Understanding & Conquering Depression
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- čas přidán 13. 05. 2024
- This episode, I explain what major depression is at the biological and psychological level and the various treatments that peer-reviewed studies have revealed can help prevent and treat depression. I explain the three major chemical systems that are altered in depression: norepinephrine, serotonin and dopamine. I discuss genetic predispositions to depression and how stress, thyroid hormone and cortisol play a role in many forms of depression. I also discuss inflammation as a common feature of many depression symptoms. I review 8 specific science-supported protocols for treating and avoiding depression, including EPA fatty acids (which have been shown to rival certain prescription treatments), how exercise protects against depression, studies of creatine, adjusting dopamine balance and more. I also discuss the results of ongoing clinical trials for ketamine and psilocybin for depression, how these compounds work and finally, I review how ketogenic diets can help in certain cases of depression, especially treatment-resistant major depression.
For an updated list of our current sponsors, please visit our website as previous sponsors mentioned in this podcast episode may no longer be affiliated with us: www.hubermanlab.com/sponsors
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Links
Review of EPAs for the Treatment of Depression - bit.ly/2Wl15ti
Review of Creatine for the Treatment of Depression - www.mdpi.com/520864
Recent Study on the Clinical Use of Psilocybin for Treatment of Depression - bit.ly/3sFSGMM
Timestamps
00:00:00 Mood Disorders & Maintaining Mental Health (Protocol 1)
00:07:10 Sponsors
00:11:15 Major Depression
00:18:40 “Anti-Self” Confabulation
00:21:42 Autonomic (Vegetative) Symptoms of Depression
00:26:58 Norepinephrine, Dopamine & Serotonin
00:31:50 SSRIs (Prozac, Zoloft, etc.): Selective Serotonin Reuptake Inhibitors
00:37:00 Epinephrine/Motor Functions, Dopamine/Motivation & Craving, Serotonin/Emotions
00:39:33 Physical & Emotional Pain are Linked: Substance P
00:41:50 Hormones & Depression: Thyroid & Cortisol
00:46:50 Genetic Susceptibility to Depression: Impact of Stress
00:50:50 Understanding Biological Mechanism Is Key: Recipes versus Skills
00:52:50 Tools for Dealing with Depression: Logic & Implementation (Protocol 2)
00:56:25 Brain Inflammation & Mental State: Cytokines, Prostaglandins, etc.
00:59:20 Protocol 3: Essential Fatty Acids (Omega-3, EPAs: Eicosapentaenoic Acid)*
01:02:50 How EPAs Help Offset Depression: Serotonin Synthesis, Kynurenine, Quinolinic Acid
01:05:25 Protocol 4: How Exercise Offsets Depression
01:11:44 Protocol 5: Creatine Monohydrate, Forebrain Function & NMDA receptors*
01:20:30 Protocol 6*: Ketamine, PCP (*Prescription-Only), & NMDA-Receptor Function
01:33:08 Protocol 7*: Psychedelics (*In Clinical Trials) for Major Depression: Psilocybin*
01:47:00 Protocol 8: Ketogenic Diet, GABA (Gamma-Aminobutyric Acid)
01:54:50 Summary of Protocols Covered
02:00:10 Support & Additional Resources
#Depression #HubermanLab #Dopamine
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
Disclaimer: www.hubermanlab.com/disclaimer - Věda a technologie
My son had Schizophrenia..He took his life in 2019..I currently am suffering from chronic depression and severe sleep disorders..i am alll over the place...😢Thank you for having this channel and helping people like me..there is no end in learning...❤
I am so sorry you experienced that :( I will hold you in my heart and pray that you may experience some peace soon. Maybe find a support group for those who have a similar experience to subside some of the loneliness.
I am so very sorry 😢. I lost my son and went through that too. It has taken a long time for me to come out on the other side but it did happen gradually. Keep loving yourself through and practice self care. So very sorry, truly a nightmare. ❤️
Mais MS
my dad had schizophrenia too . He passed away from a heart attack at 60 . I’m sorry for your loss and immense pain ❤. I do yoga nidra and celeapram helps heaps for my anxiety .. i loved my dad but schizophrenia took over . bless you ❤
Sorry for your loss, something that helped me cure my depression and negative thoughts is a supplement called 5htp , it increases serotonin in your brain and helps see the brighter side of things. Please look into it, it really helps with depression and sleep as it increases melatonin. I take 150mg per day. Do not take it with other antidepressants SSRI's which can cause too much serotonin in the brain called serotonin syndrome. 5htp doesn't have any of the side effects antidepressants do. Hope it helps, sending you prayers 🕊
Dr. Huberman your contribution to humanity is substantial. Humans being able to work at maximum potential is a beautiful thing and your work is making that possible. Thank you sir !
For real. I hope his parents are proud.
to live at maximum potential ;)
@@philosorapper5454 they fucking better be haha. This man is the ideal man. He is everything I am not and I love him for it!
Humans destroying their home planet at maximum potential…. not sure if thats such a good thing.
@@brucewayne4160 If not, they'd missed it! Simple as that ;)
This podcast is one big reason I have come out of depression and feel so much better. I get my sunlight, eat my omega 3s, vitamin d, ashwaganda, and L-theanine and I’m speechless at how big of a difference it’s made. I’ve stopped crying and falling into despair, and upsetting things aren’t a tsunami of sadness anymore. I cannot thank you enough. May God bless you and your efforts.
