PUBLIC SERVICE ANNOUNCEMENT! These 2 Facebook Accounts Are Not Me (Vigorous Steve): facebook.com/profile.php?id=100094771665529 facebook.com/vigorous.steve/ Please do me a favor and report these accounts for impersonation, let's get these 2 accounts deleted ASAP! Thanks! Citations: Wang, Y.X. et al. (October, 2004) Regulation of muscle fiber type and running endurance by PPARdelta. PLOS Biology, 2(10):e294. doi: 10.1371/journal.pbio.0020294 www.tesble.com/10.1371/journal.pbio.0020294 Narkar, V.A. et al. (August 8, 2008) AMPK and PPARdelta agonists are exercise mimetics. Cell, 134(3):405-15. doi: 10.1016/j.cell.2008.06.051 www.tesble.com/10.1016/j.cell.2008.06.051 Matthiessen, M.W. et al. (February, 2005) Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas. Scandinavian Journal of Gastroenterology, 40(2):198-205. doi: 10.1080/00365520410009573 www.bothonce.com/10.1080/00365520410009573 Ali, F.Y. et al. (November, 2009) PPARbeta/delta agonists modulate platelet function via a mechanism involving PPAR receptors and specific association/repression of PKCalpha-brief report. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(11):1871-3. doi: 10.1161/ATVBAHA.109.193367 www.bothonce.com/10.1161/ATVBAHA.109.193367 Han. J.K. et al. (June, 2013) Peroxisome proliferator-activated receptor-δ activates endothelial progenitor cells to induce angio-myogenesis through matrix metallo-proteinase-9-mediated insulin-like growth factor-1 paracrine networks. European Heart Journal, 34(23):1755-65. doi: 10.1093/eurheartj/ehr365 www.wellesu.com/10.1093/eurheartj/ehr365 Li, S. et al. (2015) Exercise Pills: At the Starting Line. Trends in Pharmacological Sciences (TIPS), 36(12):906-917. doi: 10.1016/j.tips.2015.08.014 www.wellesu.com/10.1016/j.tips.2015.08.014 Grewal, A.S. et al. (2016) Recent Updates on Peroxisome Proliferator-Activated Receptor δ Agonists for the Treatment of Metabolic Syndrome. Journal of Medicinal Chemistry, 12(1):3-21. doi: 10.2174/1573406411666150525105826 www.wellesu.com/10.2174/1573406411666150525105826 Wall, C.E. et al. (July, 2016) Nuclear receptors and AMPK: can exercise mimetics cure diabetes? Journal of Molecular Endocrinology, 57(1):R49-58. doi: 10.1530/JME-16-0073 www.wellesu.com/10.1530/JME-16-0073 Kintz, P. et al. (October 7, 2021) Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine). Toxics, 9(10):251. doi: 10.3390/toxics9100251 www.mdpi.com/2305-6304/9/10/251 Park, J. et al. (August 1, 2021) Cardarine (GW501516) Effects on Improving Metabolic Syndrome. Journal of Health, Sports, and Kinesiology, 2021, 2(2), 22-27. doi: 10.47544/johsk.2021.2.2.22 www.ingentaconnect.com/contentone/iohsk/johsk/2021/00000002/00000002/art00006?crawler=true&mimetype=application/pdf Janhavi, P. et al. (April, 2022) DoseCal: a virtual calculator for dosage conversion between human and different animal species. Archives of Physiology and Biochemistry, 128(2):426-430. doi: 10.1080/13813455.2019.1687523 www.tesble.com/10.1080/13813455.2019.1687523 dosecal.cftri.res.in/index.php Bianchi, V.E. et al. (July 28, 2023) GW501516 (Cardarine): Pharmacological and Clinical Effects. Genetics & Molecular Medicine, 2023; 5(1): 1-12 www.scivisionpub.com/pdfs/gw501516-cardarine-pharmacological-and-clinical-effects-2879.pdf
Pro-Cancer Effects: Glinghammar, B. et al. (August 22, 2003) PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells. Biochemical and Biophysical Research Communications, 308(2):361-8. doi: 10.1016/s0006-291x(03)01384-6 www.bothonce.com/10.1016/s0006-291x(03)01384-6 Gupta, R.A. et al. (March, 2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nature Medicine, 10(3):245-7. doi: 10.1038/nm993 www.bothonce.com/10.1038/nm993 Stephen, R.L. et al. (May 1, 2004) Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines. Cancer Research, 64(9):3162-70. doi: 10.1158/0008-5472.can-03-2760 www.bothonce.com/10.1158/0008-5472.can-03-2760 Yin, Y. et al. (May 1, 2005) Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis. Cancer Research, 65(9):3950-7. doi: 10.1158/0008-5472.CAN-04-3990 www.bothonce.com/10.1158/0008-5472.CAN-04-3990 Wang, D. et al. (December 12, 2006) Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proceedings of the National Academy of Sciences of the United States of America, 103(50):19069-74. doi: 10.1073/pnas.0607948103 www.bothonce.com/10.1073/pnas.0607948103 Zeng, L. et al. (August 15, 2008) Peroxisome proliferator-activated receptor-delta induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumors. Cancer Research, 68(16):6578-86. doi: 10.1158/0008-5472.CAN-08-0855 www.bothonce.com/10.1158/0008-5472.CAN-08-0855 Geiger, L.E. et al. (2009). PS 895 - Rat carcinogenicity study with GW501516, a PPAR delta agonist. 48th Annual Meeting of the Society of Toxicology. Baltimore: Society of Toxicology. Newsholme, S.J. et al. (2009) Mouse carcinogenicity study with Gw501516, a PPAR delta agonist. 48th Annual Meeting of the Society of Toxicology. Baltimore: Society of Toxicology. web.archive.org/web/20150504013406/http:/www.toxicology.org/AI/PUB/Tox/2009Tox.pdf Ritzenthaler, J.D. et al. (2009) PPARbeta/delta agonist increases the expression of PGE2 receptor subtype EP4 in human lung carcinoma cells. Methods in Molecular Biology, 512:309-23. doi: 10.1007/978-1-60327-530-9_17 link.springer.com/protocol/10.1007/978-1-60327-530-9_17 Rohrl, C. et al. (January, 2011) Peroxisome-proliferator-activated receptors γ and β/δ mediate vascular endothelial growth factor production in colorectal tumor cells. Journal of Cancer Research and Clinical Oncology, 137(1):29-39. doi: 10.1007/s00432-010-0856-1 www.bothonce.com/10.1007/s00432-010-0856-1 Wang, D. et al. (February 23, 2012) Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells. Oncogene, 31(8):1013-23. doi: 10.1038/onc.2011.299 www.bothonce.com/10.1038/onc.2011.299 Yuan, H. et al. (January, 2012) Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation. Cancer Prevention Research AACR Journals, 5(1):51-60. doi: 10.1158/1940-6207.CAPR-11-0256 www.bothonce.com/10.1158/1940-6207.capr-11-0256 Yuan, H. et al. (July 15, 2013) PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation. Cancer Research, 73(14):4349-61. doi: 10.1158/0008-5472.CAN-13-0322 www.bothonce.com/10.1158/0008-5472.CAN-13-0322 Lagu, B. et al. (Febuary 1, 2018) Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516. Bioorganic & Medicinal Chemistry Letters, 28(3):533-536. doi: 10.1016/j.bmcl.2017.11.006 www.wellesu.com/10.1016/j.bmcl.2017.11.006 Zhou, D. et al. (January 5, 2019) PPARδ agonist enhances colitis-associated colorectal cancer. European Journal of Pharmacology, 842:248-254. doi: 10.1016/j.ejphar.2018.10.050 www.bothonce.com/10.1016/j.ejphar.2018.10.050 Liu, Y. et al. (March 1, 2019) Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion. Cancer Research, 79(5):954-969. doi: 10.1158/0008-5472.CAN-18-1790 www.bothonce.com/10.1158/0008-5472.CAN-18-1790 Ding, J. et al. (August 15, 2019) Metformin inhibits PPARδ agonist-mediated tumor growth by reducing Glut1 and SLC1A5 expressions of cancer cells. European Journal of Pharmacology, 857:172425. doi: 10.1016/j.ejphar.2019.172425 www.bothonce.com/10.1016/j.ejphar.2019.172425 Wang. D. et al. (September 1, 2019) PPARδ Mediates the Effect of Dietary Fat in Promoting Colorectal Cancer Metastasis. Cancer Research, 79(17):4480-4490. doi: 10.1158/0008-5472.CAN-19-0384 www.bothonce.com/10.1158/0008-5472.CAN-19-0384 Hirao-Suzuki, M. et al. (2020) Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation. The Journal of Toxicological Sciences, 45(4):227-236. doi: 10.2131/jts.45.227 www.bothonce.com/10.2131/jts.45.227 Elie-Caille, C. et al. (August, 2020) Molecular and nanoscale evaluation of N-cadherin expression in invasive bladder cancer cells under control conditions or GW501516 exposure. Molecular and Cellular Biochemistry, 471(1-2):113-127. doi: 10.1007/s11010-020-03771-1 www.bothonce.com/10.1007/s11010-020-03771-1
