Metabolism | Fatty Acid Oxidation: Part 1

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  • čas přidán 23. 07. 2024
  • Official Ninja Nerd Website: ninjanerd.org
    Ninja Nerds!
    In this lecture Professor Zach Murphy will present on part 1 of this two part series on fatty acid oxidation. During this lecture we discuss the transport of fatty acids within the bloodstream, as well as the activation of fatty acids. We also talk about the translocation of fatty acids from the cytoplasm into the mitochondria via CPT-1, and CPT-2. We hope you enjoy this lecture and be sure to support us below!
    We also have a discussion on the 4 stages of beta oxidation:
    1. Oxidation
    2. Hydration
    3. Oxidation
    4. Thiolase activity
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    #ninjanerd #FattyAcidOxidation #Metabolism

Komentáře • 577

  • @Mani-hs8dd
    @Mani-hs8dd Před 5 lety +462

    I attend a fu**ing 4 hour lecture about this exact same content and I don't understand a word , but I understand it all in less than 30 minutes vid with this guy, dude this is unfair

    • @juancorrea8591
      @juancorrea8591 Před 4 lety +32

      Monyal Knowing that these videos are free, and that I’m gonna be paying tens of thousands of dollars in loans for inferior lectures makes me angry lol

    • @wallmethod
      @wallmethod Před 4 lety +6

      Thats bec you attended! Each lecture is a “build up” to the next level :)

    • @meghanac6128
      @meghanac6128 Před 4 lety

      Same here

    • @hhykk
      @hhykk Před 4 lety +1

      same lol i Spent three days

    • @ayushthakar691
      @ayushthakar691 Před 4 lety +1

      Might be you r dumb

  • @kevo1295
    @kevo1295 Před 6 lety +480

    Dude, you're a genius. Metabolism actually makes sense now. Thanks.

  • @zeebalz7038
    @zeebalz7038 Před 3 lety +122

    Greetings from Nigeria 🇳🇬 You’re appreciated ❤️

  • @naseelmoursy
    @naseelmoursy Před 2 lety +29

    Man you are a life saver for real!!! I would've never understood Biochemistry without your videos😭! THANK YOUUU😍

  • @nickygm3429
    @nickygm3429 Před 2 lety +59

    Thank a lot! saving me form med school. Btw I want to comment that in 20:21 the enzyme used is B-hydroxyacyl CoA dehydrogenase in order to move to B-ketoacyl CoA. Thanks a lot.

    • @chitrakarcosmo
      @chitrakarcosmo Před měsícem +1

      Yes

    • @questioneverymatter5851
      @questioneverymatter5851 Před 22 dny

      ​@@chitrakarcosmoI was like why acyl CoA dehydrogenase responsible for convertion to Enoyl acy CoA. So B-hydroxyacyl CoA dehydrogenase responsible for the conversion to B-ketoacyl CoA. Looks like the reversed process of Fatty acid CoA synthesis.

  • @alfiemed1317
    @alfiemed1317 Před 4 lety +447

    Well done, but there’s a small mistake at the beginning of the lecture. You mentioned that atp is converted to adp in fact it’s converted to amp and the 2 inorganic phosphates and the phosphoanhydride bond is broken by inorganic pyrophosphatase otherwise perfect video

  • @nidaiqbal7216
    @nidaiqbal7216 Před 3 lety +72

    I literally don't know why I get excited when I listen to you .... I just start walking with the excitement that I have got the core concept that I couldn't get when I listened 100 other videos. I think you are the most underrated man on utube , u deserve atleast 10M or more.... I can't appreciate you with Thankyou only .... U deserve award for all your efforts. I wish you never stop making videos please
    My Favrt processor in All of my life 🖤🖤🖤
    Countless blessings ❤️

  • @nizamulhaq6886
    @nizamulhaq6886 Před 2 lety +44

    no word of appreciation can entirely explain your personality SIR U ARE SUCH A GENIUS PERSONALITY ALOT OF LOVE AND RESPECT FOR YOU.U ARE JUST AMAZING SIR.