(The other factor that helped is PickUpLimes video about feeling lost, and using the printable worksheets she gives to find out what my values are and living according to those)
I'm watching this episode again & read your comment. I take the same supplements that you mentioned. I was just wondering how you feel now.
Be careful with ashagawanda the long term effects you start to feeel no happiness
@@sweetest247 I hope your doing okay i just said a prayer for you. 🩵
The tide of war has turned.
@@sweetest247 I believe in you you can get through anything I’m sending my prayers for you
I love that Huberman truly does stick to the science. Nothing really philosophical, moral, nor opinion based. Purely fact driven. It’s such a breath of fresh air.
science? more like bad science! almost the whole video is antiscientific. The seretonin/depression myth has been busted just last year by Dr, Joanna Moncrieff. do your research. psychiatry is back to 1950 again
Focus only on solutions, positivity, write on papers all solutions (good things for you, your body, your mind, your spirit) and keep the papers with you
Anxiety: Everything is important.
Depression: Nothing is important.
ADHD: I have no idea what's important.
Profound
Yep
What will be anxiety plus depression ?
Anxiety plus adhd here
Schizophrenia: I hallucinate important things all the time.
Bipolar: WHAT DO YOU MEAN ITS NOT IMPORTANT!?!?... never mind... i dont care.
Narcisistic personality disorder: In truth, I am the only really important thing in existance.
6 pages of notes. I feel like a Standford Student. Thank you Dr. Huberman for providing us all with this FREE, potentially life saving information!
Any chance you could share some of the notes??
@@ckstevenson I was thinking the same thing lol
I am so grateful that Dr. Sapolsky has a someone so worthy to follow in these footsteps of sharing needed knowledge
It’s all in the video
this video didn't touch on what depression actually is, or how to get rid of it. it attempted to use hard science to explain and solve a basic metaphysical problem. its not that complex, philosophers who didn't have access to electricity broke it down better 1000 years ago. depression is a state of hopelessness. example "grandma who I loved so much is dead and she's never coming back", "it's too late to get a higher education and better my life I need to work a terrible job forever now", "im unhappy in marriage but need to stay for my kids". these are the types of internal dialogues that cause depression, SPECIFICALLY because your subconscious feels hopeless. it may not in reality be hopeless but that's your perception. spend 5 hours alone in a room with nothing but a pen, paper and your thoughts - it will be scary but you'll gain clarity. either that or go see a shrink who can help you explore what you feel hopeless and chronically anxious about. this guy is a goof.
Your mindfulness while speaking and selection of appropriate words with the phrases of clarifying those words on the sides it's just unreal.. It shows how thoughtful you are while creating this podcast.
Greatly appreciate your work❤
Ask God for help, nothing on this earth can’t be done by God :
“Truly I tell you, if you have faith as small as a mustard seed, you can say to this mountain, 'Move from here to there,' and it will move. Nothing will be impossible for you.”
_Matthew 17:20-21.
“Come to me, all you who are weary and burdened, and I will give you rest. Take my yoke upon you and learn from me, for I am gentle and humble in heart, and you will find rest for your souls. For my yoke is easy and my burden is light.”
_Matthew 11:28-30
"For I, the LORD your God, hold your right hand; it is I who say to you, 'Fear not, I am the one who helps you.”
_ Isaiah 41:13
Focus only on solutions, positivity, write on papers all solutions (good things for you, your body, your mind, your spirit) and keep the papers with you
When I had a clinical depression I used to run around 50 miles a week. Every time I told myself “it must help my depression” but after every run I felt more and more exhausted both physically and mentally. Going for a run added more stress and anxiety because I expected it to heal me but it didn’t. Then I started blaming myself for not training hard enough which worsened the symptoms of my depression even more. Eventually I started meds which helped me to get back on track. Exercise, diet, and meditation might help but when you’re so deep into depression it might be useless
I suggest walking. Running outputs a lot of adrenaline
@@MrBUGS713 I'm going for 30 days
I absolutely agree, same was with me neither sport nor meditation helped me, only medication saved my life... but I was in to deep
i come to this conclusion due to going through the same experience as you. i think what happens is you associate the pain from running to the internal pain your experiencing, for me it was a relationship breakdown . what happens to me was over time when I trained i felt the pain of depression from the breakdown of my relationship when I wasn’t feeling too depressed. This made me realise how powerful and heavy depression is. it clinged to the things that actually made me feel good and become the association.
@@IdontspeakBro. I’ve never thought about it this way, but it makes perfect sense actually. After my depressed runs I quit running for quite a while because I probably must have linked it to all these painful emotions. Thank you for your thought. That made me look even deeper in what was going on back then
This lecture will give me knowledge to support a friend who is suffering depression. Thank you, sir, you make our world a better place !
Bless you 🎵🎵
@@dareartes4232 1111111
@@dareartes4232 1111111111
@@dareartes4232 1
@@dareartes4232 q
Andrew is a blessing to the humanity
This Andrew. But the other Andrew is not.
@@elainego5728Who's the other one?
@@IIT24Aspirant Andrew tate
Focus only on solutions, positivity, write on papers all solutions (good things for you, your body, your mind, your spirit) and keep the papers with you
Literally life saving episode. I'm just tuned in because I'm really struck by depression right now. And for someone who is described as a person with lot of positive energy, mental strength and kindness facing with this is really impossible to realise...