Anti-Cancer Effects: Hollingshead, H.E. et al. (December, 2007) Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines. Carcinogenesis, 28(12):2641-9. doi: 10.1093/carcin/bgm183 www.bothonce.com/10.1093/carcin/bgm183 Girroir, E.E. et al. (January 14, 2008) Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines. 243(1-2):236-43. doi: 10.1016/j.tox.2007.10.023 www.bothonce.com/10.1016/j.tox.2007.10.023 Foreman, J.E. et al. (February 28, 2010) Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) inhibits cell growth in a mouse mammary gland cancer cell line. Cancer Letters, 288(2):219-25. doi: 10.1016/j.canlet.2009.07.006 www.bothonce.com/10.1016/j.canlet.2009.07.006 Yuan, H. et al. (July 15, 2013) PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation. Cancer Research, 73(14):4349-61. doi: 10.1158/0008-5472.CAN-13-0322 www.bothonce.com/10.1158/0008-5472.CAN-13-0322 Ma, J.J. et al. (December, 2013) Ligand-activated peroxisome proliferator-activated receptor β/δ modulates human endometrial cancer cell survival. Hormone Cancer, 4(6):358-70. doi: 10.1007/s12672-013-0157-7 www.bothonce.com/10.1007/s12672-013-0157-7 Pechery, A. et al. (November, 2016) Apoptotic effect of the selective PPARβ/δ agonist GW501516 in invasive bladder cancer cells. Tumour Biology, 37(11):14789-14802. doi: 10.1007/s13277-016-5305-6 www.bothonce.com/10.1007/s13277-016-5305-6 Ham, S.A. et al. (September 11, 2018) Ligand-activated interaction of PPARδ with c-Myc governs the tumorigenicity of breast cancer. International Journal of Cancer, 143(11):2985-2996. doi: 10.1002/ijc.31864 onlinelibrary.wiley.com/doi/10.1002/ijc.31864 Gu. L. et al. (August 8, 2019) PPARβ/δ Agonist GW501516 Inhibits Tumorigenesis and Promotes Apoptosis of the Undifferentiated Nasopharyngeal Carcinoma C666-1 Cells by Regulating miR-206. Oncology Research, 27(8):923-933. doi: 10.3727/096504019X15518706875814 www.bothonce.com/10.3727/096504019X15518706875814
Clinical Trials: Sprecher, D. et al. () Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(2):359-65. doi: 10.1161/01.ATV.0000252790.70572.0c www.bothonce.com/10.1161/01.ATV.0000252790.70572.0c Riserus, U. et al. (February, 2008) Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. Diabetes, 57(2):332-9. doi: 10.2337/db07-1318 www.bothonce.com/10.2337/db07-1318 The University of Western Australia (February 11, 2009) Regulation of Lipoprotein Transport in Metabolic Syndrome. NCT00841217 clinicaltrials.gov/study/NCT00841217 Ooi, E.M.M. et al. (October 2011) Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity. Journal of Clinical Endocrinology and Metabolism, 96(10):E1568-76. doi: 10.1210/jc.2011-1131 www.wellesu.com/10.1210/jc.2011-1131 GlaxoSmithKline (March 19, 2012) An Exploratory Study To Look At The Effect Of Two Investigational Drugs On Body Fat And Inflammation. NCT00388180 clinicaltrials.gov/study/NCT00388180 GlaxoSmithKline (May 30, 2017) GW501516 In Subjects Who Have Low Level Of High-Density Lipoprotein Cholesterol, NCT00158899 clinicaltrials.gov/study/NCT00158899 Olson, E.J. et al. (September, 2012) Lipid effects of peroxisome proliferator-activated receptor-δ agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(9):2289-94. doi: 10.1161/ATVBAHA.112.247890 www.wellesu.com/10.1161/ATVBAHA.112.247890 GlaxoSmithKline (March 19, 2012) Effect Of GW501516X On How The Heart Obtains And Uses Energy. NCT00318617 clinicaltrials.gov/study/NCT00318617
Detection Times: Thevis, M. et al. (February 15, 2009) Doping control analysis of emerging drugs in human plasma - identification of GW501516, S-107, JTV-519, and S-40503. Rapid Communications in Mass Spectrometry, 23(8):1139-46. doi: 10.1002/rcm.3987 www.bothonce.com/10.1002/rcm.3987 Thevis, M. et al. (2010) Mass spectrometry-based characterization of new drugs and methods of performance manipulation in doping control analysis. European Journal of Mass Spectrometry, 16(3):301-12. doi: 10.1255/ejms.1047 www.bothonce.com/10.1255/ejms.1047 Thevis, M. et al. (April, 2010) Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls. Analytical and Bioanalytical Chemistry, 396(7):2479-91. doi: 10.1007/s00216-009-3283-x www.bothonce.com/10.1007/s00216-009-3283-x Sobolevsky, T. et al. (October, 2012) Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine. Drug Testing and Analysis, 4(10):754-60. doi: 10.1002/dta.1413 www.wellesu.com/10.1002/dta.1413 Thevis, M. et al. (2013) Synthesis, mass spectrometric characterization, and analysis of the PPARδ agonist GW1516 and its major human metabolites: targets in sports drug testing. Methods in Molecular Biology, 952:301-12. doi: 10.1007/978-1-62703-155-4_22 www.wellesu.com/10.1007/978-1-62703-155-4_22 Pokrywka, A. et al. (August, 2014) Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor δ (GW501516) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR). Journal of Physiology and Pharmacology, 65(4):469-76 www.researchgate.net/profile/Agnieszka-Zembron-Lacny/publication/265299631_Metabolic_modulators_of_the_exercise_response_Doping_control_analysis_of_an_agonist_of_the_peroxisome_proliferator-activated_receptor_d_GW501516_and_5-aminoimidazole-4-carboxamide_ribonucleotide_AICAR/links/565815bc08aeafc2aac17377/Metabolic-modulators-of-the-exercise-response-Doping-control-analysis-of-an-agonist-of-the-peroxisome-proliferator-activated-receptor-d-GW501516-and-5-aminoimidazole-4-carboxamide-ribonucleotide-AICAR.pdf?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InB1YmxpY2F0aW9uIiwicGFnZSI6InB1YmxpY2F0aW9uIn19 Kintz, P. et al. (July, 2020) Testing for GW501516 (cardarine) in human hair using LC/MS-MS and confirmation by LC/HRMS. Drug Testing and Analysis, 980-986. doi: 10.1002/dta.2802 www.wellesu.com/10.1002/dta.2802 Sobolevsky, T. et al. (February, 2021) High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction. Drug Testing and Analysis, 283-298. doi: 10.1002/dta.2917 www.wellesu.com/10.1002/dta.2917
As someone who has benefited from using cardarine to improve endurance with notably results (seriously, my cardio sucked and struggled to jog for 20+ min at a 11 minute mile pace, after cardarine I’m able to run a sustained 8 minute mile without passing out)I truly appreciate this video.
