Bloodwork of Centenarians VS Non-Centenarians Revealed: 3 Tests to Focus On
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- čas přidán 21. 08. 2024
- Let's discuss a new paper finding blood work differences in Centenarians VS Non-Centenarians.
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0:00 Intro
My grandmother lived to be 105. She was an exception to every rule. 😂😂
She didn’t like vegetables, so she didn’t eat them. But occasionally, she’d make a salad with ice berg lettuce, tomatoes, onions, and cucumbers with Good Seasons Italian Dressing
She refused to buy organic.
She drank beer in her younger days and wine as she got older everyday just 1 or 2 cans or glasses.
She ate out every week.
She loved Chinese food with MSG as well as nitrate loaded bacon which used to make me cringe, and she loved fried prawns. She also loved fried chicken and ice cream; and when she was younger, she’d make things from scratch like ice cream and chicken and noodles.
She also loved Sees Candy, and she would fight you for it. And she always had a candy dish full of candy.
She was a nervous person, and she worried a lot. She did a lot of crafts and knitting throughout her life. I think it helped calm down her worrying. And she didn’t sleep well. She’d be up multiple times at night, and she always went to bed after midnight. I have the same problem. I’d always get so stressed listening to health professionals telling us how vital it is to get a good night’s sleep. I’m sure it’s true, but I rarely get a good night’s sleep. So instead of letting it stress me out, I just think about my grandmother who never got a good night’s sleep and lived to be 105 pain free. 😉
She liked to walk, and she took walks most days until she was in her late 70’s.
She had lied about her age, so she worked full time at a computer chip company until she was 68 or 69, and she always worked overtime.
She liked to watch tv, play cards, sit and read, and argue about politics.
She loved to read, so up until her late 70’s, she’d go to the library every week and load up on books.
As far as her health history, she was married to my grandfather who was a heavy smoker, so she was around second hand smoke for decades. They used to take long car trips, and he’d smoke with the windows up, and the air conditioner on. It used yo make me so sick as a child, but it didn’t seem to bother my grandmother. She had a hysterectomy at a young age, and she had hyperthyroid issues off and on. She also had high blood pressure issues off and on throughout her life.
She would be prescribed various medications over the years, but she wouldn’t take them. But she did suffer with allergies her whole life, and she took various allergy medications as well as vitamins recommended by Dr. Stephen Sinatra which she started taking in her 70’s.
She outlived every one of her 12 brothers and sisters by decades. She wasn’t obese, but she wasn’t skinny either.
She announced at 103 that her memory was shot which was so funny because she was sharp as a tack and still had the ability to make spontaneous jokes. And, finally, she lived on her own until her 105th birthday. She died in her sleep 4 weeks before her 106th birthday. 😭
SHE WAS AN AMAZING WOMAN, ♥️and she defied every single piece of advice given to us to live longer.Don’t get me wrong, I’m not recommending that you follow what she did, but it’s just very interesting. And I don’t know what explains her longevity. 🤷🏻♀️
That's so cool. I guess she just got hungry for that salad. My mom used that dressing too. These days you'd use extra virgin olive oil instead of that seed oil that we used in the 50's and 60's. Maybe it was Wesson Oil.
@@Pondapple It was the Good Seasons (with seed oil) dressing that kept the 105 year old going. A few of us know the Good Seasons secret to longevity, but don't tell anyone. Otherwise, we might have difficulty getting the elixir at the local supermarket. Ingredients:
Sugar, Salt, Sodium Citrate, Garlic, Onion, Spice, Red Bell Peppers, Carrots, Xanthan Gum, Maltodextrin (From Corn), Parsley, Natural Flavor, Guar Gum, Citric Acid.
Is that’s living a full life! You were fortunate for having her around so long!
@@pete9688
Yes, she had a good life, and I miss her everyday. Thanks 🙏
Did she grow up on the farm? Clean living in the formative years? Then later in life, it all went to heck.
(Like my parents)
My Mother grew up on a farm with a milk cow and drank raw milk until she left for college. She drank a glass of milk with each meal through out her life. She is 91 now. She walks with a walker, but is very strong and has her own teeth. She told me that someone told her milk was not good for her so she was going to cut back. I told her to keep doing what she is doing.
My grandmother is 95 years old. She has eggs every single morning with breakfast and coffee. And every night she has a glass of red wine with dinner. She also loves yogurt and cottage cheese and her teeth look better than mine! 🤦🏼♀
Technically yes, high calcium while resting will increase osteoclast activity and weaker bones making her at higher risk of a break during a fall. And the opposite is true higher osteoblast activity when weight bearing so if taking a glass of milk would only really be useful before going for a walk or something.
@@iewauhedoc9970 I'm pretty sedentary, drunk at least a cup of milk daily plys other dairy, & have higher than average for my age bone density. Adequate protien bioavailable vitamin k2, d & sunlight exposure are important for apropriate bone & calcium.
Yes!!! Grew up on raw milk. Be well!
I think if you make to 91, you can figure out if milk is good for you all by yourself. Congrats to your mother!
My aunt and uncle who were farmers lived to their mid to late 90s ate bacon and eggs almost every day, and whole raw milk and butter.
My grandfather was a farmer too, ate mostly animal products, stayed active and in shape past 95 and lived past 100.
I also think avoiding doctors helps.