👆👆 look up this handle for psilocybin products l recommend for anyone looking to try it Thank me later..
Hang in there and keep listening
I had a serious episode of clinical depression. What I learned is to get care at a public, academic hospital asap.
Focus only on solutions, positivity, write on papers all solutions (good things for you, your body, your mind, your spirit) and keep the papers with you
Hubie, youre the man. U alone are helping me understand how to become the best version of myself
A nickname I haven’t heard since grade school… ha! Thanks for the feedback!
@@hubermanlabthank you sir! You’ve inspired me to learn as much as I can, to fix myself or learn how to best care for myself, and have motivated me to go back to school, surround myself with academia and to, hopefully, give back to those around me. Seriously a fantastic role model
Hubie?
@@debralbungermd8804 Huber
I suffered from depression all my life. At about 55 years old I took a food allergy test which showed I had a gluten/wheat allergy. I removed wheat from my diet and after about 2 weeks I was depression free. If I accomplish nothing else in my life, I am depression free.
That is HUGE!! Congratulations!!😁👍🏽✌🏽❤️
Focus only on solutions, positivity, write on papers all solutions (good things for you, your body, your mind, your spirit) and keep the papers with you
I am currently severely depressed and I had to muster a lot of strength to start listening to this. I hope it's good of any kind ❤😢
Hey, how are you feeling now?
I really hope it’s better
Focus only on solutions, positivity, write on papers all solutions (good things for you, your body, your mind, your spirit) and keep the papers with you
Sending you love, my friend. Congratulations on taking the step. 🤗
I hope you’re better. Been there & understand. Many prayers for you. 🙏🏼🩷
You will get through it! Stay strong
I live in Norway, and it's been common practice for 50 years, for society to promote consumption of Omega-3/EPA's, especially to help with seasonal depression due to the darkness/climate. In addition the promotion of good work/life balance, which generally leads to less long term stress - this is a powerful combination.
What forms of consumption? Fish or what specific supplement brands do you guys utilize
I’ve become hooked on your videos this year and while others (doctors) in other professional fields have more credentials on some of these things. Your insight in these podcasts has been satisfying a lot of my curiosity over the years from my depression to adhd to my anxieties on nutrition and caffeine. So many bouncy thoughts roll through my brain from a speed from 1-100, one of my Monday highlights (an off day) and also satisfies me when I’m feeling restless when it’s slow at work. Would love to hear caffeines effects on depression/adhd, or if there already is one. You’re arguably the smartest person I’ve heard talk about anything!
You felt better when stopping caffeine?
“What You Seek Is Seeking You”
Thank you for this episode, at this perfect time..
Exactly
That two-dollar philosophy lesson could just be translated as the algorithm working as intended, assuming you've searched up depression- and neurology-related content before, and maybe other health stuff and channels that the people who watch Huberman have watched.
Damn near jumped off a bridge yesterday and this pops up in my recommended to day. Cried like a damn baby
@@smallswideawake try to follow the tips of dr Huberman, I hope you feel better!
@@nakkiel7 thanks dude, hope you’re having a good one as well :)
I'm almost 40. I would guess I had my first depressive event around 10. Since then I've spent 20 +years casually learning about depression, and never has information come to me in a more digestible, empowering way. I have enjoyed your podcast for many months, but this one feels like it was for me. Thank you!
Please tell me the depression gets easier as you age :/
@@sourgummyworms8069 knowledge is your friend, use it and it will get easier. The fact that you're watching this video gives a good indication of that.
@@sourgummyworms8069 I think it depends on circumstance but if you learn to love yourself and others despite their actions, it will get better ,and, forgiveness of others will inadvertently heal you in the process.
You're not alone. I just turned 42, and I've been going through it all of my life since I was a child. It's so hard and painful. It's held me back in life, as well. But all is not lost, because I have a huge heart, understanding, deep perspective, and empathy. Please keep going, don't ever quit.
Tone back the empathy
I’ve had severe depression, getting out of bed feels like jumping into an ice lake, eating breakfast feels like eating feces. And the intensity of these feelings can vary all over the place, you cannot plan anything because your perception of reality can change just like that. What in one second felt like a nice walk in the country, feels like a stroll down a never ending corridor
We need more dopamine:-) hang in there. You are love
I am going through that now. My therapist just sent me the link to this video. But you are so right. It feels exactly like you stated
How do you feel now?
I'm watching this episode & read your comment & just wondering.
@@solarcutgemsbut from where we should get this extra dopamine. From addictions...
Lamictal and ketamine infusions helped me
Your voice is easy to listen to & even if someone is depressed, your message comes through. Teaching is your gift.
Ohhh wonderful to hear him say, "...loss of loved one or a pet..." I like him even more for recognizing the importance of the human-pet bond. 💙
He's recently lost his dog Costello whose snoring used to be the background noise for these podcasts.
@nackedgrils9302 Thanks so much for letting me know. I hadn't been able to listen lately. My deepest condolences to Dr. Huberman. I know the loss--all too well. Rest in peace, Costello🙏🏽
@@candacecrute9313 Costello was a good boy
We dont have to go to next star in this Universe to find out that we are not alone on this Earth.