@@qui1766 I usually just use it when I go for a cardio session such as running or a metabolic conditioning workout. It makes cardio less painful. I try to put in a couple of miles per week cuz I work full time and I’m a dad to young kids so my time is limited and cardarine helped me maximize my results with limited time. Yeah I could cut out cardarine and run 15-30 miles a week and workout 3-4 times a week but I just have a busy schedule and keeping up with inflation by picking up overtime but rather get decent results in 1/2 the time and effort.
People who say your experience isn’t real have likely never tried cardarine. My experience with it, as someone who is a naturally good runner, was that cardarine made running feel the same way a cycle makes lifting feel. Better even. My breathing changed the very first time I used it, a lot. It made me feel as if I’d never taken a break from running but I hadn’t ran in several months. One of the most effective things I’ve ever put in my body, and I was almost immediately depending on it to push myself further and further. It’s a very seductive thing. It doesn’t feel bad for you at all. It feels amazing
I’ve been on trt for 4 years and for the first year I did blood work every 3 months and now I do it every 6. I did my blood work 3 times with little change to LDL and HDL. HDL sits around 70 and LDL 60. 2 weeks with cardarine and HDL was 85 and LDL dropped to 53.
@@blackjack6406 I honestly just have a low fat diet. I do High protein, moderate carb, and low fat diet. All meats are lean cuts. A lot of extra lean ground beef or chicken. 90% of my fats are from extra virgin olive oil. Meal preps for me are generally jasmine rice, lean ground beef, pink salt and pepper. Then I pour a table spoon of extra virgin olive oil over it.
Another epically great video. The BEST cardarine video ever made. People who sell it should require their customers to watch this video before the sale can go through. That way they know how to treat their lab mice properly.
I think like Steve points out…. It’s better to be safe than sorry. Other videos pointed out that whether it expresses cancer genes or not don’t even risk it….. I take it but… don’t recommend it to other people.
There are zero negative effects to using Cardarine. Especially when used in conjunction with Tren. It has an amazing effect in counteracting the negative respiratory effects and lipid profiles of Tren when used in conjunction.
I’ve used carderine 4xs…. I’ve always limited the dose to NO MORE than 20mg total daily. I’ve ran it for up to 12 weeks Carderine DID increase my good cholesterol and it does work very well and very fast… that’s why it’s coined “exercise in a pill” however like Steve says some say it causes cancer and others say it has anti-tumor effects. Awesome video Steve!!!!!!!
I took 15mg the first time (actually, 10mg of GW0742, then 15mg of GW501516 a few months later), and I'm taking 10mg now. I don't see a reason to go past 10mg, but I'm super "sensitive" to things. 😜
What WOULD be interesting is a comparison of the Cancer effects of smoking, sugar and cardarine all in one video. Which one is least dangerous based on scientific data?🤔
I remember seeing a guy on a forum doing a self experiment with cardarine for his heart failure. The dud was in full heart failure, with something like less 20% ejection. After taking high dose cardarine for 6 months or so, his heart improved to 50% ejection. He included his heart test results too. I'll look for it and send it to you when I find it.
thank you for this info. I don't understand it all, but I am glad that you have the mindset to be able to go through this precisely like this. I am trying out cardarine and testolone. I definitely feel my strength has gone up and when I get up in the morning, I don't feel as weary as before. I still have great respect for these agents and am a little scared of them and am using minimum doses and will only do it for 4-6 weeks.
Last time I tried cardarine my bench strength dropped over 100 pounds, I went from repping 315 for 7 to barely able to manage 225 for 3, I got off and my strength returned... I think it switching over the body to burning fat for fuel instead of glucose really affected my fast twitch fibers. I've never experienced such a rapid fall off of strength like that before, not even if I were to fast and go with no sleep would my strength ever plummet like that.
Did you know beforehand that you would lose strenght? I tried it during a cut last year and my bench stayed almost the same, I lost the typical 2 reps from 315 x 12 to 315 x 10, but that's always the case.
@@maenlest17 Cardarine is known amongst the strength world to lower your max output... I assume mine was so drastically impacted because I train in the heavy and explosive range usually for my top sets, if I can move the weight I'm usually doing it very quickly with an emphasis on speed.... not just rushing through or flailing weight around but being as explosive as possible.... I had previously tried cardarine years back and noticed no dropping of strength, but I wasn't as strong back then nor did I train explosively... Sometimes we just get the short end of the stick when it comes to side-effects, there's a lot of stuff I used to be able to run but can't anymore because the sides are intolerable. Long story short: some of us respond differently and who's to know exactly why, I'm thinking if you're more fast twitch muscle oriented the fact that cardarine switches fast twitch to slow twitch is what makes for sometimes such a drastic fall off in strength whilst on it. I wasn't going to stick around or ride it out though since I train for strength alone. I was going to run it for it's goodness with helping out the ldl/hdl ratio and it's other anti-inflammatory effects but as soon as I saw how sharp my strength took a hit I dropped it and thankfully everything returned to normal. I had heard you can lose some strength on it so I was kinda expecting such, but when I ran it years ago I noticed no drop, it actually seemed easier to do more reps but I was working with higher reps back then anyways and not just strength focused.
It makes sense fast twitch fibers are glycolytic and cardarine forces your body to burn fat so is the wrong fuel. I think is good to use during a cut so you dont feel fatigued and accelerate fat loss but dont train with heavy weights.
@@georgen5250 You're 100% right, I think cardarine would be great for a cut or even an endurance athlete but for someone looking for strength or who even trains strength in general might want to pass... Not that one would look to cardarine itself for strength but that even with it's pluses just the negative impact it can have.... I think it's all short term though and not permanent so if you're willing to trade off the things for a short while before returning to strength then it might be worth it, but I know for myself it wasn't worth it.
It’s interesting because if you look at what cardarine does to the body it would seem that it’s anti carcinogenic. It raises your V02 max and slightly reverses metabolic syndromes. Interesting dichotomies to say the least.
I would put money on the cancer increase/decrease being similar to the studies on ketogenic diets. It probably has to do with changing metabolism types.
Can you make some videos about REV-ERB agonists like sr9009, there's some recent studies correlating to improved heart function and brain injury protection.
Thanks to Steve, my buddies all now come to me with questions about PEDs and health... I consistently send them links to Steve's videos and website to no avail. What's a good coaching fee? steve can get his 10%.
Steve your recent videos are excellent. Evidence based and citation listed 👌perfect!- Steve you should be an honorary PhD in PEDs. Thank you for the excellent content and work for educating the community 🙏🏽
I’m confused. That first conversion chart seems to demonstrate that the cancer-inducing effect starts at 8.11 mg in a 50kg person up to 19.46mg in a 120kg person. But isn’t it supposed to be 8.11mg PER kg of body weight? That would imply that the deleterious dose is +400mg/ day for a 50kg person. I’m around 80kg so isn’t my danger zone 12.97mg x 80, or 1,040mg daily?
Thank you for writing this. I am a APRN and I feel like I am not hearing something correctly. The 2mg per Kg is still a larger dose than what most people would ever take. I would love to see this clarified. I am wondering if I just heard something incorrect or if he meant to say 0.3 mg.
Yes! I was almost going to append my comment to say this! Even at the lowest 2mg) dose, it’s 8x the typical 20mg dose & 16x the 10mg dose administered in human trials where no adverse health effects were reported after 12 weeks
@@LFV_1 I looked into it and it is because of HED or Human Equivalent Dose. So 3mg per Kg for humans is different. I would suggest just googling HED and reddit. A great explanation is there. I still don’t fully subscribe to the cancerous threat
Hey Steve, there is a study showing that cardarine produced fibrosis in already damaged livers, allegedly the healing effect is much too fast. I got jaundice myself after two weeks of use, 15mg/day with 1000mg NAC as support. Stopped using it and went back to normal after a week. Going to try another source just to be sure.
I used cardarine a lot in 2020 but haven’t used it since with the cancer scares. I feel I was a hyper responder to it in terms of endurance, like I was able to push insane wattages on the bike and maintain them. It almost made me want to push too hard on the cardio lol, and this was during the time when I used the most gear in my life. It also maintained my HDL at around 40 when it should have been below 20 lol. My LDL wasn’t really affected much if at all.