  • @bhavanakathuria3697
    @bhavanakathuria3697 Před 5 lety +17

    You deserve more views. You easily explained something my "highly accredited" professor couldn't in 53min, while you did in less than 30. THANK YOU!!!

    • @elianjoensen2756
      @elianjoensen2756 Před 2 lety

      this is a scripted video. some would call that an advantage

    • @MarieKametani
      @MarieKametani Před 2 lety +1

      @@elianjoensen2756 yea but he did it in one take pretty much

    • @elianjoensen2756
      @elianjoensen2756 Před 2 lety

      @@MarieKametani teachers do that too. it’s called real life, and they don’t have a script

    • @MarieKametani
      @MarieKametani Před 2 lety +1

      @@elianjoensen2756 ohh my classes are recorded rn bc of covid lol

  • @ahmetziyaaktas9179
    @ahmetziyaaktas9179 Před 7 měsíci +3

    I adore your knowledge of Biochemistry and enthusiasm. How clean and pleasant an explanation this is! 💕

  • @Aleyofication
    @Aleyofication Před 6 lety +172

    Isn't it a Hydroxyacetyl CoA D.H and not the Ketoacyl CoA D.H in the third reaction?

    • @NinjaNerdOfficial
      @NinjaNerdOfficial  Před 6 lety +100

      +Op Nutrition You are absolutely correct! I am sorry for that mistake!!

    • @Aleyofication
      @Aleyofication Před 6 lety +6

      Np mate...great vids. btw!

    • @ZainabMostafa-gk5jc
      @ZainabMostafa-gk5jc Před 6 lety +7

      why did not u change it or added a comment till now ??

    • @baraaka5376
      @baraaka5376 Před 6 lety

      Op Nutrition
      Why???
      There is keton group😅

    • @nischayjairaj
      @nischayjairaj Před 5 lety +1

      baraa ka because the dehydrogenase is acting on the b-hydroxyacyl-coa to form your b-ketoacyl-coa

  • @moonchildc3894
    @moonchildc3894 Před měsícem +2

    I know I'm late but honestly saying you're a LIFESAVER !!!! I understood so beautifully 💜

  • @momo-mn7wn
    @momo-mn7wn Před 3 lety +3

    You're a genius man!! I spent my whole day to understand this and i got it in 40mins..hats off to you

  • @amynainan1157
    @amynainan1157 Před 3 lety +6

    You are a legend thank you so much for helping me through med school...
    You manage to do more in half an hour than hours of professors or the textbook😁

  • @Dr_Harsh07
    @Dr_Harsh07 Před 3 lety +2

    Reading my book after 30 mins of ur lecture is smooth ... Thanks a lot u are a life saviour

  • @sohaibalaa8228
    @sohaibalaa8228 Před 4 lety +1

    Brother I’m really owe u, u summarized about 2 three-hours lectures in about 30 minutes! u r incredible!!

  • @tchdkstar3944
    @tchdkstar3944 Před 5 měsíci +3

    I know I am watching this 6 years later, but I just want to say you are a genius. I used to hate biochem, but by watching your videos, I am now omw to become a biochem guru. Thx

  • @darshinimalukar3246
    @darshinimalukar3246 Před 2 lety +1

    All the praise here multiplied by 100, and that still wouldn't suffice what an amazing lecture this is.

  • @AjaySensei
    @AjaySensei Před 3 lety +2

    This is the absolute best video on fatty acid oxidation i've ever seen! I feel like I just had an epiphany.

  • @learnwithareesha458
    @learnwithareesha458 Před 2 lety

    Ninja nerd is a blessing. This channel has helped me so much that a small thank you just won't do justice. I'm so grateful 💫💫

  • @parvathitiruviluamala9870

    I never paid attention to this while in Medial School. What an AWESOME teacher !! God bless you !!

