Topics discussed in this interview: 0:00 Introduction 0:24 Are we seeing natural and vaccine induced immunity? 3:32 mRNA Vaccine safety update 6:30 Variants and COVID vaccines 10:28 Variants - concerns 12:55 Broadly neutralizing vaccine for all variants 15:18 Preparing for a virulent COVID-19 variant 16:53 Johnson and Johnson vaccine 18:52 Who should get the JnJ vaccine? 20:32 Biologics License Application (BLA) 21:18 Vaccine platforms and variants 22:15 Adverse events 23:30 Anti-vaxxers and vaccine hesitancy 26:16 Sputnik and other international vaccine efforts 30:00 When will kids get a COVID vaccine? 32:44 Mandating vaccines
Please address the issue of the elderly with the vaccines. Norway at least recognizes that the elderly may be at risk for harm with the vaccines and changed their guidance. If doctors and officials want to to know why people are distrustful, just look at how this issue is being handled in the US. Doctors and officials are brushing right over it and acting like there is nothing wrong. Maybe the dose needs to be changed for the elderly or maybe they need to wait a bit for the second dose? I don't know the answer, but at this point, I have no trust because no one is even talking about it.
Elderly are prioritized for the vaccine as they are in a high risk group for severe disease. Certainly the large risk of severe covid overwhelms any tiny risk of short-term harm from the vaccine. Elderly and others may need boosters - need time to figure that out.
Since I've made it OK through a year of this pandemic, I'm gonna go through the spring and summer without getting a vaccine and see how they all hold up against the varients...and how long immunity lasts. Right now, there seems to be a question about the length of time needed between the first and second dose of the two dose vaccine...and also whether the one-dose J&J shot gives you more immunity as time goes by. When these questions are answered, I'll be able to make a better decision about getting the vaccine that I feel is right for me.
I have a question: In 2020 and 2021 we as people allowed governments to shutdown our livelihood as well as our social lives and we accepted that we can have this things returned to us after we get a vaccine. What implications does this create for sovereignty over our bodies in the future?
Germany set a 65 year-of-age splitting between mRNA and vector (AstraZeneca) vaccine, which you discussed. If causes a lot of uncertainty among younger people.
J+J applied for a EUA almost a week ago. Why is the FDA waiting until Feb 26 to meet and discuss. Completely unacceptable when 3000+ are dying every day!!!
Thanks again uncle Howard for another excellent interview. Massively helpful and constructive with JAMA interviews very much my go-to avenue of choice leading the debate on Covid giving us hope of an eventual return to (a new) normal.
I wish Dr Offit touched base a bit on how long he feels immunity would last after the 1st dose (Moderna/Pfizer) and if the 2nd dose could be postponed for 2 months so that more folks would get their 1st now.
I think they don’t want to give the impression that you don’t need the second dose. That’s the explanation I’ve heard. Mathematically, it probably would give you more population immunity faster. The other caveat is they don’t know if your immunity might wear off faster without the second dose. And the best argument I’ve heard for 2 doses is that giving large amounts of people only one dose could lead to a higher likelihood of allowing a strain to develop resistance. Kinda makes sense to me.
@@chrisd6736 I agree. I would hope they would not increase the first dose. It’s so hard informing the general public without them developing a distrust. The 2nd dose is needed to boost the T cell response and folks need to get it, but I worry about 65 and older not getting their 1st. So far only half of the vaccines given were to older folks. It’s a mess
My question is why have those who are in charge of distribution have not considered a "shovel ready" site for administration. Sites which have emergency set ups for anaphylaxis which they treat likely more often than any setup and have trained physicians and staff in administering injections and protocols ready for treatment of adverse events. That is Allergist offices. Seems a quick easy way to at least have gotten it started.
While it is critically important to reduce hospitalizations and death, given the problems that many people have with chronic symptoms after less serious illness( “long haulers”)I think we can’t just focus on vaccine efficacy in reducing severe illness. That seems to be problem with the South African variant. The vaccines protect against severe illness, but not mild/moderate illness , correct?