I have taken several brands of Cardarine before and even at the lower end of doses it causes rectal bleeding and itchiness, seen only a handful of people who use it here and there talk about this too, but never seen anyone who is more of an expert in this talk about it. Any thoughts on this Steve?
I always wondered why GW’s effects would seemingly drop off after 4-6 weeks of use… It’s been probably close to 10 years since I’ve ran it and with the evidence you’ve laid out here it seems like it’s not worth it. I’ll take my money and run and be happy I got away with it when I did
Just from personal experience. I took cardarine 3 years ago and got Lymphoma shortly afterwards. No worries though im in remission now and bigger then ever :P but if i were you guys i would think twice or maybe three times before doing cardarine .
Derek at MDMP said cardarine doesn’t cause fat lose, and in fact its main value is only a risky choice for improving poor lipid panels because the ideal dose is close to the rat cancer dose
12.5mg Cardarine and 12.5mg Ostarine stack helped cut me up and all blood work was great, including lower cholesterol levels. However, I was also eating freakishly clean during my 12 week cycle
Okay so he did not add that this is considered the HED which stands for the human equivalent dose. This takes other factors i to consideration such as metabolic rate and size, for example.
Additional info: While cardarine has shown some promising effects on longevity in animal studies, its potential to increase human lifespan is still largely speculative and requires further research. Here's a summary of the current state of knowledge: Mechanisms: Cardarine seems to have multiple mechanisms that could potentially impact lifespan: Mitochondrial biogenesis: Cardarine has been shown to increase mitochondrial density and function in muscles, which can help reduce oxidative stress and improve energy production. Antioxidant effects: It has antioxidant properties, which may help protect cells from damage caused by free radicals. Inflammation reduction: Cardarine may reduce inflammation, which is a known contributor to aging and age-related diseases. Epigenetic modulation: It may affect gene expression, potentially influencing cellular processes involved in aging. Animal studies: Some animal studies have demonstrated that cardarine: Increased lifespan: Mice fed a high-fat diet supplemented with cardarine lived longer than those on a standard diet. Improved insulin sensitivity: Cardarine-treated mice showed improved insulin sensitivity and reduced glucose tolerance. Reduced age-related diseases: Studies found that cardarine decreased the incidence of age-related diseases, such as cancer, cardiovascular disease, and neurodegenerative disorders. Human studies: While there are no human trials specifically designed to study the effect of cardarine on lifespan, some clinical trials have explored its use in conditions like type 2 diabetes and obesity. These studies suggest that cardarine may have beneficial effects on metabolism, insulin sensitivity, and cardiovascular risk factors.
Question: what does a jacked non-PED user in late 30s or 40s take if they want to keep up a great look and dip their toe in the PED waters? [Both fertile and non-fertile based]
My experience: Cardarine has crushed my LDL BELOW my HDL every time i’ve used it (twice), once i assumed it was me being at near contest shape from an extreme diet given by a coach in conjunction with cardarine and a heavy (for me at the time) stack of anabolics The next time i was coaching myself, decently lean but nothing crazy, bloodwork at end of cut after using cardarine, aas stack and gh about equivalent to previous, same thing HDL higher than LDL Bloodwork to prove it if you want to take a look steve!
same here... my LDL was in the 140s earlier in my life when natural and taking no meds. 10mg ea of rosuvastatin and ezetimibe brought it down to 80-100. adding cardarine along with some potent anabolics my LDL now is 40 which is below my HDL. I also use SR9009 (injectable or sublingual) which may be helping with that too.
Steve I’m curious which do you think is the most synergistic? Growth hormone/ growth hormone secretagogue + cardarine, Growth hormone/ growth hormone secretagogue + metformin or Growth hormone/ growth hormone secretagogue + berberine for insulin resistance?
Hi, for me fatt loss is ussles but for endurence i feel like king(I wish could take gw all year), and for fat less hdl ldl extremly low that was shock for me. For fatt loss woud take only idiots but for endurence so good.
Steve, if you want to i can email you my hdl and ldl results while running 300mg test and 150 mast . Both improved. Hdl went from 28 to42 in a month at 12.5 of taking GW. Ldl dropped 40 points i believe as well.
I have some labs from my last prep (fall of 2023) where I used cardarine and ldl and hdl improved but diet and cardio also improved during this time so maybe not all due to cardarine if any.
I always link them in the comment section in a pinned comment, as there's too many citations for the description section, which has a 5,000 character limit.
PUBLIC SERVICE ANNOUNCEMENT! These 2 Facebook Accounts Are Not Me (Vigorous Steve):
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Please do me a favor and report these accounts for impersonation, let's get these 2 accounts deleted ASAP! Thanks!
Citations:
Wang, Y.X. et al. (October, 2004) Regulation of muscle fiber type and running endurance by PPARdelta. PLOS Biology, 2(10):e294. doi: 10.1371/journal.pbio.0020294
www.tesble.com/10.1371/journal.pbio.0020294
Narkar, V.A. et al. (August 8, 2008) AMPK and PPARdelta agonists are exercise mimetics. Cell, 134(3):405-15. doi: 10.1016/j.cell.2008.06.051
www.tesble.com/10.1016/j.cell.2008.06.051
Matthiessen, M.W. et al. (February, 2005) Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas. Scandinavian Journal of Gastroenterology, 40(2):198-205. doi: 10.1080/00365520410009573
www.bothonce.com/10.1080/00365520410009573
Ali, F.Y. et al. (November, 2009) PPARbeta/delta agonists modulate platelet function via a mechanism involving PPAR receptors and specific association/repression of PKCalpha-brief report. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(11):1871-3. doi: 10.1161/ATVBAHA.109.193367
www.bothonce.com/10.1161/ATVBAHA.109.193367
Han. J.K. et al. (June, 2013) Peroxisome proliferator-activated receptor-δ activates endothelial progenitor cells to induce angio-myogenesis through matrix metallo-proteinase-9-mediated insulin-like growth factor-1 paracrine networks. European Heart Journal, 34(23):1755-65. doi: 10.1093/eurheartj/ehr365
www.wellesu.com/10.1093/eurheartj/ehr365
Li, S. et al. (2015) Exercise Pills: At the Starting Line. Trends in Pharmacological Sciences (TIPS), 36(12):906-917. doi: 10.1016/j.tips.2015.08.014
www.wellesu.com/10.1016/j.tips.2015.08.014
Grewal, A.S. et al. (2016) Recent Updates on Peroxisome Proliferator-Activated Receptor δ Agonists for the Treatment of Metabolic Syndrome. Journal of Medicinal Chemistry, 12(1):3-21. doi: 10.2174/1573406411666150525105826
www.wellesu.com/10.2174/1573406411666150525105826
Wall, C.E. et al. (July, 2016) Nuclear receptors and AMPK: can exercise mimetics cure diabetes? Journal of Molecular Endocrinology, 57(1):R49-58. doi: 10.1530/JME-16-0073
www.wellesu.com/10.1530/JME-16-0073
Kintz, P. et al. (October 7, 2021) Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine). Toxics, 9(10):251. doi: 10.3390/toxics9100251
www.mdpi.com/2305-6304/9/10/251
Park, J. et al. (August 1, 2021) Cardarine (GW501516) Effects on Improving Metabolic Syndrome. Journal of Health, Sports, and Kinesiology, 2021, 2(2), 22-27. doi: 10.47544/johsk.2021.2.2.22
www.ingentaconnect.com/contentone/iohsk/johsk/2021/00000002/00000002/art00006?crawler=true&mimetype=application/pdf
Janhavi, P. et al. (April, 2022) DoseCal: a virtual calculator for dosage conversion between human and different animal species. Archives of Physiology and Biochemistry, 128(2):426-430. doi: 10.1080/13813455.2019.1687523
www.tesble.com/10.1080/13813455.2019.1687523
dosecal.cftri.res.in/index.php
Bianchi, V.E. et al. (July 28, 2023) GW501516 (Cardarine): Pharmacological and Clinical Effects. Genetics & Molecular Medicine, 2023; 5(1): 1-12
www.scivisionpub.com/pdfs/gw501516-cardarine-pharmacological-and-clinical-effects-2879.pdf
Pro-Cancer Effects:
Glinghammar, B. et al. (August 22, 2003) PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells. Biochemical and Biophysical Research Communications, 308(2):361-8. doi: 10.1016/s0006-291x(03)01384-6
www.bothonce.com/10.1016/s0006-291x(03)01384-6
Gupta, R.A. et al. (March, 2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nature Medicine, 10(3):245-7. doi: 10.1038/nm993
www.bothonce.com/10.1038/nm993
Stephen, R.L. et al. (May 1, 2004) Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines. Cancer Research, 64(9):3162-70. doi: 10.1158/0008-5472.can-03-2760
www.bothonce.com/10.1158/0008-5472.can-03-2760
Yin, Y. et al. (May 1, 2005) Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis. Cancer Research, 65(9):3950-7. doi: 10.1158/0008-5472.CAN-04-3990
www.bothonce.com/10.1158/0008-5472.CAN-04-3990
Wang, D. et al. (December 12, 2006) Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proceedings of the National Academy of Sciences of the United States of America, 103(50):19069-74. doi: 10.1073/pnas.0607948103
www.bothonce.com/10.1073/pnas.0607948103
Zeng, L. et al. (August 15, 2008) Peroxisome proliferator-activated receptor-delta induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumors. Cancer Research, 68(16):6578-86. doi: 10.1158/0008-5472.CAN-08-0855
www.bothonce.com/10.1158/0008-5472.CAN-08-0855
Geiger, L.E. et al. (2009). PS 895 - Rat carcinogenicity study with GW501516, a PPAR delta agonist. 48th Annual Meeting of the Society of Toxicology. Baltimore: Society of Toxicology.