I’m in my 40’s-My total cholesterol is above 200…traditionally that’s “cause for alarm” but my HDL is whopping 91😆. Last year, it was 88!! I strength train 2/3 x/week. We eat eggs everyday. Water, Coffee, Veggies, some fruit, no juice, little processed foods ❤ 😊
I'm 35 and have perfect blood test results except for a similar case to yours. I lift 5 days a week, eat no added sugar(so only from occasional fruit and berries), no processed food and high quality meat/eggs/veggies. I am routinely told I look and even sound 15 to 20 years younger than all of my friends my age.
I don't plan on changing my diet any time soon and I at times will eat up to 6 eggs in a day.
That’s amazing; last time I checked a 200 or less is dangerous
@@TrueLife.. Obama says he eats 4-6 eggs every day.
im right here with you friend, but realizing now that although the ratio is excellent, overall its better to get the ldl down- and that means reducing (not eliminating) the copious amounts of saturated fats i consume. still doing keto but not the gratuitous amounts of saturated fats
Thats good and all, but i reconment you to test your:
-Coronairy Arteries Calcification (CAC score)
-Total Plaque Score (TPS)
-Getting a CT-angiogram
You are at the age that they allow a CT scan (not below your 40's in europe because of the radiation exposure(dont know how that works in other parts of the world))
To know the condition of your arteries.
Lipoproteins are not the only cause of plaque buildup and cardiovasculair disease is multi-factorial.
Kind regards
My 101 yr and 10 month old mom lives with us. As her caregiver,I have learned a lot of what to do and what not to do.
TO DO:
1. Stay active and exercise as long as possible!!!
She was never an athlete, but was always active. Now she does exercises in bed before getting up. She walks with a walker and can do many things by herself.
2. Eat an omnivorous clean diet. We owned a cattle ranch in NWMO. We grew a few vegetables for the family.
3. Maintain healthy relationships which includes building one’s faith especially within a community (church, temple, etc)
4. Be a life long learner with reading, puzzles, etc
5. Have a sense of humor and positive outlook (She no longer has sundowners syndrome since stopping the glass of wine at night)
6. Spend a lot of time outdoors
NOT TO DO:
1. Overeat
2. Drink alcohol or smoke cigarettes or marijuana, or take drugs of course
3. Take a statin. She took a 1/2 of a statin for years and due to this and drinking wine in her 70s-90s she developed peripheral neuropathy in her legs.
4. Sit more
Thanks for the heads-up and reaffirmation by the above. It is not easy to see that age and especially to see it "in one piece".🤪
Cannabis* "marijuana" is racsist terminology
Thanks for taking the time to share. Exercise, mindset and no bar code on a box nutrition.
Point 4!!! The mind is SO important and often neglected when talking about quality of life and longevity. Learn a new language, learn to play an instrument, stay curious! And keep sharp at math, is the language of the universe! More often than not the mind goes away before the body, which is a terrible fate.
Fine but carnivory is even better.
Thanks Mike, you have a real gift for science communication and sifting through the sea of garbage papers to find gems. Much appreciation from me, so much that you are one of a handful of active subscriptions on CZcams that I keep.
He has a gift of misrepresenting the science just as he did again with this paper. Almost every video, he misleads.
@@jakubchrobry3701you are qualified to interpret research?
@@rebeccacarraway480 Yes, it's simple to see in the study that 53% of the centenarians have lower total cholesterol than everybody else. The other 47% represent only 1.27% of the population. These people probably had the genetics that protected them against the buildup of plaque. It not uncommon to find centenarians that don't live healthy lives. They won the genetic lottery. Do you believe you are part of that 1.27% of the population?
This study is stupid because 100 is just a number. Why not choose 96 years, 3 months, 17 days as the demarcation?
@@jakubchrobry3701 Based on what? You're wrong, get over it.
"You do not know what will happen tomorrow. For what is your life? It is even a vapor that appears for a little time and then vanishes away" James 4:14.
FASCINATING!! I am recently 70 and walk most days at least 4 miles, work with weights and do mandatory squats.. yes my cholesterol was something like 230 which I could have cared less.. but my ALT was around 45 and no one gave a damn. Well, I do. I am going to repeat that lab + the GGT. You have confirmed that I am on the right path with my diet and lifestyle. Even if I don't make the big 100, I hope to have a great quality of life while I am alive. Thank you for this video!
Good for you. I wish you a happy long healthy life.❤
@@angelika77st Thank you! You are young - you can get a great start on a long, blessed life!
I have a neighbor, Fred, who’s 94. He walks past my home every day - weather permitting- no cane , no walker … full head of hair , pretty sharp mentally too. I asked him one day what he attributes to his longevity. He said that when he and his late wife retired @ 63… they walked every day. When it rained or snowed , they’d walk at a nearby Indoor Shopping Mall. No vitamins , but eat very small portions. He also has a “ small” glass on red wine once in awhile. He’s Italian.. so he like the grape. Keep walking. Never stop, as my dad used to tell me. 👍🏼
Qq❤❤w
Thank you for your passion, & your dedication to real health science. As a nurse that was ejected from the sick care system for not confirming to dogma, it’s very, very refreshing 🙏
if your cholesterol is high, get a calcium artery scan. My husband and I have high cholesterol, but at 50 years old we have perfect 0 scores on any junk in our arteries.