That's what sent me down my latest spiral was losing my best Kitty friend of 23 years a year-and-a-half ago. The last few years of her life I was just living for her to take care of her and make sure she was comfortable and well taken care of. Now I feel completely spun out and literally all alone. I got other things going on that are pressing on me but that was the major catalyst. I keep thinking I'll surface again but these are dark dark days. It doesn't help that it feels like the world is crumbling all around us as well.
You are a true ACE* for humanity!!! Your *ALTRUISTIC/COMPASSIONATE/EMPATHETIC* nature and contributions to make neuroscience more accessible, in order to improve lives, is a true gift to humanity and the future. Thank you
I've suffered depression probably my entire life. Especially since I got my diploma. The fear of failure, the expectations, the feeling of being lost has caused me depression for years. I sleep too many hours and I wouldn't need all those hours to be honest, but I feel exhausted. When I trip I notice different habits and improve my sleep schedule. Thanks for being a positive energy in my life Andrew
Nailed it. Dang, that description of the symptoms sent me right back there. Thank god for medication and my friends and family. You feel like I may not end it but I can’t live like this. So grateful to be alive today.
These podcasts are priceless thank you
Not only priceless, but they're FREE too!
P. T. S. D. From childhood often causing chronic depression in adulthood. It's often neglected in families because of denial and shame. Mental illness is now so common that it's acceptance is very common but under treated. Get help with issues like these and have a satisfying life.
Focus only on solutions, positivity, write on papers all solutions (good things for you, your body, your mind, your spirit) and keep the papers with you
Been there, diagnosed with clinical depression few years ago. For me it was running and reading that saved me. Thank you for the material and some insights that I had in this podcast. Keep it up
Would you consider yourself « cured » or « free » from depression ? I just need some hope with some positive testimonies of people who overcame that. Thanks
@@Zezeguizee I have suffered depression. My best advices to you: 1) Do exercise. Lift weights. 2) Don't take things personally. 3) Improve your relationships. 4) Practice Gratitude for what you already have.
@@Zezeguizee 5) And keep going! No matter how unbearable life seems to be as long as you stay on course you will get better!
I'm bipolar, and this year Andrew saved me with his podcasts... it gave me hope to try to help myself. Pls join us in the FB grp "Notetakers of Huberman Lab's Podcasts."
@@Zezeguizee Yes, i consider myself not only free but so much more powerfull than in that period because now I know hot to detach myself in a period that is going to happen something similar.
im struggling right now and andrew has helped me more than the hotline has. he gives actual steps, the light at the end of the tunnel. i hope to thank him one day
Focus only on solutions, positivity, write on papers all solutions (good things for you, your body, your mind, your spirit) and keep the papers with you
I hope you are better 🙏🏼
You’re very kind to the people who suffer. Thank you for this episode 🙏🏼♥️
Psychiatrist here - thank you so much for posting such amazing content. This podcast alone has taught me so much. Thank you. Wondering if you could do a similar one discussing anxiety. Would complement this episode nicely. Also discussing relationship between anxiety and depression. My apologies if you have one out on anxiety already and I've missed it!
Tool "Unwinding anxiety" of the psychiatrist and scientist Dr Jud Brewer.
Anxiety as a thought habit loop.
A lot of podcast on you tube from him.
On changing habitual behaviors. Thinking one way or another can also be viewed as a behavior.
I have subscribed to his App and it works.
Better than medication.
Brilliant idea
Anxiety is always the first step of my depression. Irritation -> Anxiety -> Depression -> okay again, repeat
@@KellyandJennaO definitely agree
@@KellyandJennaO ditto
Thank you soo much for this. My daughter has been suffering from severe depression and your discussion is a god send. People, family especially tend to find it difficult to believe the physical aspect of depression on a person. They call her lazy and mentally weak for not knowing how to deal with stress. They say just suck it up what you're feeling isn't real you just want to deal with difficult aspects of life. I can now share this video where you thoughtfully and thoroughly dissect depression in a way that is understood and for me personally you give me hope. My daughter has tried to take her life 5 time now and is just turning 21. Thank for this gift and please continue to shed a positive light on mental illness and bringing hope to those who struggle from it or are directly affected by it like myself who as a parent wants their child to thrive and find happiness. Than you again!
You are a lovely parent. Best wishes for you and your daughter. I have depression but never suicidal. It is a terrible illness. ❤
Is she better? Depression is hard for everyone, sending love and hope you guys are okay!!❤️
Thank you! We're blessed She hasn't had an attempt in about 2 years now. She's far from being better, still a lot of bad days but with more strategies we learn of, the more tools we have to turn the darkness off or at least silence it and have the will power to continue being consistent. She's working in the mental health field now and is in her 3rd Year of college. Always be Blessed to have the ones we love by your side every day you have a chance.
Explain to them that telling someone to “suck it up” or that “they’re mentally weak” is like telling someone with cancer to just suck it up. Depression isn’t a choice it’s a mental illness
Has she tried a carnivore diet
Great episode. My comment regarding crying: quite often people living in depression do not cry at all. Even during the hardest experiences. They are like frozen. Do not process emotions spontaneously. Only by revealing the past traumas, and crying them out they can heal and start enjoying life in its all aspects.
And for some crying happens quite a lot, and the numbness comes after the breakdown.
I so much appreciate all of your time and care to give us the knowledge and tools that empowers us to heal.