  • @fayyoosh7870
    @fayyoosh7870 Před 3 lety +3

    I like how we all in comments are amazed and thankful for ur great explanation .. thx ! ❤️

  • @zainab-dr9sy
    @zainab-dr9sy Před rokem +4

    My exam is in 2 weeks thankssssss you just saved meee and ur lecture notes are rlly so legit!! Keep uppp ur saving billions of medical students

  • @afrozayaz7871
    @afrozayaz7871 Před 4 lety +3

    I can't even imagine looking at my book for metabolism buhh you're awesome. The legend ninja.

  • @Hugo-no1si
    @Hugo-no1si Před 6 lety +43

    In one word: LIFESAVER. Thank you so much!

  • @jackjyoung
    @jackjyoung Před 3 lety +1

    You explain things so well I watched it twice and probably will watch it again.

  • @kusocm
    @kusocm Před 5 lety +5

    Nice and concise, I really appreciate what you're doing, particularly for people that cant afford education...but bear in mind, palmitoleic acid is a monounsaturated acid, necessitating more reactions that you drew, but for palmitic acid it is perfectly correct, and the thiol group is what connects the CoA to the acyl group.

  • @shanicem3929
    @shanicem3929 Před 5 lety +5

    So excited when we finally got to the acetyl CoA. Yaaay. Finally

  • @sarahgutierrez5628
    @sarahgutierrez5628 Před 6 měsíci +1

    This was the best teaching video I've ever seen, you're a great teacher ! Thank you so much!!

  • @vincentarthur8699
    @vincentarthur8699 Před rokem +2

    Thank you very much Prof,you make Biochemistry more comprehensible,greetings from Ghana🇬🇭

  • @jokodubga6535
    @jokodubga6535 Před rokem +1

    Thank God, I finally understand the topic. Thank you Ninja Nerd, God bless you!

  • @osedunmeevans7051
    @osedunmeevans7051 Před rokem

    With your videos I don’t have to necessarily memorize but rather, to understand. Thank you so much!

  • @asserm.8047
    @asserm.8047 Před 5 lety +31

    Great video!!!!! If only my professors were as good at teaching as u are 😂😂

  • @user-vw4yh6ld7n
    @user-vw4yh6ld7n Před 5 lety +1

    You’re saving my life with your videos

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    @amirrezag Před 8 měsíci +1

    You are a lifesaver for real!!!! Thank youuuu.

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    @ahmednaser7770 Před 4 lety +2

    thank you for making everything we much easier and enjoyable.. you are putting a lot of effort ..I appreciate.

  • @sophias4280
    @sophias4280 Před 3 měsíci

    You're such a gem, thank you SO much for making all these videos

  • @marysia5525
    @marysia5525 Před rokem

    You are helping me get that exemption from biochem exam and I could not be more thankful!!!

  • @roshan6253
    @roshan6253 Před rokem

    Normally i wouldnt even like subscribe and pay for this knowledge but you my friend explain it soooooo easy im sold.

  • @igj3224
    @igj3224 Před 5 lety +2

    Guys, amazing job! Just amazing!

  • @chisomongalande8745
    @chisomongalande8745 Před rokem

    can't figure the actual words to use to thank this guy😁.. he's absolutely the best of the best😍, thank you@ Ninja Nerd

  • @masoodahmed6276
    @masoodahmed6276 Před 24 dny

    Brilliant. What a pleasant and rewarding experience for learning biochemistry with clarity.

  • @markmuravec8624
    @markmuravec8624 Před rokem +15

    Amazing explanation! Thank you ninja master. I think you flipped the CoA-SH in the opposite direct. I believe it should be Acetyl-S-CoA, so that CoA is bound to acetyl with thioester bond:)

  • @awetyeman5315
    @awetyeman5315 Před měsícem

    Great job Nija nurd.I was struggling my head to get around this.Thank you as always

  • @MohsinAli-bu2os
    @MohsinAli-bu2os Před 2 lety

    I have no words to praise ur hardword , such an excelent work , mindblowing. U r a hero bro .