That score is for calcified plaque, it aims to find advanced plaque but a 0 score doesn’t mean you don’t have plaque in your arteries, just fyi 👍🏼
Here's a ChatGPT summary:
- Study compared biomarkers in individuals who reached their 100th birthday to those who did not
- Study involved over 44,000 subjects, with 2.7% reaching their 100th birthday
- Strong associations found between biomarker levels and probability of reaching 100 years of age
- Biomarkers such as cholesterol, glucose, GGT, and uric acid were linked to longevity
- Prevalence of cardiovascular disease and metabolic diseases was lower in centenarians
- Cholesterol levels were associated with higher chances of becoming a centenarian
- Non-centenarians had higher rates of common conditions such as heart attack and heart failure
- Lifestyle factors, genetics, and environment likely play a role in exceptional longevity
- Higher total cholesterol and iron levels, and lower glucose, creatinine, uric acid, AST, GGT, ALP, total iron binding capacity, and LDH levels were associated with greater likelihood of becoming a centenarian
- Differences in biomarker values more than a decade prior to death suggest genetic and lifestyle factors may play a role in exceptional longevity
Thanks you just saved 30 minutes off my life listening to endless repeats.
GPT has one sentence that was of value.
Otherwise, had no idea that centenarians would have fewer heart diseases. Who knew? (no offence to the OP, here. Directed to gpt)
BTW, were the centenarians mobile/healthy/strong?
@@roginutahMy question too, but I think they didn’t know to check strength in decades past as a relevant factor to compare for longevity.
But damn if it’s clear that my grandmother isn’t going to live nearly as long because of her lacking physical capacity and therefore exercise and frankly the impact on quality of life. Wild that it has taken science so long to grasp something so obvious.
What a useless summary.
Bullet train
My cholesterol has never been below 220 high was 330 and they wanted me to do statins....I refused!! so glad I did! Yes more of this!!
Cholesterol is an essential nutrient, period.
This tells us nothing. What were the component levels that made up the total cholesterol? Plus, this study doesn't prove causality.
@@jimdandy8996 It correlates with other mortality studies and is consistent with human evolution and physiology of every organ system. And it is infinitely more credible than the junk associative "science" like China study and blue zones which are utter fabrications to suit an agenda.
@@jimdandy8996No it doesn't prove that high cholesterol aids in longevity but what it absolutely does indicate is that *high cholesterol does not prevent longevity* which is in fact just as, if not more, signficant.
@@jimdandy8996Look up the Korean Cholesterol Mortality Study published in 2019. Over 12 million subjects. Those with Cholesterol levels under 200 had higher risk of dying from all causes, including suicide and violence. Low cholesterol effects the brain negatively.
@@TheCompleteGuitarist Nothing inherently prevents you from living to 100 years old besides the acute development of disease or death by some other means, because it's all luck and hazard ratios. The question isn't "will high cholesterol prevent me from living to 100?" the question is "Which behaviors can I engage in that make it more or less likely to make it to 100 years old?" Unfortunately, this study does not answer the second question at all. The tiny minority of people that made it to 100 likely got very lucky as a result of many different environmental and genetic factors which are very difficult to disentangle from anything else here.
Just remember most of the centenarians today didnt grow up with all the junk food and processed food from birth, Compared to children from the last 50 years.
They also weren't loaded up with vaccines. Kids today are on a schedule to receive 72 vaccines by the age of 18, as recommended by the geniuses at the CDC. That's right, seventy-two.
Yes, but the popularity of grain based diets began in the late 1800s then in about 1910 centralized mass production of food was introduced along with Mars candy bars ....then in the 1960s the Federal government gave the sugar industries special protection...poor health used to be for the wealthy now everyone can participate
💯 One more reason the average lifespan is decreasing, not increasing.
That's the point. Its not the high cholesterol its the junk causing the heart disease etc
Eggs, Eggs, Eggs!!! 🤗
My son eats at least 6 eggs per day.
He lost over 30 pounds and is incredibly fit and healthy... Fermented Sauerkraut on empty stomach every morning.
Careful! Do NOT confuse blood cholesterol with dietary cholesterol! Also, correlation and causation are NOT the same thing, more often than not they are even the opposite!
Eggs are injurious to health, kindly visit nutritionfacts youtube channel and educate yourself about dietary habits. A MD medicine doctor unveils the truth!
My grandmother is 95 and she makes eggs every single morning. Eggs and coffee, eggs and coffee and she has a glass of red wine with dinner every single night.
There is a reason animals go to great lengths to steal eggs from nests. If an egg gets broken in the nest, chickens will eat their own eggs.
🤦 There is NEVER an easy solution to a complex problem. If anyone suggests otherwise… RUN! For your life!
Decades ago there was a British study that examined populations of age 80 and above, and those with the lowest total cholesterol had the highest mortality and vice-versa for those with the highest total cholesterol.
You are probably thinking of the 2021 Denmark study (data starting in 1980s, not sure) published in the BMJ that compared all cause mortality to cholesterol level and found higher mortality with very low cholesterol levels. The problem with that study is the exact same as the problem with this study, all epidemiological data on lipids is perverted because 30% of the over 60 population is on cholesterol lowering drugs, the 20% of the population that is the most sick (smokers/T2D, BMI>40) are the most aggressively treated with lipid lowering drugs, and although the cholesterol lowering drugs reduces their risk ratio from 5x down to 3x, they will still have a very high mortality rate.
No, this was a large British observational study at least 15 years ago.@@robertdaymouse3784
@@robertdaymouse3784
Which perfectly illustrates that cholesterol lowering fixes nothing.
Great live and breakdown info without getting too long. Definitely warrants a deeper dive. Please drop the links to papers. I save them all myself! :)
I’ve since found the document 🤓
can you post the link to the document for the rest of us --- thanks@@YVM3311
I'm afraid for Doctors and people like you. CZcams demonetized Dr. Eric Berg for speaking out of compliance to what the conventional treatments to our ailments should be. We live in strange times. The "Associations" are so powerful.