Very useful episode for everyone, professionals and patients. However, I think a topic addressing the effects of cognitive behavioral therapy would also be really cool!
Came here to leave this exact comment thank you!
Excellent contribution. I’d find that fascinating
Based on my experience I think CBT is mostly effective only when a person resolves the biological component of depression.
Trueee
@@dp26385 my personal experience has shown that you are correct most of the time
We, bookworms, literally need a book full of example about each topic you discuss by you professor.
Yes, I really wish he would write a book
He said he is working on a book right now :)
I will preorder his book so dang fast once it is finished! haha
NE, dopamine and serotonin are covered in psycho-pharmacology.
Focus only on solutions, positivity, write on papers all solutions (good things for you, your body, your mind, your spirit) and keep the papers with you
I almost fell out of my chair when you mentioned tryptophan converting to a neurotoxin where there is extreme inflammation because every time I take it, instead of becoming happier, I'm more depressed and anxious. This is fascinating stuff. Thank you for shining a light on something that has been baffling me.
Thank you for sharing this, I was almost about to start supplimenting with tryptophan. Now that I know what the pathway is I am not about to do that because I can tell there is quite a bit of inflammation in my body right now.
Fascinating. Do you know if 5-htp causes this also?
@@kavonnowroozi9650 it did for me. 5-htp coverts directly so it is the precursor to serotonin. Tryptophan would have to first be converted to 5-htp then to serotonin. This is why for me personally both of those agents ended up causing more issues than support. :(
I also could not tolerate tryptophan or 5-htp so take SAM-e, or s-adenosylmethionine, and that has helped
@@susanrenick469 that’s really good to know! I’ll explore those! I also started Saffron as that seems to be a bit better
just listening to your lecture has made feel better. I feel the anchor of depression what weights me down get lighter. I think it's because you explain the complex emotions and thoughts going through us in a simple way and makes you feel normal.
You're helping so many people with this information. This is just what the internet needed, and it only took it about three decades
🥳
Focus only on solutions, positivity, write on papers all solutions (good things for you, your body, your mind, your spirit) and keep the papers with you
I want to express my gratitude for this, Prof. Huberman. Since the day you announced that you were going to start a podcast, I have been waiting patiently for an episode on depression and here it finally is. One always has an eagerness to know of one's own afflictions if there is a will to get better. Thank you so much.
Pretty much repeating what others have said. This is pure gold. Dr Hubberman - thank you thank you thank you 🙏🏻
I had an experience that surprised me. I am 74 and wanted my testosterone checked. The free testosterone was low. I started taking androgen gel. What surprised me was the impact on my mood. I did not think there was a problem, and am already taking Zoloft. But after staring androgel, my mood was significantly impacted. Particularly in the sense of much less easily irritated. And generally enjoying life a bit more. Probably less anxiety
This is the most info dense podcast I've ever listened to in the past decade.
Huberman legend in the making
The most organized and comprehensive episode and podcast ever! My dopamine level is through the roof because of the topics of this month. I have been waiting so long for this... Thank you
Glad it was helpful. Thank you!
I could remember several years ago i suffered severe depression and mental disorder. Not until my mom recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 6 years totally clean. Never thought I would be saying this about mushrooms.
they saved you from death bud, lets be honest here. and mushrooms are one of the most amazing things on this planet i wish people would all realize. they could solve a lot of problems, more than just mental treatments, environmental clean up; the possibilities are endless with fungus.
Can you help with the reliable source I would really appreciate it. Many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Australia. Really need!
YES very sure of Dr.alishrooms. I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.
I hate that psilocybin gets grouped with drugs like cocaine and heroin. Mushrooms are a remedy, not a vice! I went on a microdose treatment for a couple of months and within the first week, every sight of a cigarette got me questioning why I was doing all that to myself. It really works.
How do I reach out to him? Is he on insta
I've listened to several episodes of this podcast. They've all been helpful but this one literally saved my life. I can't thank you enough for sharing this knowledge.
Thank you Andrew and crew for all the countless hours you put in to bring us such wonderfully high quality educational material to glean from. All the hard work you put out is dearly appreciated! Thank you!
I listened to this episode and I sobbed. I've been through years of depression, it's hell. But there's always science and it has helped me all these years. Thank you Andrew , for so many of us your voice inhibits the re-uptake of serotonin better than any pills.
Poo
I love you babysitting we’re safe love
E yes e e
Pw
W we wee
The greatest thing about all that you've said throughout this sessiom is - you've made it clear thst those who are actually depressed or close to being so, are most likely not at fault for it. The opposite of what they feel like.
You give them hope that they can get better amd that it often doesn't even require medication to achieve that goal.
Thank you for this extensive, very informative and uplifiting session, I really appreciate it, as do many many others without a doubt.
I am so grateful that I found this podcast, there is such an abundance of information available for free!
Shared with my anxiety group. I can’t thank you enough for all you do. On behalf of all of us, thank you!!!
Wow, I refreshed my CZcams feed at just the right moment!
dopamine paying off
Focus only on solutions, positivity, write on papers all solutions (good things for you, your body, your mind, your spirit) and keep the papers with you
Hugely appreciate the time stamps, its a real asset when re-watching/ scanning for information relevant to my studies.