Newsholme, S.J. et al. (2009) Mouse carcinogenicity study with Gw501516, a PPAR delta agonist. 48th Annual Meeting of the Society of Toxicology. Baltimore: Society of Toxicology.
web.archive.org/web/20150504013406/http:/www.toxicology.org/AI/PUB/Tox/2009Tox.pdf
Ritzenthaler, J.D. et al. (2009) PPARbeta/delta agonist increases the expression of PGE2 receptor subtype EP4 in human lung carcinoma cells. Methods in Molecular Biology, 512:309-23. doi: 10.1007/978-1-60327-530-9_17
link.springer.com/protocol/10.1007/978-1-60327-530-9_17
Rohrl, C. et al. (January, 2011) Peroxisome-proliferator-activated receptors γ and β/δ mediate vascular endothelial growth factor production in colorectal tumor cells. Journal of Cancer Research and Clinical Oncology, 137(1):29-39. doi: 10.1007/s00432-010-0856-1
www.bothonce.com/10.1007/s00432-010-0856-1
Wang, D. et al. (February 23, 2012) Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells. Oncogene, 31(8):1013-23. doi: 10.1038/onc.2011.299
www.bothonce.com/10.1038/onc.2011.299
Yuan, H. et al. (January, 2012) Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation. Cancer Prevention Research AACR Journals, 5(1):51-60. doi: 10.1158/1940-6207.CAPR-11-0256
www.bothonce.com/10.1158/1940-6207.capr-11-0256
Yuan, H. et al. (July 15, 2013) PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation. Cancer Research, 73(14):4349-61. doi: 10.1158/0008-5472.CAN-13-0322
www.bothonce.com/10.1158/0008-5472.CAN-13-0322
Lagu, B. et al. (Febuary 1, 2018) Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516. Bioorganic & Medicinal Chemistry Letters, 28(3):533-536. doi: 10.1016/j.bmcl.2017.11.006
www.wellesu.com/10.1016/j.bmcl.2017.11.006
Zhou, D. et al. (January 5, 2019) PPARδ agonist enhances colitis-associated colorectal cancer. European Journal of Pharmacology, 842:248-254. doi: 10.1016/j.ejphar.2018.10.050
www.bothonce.com/10.1016/j.ejphar.2018.10.050
Liu, Y. et al. (March 1, 2019) Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion. Cancer Research, 79(5):954-969. doi: 10.1158/0008-5472.CAN-18-1790
www.bothonce.com/10.1158/0008-5472.CAN-18-1790
Ding, J. et al. (August 15, 2019) Metformin inhibits PPARδ agonist-mediated tumor growth by reducing Glut1 and SLC1A5 expressions of cancer cells. European Journal of Pharmacology, 857:172425. doi: 10.1016/j.ejphar.2019.172425
www.bothonce.com/10.1016/j.ejphar.2019.172425
Wang. D. et al. (September 1, 2019) PPARδ Mediates the Effect of Dietary Fat in Promoting Colorectal Cancer Metastasis. Cancer Research, 79(17):4480-4490. doi: 10.1158/0008-5472.CAN-19-0384
www.bothonce.com/10.1158/0008-5472.CAN-19-0384
Hirao-Suzuki, M. et al. (2020) Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation. The Journal of Toxicological Sciences, 45(4):227-236. doi: 10.2131/jts.45.227
www.bothonce.com/10.2131/jts.45.227
Elie-Caille, C. et al. (August, 2020) Molecular and nanoscale evaluation of N-cadherin expression in invasive bladder cancer cells under control conditions or GW501516 exposure. Molecular and Cellular Biochemistry, 471(1-2):113-127. doi: 10.1007/s11010-020-03771-1
www.bothonce.com/10.1007/s11010-020-03771-1
Anti-Cancer Effects:
Hollingshead, H.E. et al. (December, 2007) Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines. Carcinogenesis, 28(12):2641-9. doi: 10.1093/carcin/bgm183
www.bothonce.com/10.1093/carcin/bgm183
Girroir, E.E. et al. (January 14, 2008) Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines. 243(1-2):236-43. doi: 10.1016/j.tox.2007.10.023
www.bothonce.com/10.1016/j.tox.2007.10.023
Foreman, J.E. et al. (February 28, 2010) Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) inhibits cell growth in a mouse mammary gland cancer cell line. Cancer Letters, 288(2):219-25. doi: 10.1016/j.canlet.2009.07.006
www.bothonce.com/10.1016/j.canlet.2009.07.006
Yuan, H. et al. (July 15, 2013) PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation. Cancer Research, 73(14):4349-61. doi: 10.1158/0008-5472.CAN-13-0322
www.bothonce.com/10.1158/0008-5472.CAN-13-0322
Ma, J.J. et al. (December, 2013) Ligand-activated peroxisome proliferator-activated receptor β/δ modulates human endometrial cancer cell survival. Hormone Cancer, 4(6):358-70. doi: 10.1007/s12672-013-0157-7
www.bothonce.com/10.1007/s12672-013-0157-7
Pechery, A. et al. (November, 2016) Apoptotic effect of the selective PPARβ/δ agonist GW501516 in invasive bladder cancer cells. Tumour Biology, 37(11):14789-14802. doi: 10.1007/s13277-016-5305-6
www.bothonce.com/10.1007/s13277-016-5305-6
Ham, S.A. et al. (September 11, 2018) Ligand-activated interaction of PPARδ with c-Myc governs the tumorigenicity of breast cancer. International Journal of Cancer, 143(11):2985-2996. doi: 10.1002/ijc.31864
onlinelibrary.wiley.com/doi/10.1002/ijc.31864
Gu. L. et al. (August 8, 2019) PPARβ/δ Agonist GW501516 Inhibits Tumorigenesis and Promotes Apoptosis of the Undifferentiated Nasopharyngeal Carcinoma C666-1 Cells by Regulating miR-206. Oncology Research, 27(8):923-933. doi: 10.3727/096504019X15518706875814
www.bothonce.com/10.3727/096504019X15518706875814
Clinical Trials:
Sprecher, D. et al. () Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(2):359-65. doi: 10.1161/01.ATV.0000252790.70572.0c
www.bothonce.com/10.1161/01.ATV.0000252790.70572.0c
Riserus, U. et al. (February, 2008) Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. Diabetes, 57(2):332-9. doi: 10.2337/db07-1318
www.bothonce.com/10.2337/db07-1318
The University of Western Australia (February 11, 2009) Regulation of Lipoprotein Transport in Metabolic Syndrome. NCT00841217
clinicaltrials.gov/study/NCT00841217
Ooi, E.M.M. et al. (October 2011) Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity. Journal of Clinical Endocrinology and Metabolism, 96(10):E1568-76. doi: 10.1210/jc.2011-1131
www.wellesu.com/10.1210/jc.2011-1131
GlaxoSmithKline (March 19, 2012) An Exploratory Study To Look At The Effect Of Two Investigational Drugs On Body Fat And Inflammation. NCT00388180
clinicaltrials.gov/study/NCT00388180
GlaxoSmithKline (May 30, 2017) GW501516 In Subjects Who Have Low Level Of High-Density Lipoprotein Cholesterol, NCT00158899
clinicaltrials.gov/study/NCT00158899
Olson, E.J. et al. (September, 2012) Lipid effects of peroxisome proliferator-activated receptor-δ agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(9):2289-94. doi: 10.1161/ATVBAHA.112.247890
www.wellesu.com/10.1161/ATVBAHA.112.247890
GlaxoSmithKline (March 19, 2012) Effect Of GW501516X On How The Heart Obtains And Uses Energy. NCT00318617
clinicaltrials.gov/study/NCT00318617
Detection Times:
Thevis, M. et al. (February 15, 2009) Doping control analysis of emerging drugs in human plasma - identification of GW501516, S-107, JTV-519, and S-40503. Rapid Communications in Mass Spectrometry, 23(8):1139-46. doi: 10.1002/rcm.3987
www.bothonce.com/10.1002/rcm.3987
Thevis, M. et al. (2010) Mass spectrometry-based characterization of new drugs and methods of performance manipulation in doping control analysis. European Journal of Mass Spectrometry, 16(3):301-12. doi: 10.1255/ejms.1047
