but with a little knowledge and common sense, it just isn't a problem. Unfortunately, misperceptions of risk have led to MAOIs being mostly shelved, even though they are highly effective antidepressants and anxiolytics that often work when everything else, even shock therapy, has failed. Candidly, once you've seen the effect a drug like tranylcypromine can have on someone, people who once looked like walking corpses now restored to life, suddenly filled with joy and passion, you will wonder why anyone would accept "I'm not sure if it's placebo" SSRIs.

  • @samlazar1053
    @samlazar1053 Před 3 dny

    A barbiturate mixed whit a opiate And you will sing the truth as Stalin would say

  • @erock.steady
    @erock.steady Před 3 dny

    oh kay, i wasn't sure, but now that it's done - totally a diy thing :snark:

  • @jameshatton4405
    @jameshatton4405 Před 3 dny

    So for someone with narcolepsy and already taking dex; this seems like an awful lot of chemistry to create something probably not even a blip on my radar compared to my medication? I dunno; all these benzoyl compound solutions seems a little bit hazardous for my liking, i think I might pass. Cheers

  • @goodstuff
    @goodstuff Před 3 dny

    Alex jones wants to know where you put the babies. jk

  • @mauro2396
    @mauro2396 Před 3 dny

    I think we will see it on sexual lubricants...

  • @_general_error
    @_general_error Před 4 dny

    I think it's called "defensive patents" - They invent something, patent it so no one else can make it, and then they don;t make it themselves... no one can, which help keep them in the business. Also they can sue others who do and make money of it anyway.

  • @mikeb1085
    @mikeb1085 Před 4 dny

    s-modafinil is the future

    • @mikeb1085
      @mikeb1085 Před 4 dny

      but idk why a company like redbull would be interested in making such a compound for use in their energy drinks since redbull is famous for being mixed with alcohol. & s-moda + alcohol is prob a combination that wouldnt work out....prob they are patent squatting

  • @KCJbomberFTW
    @KCJbomberFTW Před 4 dny

    It’s cocaine..

  • @TecraTube
    @TecraTube Před 4 dny

    take my money

  • @Salt_and_Peroxide
    @Salt_and_Peroxide Před 4 dny

    MMMMMMMMM

  • @user-sz4kh6iq5z
    @user-sz4kh6iq5z Před 4 dny

    27:03 "after 100 years" LMaooo

  • @vevenaneathna
    @vevenaneathna Před 4 dny

    rofl. youre so gifted dude

  • @xuankhainguyen2112
    @xuankhainguyen2112 Před 5 dny

    I love the history lesson in addition to the chemistry part

  • @Rwosme
    @Rwosme Před 5 dny

    !!!!!!!!!!!NARCOLEPSY MENTIONED!!!!!!!!!!!!

  • @user-to2gh7sg3l
    @user-to2gh7sg3l Před 5 dny

    Make a list of the ones you know and love!

  • @TigerTankIII
    @TigerTankIII Před 5 dny

    what a vid, subscribe