I'm a holistic nutrition student, and wanted to further understand the tryptophan/serotonin pathway. Something I found pertinent to the discussion:
Carbohydrates w low tryptophan concentration trigger the serotonergic pathway by way of insulin secretion; insulin decreases circulating AA's which compete w tryptophan, allowing said tryptophan to cross blood brain barrier.
I'm 21 years old right now and i would like to thank you so much.. I started watching you in 2022.. And 2023 till now is the year that i'm changed mentally, you had major role in it.
Now i know my self more.. I can understand a lot of social events that happened before to me, with people.. Friends.. Family.. I hope that everyone know about you more and watch these videos.. they are game changing on how to live literally.. Thank you❤❤❤
Thank You Prof. Huberman. I have OCD and Depression which seems like Bipolar and learning about it through your videos is helping me understand the illness. Thank you for your work.
It is so brilliant that this high quality, science based content is available to us. Amazing job Andrew, thank you 😊
I have been feeling extreme negative mood swings for the past few weeks, after listening to this podcast I effectively recognised the cause and stopped it. I'm immensely grateful to Dr.Andrew Huberman 🙏
Applause! Incredible job Dr.Andrew Humberman. I myself suffer from clinic depression for the last two and half years , tried therapy and medication but found no major relief . I gained a lot of insights about depression backed my scientific evidence. I hope it will change many people lives for better. Keep it up man
I've been going to downsub to get the subtitles so I can pour over them and make perfect notes, every monday morning, 2 hour bike ride so I can listen to it all in one go in a focused way. Thank you Sifu! I had lost inspiration for these topics before this podcast, you tell us everything, the whole picture, the whole mechanisms, so we can make our own tools real time, that is beyond my dreams brother
Always looking forward to the weekly episode, thanks dr Andrew for the tremendously hard work! These are truly making the world a better place
Thank you Dr. Huberman for this incredible episode! Your ability to breakdown and explain science is honestly so impressive. I learned a lot from this and will definitely be coming back to it 🙌🙏
Just watching and listening content like this episode alleviates my symptoms. Everything about the pleasure-seeking, pleasure/pain imbalance, and anhedonia were especially enlightening. My emotions, actions and everything makes sense now, and I don't have to blame myself for just being miserable. You also describe many things I've found useful in battling my demons.
Dr. Huberman, you have an excellent understanding of how depression works and are great communicating it clearly, and precisely. What a great man, you deserve much more recognition for your hard work. Thank you so much for sharing the information and your wisdom, everyone should watch this.
You said it perfectly and took the words right out of my mouth
Thank you Dr. Huberman. It’s refreshing to find such honest and informative content on this platform. I hope the algo suggests your content well beyond the incredible number of people that need to hear this. Stay awesome!
I can't wait to finish this!
I just can't believe we have access to someone like you, and have the chance to learn so much from your vast knowledge...it's deeply appreciated!!
He’s a STAR!
I too have become addicted to these outstanding and highly interesting/informative podcasts by Dr. Huberman. I was diagnosed with Bipolar II , yet I feel more like its major depression as I can't think of many times I ever feel joy. I thank you Dr. Huberman and I have ordered creatine and fish oil pills from Momentous. God bless you !! And thank you !!
I have been learning about this topic for quite awhile. I was familiar with many of the conceps mentioned. i have a basic anatomy and physiogy knowledge and have already read Dr. Lembke's book, but I still learned some new information. Guilty of confabulatuon. I also may benefit from adjusting my sodium and other electrolytes. I find all Dr. Hubermans podcasts very interesting in the way they simplify and connect well known concepts and ideas, and bring a new albeit somewhat controversial to the medical establishment point of view. I am grateful for his work and will continue listening to all of his podcasts. However, I have to say it was easy to see that Dr. Huberman has never suffered from depression. I was a bit bothered by the way he started the podcast explaining dopamine pleasure/pain balance and connecting depression to addiction. I do believe they are connected in a way that depression may cause addiction through self medication, but that's not what he was eluding to. I felt that many people may benefit from understanding how the behaviors such as exercise, cold showers, diet, etc can influence their chemical balance, on the other hand I worry this may contribute to the public perception that truly depressed people can pull themselves by the bootstraps. I personally believe that some people are born with a lower or unbalanced baseline, and no amount of running can solve that, given they aquire the motivation to do so.
I cannot pay attention to his lessons for the whole hour and half he speaks. Its because of my chronic depression and chronic resulting laziness. I still appreciate what he is doing with his time. Social media is a poison. But things like this. Some youtubers. They make me feel like internet really has made life for some people better. Especially underprivileged people with no formal education or the availability of these discussions in their lives.
Huberman has connected millions of people all over the world into a community of self improvement. Real science based self improvement. Making our lives better has never been easier. I am grateful to exist in this time and in this place right now. Thank you Dr Huberman. I hope one day you realise the utter magnitude of people you are helping all over the world.
It seems whenever his content is published, it perfectly aligns with my own focal points of the day.
Same
Me too. I was talking to someone about matt Walker on jre, they mentioned Huberman as well. Next day they he released the episode together with Matt Walker. It's crazy how this is happening 🤯
I was diagnosed with neuropathy pain caused by depression. I went through four months of antidepressant treatment that helped me sleep, but that's all I did. At the beginning of the year, I set out to get on my feet and started looking for answers, and that's how I came across this podcast. In the last two months I have applied many tools learned here. It's not a day when I don't have muscle aches, but every day when the pain is below 5, on a scale of 1 to 10, is a good day.