Mike misrepresented this research, just as he always does. He and Eric Berg are either quacks or grifters. CZcams has not demonetized either Mike or Eric Berg. Eric Berg is just playing the victim. He has 11 million subscribers and most his videos get over 1 million views. He making millions from CZcams. Quit playing the victim. That is so beta.
Berg just gives that money to Scientology, he's basically at the top of food chain as an OT8. Sounds ridiculous but it's true.
How can a smart man like Berg be in that shit??? Maannn thats awful
@@sirmrguitardudedoesn’t mean the information he provides is any less valuable.
@@sirmrguitardude whoa that's crazy. I had no idea. Where did you learn of this?
This makes me reconsider his credibility.
Cholesterol. I was waiting in line at Kaiser to get a blood draw and my line neighbor was a doctor. We started talking about keto. He told me, keto is great -- so long as you exercise. "Don't have a skinny heart attack." So I don't think it's the cholesterol that is the danger, it's how a particular body handles cholesterol that's the issue. And that handling requires an active lifestyle with exercise. I always feel great at the end of a trip where I missed a lot of meals, walked miles everyday, carried a heavy backpack up and down mountains.
Strange TG was not looked at how about HDL? Very helpful and greatly appreciated!!!!
My paternal grandparents both lived to 99 and my dad's paternal grandfather lived to 99 also. My maternal grandfather lived to 97 and my mom's maternal grandfather lived to 106. I ran my 23andme raw data I have all dominant foxo3 longevity genes. I wasn't surprise😂
You re set then😂😂😂🎉🎉🎉🎉 take care with the environmental factors ok?
Bully for you.
Did any of them smoke?
Ok, don’t screw it up! See you at 99! Lol
@@HH-gv8mx My grandparents all lived VERY long with the oldest at 105 and yes they all smoked, but werent chain smokers - one after a meal, one after a funeral, maybe a few at a big party with alcohol
Riding horses and all the work involved with horse care is a great general workout for all ages. It also promotes mental health and general feelings of wellbeing. At 64 I want to age well - especially as I lost a good proportion of my life to ME/CFS which left me bedbound/housebound for much of my 40's and 50's. I am now 99% recovered and I am OMAD, mostly carnivore - I am human and do fall off the wagon sometimes but more from social occasions rather than feeling hungry or having cravings which is sort of okay in my book. I can soon climb back on. BUT I no longer have fatigue, brain fog or joint pains.
Most horse activities involve a good amount of weightbearing activity and riding promotes core balance which is especially good for ladies of a certain age.
Horses are way more trouble than they are worth for the vast majority of people. They eat way more than cattle (and require much better forage) many are injury prone and are generally an antiquated nuisance.
@@marktapley7571 Fair point. But for a great many years i couldn't indulge my own passion for horses because I was BEDBOUND with ME/CFS. Thankfully, due to the canivore diet, I am significantly improved and able to enjoy my horses once more. But thank you for your opinion - it doesn''t negate my observations, though, does it?
@@marktapley7571while working at Cornell, i rented a room at an Airbnb who had a couple Painted Hourses. I could ride and helped to care for these wonderful animals. They are like big puppies and have a way to reduce your stress levels.
I’m feeling great on the carnivore diet too. I also succumb to social pressure at times but so far, it’s been easy to revery back. Being without cravings for the first time in my adult life has been an incredible relief.
It is well known in the medical profession that people with disease and illness often develop low cholesterol as their disease becomes more serious and the patient nears death. Perhaps that is why those that died had more comorbidities. The illnesses caused the lower cholesterol levels as the patients approached death.
Love information of this type. I have been OK with my “high choles.” Levels (220-240) for the past 35+ years (I’m now 74 and still doing step aerobics classes).
My grandmother just turned 95. She still gets almost every question right on Jeopardy and does the New York times crossword puzzle every Sunday! The one thing that bums me out is that my mom lets her eat whatever she wants. She has her regular eggs every single morning with coffee. But if she wants to have macaroni and cheese and potato chips and cookies, or even donuts, my mom will get them for her.
She's 95! She can have what she wants! For almost 25 years, every day she lives is beating the odds!
At some point you have to live the life you want to live for however long it lasts. If she has all of her teeth, toes, fingers, liver and kidneys, her diet couldn't have been too terrible.
That’s what my mom says. She can have what she wants, she’s 95! 🎉 @@whopua
She has a hold of her appendages, and her teeth look better than mine! (Turns out lemon water & ACV are not good for tooth enamel)
We have a very different diet. I would not eat what she eats. I need a lot of salads and fish and vegetables… She is the opposite. I do not eat red meat or bread. She eats sandwiches, pasta, red meat etc. She’s always been a very peaceful and happy person. Everyone loves her. And she worked at a golf shop well into her 80s. She loved to be around young people.@@maam-yj8ph
@@arcadepiano they are low in albumine because digesting proteine decreases. low albumine is not a sign of health, it is just a sign of age.
I have been told by doctors for the last 30 years my high cholesterol is going to kill me. Im at the point where I dont think I will let them test my cholesterol anymore because they just freak out and pressure me to take something . I took a statin once and it caused some real damage so its not even an option . I am 63 yr. female. Walk 3 miles a day. Strength train. I only eat real whole food, use no oils just whatever fat come on the meat. Protein, eggs, veges, some fruit and icecream once a week. My cholesterol is 336 and ldl 236. Not proud of it but it's just my body and diet doesn't budge it. The 2 people that I know that had heart attacks didn't have high cholesterol so it's very confusing. They did have prediabetes though. I really don't want to live to 100 either. So I might have to sue my doctor ( if he's alive still) if this heart attack he says is coming never comes and I live to 100.