"The vaccines protect against severe illness, but not mild/moderate illness , correct?" Not quite, it seems to be a bit more complicated than that. The efficacy figures we get first is how many people in the trials got *any* illness. ie anything symptomatic enough to get them tested (and I imagine the bar was quite low for this). Because of the conundrum with a/pre-symptomatic spread the whole question of protection against disease vs protection against infection has been talked about a lot, and this muddles things quite a bit. (No big trials really looked at protection against infection, and hence also not on effect on transmission.) So a positive read on the vaccines are that they are highly (like 70-95+ %) effective against illness that's severe enough to get diagnosed (for which the bar isn't very high). The other positive is that of the illness that gets diagnosed next to none are severe (ie requiring ICU). The "long covid" then complicates things further because it doesn't seem to be one thing, but several things. You have people who are moderately sick for a very long time, you have people who have various post-viral symptoms for a long time after an initial acute illness, you even have people in whom the acute illness was very very mild but who then develop persistent symptoms. All but the last group would have been picked up in the vaccine trials, so a vaccine of x% efficacy _should_ eliminate those to whatever x% is. That last group is the big question mark. I don't think we know how big it is in unvaccinated people, and we definitely don't know if this form of long covid could be something lurking in the vaccinated population.
They will live a long and healthy life most likely. I know a younger HCW who had Covid and later got the vaccine, he said the vaccine side effects were way worse than the Covid was.
Please address the supply issue in future editions. Given that we must vaccinate the world, should the Defense Production Act be used to override the production monopolies of Pfizer and Moderna? Should other lagre pharma companies like Merck be brought into the production supply chain? Thank you for your informative talks in this series.
Ho thanks google algorithme I saw both of you on ZDoggMD and it’s my first JAMA video I love to learn the facts and the truth and my version of google algorithm provides me with that so I am lucky 🍀
US criticism of China on this issue at this time is hypocritical. Start shipping vaccines globally to poor countries and then let's talk, but given the US posture in the past year and it's mishandling of the COVID response, we should be learning from China at this point and not casting aspersions. Yes, let's see the data, including infections and fatalities of various countries.
Illinois DOH: *"Even if you died of a CLEAR ALTERNATE CAUSE, it's still listed as a COVID death"* - (Video: "Dr. Ngozi Ezike | How COVID Deaths are Classified")
@@gorgig9136 It might be 0% since the test has never been properly evaluated and has been demonstrated to give extremely high false positives. JAMA Study: "Only 1 of 32 COVID survivors testing positive had live virus." That's a 97% false-positive rate for "covid" diagnosis.
A lot of those 40 million doses are due to second shots. So the true number of people vaccinated is much less. Should be doing one shot to as many as possible due to variants.
Maybe a bit too optomistic these two doctors..They should have mentioned the B117 Varient that doubles every ten days. Is this a hurricane 200 feet away ?!
Recorded the 34 minutes video first. Then posted it 22 minutes before you watched it. People over the world was watching it. Some people know this host and gave thumbs up right at the beginning. I usually do it to my favorite hosts.
Topics discussed in this interview:
0:00 Introduction
0:24 Are we seeing natural and vaccine induced immunity?
3:32 mRNA Vaccine safety update
6:30 Variants and COVID vaccines
10:28 Variants - concerns
12:55 Broadly neutralizing vaccine for all variants
15:18 Preparing for a virulent COVID-19 variant
16:53 Johnson and Johnson vaccine
18:52 Who should get the JnJ vaccine?
20:32 Biologics License Application (BLA)
21:18 Vaccine platforms and variants
22:15 Adverse events
23:30 Anti-vaxxers and vaccine hesitancy
26:16 Sputnik and other international vaccine efforts
30:00 When will kids get a COVID vaccine?
32:44 Mandating vaccines
Do you have any monetary interest in promoting vaccines?
Please address the issue of the elderly with the vaccines. Norway at least recognizes that the elderly may be at risk for harm with the vaccines and changed their guidance. If doctors and officials want to to know why people are distrustful, just look at how this issue is being handled in the US. Doctors and officials are brushing right over it and acting like there is nothing wrong. Maybe the dose needs to be changed for the elderly or maybe they need to wait a bit for the second dose? I don't know the answer, but at this point, I have no trust because no one is even talking about it.