Thank you Dr. Huberman
@@andreabakacs9804 I wonder if you tried CBD? I have thyroid depression and CBD helps me a lot.
@@andreabakacs9804 You're looking for hard scientific answers to basic metaphysical questions. Great philosophers of the past are 10x more intelligent than the average modern scientist. They have more practically knowledge about depression, can accurately describe exactly what it is and how to solve it. To do that you'll need to climb up through hell, so it's not a surprise most people just want a pill. If you actually want functional solutions go look up depression from a philosophical perspective..
You must increase your blood volume and make breath exercise to increase your co2= muscles will
Be finde than.
@Andrea Bakacs please try the medicinal mushrooms either lions mane or Turkey Tail. Changed my life!! Fibromyalgia, chronic fatigue, adhd depression and anxiety. X
Google Alan Gordon and somatic tracking. Also the podcast "tell me about your pain". Maybe it'll help you. New approach. Good luck.
I find it interesting to hear emotion tied in with depression because when I had MDD I didn’t have emotion, I didn’t cry I didn’t feel sad I felt complete nothingness, a shell of a human. Oh also the exercising thing from earlier on, that depressed people lack motivation to go for a run, it feels physically impossible, we don’t lack motivation we just feel like we are slowly dying and standing up is at times too much. That’s why so many people with depression sit in the shower
How are you now?
When I'm depressed, getting in the shower is the last thing I wanna do!
@@carynmartin6053
If you work you likely have to do it but for me yes it is soooo hard however once I do it when I have any urge it makes a world of difference for me & just leaving the home in my car. A drive. I think it is vital however for you to make that decision when your ready. It doesn't help when another tells you. If you have that shut it out. It is like telling an addict to stop. Sure they may even decide to stop temporarily but they relapse for many reasons but being forced into something is just going thru the motions usually for another. You take full control over your depression, your mind & body. That means your time. Try 1 just one small thing & a shower is a great place to start. If you don't feel well after then rest then start again. Really small steps. One step at a time. 🙏
Damn, I could’ve written this
@@carynmartin6053sometimes people with depression will take multiple showers as an escape from reality.
You have the best podcast. Not just because I enjoy it but because you are educating many people on things they may never come across. Thank you for your service
It is hard to find good and reliable source of information usually lost in a mass of self appointed "experts". This one is a jewel a well presented, clear, research based multilayered class. Very informative, enlightening and kind. Delivered with empathy and hope for people suffering from depression and other mental illnesses. I have a degree in medicine and i am now studying counselling. Plus I have loved ones living with depression. Thank you!
Thank you from the bottom of my heart for explaining so beautifully and simplyfying it for the public from non science field too
Dr Huberman you are amazing human being.
God bless you !!
To have an access for free to this kind of knowledge is just unbelievable. I am so grateful for you for spreading awareness about science to the world. We need people like you
Tremendous work Doc. Thank you so much. It would be great for you to cover episodic events that trigger depression and how someone might go from a relatively happy state under most circumstances to a deeply depressed state after loss or grief. Thank you for the scientific work you are doing to heal our minds and bodies.
Huberman, you amaze me every week. Thank you for using your intellect to educate the masses and your love of science and your personality to make it appealing to all. I enjoy this podcast so much.
You make complex information digestible and more simple to understand. Thank you for sharing your gift. 🙏🏽
Thank you so much for the well-rounded approach to talking about depression and addressing the struggle of someone deep in depression faces in treatment. Providing accurate information is the only way to combat stigma that prevents many people from seeking help. As someone that has battled depression, for as long as I can remember, I love hearing reliable information that provides more tools to fight the good fight ❤️ many thanks 🙏
After a major stressor 4 days ago and being in what you called a vegetative state ever since, I started watching this. I just took 1600 mg of EPA/DHA 1:1 and 5g of Creatine and I feel like I can maybe go take a walk. Thank you! ❤
Fantastic!!
I experienced the same!
That May temporary help but it’s just a temporary solution. Depression literally damages your neurons and your brain.
@@StunningTransformationshis person isn't experiencing long term depression, so if it's working immediately and they are no long depressed, it has worked. There would be no damage. In any case, the brain can always heal given the right conditions.
Did you take the creatine & if so what happened?
@@nataliebutler well said. When things get better, brain recovers from anything and neuroplasticity is fantastic
Even before this video starts, I am so happy that this issue is getting covered. Thank you !!
Every time I get notifications from the Hubberman lab Podcast is like getting dopamine of pleasure lol Happy Monday everyone! Feed your brains 🧠 👍🏼
Ditto
Someone isn't paying attention to what Andrew says about dopamine...
@@AF-tp4rh I did. Omg, It’s a joke!
It's definitely addicting lol
@@AF-tp4rh explain
I listened to this and found I was doing most things already.(not the drugs) My biggest trigger is low energy. I went out and bought some creatine and the effect is just amazing! I have been taking 2.5g at breakfast and 2.5g mid afternoon. I am the same happy energiser bunny I was in my youth. I am 65yrs. No procrastination or scrolling. Yay! Thankyou so much!
You should check your methylation in that case (Vitamin B2, B12 and folic acid) are all needed for creatine synthesis
@@mosalami1548 thanks for that! I did that and have added Floradix. It has B1 B2 B6 B12 and Iron. Gave me an added boost 😊
I love this community. Smart empathic people helping each other out to be the best. I will try out creatine. This is my problem rn.