When the docs want to put you on something, you just tell them you will consider lifestyle changes first , so you don't get fired by your doctor. Good luck!!!
Look up homocysteine and its link to high cholesterol. Some people are genetically prone to high homocysteine as is my husband. Lowering homocysteine is easy. Methylated B’s. A good cardiologist will check homocysteine but by then that wouldn’t be a good stage to be at. We check my husband’s homocysteine by ordering our own labs. The methylated B’s have brought it to normal and therefore his cholesterol has normalized with continued proper diet and exercise. Before it wouldn’t. Good luck!
high total cholesterol is ok, as long as LDL/HDL and Triglycerides/HDL ratios approximately = 1 in best case scenario, or at least less than 2. Also A1c less than 5%.
"Next time you go to your doctor". Doctor? I'm 65, have no doctor, am very fit, on zero meds, never on TRT, PEDS, creatine. 33+ years eating 100% whole food plant-based and *all* my parts work. Loving life. Wishing you all vibrant good health.
Yikes
I’ve heard of the interesting correlation in longevity and general curiosity and interest. That being, (to paraphrase) if you keep learning new things, or discovering new interests and come across at least one new idea or concept daily that it keeps people sharper and more engaged into older years. Helping to prevent alzheimers and neurones from degrading, all the people I have met over 90 who were still sharp and discerning never assumed there wasn’t anything left to learn or understand. They enjoyed new discoveries.
Not sure if any thorough studies have looked at this extensively, but I genuinely believe that Wonder & Curiosity is life altering, and life-extending.
I had a dental patient in his 90's. He never brushed or flossed. Each visit his teeth were encrusted with build up. Yet he had all his teeth. No decay, no fillings. And all of his teeth were solidly secure. No mobility. Can't beat great genetics!
You've been told it's genetics. But probably it's not.
@@Notme-tq4xs I think I'll let the medical researchers have a chance to figure it out before taking the word of an anonymous internet poster. No offense. I'm sure you are an expert too.
what about the build up protecting from decay ?
@@gregsmoluch9859 It can. But at the same time the gums will suffer, often progressing from simple gingivitis to irreversible periodontitis. Build up is also host to bacteria which is a threat to systemic health.
That's my goal. Going for blood tomorrow. Will demand a GGT test as well.
I don’t think he was demonetized. He said the algorithm was changed so that he isn’t displayed as frequently in search results.
He is shadow-banned, he does not show up at all unless you search for his name explicitly
Exactly
Glad people like you exist
The most exceptional informational pitches I can find anywhere, surpassing the usual offerings.
13:20 shows that:
- Cholesterol levels are very close between centenarians and non-centenarians (actually LOWER for centenarians on 2/3 of the populations displayed at the 90th!!!)
- Glucose levels seem to clearly be the main factor here (being borderline or well into diabetic range for non-centenarians)
- …so the authors of the article seemed to push out an easy clickbait (unsurprisingly). I wonder what the actual study had as conclusion? Would be interesting to compare.
- (Bottom line: no “revelation”, nothing new, all looks pretty much as expected, I’ll continue listening to my doctor, thank you!)
I'm so very confused about my blood work.
I eat all grass fed grass finished beef
Free range chicken
Wild caught fish
Only organic vegetables and fruits
Very minimal carbs
Eat ZERO processed foods
I also exercise at least 4 days per week and yet my cholesterol is high, tryglicerides are high, uric acid is high, blood pressure is high and now my sugar levels are even getting elevated.
I really am at a loss so any and all advice is appreciated
Here's my catch 22. As Genetic Genealogy is my personal History passion, I cannot fail to observe the ages at which my various ancestors died, and indeed even those of my DNA cousin matches / relatives ancestors, and this motivates my interest in nutrition to make sure that I live as long and as healthy as possible to be able to maximize my research time.
My ancestors regularly lived to 85-105 even in the late 1700s. The ones that survived childhood and wars, that is.
Hard work. Porridge, bacon, lamb, rabbit, eggs, cabbage, tea, milk, apples, turnips, berries, potatoes, butter and bread.
My grandma, born in 1899 died 1993, told me (and my dad) all about the food they ate on the farm where we had lived for at least 5 generations. She learnt her diet from her parents who also lived for 90ish years and so did the generation before them. Her grandma lived to a hearty 105 after having 14 children of whom 2 died from infection as kids and 2 died in farm accidents.
I've got a picture of my great great uncle aged at least 80 pushing a wooden wheeled wheelbarrow carrying two kids in it.
I don't think my own health is even a tenth as strong. I can think of 3 times I almost certainly would have died without a hospital and I'm not even 40 yet. And my bones are weak.
Gonna try the hard work and ye olde' English farm diet for the next two years and see if my bone strength goes up. ❤
Lol, to be able to maximize my research time. ❤. Are you an Aquarius?
I can't imagine living in this earthly realm for 50 more years. Everyone you love would no longer be with you.
Kids, grandkids?
Right on.what fun would a hundred be if spent in wheel chair with drool running down your chin and no idea of existence.
Is that what President Jimmy Carter looks like? No
Find some new people to love!