Elderly are prioritized for the vaccine as they are in a high risk group for severe disease. Certainly the large risk of severe covid overwhelms any tiny risk of short-term harm from the vaccine. Elderly and others may need boosters - need time to figure that out.
Since I've made it OK through a year of this pandemic, I'm gonna go through the spring and summer without getting a vaccine and see how they all hold up against the varients...and how long immunity lasts.
Right now, there seems to be a question about the length of time needed between the first and second dose of the two dose vaccine...and also whether the one-dose J&J shot gives you more immunity as time goes by. When these questions are answered, I'll be able to make a better decision about getting the vaccine that I feel is right for me.
Get the first one available
Those are quiet funny questions from someone who has ZERO immunity against any variant at the moment... 😂
I wish most Americans would give the time to understand this disease and vaccines. Thanks for the information
I have a question: In 2020 and 2021 we as people allowed governments to shutdown our livelihood as well as our social lives and we accepted that we can have this things returned to us after we get a vaccine. What implications does this create for sovereignty over our bodies in the future?
Germany set a 65 year-of-age splitting between mRNA and vector (AstraZeneca) vaccine, which you discussed. If causes a lot of uncertainty among younger people.
I am much more concerned about the duration of the immunity after the second dose.
The new strain will be out by now so this vaccine is useless in the next months.
@@vipsupermode2824 That is NOT what they said. They said so far the vaccine has been effective against the two other strains.
Thank you, gentlemen, your work is very much appreciated!
J+J applied for a EUA almost a week ago. Why is the FDA waiting until Feb 26 to meet and discuss. Completely unacceptable when 3000+ are dying every day!!!
Takes time to carefully review and vet all the submitted data.
I am expecting another interesting discussion with Dr.Offit. Thank you JAMA
Such clarity of thought! Thank you!
Great . Topics and times listed make things easy.
Thanks again uncle Howard for another excellent interview. Massively helpful and constructive with JAMA interviews very much my go-to avenue of choice leading the debate on Covid giving us hope of an eventual return to (a new) normal.
I wish Dr Offit touched base a bit on how long he feels immunity would last after the 1st dose (Moderna/Pfizer) and if the 2nd dose could be postponed for 2 months so that more folks would get their 1st now.
I think they don’t want to give the impression that you don’t need the second dose. That’s the explanation I’ve heard. Mathematically, it probably would give you more population immunity faster. The other caveat is they don’t know if your immunity might wear off faster without the second dose.
And the best argument I’ve heard for 2 doses is that giving large amounts of people only one dose could lead to a higher likelihood of allowing a strain to develop resistance. Kinda makes sense to me.
@@chrisd6736 I agree. I would hope they would not increase the first dose. It’s so hard informing the general public without them developing a distrust. The 2nd dose is needed to boost the T cell response and folks need to get it, but I worry about 65 and older not getting their 1st. So far only half of the vaccines given were to older folks. It’s a mess
Thanks so much !
Thank you both.. this is a treat to be Guardedly optimistic!
I haven't heard anyone discuss life after the 2 vaccines in terms of safe activities that are now possible. Could you kindly address this? Thank you.
Look up Vinay Prasad, he is talking about this (and making lots of people angry by being reasonable and realistic).
We are being vaccinated with Sinovac. It may not be 100% effective, but it is 100% available and it can be stored in a normal fridge.
My question is why have those who are in charge of distribution have not considered a "shovel ready" site for administration. Sites which have emergency set ups for anaphylaxis which they treat likely more often than any setup and have trained physicians and staff in administering injections and protocols ready for treatment of adverse events. That is Allergist offices. Seems a quick easy way to at least have gotten it started.
While it is critically important to reduce hospitalizations and death, given the problems that many people have with chronic symptoms after less serious illness( “long haulers”)I think we can’t just focus on vaccine efficacy in reducing severe illness. That seems to be problem with the South African variant. The vaccines protect against severe illness, but not mild/moderate illness , correct?
"The vaccines protect against severe illness, but not mild/moderate illness , correct?"