@@trudibarraclough478It helps to be mindful when supplementing with B6 because even though it's water soluble it does get stored in the body. My daily multivitamin and protein shake contained B6. After 6 months of taking both I was diagnosed with B6 toxicity. It seems many "popular" protein shakes, energy drinks and hair/skin/nail supplements add vitamin B6. :)
Wow, I am going to try that. I am 65 as well. Thanks
Watching this video this morning has me celebrating my insomnia this morning. Competence like this is so comforting, helpful and insightful . Such a positive impact that you make on society from your contagious hard work and intelligence. Wow!
Ask God for help, nothing on this earth can’t be done by God if you have faith:
“Truly I tell you, if you have faith as small as a mustard seed, you can say to this mountain, 'Move from here to there,' and it will move. Nothing will be impossible for you.”
_Matthew 17:20-21.
“Come to me, all you who are weary and burdened, and I will give you rest. Take my yoke upon you and learn from me, for I am gentle and humble in heart, and you will find rest for your souls. For my yoke is easy and my burden is light.”
_Matthew 11:28-30
"For I, the LORD your God, hold your right hand; it is I who say to you, 'Fear not, I am the one who helps you.”
_ Isaiah 41:13
“Cast All Your anxiety on HIM
because He cares for you”
_Peter 5:7
Dr. Huberman, you are an angel on Earth. What you are doing is so huge and important for everyone! Thank you, you are immensely appreciated! 🙏🏻
God bless you man. You're showing common people the light by showing them a way out that they just don't have the tools to find themselves.
Thank you so much for your informative podcasts, Dr. Huberman. I'm currently dealing with potential physiological symptoms of stress-induced depression. Understanding the mechanisms helps me feel more confident in my ability to push back against the affliction. Your work is important- thank you again.
The absolute most informative podcast about depression that I've ever listened to. So opening for many people.
This is how learning should be!!! These podcast are like gold!! Thank you Dr. Huberman!!
I cannot thank you enough for your work and contribution to society. Thank you Dr. Huberman. You are one of the most important voices heard today.
Thank you for validating my life experience. Your discussion about episodes of stress related to depression- explains what I have been through and how I ended up in a severe depression. Long story here but the pathway makes a lot of sense
How are you doing now? Same for me where lengthy periods of stress send me into a deep depression. I hate it with a passion. Best wishes to you.
Very helpful. Many doctors do not have the time or ability to educate their patients on this level. I love you and your channel Andrew!
Your work is incredible.
I am so grateful you are bringing all this knowledge to the public 🙌
I would love for you to do an episode about OCD. I have it and I don't actually understand what is happening in my brain. Would love to hear your thoughts.
The world is a better place for having you, thank you so much for your amazing work and communication skills 🙏
Thank you so much for this episode and all the explanations how different systems affect our brain and makes us prone to depression. Absolutelly amazing.
Dr Huberman I have watched hundreds of vlogs on health. However, I place you in top 3 among hundreds of health experts. Thank you for covering thoroughly each subject you deal with . My understanding of health issues have skyrocketed by you vlogs.
The last two podcasts are right up my street, thank you
Dr. Huberman we are speechless about your knowledge , I am MD but when to your speech I can see clear pictures that I couldn't see before and was my questions , your are the greatest of all and I can say we all love you for your work.🙏
I love learning about the mechanism of various things in the human mind and body. So glad I found your podcasts, it's the perfect way to listen to intriguing topics and learn while doing household chores as a stay at home mom.
Thank you for pushing to make information like this accessible to everyone, it really means a great deal to alot of people, especially content with this amount of depth and cover. This very video finally gave me the final nudge to make my appointment with my GP to get my symptoms checked on. I've had depressive symptoms on my shoulders for almost 2 years now and I hope this can help. Again, thank you for what you do, and without videos like these I don't think I would be able to make the steps I need to take on my own. You've probably moved thousands to do something similar, whether it is taking that step, or making them aware of what they might have on their shoulders too.
Good for you, I really hope you were able to get some help and answers. Taking the first step and talking about it is the hardest.
@Josie Adams
thank you!
I was able to get some help, I'm on week 2 with my Prozac prescription, and I'm starting therapy in 2 months.
The first step was definitely difficult, but I really do think it'll be worth it in the future
You are helping so many, just by being your self. Thank you for all of your work, providing free, incredible, available, trusted science. Powerful stuff my friend.
I'm a therapist and your information is so helpful to my clients who want to understand the reasons behind their struggles. The labeled thumb nails in the podcasts are an excellent way for me to tell clients where to stop and really digest what you are explaining.
Thank you for being a therapist who does this for people
As a paramedic from Australia, I continue to learn from your amazing podcasts.
Amazing episode, thank you. It addresses the physical/biological aspects. Would you recommend a similar episode or another podcast on the emotional and psychological aspects and what can be done about them? Hope someone sees this!
Wow you are honestly incredible. Ive been a fan since day 1 and recently I moved to a new city which due to the fact that ive been socially isolated for 2 yrs and I know nobody here and I had some pretty depressing days for the last month cuz I never felt so incredibly sad and wanted to just end everything for no reason. and just when I was like what can I find online to help, andrew returns with yet another banger. this man is a blessing to us all
🌹