Thank you, Mike! If you do ever get the data set, it would be interesting to see what the specifics of the higher cholesterol are. Hdl/ldl/trigs etc are important information, and I dont understand why that info was witheld. We need more of the full picture as to what higher cholesterol in centurnarians actually looks like.
Cholesterol has not been shown to be causal factor for any disease after 70 years of research.
Cholesterol levels are ultimately dictated by our genes which have survived 4000 million years of positive and negative selection pressure. They know what they are doing, you average GP does not.
Therefore cholesterol numbers are not interesting.
I’m only about 30% through your video, but wow, you do a great job of exploring the details. Subscribed!
Processed foods should definitely be avoided.
I did a research paper on refined sugar and longevity. The remote Mongolians substitute honey for sugar. They had the highest rate of longevity.
Great video, love the topic of longevity Mike, well done 💥👍. The markers of importance from this study are super interesting, especially GGT. I recently started using NAC and glycine with very noticeable positive improvements, especially in the first 3-4 weeks (significantly less brain fog+improved cognition, much calmer disposition, better overall mood, better sleep quality etc..). The improvements were less noticeable after the first month so perhaps there is a honeymoon-type effect where a long term mild deficiency, addressed by supplementation, restores Glutathione homeostasis
My thoughts on GGT and Glutathione more broadly: by supplementing both Glycine and NAC, symptoms improved clearly suggesting there was insufficient Glutathione being produced SO, perhaps my GGT levels actually went even higher in the process (of making more Glutathione, which led to the improvements). The issue then becomes, how do we reduce the demand for Glutathione overall so that GGT goes down over time, leading to the strong association with increased lifespan as shown in the study...food for thought 🤔
Mike was less organized than usual, but that matters zero. The material is mind-blowing. Starts for real at the 5 minute point. Five-stars out of five
I knew that for years, anout high cholesterol + living to a really high old age.
Thanks Mike, this analysis is game-changing. At 69 y-o male, I maintain card at 200grams/day with honey vegetable (cabbage & some other leaves) and mangoes + 4-5 eggs/day (medium to jumbo size) + 1/2 small can sardines/day
Make sure to get pasture raised eggs. I’m an egg lover too. The regular eggs have tons of antibiotics. Even cage free eggs.
I love your sharing about total cholesterol so much! I have been telling people about the importance of good fats vs transfat ratio and inflammation, it is not total cholesterol that causes cardiovascular diseases! People don’t understand
It is inflammation that causes it, and if you have inflammation whether it's hereditary or from lifestyle choices having high cholesterol is harmful.
I have LMHR profile, so this research a fresh air for me. I'm doing keto + OMAD most of the time (except weekend). My LDL 223, Im 34 yo with 6 pack abs 😁
I refuse to take statin, Im waiting to Dave Feldman new research come out next year, depend on that I may make adjustment to my diet
I have been arguing with my doctor about this. He says my cholesterol is too high and I tell him it is not high enough.
Great! Please put all language caption for international audience. Thanks.
Thanks for this video, watching from Switzerland.
A fascinating paper, thank you for the explanation Mike.
This is so cool!! And here I was panicking a few months back over seeing my cholesterol was high. I don’t eat dairy and hardly any meat other than eggs and occasionally oysters. I cut back on coconut oil, but I was still perplexed. I hardly ever eat processed foods, cardio and weight lift 4x/week…. The doc told me that’s just because my good cholesterol was so high, and my bad cholesterol was low. But still I read stuff online about overall high cholesterol being bad, even when due to high HDL. This news clearly contradicts that idea.
Like many markers, HDL follows a Ucurve or Jcurve with respect to mortality. Neither high nor low appears to be great Lowest all cause mortality differs depending upon sex and study. Here is meta-analysis of several studies
Thirty-seven studies, involving 3,524,505 participants and more than 612,027 deaths, were included. HDL-C level was found to be associated with mortality from all causes, cardiovascular disease and cancer in a J-shaped dose-response pattern, with the lowest risk observed at HDL-C levels of 54-58 mg/dL, 68-71 mg/dL and 64-68 mg/dL, respectively. Compared with HDL-C level of 56 mg/dL, the pooled hazard ratios for all-cause mortality were 1.03 (95% confidence interval (CI) 1.01, 1.05) and 1.10 (95% CI 1.09, 1.12) for each 10-mg/dL increase and decrease in HDL-C levels, respectively; furthermore, compared with the reference category, the pooled hazard ratios for all-cause mortality were 1.21 (95% CI 1.09, 1.36) and 1.36 (95% CI 1.21, 1.53) for the highest and the lowest categories of HDL-C levels, respectively. Similar results were obtained for cardiovascular and cancer mortality.
Zhong GC, Huang SQ, Peng Y, Wan L, Wu YQ, Hu TY, Hu JJ, Hao FB. HDL-C is associated with mortality from all causes, cardiovascular disease and cancer in a J-shaped dose-response fashion: a pooled analysis of 37 prospective cohort studies. Eur J Prev Cardiol. 2020 Jul;27.
With respect to LDL and TC, there are a lot of conflicting studies and data. At least with HDL, there appears to me to be some consistency.
I don’t want to live to be 100. But for the years I have left, I want to be healthy and active. Studies like these are helpful.
Thanks Mike. ❤
Me either. It amazes me people are fascinated with wanting to live this long.
But you don’t want to die now, right? Neither will you then.
@@rebeccacarraway480why’s that? What about Kids, Grandkids? What if you gave this info to those around you and you all lived longer?
@@lorenzomuhammad1715 don’t have any :)
I take care of my mom.
