Unlocking the Secrets of Our Circadian Rhythms
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- čas přidán 13. 06. 2024
- The trailblazing chronobiologist Carrie Partch has a deep fascination with the biochemical mechanisms that living cells use to track time. Utilizing state-of-the-art nuclear magnetic resonance (NMR) technology and crystallography, her laboratory delves into the intricate workings of pivotal clock molecules such as CLOCK, BMAL1, and the PER and CRY proteins in our cells, investigating their roles in the regulation of circadian rhythms that control the human sleep-wake cycle. Despite the challenges of an ALS diagnosis, Partch is undeterred in her quest to unravel the mysteries of how the human body synchronizes itself with the natural cycles of planet Earth.
Read the full article at Quanta Magazine: www.quantamagazine.org/in-our...
00:00 Biological clocks and chronobiology
01:21 The history of the study of biological clocks
02:30 Circadian rhythms govern more than just sleep-wake cycle
03:10 How modern life negatively impacts biological clock
03:50 Using Nuclear Magnetic Spectroscopy to study the proteins involved in the clock
05:30 How clock proteins regulate the 24-hour body clock
06:40 Fixing broken biological clocks
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#biology #circadianrhythm #biologicalclock - Věda a technologie
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It's not the main topic of the video, but this is the first time I've seen AI voice recreation being used in the "wild". Awesome to see it put to good use, and glad it can help her
Yes, thank you for pointing that out
Same
45th like
4w
Dr Carrie Partch you are a heroine.
Thanks ; great program - much needed ⏳️
To learn more, read the Quanta Magazine article about Dr. Partch and her research studying the human biological clock. www.quantamagazine.org/in-our-cellular-clocks-shes-found-a-lifetime-of-discoveries-20231010/
Music does not help if you are trying to listen.
Thanks Carrie 😊
Excellent work, thank-you
Looking at rest at the molecular level is just absolutely fascinating! Thank you for introducing me to such an important part of how we operate! 👍
I find it interesting that some people wake up at 5 and some people go to sleep at 5, if there was a tribe, someone would be awake in the 24 hours cycle. Are people trying to fix something that isn't technically a defect. The flexibility a drug would help those who need to change their rhythm, I would suggest that they not only look into creating a drug that causes a "normal" Circadian Rhythm but also an "abnormal" Circadian Rhythm one also. There are uses for such things like military applications, or you could do it the easy way and just classify people with Circadian Rhythm type.
Industrial society and its future
shearing unwanted parts off human beings to better fit the system rather than vice versa
I agree. Its cool research, but it makes me feel a little uneasy and wary when they say they'd like to make something that could help people do something like shift work. There is so much stigma for night owls too. They are "lazy" and considered not-normal. I think we need our society to acknowledge that people are just different, and thats okay, *before* we give corporations yet another tool to force human bodies to be more efficient machines for their bottom line. The implications are concerning.
@@DeLaSoul246 I am a night owl. Yea, this occurred to me as well but I didn't want to dwell on it. It's the ultimate problem for human society, will humans become homogenised and monocultured to be a productive workforce or will society become more reflective of the true diversity of people. Not only am I a night owl but coffee does nothing for me and I don't smoke. It seems to me that people who wake up normally and live off coffee and nicotine are a different human being and I actually can't compete with them in their domain. They self sooth and de-stress with nicotine and drive themselves forward on caffeine. The use of chemicals that drive corporatization and capitalism is interesting. Is it a surprise that cannabis, the drug known for relaxing and zoning out is or used to be endlessly demonized and illegal while drugs that are supportive of productivity are basically ok. Cocaine can be prescribed by a doctor, it's used in high society jobs, alcohol is for socializing and unwinding from work on weekends.
@@NanoNutrinoI also don't believe it's a coincidence that drugs that help with the bottom line are less stigmatized. I hope humanity recognizes some day that our diversity is what gives us strength and adaptability as a species. The more homogenized we get as people, as a culture, the less complicated a problem needs to be in order to topple us all. And our problems are doing nothing but getting more complex! Sigh.
@@DeLaSoul246 Amen Brudda
Amazing!