www.bothonce.com/10.1255/ejms.1047
Thevis, M. et al. (April, 2010) Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls. Analytical and Bioanalytical Chemistry, 396(7):2479-91. doi: 10.1007/s00216-009-3283-x
www.bothonce.com/10.1007/s00216-009-3283-x
Sobolevsky, T. et al. (October, 2012) Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine. Drug Testing and Analysis, 4(10):754-60. doi: 10.1002/dta.1413
www.wellesu.com/10.1002/dta.1413
Thevis, M. et al. (2013) Synthesis, mass spectrometric characterization, and analysis of the PPARδ agonist GW1516 and its major human metabolites: targets in sports drug testing. Methods in Molecular Biology, 952:301-12. doi: 10.1007/978-1-62703-155-4_22
www.wellesu.com/10.1007/978-1-62703-155-4_22
Pokrywka, A. et al. (August, 2014) Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor δ (GW501516) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR). Journal of Physiology and Pharmacology, 65(4):469-76
www.researchgate.net/profile/Agnieszka-Zembron-Lacny/publication/265299631_Metabolic_modulators_of_the_exercise_response_Doping_control_analysis_of_an_agonist_of_the_peroxisome_proliferator-activated_receptor_d_GW501516_and_5-aminoimidazole-4-carboxamide_ribonucleotide_AICAR/links/565815bc08aeafc2aac17377/Metabolic-modulators-of-the-exercise-response-Doping-control-analysis-of-an-agonist-of-the-peroxisome-proliferator-activated-receptor-d-GW501516-and-5-aminoimidazole-4-carboxamide-ribonucleotide-AICAR.pdf?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InB1YmxpY2F0aW9uIiwicGFnZSI6InB1YmxpY2F0aW9uIn19
Kintz, P. et al. (July, 2020) Testing for GW501516 (cardarine) in human hair using LC/MS-MS and confirmation by LC/HRMS. Drug Testing and Analysis, 980-986. doi: 10.1002/dta.2802
www.wellesu.com/10.1002/dta.2802
Sobolevsky, T. et al. (February, 2021) High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction. Drug Testing and Analysis, 283-298. doi: 10.1002/dta.2917
www.wellesu.com/10.1002/dta.2917
these are drugs that are usually only to be used for soldiers and stuff usually speaking
For the past weeks I’ve been looking at Cardarine to improve my endurance and now Steve makes a video damn can u read my mind?
As someone who has benefited from using cardarine to improve endurance with notably results (seriously, my cardio sucked and struggled to jog for 20+ min at a 11 minute mile pace, after cardarine I’m able to run a sustained 8 minute mile without passing out)I truly appreciate this video.
How long were you on it, what was your dose, and what was your training experience prior?
@@qui1766 I usually just use it when I go for a cardio session such as running or a metabolic conditioning workout. It makes cardio less painful. I try to put in a couple of miles per week cuz I work full time and I’m a dad to young kids so my time is limited and cardarine helped me maximize my results with limited time. Yeah I could cut out cardarine and run 15-30 miles a week and workout 3-4 times a week but I just have a busy schedule and keeping up with inflation by picking up overtime but rather get decent results in 1/2 the time and effort.
You progress fast when running. it wasn't the drug lol
People who say your experience isn’t real have likely never tried cardarine. My experience with it, as someone who is a naturally good runner, was that cardarine made running feel the same way a cycle makes lifting feel. Better even. My breathing changed the very first time I used it, a lot. It made me feel as if I’d never taken a break from running but I hadn’t ran in several months. One of the most effective things I’ve ever put in my body, and I was almost immediately depending on it to push myself further and further. It’s a very seductive thing. It doesn’t feel bad for you at all. It feels amazing
Agree. That stuff does work. Considering I did track back then…
I’ve been on trt for 4 years and for the first year I did blood work every 3 months and now I do it every 6. I did my blood work 3 times with little change to LDL and HDL. HDL sits around 70 and LDL 60. 2 weeks with cardarine and HDL was 85 and LDL dropped to 53.
what is your nutrition like that you LDL is this low? Do you supplement a statin/red yeast rice?
@@blackjack6406 I honestly just have a low fat diet. I do High protein, moderate carb, and low fat diet. All meats are lean cuts. A lot of extra lean ground beef or chicken. 90% of my fats are from extra virgin olive oil. Meal preps for me are generally jasmine rice, lean ground beef, pink salt and pepper. Then I pour a table spoon of extra virgin olive oil over it.
Only supplement I religiously take is astragalus root extract
Do you keep the lipid level “gains” after you stop the cardarine cycle? Did your levels revert back to where you were?
@@bapbap22They usually revert back slowly. It's weird. I'm not even sure it improves health. Might work for familial hyperdislipidemia? 🤷🏼♂️
Another epically great video. The BEST cardarine video ever made. People who sell it should require their customers to watch this video before the sale can go through. That way they know how to treat their lab mice properly.
Steve, I think you could be my father
"I'm not your father with those blonde bangs and skinny ankles" - Dr vigorous lmao
Dad? Is that you?
You do look like a sock.
He is a sperm donator
I can be your uncle
Damn! Another phd level presentation from Professor Steve. Keeping us jacked, ripped and safe!
To cancer or not to cancer? that is the question!
I think like Steve points out…. It’s better to be safe than sorry. Other videos pointed out that whether it expresses cancer genes or not don’t even risk it….. I take it but… don’t recommend it to other people.
There's Tons of Perscription Medicine 💊 that possibly cause Cancer as well..
It doesn't. It never has and its results are nothing short of amazing when used to combat the negative effects of using Tren.
There are zero negative effects to using Cardarine. Especially when used in conjunction with Tren. It has an amazing effect in counteracting the negative respiratory effects and lipid profiles of Tren when used in conjunction.
Many drugs that work miracles for longevity get abandoned or pulled from the market. Like oxandrin did not long ago. More than meets the eye really
"Remember to pick the right parents" damn, I had a feeling I messed up somewhere along the way.
I’ve used carderine 4xs…. I’ve always limited the dose to NO MORE than 20mg total daily. I’ve ran it for up to 12 weeks Carderine DID increase my good cholesterol and it does work very well and very fast… that’s why it’s coined “exercise in a pill” however like Steve says some say it causes cancer and others say it has anti-tumor effects.
Awesome video Steve!!!!!!!
I couldn't imagine wanting to take a higher dose anyways. 20 *WORKS*. Hell, 15 is probably enough.
Less is BETTER always 60-90 On 30 days off SIMPLE
So what do you think ? 10mg is better and non cancerous for a month?
