Ozempic Prevents Multiple Sclerosis?
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- čas přidán 9. 04. 2024
- A study done on the US Food and Drug Administration Adverse Event Reporting System (FAERS) surprisingly showed that people taking certain weight loss drugs appear to have a dramatically lower risk of multiple sclerosis. Is this real? I review the study and show some of the problems with the methodology and the theory behind a possible association of MS with obesity.
The article I am discussing: pubmed.ncbi.nlm.nih.gov/38566...
Selected Sources:
Association of obesity with disease outcome in multiple sclerosis: pubmed.ncbi.nlm.nih.gov/36319...
Association of Obesity With Multiple Sclerosis Risk and Response to First-line Disease Modifying Drugs in Children: pubmed.ncbi.nlm.nih.gov/31305...
Dulaglutide Modulates the Development of Tissue-Infiltrating Th1/Th17 Cells and the Pathogenicity of Encephalitogenic Th1 Cells in the Central Nervous System: www.ncbi.nlm.nih.gov/pmc/arti...
Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome: pubmed.ncbi.nlm.nih.gov/35364...
GLP-1 Analogs: tmedweb.tulane.edu/pharmwiki/...
Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome: www.neurology.org/doi/10.1212...
Molecular Mechanisms of SGLT2 Inhibitor on Cardiorenal Protection: www.mdpi.com/1422-0067/21/21/...
Metformin as a Potential Agent in the Treatment of Multiple Sclerosis: www.ncbi.nlm.nih.gov/pmc/arti...
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information. - Věda a technologie
Nice Video!
Yah, it's Aaron! 🤘🏼
Thanks! I would be interested to know your opinion on the topic.
two of my favorite neurologists (you too Dr. Okuda!)
Hi. I am in Phoenix AZ. I have RRMS. I was at normal weight until til 1oo6. 26 yes old. My weight gain was due to taking Amitryptaline (Elavil) . This medication was given to me to help with sleep because I was in chronic pain. At that time I was diagnosed with fibromyalgia. I was diagnosed with MS in 2004. I saw a neurologist in mid 1990s who thought I had MS but couldn't diagnose MS because I didn't have the findings necessary for the MS diagnosis. In 2010 the doctors were watching my A1c because I couldn't get my weight down. At the beginner of the covid pandemic my A1c skyrocketed to 9.8 and my dr put me on metformin and started taking 1000 MG 2 times a day. Now my A1c is 5.6 I only take 500 MG in the morning. My weight has been up and down. I will not take Elavil for this reason. I am curious if metformin and the other diabetic and weight loss drugs will have a positive effect on MS and at which dose. Remember, my obesity wasn't childhood and was brought on by a drug 's side effect. Thank you for the really informative videos. Thanks, Susan
Of met.
Thank you and all the other research doctors that are making so many strides in the medical community. You guys seem to be the frontline doctors, making our lives so much more livable.
I have done very little research in my career, but I appreciate the kind words.
@@DrBrandonBeaber No worries, thank you for the honesty
Future video topic: The name of the pathologist who reportedly found novel tapeworm larvae in the brains of all ten MS patients he examined is Alan MacDonald. You can read the paper summary online, as well as view slide images of the parasites. It is my understanding that this paper was not peer reviewed. How about taking a look at this for us doctor? Maybe even have Dr. MacDonald on for a Zoom call? Many scoff at the parasite connection, but we know several parasite infections that already effect the nervous system (toxoplasmosis, malaria,) The pet food company Science Diet even conducted a study that states there may be a correlation between having lapdogs near humans during adolescence and preadolescence and MS. My wife has had MS over 25 years, and like 25% of Americans had pinworms as a child. Thank you
Yup, pinworms in 2013, couldn't breathe. 2016: Diagnosed with MS.... 😮
Thanks for the lesson Dr B. I agree with your skepticism.
My dream study would be one that looks at MRIs and the TRUE start of MS. I think that if you did a large study with healthy adolescents, you would find some with lesions similar to MS (periventricular), but with no MS symptoms. Observe these participants for a period of time (maybe 15 years) and see how many with non-symptomatic lesions go on to develop MS. My hypothisis is that MS starts at a much younger age on average than currently thought (30 years). I also believe the neuroplasticity of an adolescent brain is exceptional and can compensate for deficits accrued early on in the disease process and not be noticed by young people with MS. I am of the opinion that a brain and spine MRI should be done one time during an adolescent physical examination (age 12-15). I realize this would not be possible today due to price and lack of MRI machines.
It is already well known that MRI lesions typical of MS can be present years prior to the onset of symptoms. You may appreciate this video on radiologically isolated syndrome: czcams.com/video/GyxUPJ7mZbY/video.html There are studies on random MRIs on healthy individuals. This is not possible in the general population for the exact reason you describe.