Inspiration
It is misleading that this video portrays the bound CLOCK-BMAL complex performing transcription directly. They are transcription factors, not a form of RNA polymerase.
I wish I was smart enough to have been misled by that
Yep. My main gripe to that animation as well.
Can we turn the music up, I can almost hear what she’s saying
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Most Circadian Rhythm charts are wrong. They show fixed times, like midnight and noon at 12, and morning and nightfall at 6. The times of these phases change daily, like sunrise, sunset, sun peak and midnight. You can use Salah charts instead. As Muslims, we have 5 obligatory daily Salah, that help us sync our Circadian Rhythm with nature. People have been doing it for millennia.
The synergy between mAss and Energy
It would be pretty funny if it turned out that earth's gravity and spinning 24 hours a day mixed aminos around until they eventually created proteins leading to life, starting the clock's gears going.
This feels like the lost dumbed down quanta magazine video. Please keep these videos detail rich, thanks.
She will win nobel prize one day
Where are the references?
where is Aziz Sancar?
Its not simply a "24 hour" clock. The clock length is variable even within a single person and even over a few months or weeks.
For example you can have a cycle of 24 hours consistently in a completely dark room 24/7 without clock feedback.
Or a 30 hour clock, or a 40 hour clock, or a 20 hour clock.
All can be very consistent all in darkness and all without clock feedback.
Calling it a "24 clock" and "using the sun" is an oversimplification.
Also technically it isnt exactly a clock of a certain length. Its more like a clock length and wake up time and sleep time. And they can differ in their impact.
In some people at some periods of time in their life are dominated by a wakeup time, or instead a sleep time, or say a cycle length.
What was said was over simplified to the point of stating falsehoods.
I feel like you are missing the point of the entire video. They never said 24 hr cycles are used by everyone or that it isn't variable.
So did they state any falsehoods or are they just being succinct in their exposure of the work of this particular researcher?
@@mazo- They specifically said a 24 hour clock.
@@mazo- Also idk about being succinct.
Its easy to succinctly say that it a clock of variable duration that gets input from external factors. Aswell as a wakeup time and sleep time.
Yet that wasnt what was said. Unsuccinct false information was said.
@Dogo.R Reread what I said. They never explicitly say that 24 hr cycles are used by everyone. Give me a timestamp in which they say that it's all 24 hrs and I'll give you a timestamp in which they say all types of rhythms and cycles. Sure they could have expanded that to be more precise but they're not wrong. Tell me exactly what falsehood they said. Being brief in their explanation is not a falsehood. It's not overcomplicating things because that's not the point of the video
@@mazo- I just wrote a more accurate explaination that takes seconds to read. Their video is not limited by breifness
👀ツ
My interest is piqued
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5:37
6:36
Please ad hindi voice track in your videos please 🥺
Because I'm from India ♥️♥️
Was this video about Lou Gehrig's disease or the circadian cycle? Video also misses latest research! A very basic video of mostly well known facts.
Which research does it miss? Can you share some links?
Understanding this will be useful for when humans inhabit different planets with orbits drastically different from Earth's.
Perhaps, albeit likely not much. There's no celestial object out there where we could live in their natural environment. So we'd be living in entirely artificial environments. Those environments can be tailored to essentially mimic the patterns of Earth. Of course sometimes you'd have to go to work during the simulated 'night', that happens to be that planets' day, but that's not really different from working the night shift today. Some planets, like Venus, even rotate too slowly for us to follow their cycles, so we'd have to use an artificial alternative.
You guys only post on speculative stuff tbh. I havent seen you talk about real complete science for a long while
Let me tell you a fact , we have more then 5 sense . 5 sense is just a myth . We have more then 22 sense
but it’s a lie that the influence of circadian rhythms was noticed and began to be studied only in the 17th century! why say that?
The sun controls all...
🤔
shaped us
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I think you lost the plot a little. Going about stating people who go to bed at 5pm or 4am. We all need similar amount of sleep and light exposure is a crucial factor. I think I can say I've programmed myself to sleep from 10am to 6pm daily, in a certain sense it's not natural but in another we have availability to so much light at will or vitamin supplements
Not informative
This feels like the lost dumbed down quanta magazine video. Please keep these videos detail rich, thanks.