Not quite, it seems to be a bit more complicated than that. The efficacy figures we get first is how many people in the trials got *any* illness. ie anything symptomatic enough to get them tested (and I imagine the bar was quite low for this).
Because of the conundrum with a/pre-symptomatic spread the whole question of protection against disease vs protection against infection has been talked about a lot, and this muddles things quite a bit. (No big trials really looked at protection against infection, and hence also not on effect on transmission.)
So a positive read on the vaccines are that they are highly (like 70-95+ %) effective against illness that's severe enough to get diagnosed (for which the bar isn't very high). The other positive is that of the illness that gets diagnosed next to none are severe (ie requiring ICU).
The "long covid" then complicates things further because it doesn't seem to be one thing, but several things. You have people who are moderately sick for a very long time, you have people who have various post-viral symptoms for a long time after an initial acute illness, you even have people in whom the acute illness was very very mild but who then develop persistent symptoms.
All but the last group would have been picked up in the vaccine trials, so a vaccine of x% efficacy _should_ eliminate those to whatever x% is. That last group is the big question mark. I don't think we know how big it is in unvaccinated people, and we definitely don't know if this form of long covid could be something lurking in the vaccinated population.
What happens to people who have refused the vaccine
They will live a long and healthy life most likely. I know a younger HCW who had Covid and later got the vaccine, he said the vaccine side effects were way worse than the Covid was.
They will get Covid 19, sooner or later. 2021, 2022,.. If they survive, they will be immune.
They will survive on this planet .
Double doses of LSD is all i want!
Thank you!
Keep packing the planes - spreading the variants - that create new variants - South Africa is in summer right?
Please address the supply issue in future editions. Given that we must vaccinate the world, should the Defense Production Act be used to override the production monopolies of Pfizer and Moderna? Should other lagre pharma companies like Merck be brought into the production supply chain? Thank you for your informative talks in this series.
He said 92 percent that died of the virus were 55 yrs and older...
In the UK its 99% that died were 45 yrs and older.
@@janefromthecountry1820 I listened to that podcast also... A different message from Jama podcast.
I don't understand
Ho thanks google algorithme I saw both of you on ZDoggMD and it’s my first JAMA video I love to learn the facts and the truth and my version of google algorithm provides me with that so I am lucky 🍀
I’m trying so hard to find an available vaccine to get.
Why doesn’t the rt-PCR diagnostic test pick up the synthetic mRNA?
The vaccine mRNA enters cells and doesn't circulate. The rt-PCR test is typically performed on nasopharyngeal specimens. So 2 different sites.
@@JAMANetwork Thank you!
US criticism of China on this issue at this time is hypocritical. Start shipping vaccines globally to poor countries and then let's talk, but given the US posture in the past year and it's mishandling of the COVID response, we should be learning from China at this point and not casting aspersions. Yes, let's see the data, including infections and fatalities of various countries.
Illinois DOH: *"Even if you died of a CLEAR ALTERNATE CAUSE, it's still listed as a COVID death"* - (Video: "Dr. Ngozi Ezike | How COVID Deaths are Classified")
Some officials said it's only 6% real deaths from Covid-10
@@gorgig9136 It might be 0% since the test has never been properly evaluated and has been demonstrated to give extremely high false positives. JAMA Study: "Only 1 of 32 COVID survivors testing positive had live virus." That's a 97% false-positive rate for "covid" diagnosis.
@@robotron17 I agree
A lot of those 40 million doses are due to second shots. So the true number of people vaccinated is much less. Should be doing one shot to as many as possible due to variants.
Maybe a bit too optomistic these two doctors..They should have mentioned the B117 Varient that doubles every ten days. Is this a hurricane 200 feet away ?!
They did mention it.
When I first clicked this link it was posted 22 minutes ago and the video was 34 minutes long and it already had 90 thumbs up I don’t get it
Most channels allow early access for Patreon subscribers.
Recorded the 34 minutes video first. Then posted it 22 minutes before you watched it. People over the world was watching it. Some people know this host and gave thumbs up right at the beginning. I usually do it to my favorite hosts.
SO WHAT ABOUT MASKS???????