  • @user-hc2yx9tp2n
    @user-hc2yx9tp2n Před 2 lety +2

    you help us alot I'm so thankful to what you do 💙💙💙
    عاششش يا كبير

  • @uroojmustafamalik9249
    @uroojmustafamalik9249 Před 5 lety +13

    superb...💕💕MAY ALLAH BLESS YOU SIR💛💛

  • @imeneamina2342
    @imeneamina2342 Před 6 lety

    can't find a better video sooo simple thaaank youu from north africa

  • @Amanda-bk9lu
    @Amanda-bk9lu Před 3 lety

    Better than my metabolism prof. I have a metabolism midterm tomorrow and you are SAVING me

  • @tejasvidalla2982
    @tejasvidalla2982 Před 6 lety +92

    Nice video sir.. but a small correction .... in the first step.... ATP is converted to AMP + PPi... which is converted to Pi by an enzyme inorganic pyrophosphatase ... this makes the first step irreversible!!!

  • @reyazeram
    @reyazeram Před 4 lety

    i cant stress how much your videos have helped me . thank u so much :)

  • @pavkata97
    @pavkata97 Před 4 lety +2

    You are a very talented teacher. Love your videos!

  • @beautifyingnaturewithcreat2498

    Just amazing man...urs lecture just cleared my all concept related to oxidation of fatty acid...m very thankful for it

  • @laceymauritz8053
    @laceymauritz8053 Před 4 lety

    you're like the guardian angel of grad school. thanks for teaching me science!

  • @user-vu9st6fd7v
    @user-vu9st6fd7v Před 2 lety

    This is beyond description ...
    Thank you so much!!!

  • @golgiskarimi927
    @golgiskarimi927 Před 4 lety

    It was amazing, thanks for the smooth and understandable explanation

  • @gihanimanodara4264
    @gihanimanodara4264 Před 2 lety +11

    Thank you for your determination and the excitement in explaining the processes so well! Love from Sydney Australia

  • @stavhen7753
    @stavhen7753 Před 2 lety +2

    You're amazing.
    I had no idea how simple this could be, thank you so much for your efforts!

  • @zainabs4159
    @zainabs4159 Před rokem

    this guy is a LIFESAVER

  • @kattran3798
    @kattran3798 Před 3 lety

    This helps me sooo much with the MCAT, thank you!

  • @AhmadAhmad-rv6ms
    @AhmadAhmad-rv6ms Před 5 lety +3

    i just wish that in the other videos like glycolysis if you explain the chemical structure like here :( i had to search about it back then :( thank you for your effort :D you are really amazing

  • @user-wi6ri4fz9k
    @user-wi6ri4fz9k Před 3 lety

    You are just a real biochemistry savior, god bless you

  • @gayathrid753
    @gayathrid753 Před rokem

    Iam doing my ug.... And u r the most helpful part of my life for physiology and biochemistry✨ thanks a ton✨

  • @franckynjantou8124
    @franckynjantou8124 Před 3 lety

    I don't even need to watch your videos lesson before liking...I like it with blink eyes.......I love your Teaching Professor...you are just amazing. I wish to be like you someday...really you overmotivate me. Thanks a lot/ Be blessed

  • @parthajitdevpurkayastha2515

    It's Just too good....U Are really doing a great job ..Thanks a lot for your priceless efforts..

  • @MaylinGinestra
    @MaylinGinestra Před 5 lety

    I am in love with your videos !!! Thanks so much

  • @hakonskog480
    @hakonskog480 Před 6 lety

    Thanks again, Ninja! Now I can face my exam head on!

  • @emtiazsproduction9455

    Great i understood beta oxidation fully with your video sir, while i couldn't understand anything from my BIOC professors..
    Thanks a ton.

  • @mhmde7260
    @mhmde7260 Před 2 lety

    You deserve major respect
    Thanks alot for your videos

  • @hibazahid190
    @hibazahid190 Před 4 lety +1

    Thanks sir.You cleared all my concepts.A Clap of appreciation from PAKISTAN 👌👋👋👋

  • @raghadalomari4058
    @raghadalomari4058 Před 6 lety

    why would 4 people dislike this phenomenal video???
    Thank you tons!

