Microscopy: Optogenetics (Karl Deisseroth)
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- čas přidán 18. 05. 2024
- Learn more: www.ibiology.org/talks/opsin/
Optogenetics is a combination of genetics and optics to achieve a gain or loss of function of biochemical events such as action potentials in a particular neuron or tissue. Opsin genes encode proteins that receive light and give rise to ion flow. This talk gives an introduction to optogenetics followed by examples of how optogenetics is being used to study the brain. - Věda a technologie
It would be easier to follow if the video had subtitles, like on the Eva Nogales video. Sometimes I couldn't catch what he was saying and got a bit lost.
Dr. Disseroth, as your 99th viewer (on youtube), you have my thanks.
Impressive work.
When there is intense excitation....sprinkling of multicolored light in wide open spaces....what is the most accurate type of microscopy to determine cell-damage?
Karl can you elaborate on the purpose of VTA dopamine neurons activation in order to provoke reward feeling and make the animals work for it? Where is the funding coming from for this? What is the ultimate goal - wiring humans for reward pokes and controlling them to do what they should? I can't think of any other purpose, please explain.
Understanding motivation and reward feeling is most probably useful for dealing with depression and similar diseases and may also be useful to improve how convicts are being dealt with (damning them to a life in criminality and imprisonment as is common practice in the USA is not very humane). Knowledge of how a reward feeling works could also be applied to make school and work more rewarding and less stressful - without plugging light-fibres into those who are to benefit thereof.
the voice is
Light is Like Water. Gabriel García Márquez. Optogenetics. Manipulating memory with light: Scientists erase specific memories in mice. www.sciencedaily.com/releases/2014/10/141009163803.htm
Will you be able to turn on 100% of the brain?
Most of your brain is actually active all the time, so the more percentage == more power you usually see in movies makes no sense. However, you could enhance brain activity by enabling the signals to be transported quicker or with a higher efficiency in accordance to their goal. Doing this for the entire brain will make you "smarter" but will leave you equally exposed to any other negative aspect of brain functioning, e.g. increased risk of neuronal disfunctioning.
Well said +Jesper Vernooij. This myth is actually very popular
Especially among people who don't use 100% of their "brain".
o_O
;-)
xDxDxD
Stay hummble