Thank you for the information on NAC Glycine I am going to try that at nighttime for better sleep.
Higher cholesterol associated with longer life, and always has been. But they still advise against it. So...
By reducing carbs, it's bad carbs (highly-processed), not complex carbs) that is the key. Low number of cholesterol particles is also a key to health.
Such an interesting study! Thx for sharing this!
We need this on the podcast also my man thank you for everything!
Great info! Love this study.
My grandmother had high glucose, high cholesterol, 3 different autoimmune diseases, and high blood pressure. She also smoked and drank. She did, however, eat a lot of raw vegetables. Final age at check-out: 100.
Thanks for all your ongoing hard work!
Everyone may want to take a look at the research Dave Feldman is conducting regarding high cholesterol levels and metabolic health and overall health. About to release his first research findings and he has grown his team and will be conducting a second more involved study. At Low Carb Denver 2023 he had a talk in which he reveals a bit of what his research has uncovered - seems to be following Mike's discussion today. And Dave Feldman and team is looking at Cholesterol numbers that are higher than Mike is talking about here.
😊yeah, the team Mass hyper responders he was looking for have higher HDL, lower trigs, and higher LDL than I even have and I thought I would fall in his parameters.
Absolutely
Doesn't the study show only that higher cholesterol may be protective at older ages?
I have long suspected cholesterol to be very healthy
If you are told that it’s unhealthy it’s not
The great cholesterol con... thanks to Ancel Keys.
If you think about it, Ancel has killed more people than all the dictators in the last 100 years. He was a corrupt tyrant in many regards.
Not a con... Keys lived to 100, his wife till 97...His whole team into their 90s...The low cholesterol and sat fat Mediterranean diet yields predictable results.
@markaguilera493 Keys: do as I say, not as I do. I bet he didn't do the 12 servings of grain he pushed on the common folk.
@@markaguilera493 absolutely a con by cherrypicked data. there's no such thing as a mediteranean diet, there's only a wishy-washy something that can be framed as such.
@@nootri Gross revisionist nutrition misinformation. Whatever Keys and his folk did was low in sat fat and cholesterol call it whatever you like if you don't like to call it the Mediterranean diet. The point is that it made them all live well into their 90s.
Of course, people 100yo were born in 1923. Pre industrialised food, pre GMO, pesticides, and all the dietary advice we get now. Early nutrition is a key too.
I have suspected for a long time now that low cholesterol is killing us. My mom used to walk around with her low numbers (due to statins) as if it was her ticket to a long life. Alas, she got cancer and went quickly. There are studies saying that high cholesterol gives you a survival advantage in cancer.
These studies are really difficult when almost everyone over 60 is using statins or other LDL lowering medicine / foods (e.g. plant sterols)
Chronic medication should have been recorded as interesting risk factor among these biomarkers.
I would not say they are difficult, I would say they are useless. All recent epidemiological data on lipids is perverted because 30% of the over 60 population is on a cholesterol lowering medication. The most at risk people (smokers/T2D/Obese) are disproportionately placed on cholesterol lowering drugs, creating an enormous unhealthy user bias.
This is excellent research! Thanks for sharing this. ❤
Thanks so much for sharing and explaining this study. Great info!
Great information regarding cholesterol levels and longevity. I wish that Study would have shown the hormone levels of the women, I’m most concerned with estrogen levels in older women and whether or not they supplement with some form of HRT. It’s probably too late for me to do anything like that, but I would like to really understand this information For my adult daughters.
I'm 77 and never used HRT during my 50's or at any time. If you are worried about osteoporosis or osteopenia, I've been taking vitamin D3 for decades and attribute that to why I don't have those problems. A great recent bone density test. They have not recommended calcium supplements for several years now. Also I never smoked.
After a mild heart attack, I had 5 stents 10 years ago. I’ve had no subsequent issues. Recently my TC was 148, LDL 80, HDL 45. My cardiologist wanted to add an additional medication to drive my LDL down further. He told me recent research suggests getting it into the single digits. I was shocked and told him no, absolutely no. I am still worrying and wondering about this.
Please DO LINK THE STUDY.
The URL to the study is in the video at the start
The Great Cholesterol Myth by Dr. Stephen Sinatra is a great book!
My Dutch centurian grand dad loved his haring walked, till 95 and smoked till 95 ... ones he couldn't/didn't walk he went down hill fast (6 years)
Thanks for analysis. Please mention this centenarian study link in the description! Thanks
Lower ccholesterol leads to more comobilities which makes the person far more profitable for the doctors.
Amen
You're awesome and sound is great. Good luck with camera!
The audio is perfect. The script is almost unintelligible, making such "fascinating points" as that people with CVD don't live as long. Had to rewind that one a couple of times to be sure you really are joking that this is interesting, rather than a finding to the contrary.
How do you think the cholesterol levels play into becoming a centenarian for those with the APOE 4 gene?
6:50 Glad they still show the actual data. This is the top left rectangle. TC, mmol/L
The data doesn't show a difference as significance as the verbal claim, but it does show that TC does not matter. (even intelligent vegans know this. HDL is included in TC and it skews the picture).
The most significant difference is GGT. High levels of GGT in the blood may be a sign of liver disease or damage to the bile ducts.
I thought I read&heard that 180-200 is a proper level for cholesterol. If people are worried about blood pressure and clots they should just walk more and reduce that inflammation response that can create the cholesterol to become more waxy. I mean at its core isn't cholesterol a blood lubricant besides a helper with hormone production?