@DrBrandonBeaber if we lived in a world where this was possible (to diagnose MS at a much younger age), then it seems to me we could reduce disability rather markedly when these people got older by starting a DMT earlier. Possibly by doing aHSCT. Just wishful thinking, I suppose. 😊
I don't know if that's accurate. I have a lot of brain and spinal cord lesions and I don't feel well at all.
I wonder what percentage of the general population have brain lesions (and not diagnosed with any neurological condition)?
@@andrewreisinger6860that’s what they’re doing ! Even those diagnosed with CIS are started on the top tier DMTS bc there’s enough evidence to show MS without all the progression and years of guessing and accruing more damage. I agree w the thought process that it seems like as part of our physical as a new adult maybe we get our own baseline MRI & neuro cog exam (elective) so we have a way to monitor changes for those that want it. I know I would’ve done it ! :) I gratefully did get MRIs in 2013 prior to lesions being detected so when I became symptomatic in 2020, I had MRIs as a comparison and was able to get diagnosed quickly and started on Kesimpta.
Very interesting study! Perhaps it works on the nrf2 pathway as it simulates a fasting stress response. This may be similar to the method of action in drugs like DMF / tecfidera/ vumerity. The mechanism may work through reducing oxidative stress and associated inflammatory response (perhaps like a chain reaction). I am very interested in how it would impact annual relapse rates in people with MS. Perhaps it could be a "supplement" drug on top of DMT where ozempic would be taken at a lower dose perhaps.
Video suggestion: Update on clemastine trials if available? :)
None available at this time but I will do an update when appropriate
Because they are profiting from this disease instead of Curing it. I used to be the Branch Manager for NMSS here in Central California. Heard the suffering as I manned the hotline, so instead of just sitting here for years; especially when I myself was diagnosed.., I began looking for a cure, and from what I'm doing, it seems to be helping, as I lost a good and dear friend to MS in 2017. So: just check my comments, you may like what you find, because I'm up and walking now Without my Cane. Best, MM, JD CANDIDATE ✌👍❤❤❤
Why isn't HSCT not preformed in the US full time other than some small institutions and not covered by insurance?
#1 way to halt the progression of Multiple Sclerosis
Insurance Companies would save Billions in medical cost compared to products like Ocrevus at 60k a sack X2 times a year for 120k. Average cost is 60k out of pocket for HSCT in other Countries.
big pharma likes to keep MS patients on tab for life in my opinion. I live in NL and you need to be in a wheelchair and crippled to use HSCT - Netherlands is an absolute joke when it comes to MS treatment
Rhetorical question. WAY too much money in keeping people on a lifetime of infusions rather than a discontinuous therapy. This is why big pharma LOVES the GLP-1 drugs---u need to keep taking them because they only work if you stay on them for life.
Good info here! 👍
Video suggestion: pediatric ms. What are signs to look for? Are they the same as adults and what age does it typically get diagnosed.
Future Video Recommendation
Explanation of labs done between past and upcoming Rituximab (or B-cell depleter in general).
What labs are done?
What are normal/concerning results?
What are the main markers that are looked at?
Detailed information.
ETC.
Hopefully, I'm making sense.
Thanks in advance
Thanks for the suggestion.
Thank-you for the video Dr Brandon, always enjoy the information you share.
:)
@@DrBrandonBeaber sir I just have to let you know in my opinion you one of the best out there and I wish to God that I could come out and have a visit with you but I know you only accept certain insurance and I'm hoping maybe one day you have your own practice so you have a little more leeway with that.
Great video - thank you for your work
I would love a Dr. Beaber video on triggers of bad genes (getting turned on, gut inflamation. the immune system in the gut etc.. I watched some Dr. Chanu Dasari videos on utube...
Very interesting video as I myself often wonder do to some studies as you shown if my childhood obesity played a part in making me more likely to develop ms ... as by age 11 my weight started to climb by 14 I was 405lb .... as much as I have high likely hood for diabetes as both sides of my fam meny peole have had it ...I do not .... my mom is type two I can't remember what med she's on but I think it's metform and she the first in my immediate fam to get m.s ..... she got diabetes after her ms diagnosis and has had relatively low ms like me hasent had meny new spots show up.... she did lose alittle weight when she started the diabetes med but as of now it's been apparent her brain has deff been shrinking or as her last mri said parchnchemal volume loss as she had been having more falls.... so while she hasent had new lsion the diabetes meds deff hasent prevented brain volume loss .... she is in her 60s and got diagnosed in her 40s with ms ...... it is in my opinion do to my fam as we all have been over weight alot at time or currently in my family I deff feel it's played a role and that we already had a distant family history with ms as my mom had cusion and uncle who also had ms ...... I'm not sure though these meds would play a significant part or role with m.s ...... jusy from my mom experience with diabetes meds and her ms .... I also think my middle sister is also taking weight loss meds do to her being obese but I can't remeber what med she's on her ms is also very mild only 3 liosn but she says ine is allways slightly enhanced..... all of my moms children got ms diagnosed in there 20s
Isnt metformin what David Synclair takes for longevity?