I took 15mg the first time (actually, 10mg of GW0742, then 15mg of GW501516 a few months later), and I'm taking 10mg now. I don't see a reason to go past 10mg, but I'm super "sensitive" to things. 😜
I have used 10-20 mg of cardarine on TRT for short durations of time and it did improve my cholesterol levels in blood test.
What WOULD be interesting is a comparison of the Cancer effects of smoking, sugar and cardarine all in one video. Which one is least dangerous based on scientific data?🤔
Lol.. I do all 3 sometimes. Hope it's the secret to a long life!
I remember seeing a guy on a forum doing a self experiment with cardarine for his heart failure. The dud was in full heart failure, with something like less 20% ejection. After taking high dose cardarine for 6 months or so, his heart improved to 50% ejection. He included his heart test results too. I'll look for it and send it to you when I find it.
We waitin
Still waitin@@ggod4185
@@ggod4185 MPMD actually made a video about this called “SARM’s saved my life” .
@@EL_N0IR_2201 search: Sarms saved my life MPMD
@@EL_N0IR_2201I don't think it was on Reddit. I thought it was on MesoRX but I looked there and couldn't find anything. It bugging me now.
If I remember one cancer promoting study had the mice on a dose that was very high and in 2 years of duration.
Yeah, he mentioned that.
This is OG Vigorous Steve Material love it! I know these videos take alot of work but they are what I subscribe for!
thank you for this info. I don't understand it all, but I am glad that you have the mindset to be able to go through this precisely like this. I am trying out cardarine and testolone. I definitely feel my strength has gone up and when I get up in the morning, I don't feel as weary as before. I still have great respect for these agents and am a little scared of them and am using minimum doses and will only do it for 4-6 weeks.
10 mg in day, 12 weeks, thanks coach 🤚😊
Last time I tried cardarine my bench strength dropped over 100 pounds, I went from repping 315 for 7 to barely able to manage 225 for 3, I got off and my strength returned... I think it switching over the body to burning fat for fuel instead of glucose really affected my fast twitch fibers. I've never experienced such a rapid fall off of strength like that before, not even if I were to fast and go with no sleep would my strength ever plummet like that.
Did you know beforehand that you would lose strenght? I tried it during a cut last year and my bench stayed almost the same, I lost the typical 2 reps from 315 x 12 to 315 x 10, but that's always the case.
@@maenlest17 Cardarine is known amongst the strength world to lower your max output... I assume mine was so drastically impacted because I train in the heavy and explosive range usually for my top sets, if I can move the weight I'm usually doing it very quickly with an emphasis on speed.... not just rushing through or flailing weight around but being as explosive as possible.... I had previously tried cardarine years back and noticed no dropping of strength, but I wasn't as strong back then nor did I train explosively... Sometimes we just get the short end of the stick when it comes to side-effects, there's a lot of stuff I used to be able to run but can't anymore because the sides are intolerable.
Long story short: some of us respond differently and who's to know exactly why, I'm thinking if you're more fast twitch muscle oriented the fact that cardarine switches fast twitch to slow twitch is what makes for sometimes such a drastic fall off in strength whilst on it. I wasn't going to stick around or ride it out though since I train for strength alone. I was going to run it for it's goodness with helping out the ldl/hdl ratio and it's other anti-inflammatory effects but as soon as I saw how sharp my strength took a hit I dropped it and thankfully everything returned to normal.
I had heard you can lose some strength on it so I was kinda expecting such, but when I ran it years ago I noticed no drop, it actually seemed easier to do more reps but I was working with higher reps back then anyways and not just strength focused.
It makes sense fast twitch fibers are glycolytic and cardarine forces your body to burn fat so is the wrong fuel. I think is good to use during a cut so you dont feel fatigued and accelerate fat loss but dont train with heavy weights.
@@georgen5250 You're 100% right, I think cardarine would be great for a cut or even an endurance athlete but for someone looking for strength or who even trains strength in general might want to pass... Not that one would look to cardarine itself for strength but that even with it's pluses just the negative impact it can have.... I think it's all short term though and not permanent so if you're willing to trade off the things for a short while before returning to strength then it might be worth it, but I know for myself it wasn't worth it.
The takeaway that I get from your videos and others is: low does over time and increase moderately as needed.
Hahaha yeah that's basically how you should approach any compound, unless it's some ancillary medication and you need immediate relief XD
It’s interesting because if you look at what cardarine does to the body it would seem that it’s anti carcinogenic. It raises your V02 max and slightly reverses metabolic syndromes. Interesting dichotomies to say the least.
I would put money on the cancer increase/decrease being similar to the studies on ketogenic diets. It probably has to do with changing metabolism types.
Worst part of cardarine is it deystroys your strength shifts muscle fibers into slow twitch hence cardio increase
bro how is steve all of sudden pumping out videos related to my upcoming cycles
Can you make some videos about REV-ERB agonists like sr9009, there's some recent studies correlating to improved heart function and brain injury protection.
Good video. The benefits don't outweigh the risks for me. It's a no from me.
Great clip, just when you thought you knew everything about Cardarine.
Steve unloadeds a ton of great findings and research!
Great tutorial!! 💪
Steve, thank you for making this video rather quickly after a few requests from the Q/A
You are a true scientist my friend 👏
Great video, coach! Love you long time.
the only experience I got from cardarine was uncontrollable vomiting at work and nausea. go ahead. its safe
Hey Steve, love you bro! Thanks for all!! )
Thanks to Steve, my buddies all now come to me with questions about PEDs and health... I consistently send them links to Steve's videos and website to no avail. What's a good coaching fee? steve can get his 10%.
Steve your recent videos are excellent. Evidence based and citation listed 👌perfect!- Steve you should be an honorary PhD in PEDs. Thank you for the excellent content and work for educating the community 🙏🏽
I’m confused. That first conversion chart seems to demonstrate that the cancer-inducing effect starts at 8.11 mg in a 50kg person up to 19.46mg in a 120kg person. But isn’t it supposed to be 8.11mg PER kg of body weight? That would imply that the deleterious dose is +400mg/ day for a 50kg person. I’m around 80kg so isn’t my danger zone 12.97mg x 80, or 1,040mg daily?
You're way too sober!
Thank you for writing this. I am a APRN and I feel like I am not hearing something correctly. The 2mg per Kg is still a larger dose than what most people would ever take. I would love to see this clarified. I am wondering if I just heard something incorrect or if he meant to say 0.3 mg.
Yes! I was almost going to append my comment to say this! Even at the lowest 2mg) dose, it’s 8x the typical 20mg dose & 16x the 10mg dose administered in human trials where no adverse health effects were reported after 12 weeks
@@LFV_1 I looked into it and it is because of HED or Human Equivalent Dose. So 3mg per Kg for humans is different. I would suggest just googling HED and reddit. A great explanation is there. I still don’t fully subscribe to the cancerous threat
@@PsychiatricParfums read up a bit on this too, but the dosage still seems minuscule. 8mg as the low-end HED for cancer induction? 50-60mg, ok. 8?
My new favorite channel
Amazing video!
The one we have been waiting for 🏃♂️🏋🏻♂️🚴♂️
Another stellar video Sir
Thanks for your educational wisdom
Hey Steve, there is a study showing that cardarine produced fibrosis in already damaged livers, allegedly the healing effect is much too fast.
I got jaundice myself after two weeks of use, 15mg/day with 1000mg NAC as support.
Stopped using it and went back to normal after a week.
Going to try another source just to be sure.
Interesting video Steve, appreciate the research.
First time seeing your videos.. solid information subscribed and liked appreciate the research 🙏
Algo comment, thank you Steve
Love your videos 📹 Very informative great job thank for These Informative videos
Thanks for the video Steve
Thank you Steve.
I used cardarine a lot in 2020 but haven’t used it since with the cancer scares. I feel I was a hyper responder to it in terms of endurance, like I was able to push insane wattages on the bike and maintain them. It almost made me want to push too hard on the cardio lol, and this was during the time when I used the most gear in my life. It also maintained my HDL at around 40 when it should have been below 20 lol. My LDL wasn’t really affected much if at all.