  • @KingSpark-bc1zd
    @KingSpark-bc1zd Před 21 dnem

    I really enjoyed your lessons and have recommended to all my friends

  • @maryamnisar3874
    @maryamnisar3874 Před 2 lety +1

    You are life saver Zach 🙌

  • @serena3135
    @serena3135 Před 3 lety +10

    Is it weird to say I love you? No? Okay. because This video just saved my life

  • @karolinaverbanova3165
    @karolinaverbanova3165 Před 5 lety +2

    I spent 15 minutes watching this and I already know some badass stuff to shut everyone's mouth tomorrow Haha. You're making me the best student in the class!

  • @DaRa-lw6rw
    @DaRa-lw6rw Před 3 lety

    Bravo man! I'm and grateful and full of inspiration to get more and more! thanks!

  • @أبواب-الجنة-8

    Thank you so much, you have made the concept easier.

  • @user-cs9nm3nz6o
    @user-cs9nm3nz6o Před 7 měsíci

    Amazing video now i got the concept thanks ninja😊

  • @sapphiregem12
    @sapphiregem12 Před 3 lety

    This really help! Thank you for making this video

  • @vinayakkapatral4246
    @vinayakkapatral4246 Před 4 lety

    Zach... You are amazing I am hooked to your lectures,

  • @ahmedallam1457
    @ahmedallam1457 Před 5 lety

    Yeah.. Thanks alot.. Keep going u r the best for me ♥️🙆‍♂️

  • @Didsomebodysayslay
    @Didsomebodysayslay Před 2 lety

    i attended the lecture at uni but didn't get a word and here i am completely understanding the whole thing thanks to u

  • @anngitau810
    @anngitau810 Před rokem

    Beautiful work!

  • @hayllatte
    @hayllatte Před 4 lety +1

    thank you so much. you helped me for my final ❤️

  • @aniketbrar4759
    @aniketbrar4759 Před 4 lety

    God bless yall at ninja nerd. Ily. ❤️

  • @SxCR4WR
    @SxCR4WR Před 3 měsíci

    I love this man, makes me love biochem

  • @vinayakkapatral4246
    @vinayakkapatral4246 Před 3 lety +10

    Genius for sure... wonder how many hours of reading Zach has put in and his team getting this type of lecture..
    Congratulations to Zach and his team!!! Best!
    Obama should see this and endorse it.

  • @dler5360
    @dler5360 Před rokem

    man I don't have words to describe how much i'm thankful for you. You didn't just make biochem esaier, but science in all its branches. thank you very much professor Zach i love you. ❤❤🤍🤍

  • @sinombulelozamani7361
    @sinombulelozamani7361 Před 4 lety

    wow your videos are the BEST!! Thank you soo much they are so awesome, God bless you

  • @sploallthyme
    @sploallthyme Před 3 lety

    Thank you! This has helped me tremendously.

  • @maxdb550
    @maxdb550 Před 2 lety

    All my classmates study with your videos :) They are amazing

  • @ritikatripathi7095
    @ritikatripathi7095 Před 4 lety

    Best explanation on CZcams

  • @fifi774
    @fifi774 Před 3 lety

    You're saving my year !

  • @vetsathi9154
    @vetsathi9154 Před 5 lety

    love you sir. your lectures are excellent and detailed.

  • @anuachu2146
    @anuachu2146 Před 6 lety

    Sir,now i started to love my subject.sir you are really great😃😃😃😃

  • @camilleseguin2316
    @camilleseguin2316 Před rokem

    Thank you for your videos, they are so helpful!!

  • @christavernon4198
    @christavernon4198 Před 5 lety +2

    Thanks for helping me get an A in biochemistry!

  • @mirembechristine3942
    @mirembechristine3942 Před 2 lety

    thanks cause you have really simplified medical school for me

  • @niusha3323
    @niusha3323 Před 3 lety +1

    Cant imagine getting my degree without this channel

  • @mdnajmulhosen7259
    @mdnajmulhosen7259 Před 4 lety

    Best lecture with good explanation