Also an important immunologic signal
Lubricant or not, in excess it's bad. Same as water or oxygen. Vital and yet... Too much of a good thing....
We also need cholesterol in our skin to make vitamin D when we get sunshine.
@@markaguilera493stop trolling, buddy. Are you being paid to do what you are doing here?
@@markaguilera493What is never observed by the medical industry is how cholesterol levels change in response to probably a wide variety of factors. There is one guy (Dave Feldman) doing this independtly, studying how serum cholesterol changes in response to diet. The lowest levels were observed in those with the poorest high carb diets and the highest in those with high fat such as keto. A massive function of cholesterol is to transport fat around the body so you would suppose that an increase in fat intake over glucose foods would be an increase in the need for the fat transport. Fat doesn't travel freely in the blood hence high triglycerides are associated with poor health outcomes. He also observed that you can go from incredibly low cholesterol to incredibly high cholesterol in a matter of days and then back to incredibly low, all switched by dietry choices.
The worst hypothesis in the world of cholesterol is that it randomly and without any really verifiable reason simply sneaks under the endothelium to cause plaques. Considering that nothing else makes it through the endothelium without just cause makes this theory incredibly weak and yet is the premise for the whole heart health approach to medicine and it is clearly absurd.
Of course there is also another doctor (Malcolm Kendrick) actually studying what actually causes plaques to occur (and it's not simply having high cholesterol). His research alone could help with treating heart health yet the industry isn't interested.
When I click on your Blood Work Cheat Sheet it goes to a page that says FORBIDDEN
Thanks for reporting on this!
VERY encouraging Mike.
No significant difference between drinking soda and fruit juice, both are high in sugars that cause blood sugar spikes and metabolic problems. Eat fruits whole so that the fiber that juicing removes will slow down the absorption of the fructose and will of course make digestion better for all your foods;)
Intuitively it doesn’t make sense for HIIT to be the best exercise for longevity.
Low to moderate exercise over the course of day seems far more likely. Ie. Walking, construction, wood-chipping, cleaning, cooking, gardening. Exercises which don’t put excess stress on the body. Also I would argue that when people aren’t moving, they’re more likely to be sitting down.
Recent studies on alcohol have shown drinking can reduce cardiovascular disease, stroke and diabetes. I would also hypothesise that drinking low amounts of alcohol in combination with food would enhance longevity and lead to lower stress.
Thanks Mike, I appreciate you from Sequim Wa!
Great eye opening health information🤔😊
Interesting. Where did you get those figures that you showed? I can't find them in the original article.
My cholesterol has been slightly elevated for 30 years. So has my triglycerides. My blood pressure is actually slightly lower than most 111/74
Ferritin is an inflammatory marker and will increase with sepsis cold autoimmune etc
Berberine although wonderful in many ways, Dr William Davis mentioned that it's not great for long periods of time especially if we aren't ingesting fermented food's such as kimchi, sauerkraut, kombutcha
IE our good microbes need activating and nurturing because berberine can affect it..
Ferritin is an acute phase reactant. So it would be elevated if you were sick.
How interesting! I have high cholesterol and low blood glucose levels and low blood pressure. I have been on a predominantly whole foods, plant-based diet for decades, and I eat a lot of fresh fruit, salad, purple sweet potato, some ordinary potatoes, and regular tofu, or pulses, and Bonsoy soy milk. I eat salmon once a week, and an egg or two at most per week, which are my only animal foods. I also walk a lot, and have run regularly throughout my life, and very rarely drink alcohol. I'm female, too (longevity advantage!) I stay up too late, though. Time will tell, I suppose.
what are your LDL/HDL and Triglycerides/HDL ratios? Also what is your A1c?
What is missing is the relationship GGT and bone status [GGT is a test that can help distinguish between bone disease and liver or bile duct disease] high GGT is reflective of bone loss
I'd have hoped the paper was linked below the vid. That would be helpful. Am I missing it?
Thanks 4 sharing!!!
My doctor does not like me asking questions.
They interrogate me.
You need a better doctor.
Fire your Dr. You’re the customer, they’re providing the service.
My Dad's dr hates that accompany him at every apt. He always try to scare me to have him on statins and asks me to send him the studies i have against statins. So if he is knowledgeable on cholesterol and he continues to push his poison, is he committing malpractice?
@@dawn1913 i was put on statins 10 years ago. after 8 months my cholesterol was so low i was in muscle pain, muscle twitches, and suicidal. i called the dr and told him no more. still 10 yrs later, i have muscle pain and twitches. it was the worst decision i have ever made in my life.
@@sirenmuscle im so sorry that you went through that, and have lingering effects. My dad would also have muscle pain and weakness, and his dr added another pill for leg cramps. That got me questioning everything coming out that mans mouth. Our "health care" system is so disturbing.
Doesn't this total cholesterol longevity correlation speak more to the power of HDL rather than Total Cholesterol being beneficial? Do we really think raising LDL will ADD to longevity even though it will raise total cholesterol?
Read
My husband's grandmother was 105 years old. their diet was simple. Every day the same breakfast and dinner, consisting of bread, butter and German sausage, in the morning rolls, butter, egg and jam. Lunch was always freshly cooked. meat, potatoes and cooked vegetables every day. never raw vegetables except raw sauerkraut. Nothing was eaten on Sundays, only coffee was served in the morning. This grandma never ate fast food in her life. She always cooked with butter and ate an egg every morning. Her weight until death was 55kg like in her 20s. I believe that such people have an extremely good immune system
What’s the ratio of LDL/HDL in the total cholesterol?