I would LOVE to see a lifepan study n not just toxticity study. When our mito is enhanced by such extent, it have to extend lifespan
I have taken several brands of Cardarine before and even at the lower end of doses it causes rectal bleeding and itchiness, seen only a handful of people who use it here and there talk about this too, but never seen anyone who is more of an expert in this talk about it.
Any thoughts on this Steve?
I had rectal bleeding and itchiness prior to my cardarine cycle lmao
Did your diets change? Spicy food and more fiber are good for cutting and coincidentally cause an irritated bootyhole
I always wondered why GW’s effects would seemingly drop off after 4-6 weeks of use…
It’s been probably close to 10 years since I’ve ran it and with the evidence you’ve laid out here it seems like it’s not worth it.
I’ll take my money and run and be happy I got away with it when I did
If cardarine can lower fast twitch would it be wise to add another ped with it?
Thanks Steve
Can you do an injectable L carnitine deep dive?
love your content
Whatever it takes, honestly this cardarine is really good to me.. I used it during PCT and it helped a lot
Brilliant, thank you.
Good stuff!
Just from personal experience. I took cardarine 3 years ago and got Lymphoma shortly afterwards. No worries though im in remission now and bigger then ever :P but if i were you guys i would think twice or maybe three times before doing cardarine .
My man! Let’s go
Derek at MDMP said cardarine doesn’t cause fat lose, and in fact its main value is only a risky choice for improving poor lipid panels because the ideal dose is close to the rat cancer dose
Thats actually NOT what he said LMAO
@@southsidetee7152 that’s exactly what Derek @ MPMD said. You need to find that video and watch it again.
Great video. So what drugs would be good for an athlete to increase endurance? That isn't cardarine and can be bought easily ??
Hi Steve how do I get a consul station mate loving the videos keep up the great work
Looks like I won’t be running this again
😂
Cardarine completely removes all the crash and cravings associated with a zero-carb/keto diet. It's miraculous.
if cardarine allegedly seems to be carcinogenic, then why is telmisartan not carcinogenic? it agonises the ppar too
12.5mg Cardarine and 12.5mg Ostarine stack helped cut me up and all blood work was great, including lower cholesterol levels. However, I was also eating freakishly clean during my 12 week cycle
Please clarify. Did you say 3mg PER kg? If you did, then I am missing something on the math.
Okay so he did not add that this is considered the HED which stands for the human equivalent dose. This takes other factors i to consideration such as metabolic rate and size, for example.
Additional info:
While cardarine has shown some promising effects on longevity in animal studies, its potential to increase human lifespan is still largely speculative and requires further research.
Here's a summary of the current state of knowledge:
Mechanisms: Cardarine seems to have multiple mechanisms that could potentially impact lifespan:
Mitochondrial biogenesis: Cardarine has been shown to increase mitochondrial density and function in muscles, which can help reduce oxidative stress and improve energy production.
Antioxidant effects: It has antioxidant properties, which may help protect cells from damage caused by free radicals.
Inflammation reduction: Cardarine may reduce inflammation, which is a known contributor to aging and age-related diseases.
Epigenetic modulation: It may affect gene expression, potentially influencing cellular processes involved in aging.
Animal studies: Some animal studies have demonstrated that cardarine:
Increased lifespan: Mice fed a high-fat diet supplemented with cardarine lived longer than those on a standard diet.
Improved insulin sensitivity: Cardarine-treated mice showed improved insulin sensitivity and reduced glucose tolerance.
Reduced age-related diseases: Studies found that cardarine decreased the incidence of age-related diseases, such as cancer, cardiovascular disease, and neurodegenerative disorders.
Human studies: While there are no human trials specifically designed to study the effect of cardarine on lifespan, some clinical trials have explored its use in conditions like type 2 diabetes and obesity. These studies suggest that cardarine may have beneficial effects on metabolism, insulin sensitivity, and cardiovascular risk factors.
Awesome🎉
Vigorous Steve my new Derrick Plates for Dates
Is 10mg enough to get the endurance benefits? Is that effect dose-dependent?
Steve, I've been thinking about a cardarine with a retratutide stack for strength and endurance building/cutting stack. What's your thoughts.
I didn't quite understand was he saying it makes skin thinner?
I will admit my rbc/wbc count came back low while on cardarine. Went back to normal after stopping. 15mg every other day.
Steve please make a video on YK11 as a myostatin inhibitor
Steve, how does Acetyl L-carnitine compare to L-carnitine Tartrate?
Your fucking awesome bro
Would you say a lot of HYROX athletes are on Cardarine?
Question: what does a jacked non-PED user in late 30s or 40s take if they want to keep up a great look and dip their toe in the PED waters? [Both fertile and non-fertile based]
Hgh, injectable l-carnitine, cardarine etc
@@lolwtfbbq111 OP dont listen to this advice
My experience:
Cardarine has crushed my LDL BELOW my HDL every time i’ve used it (twice), once i assumed it was me being at near contest shape from an extreme diet given by a coach in conjunction with cardarine and a heavy (for me at the time) stack of anabolics
The next time i was coaching myself, decently lean but nothing crazy, bloodwork at end of cut after using cardarine, aas stack and gh about equivalent to previous, same thing HDL higher than LDL
Bloodwork to prove it if you want to take a look steve!
same here... my LDL was in the 140s earlier in my life when natural and taking no meds. 10mg ea of rosuvastatin and ezetimibe brought it down to 80-100. adding cardarine along with some potent anabolics my LDL now is 40 which is below my HDL. I also use SR9009 (injectable or sublingual) which may be helping with that too.
@@Kovalser super potent in that effect especially if you manage saturated fat intake and do adequate daily activity
I have a rugby tournament soon ima take this and go hard
Let me know how you performed bro, im also thinking of hopping on
@@Robert26122 didn’t take this. I’m on BPC-157 and it’s a game changer
Thanks for the front double bicep
Steve I’m curious which do you think is the most synergistic? Growth hormone/ growth hormone secretagogue + cardarine, Growth hormone/ growth hormone secretagogue + metformin or Growth hormone/ growth hormone secretagogue + berberine for insulin resistance?
What happens to dietary carbohydrates when taking cardarine? If they are not used as energy than they have to go somewhere right?
30:00 Rodchenkov! The star of Netflix documentary Icarus, and mastermind behind Russian doping program. Probably knows what he's talking about
DAMN! I knew his name sounded familiar! I would've surely mentioned that if I remembered that when I was reviewing the studies!
Hi, for me fatt loss is ussles but for endurence i feel like king(I wish could take gw all year), and for fat less hdl ldl extremly low that was shock for me.
For fatt loss woud take only idiots but for endurence so good.
Steve, if you want to i can email you my hdl and ldl results while running 300mg test and 150 mast .
Both improved. Hdl went from 28 to42 in a month at 12.5 of taking GW. Ldl dropped 40 points i believe as well.
I wish injectable carderine lipoline and stenabolic were more readily available
Thankful as fuck for this video 💜
Thank you for everything you do Steve
I have some labs from my last prep (fall of 2023) where I used cardarine and ldl and hdl improved but diet and cardio also improved during this time so maybe not all due to cardarine if any.
Does Cardarine not make you weaker via conversion of type 2 muscle fibers to type 1?
I think that was SR9009 which works via a different mechanism.
This is high level shit Steve. You're the fucking man!
Please start linking studies in your description for your viewers to review.
I always link them in the comment section in a pinned comment, as there's too many citations for the description section, which has a 5,000 character limit.
If you’re using telmisartan can you use cardarine ?
why you always gotta scare me with facts steve, haha much love
Would cardarine pair nicely with tirzepatide?
I’ve been seeing dark colored gums while on, I’m thinking I’m having an allergic reaction to it…
It made a friends skin tags grow 🤔 for me it’s just not worth it
So is it okay to take just cardarine 10mg a day? And what markers schould i check?
I cannot take carnitine. I get a bad reaction, flushing, extreme sweat, like i want to pass out but don't.
Bulky Double 💪 to give some late night algoboost 🔥💯💪‼️
Is it a problem if i supplement with L-Carnitine instead of L-Carnitine-L-Tartrate?