We should look into metabolic issues, even with a low weight!
Thank you!. Suggestion: Remyelination in multiple sclerosis
Thank you very much Doctor!
Video suggestion: CAR-T therapy for multiple sclerosis.
Thank you, Dr Beaber!
You're very welcome
Then why is it so difficult for someone to get these types of medication when it is so beneficial for a person with MS to lose weight. I am 43 diagnosed at 39.5. I lost 115 pounds with diet and phentermine prior to dx. Thanks to solu-medrol, methynprednezone, and gabapentin I gained it all back. I’m trying to lose it but exercise is hard for me. I live in TX and what gyms are kept at here it doesn’t take me long to over heat. I push myself I have always been that way but I know that I have limits but they can sucker punch you out of nowhere. Is it safe in a gym for me in all honesty unless I can control the thermostat then no.
What if someone is already diagnosed with MS and uses these drugs? Would it be similar to other DMTs?
Very interesting!!
What a video on Cognitive Rehabilitation for MS?
You may appreciate this video where I interview neuropsychiatrist Professor Feinstein: czcams.com/video/aKqYjoBgvAU/video.html
@@DrBrandonBeaber
Thank you!! 🙂
I will have a look….
Another Great Video!
Thanks
As you can see: The Doctors have been Conditioned to understand The Body's { Reaction } to the Disease in order to Treat the Disease; Not Figure Out { The Cause of The Disease } , ...which essentially Guarantees Decades of Treatment, but in lieu of The Patient's ability to Live a Normal Life..., Argh.. 🧐🤑🤑🤨🤨🤔🧐🧐
I tried Ozempic starting at .25mg. I felt as I slowly increased the dose I had increased leg weakness. I was losing weight, but was I losing muscle?
I have PPMS, EDSS 6, 68 yr
Interesting.
As alway DR.B ecellent video and you alway keep an open Mind.
As always DR.B excellent video and you always keep an open Mind.
Thanks
You’re awesome
What about if a person has MS does Ozempic help MS Symptoms ?
There is no evidence that it would in my opinion (unless the symptoms are also associated with weight or type 2 diabetes).
❤ interesting.
If they help a few
That’s a win.
#Sharingiscaring
As we are all different- and those who have diabetes/ overweight- do need treatment of these- to overall improve health.
But I was NEVER obese, so WHY, despite the Ocravus, has the MS been progressing so d___ rapidly? 🤬😫
So sorry to hear. Just as I lost use of my right hand and numb from chest down, FDA approved Ocrevus. I went in a month later. It took about two weeks before everything was back to normal. I just have permanent neuropathy in my feet and horrible fatigue.
I take armodafinil for energy. Though it’s starting to not work as well.
There are some people who have healed their ms through diet. You can research.
Did we watch the same video? Where did he claim obesity is THE cause of MS progression? Also - are you on a highly effective DMT?
Oh no... I'm going to be switching to Ocrevus....
What else have you been on and do you think they suited you better? 🙏🏻
Do you have any other comorbities or smoke.
No, no, Ocravus is about the best treatment out there, relax, it'll be great. It's just that sometimes the disability progresses despite everything. 😝@ellie698
So I have MS and take Ozempic for about 12 weeks
I feel my MS is slowly getting worse. My age 64 almost 65
Hm. That's unfortunate
I became overweight because of the steroids following the MS diagnosis.
All my life I’ve been underweight! I was also born as a premie (3 pounds),
In our study in Southern California, we did look at prior BMIs to avoid potential confounding with steroid side effects or less physical activity due to symptoms from multiple sclerosis.
Of all the people met in 15 years, also affected by MS, only one was obese. The majority had a normal body weight and only few were overweight. I was diagnosed at 22 with a normal (low) weight but never been overweight, and for the most of the time I was underweight. On top of this I had a Mediterranean diet but it did not matter. EBV is the sure cause of my MS, with genetic predispositions.
@SaraC-us5ky My thoughts exactly! I've never seen an obese MS pt in the clinic wait room either. All look borderline anorexic. Also, the celebrities w recent MS dx who r always in public view are /were extremely thin as well. It doesn't mean anything, just my observation.
I've always been on the lowest side of normal weight for my height & EBV negative.
Some specialists believe chlamydophila pneumoniae is a critical and necessary factor (along with the other respiratory infection - Epstein Barr Virus) for the development of Multiple Sclerosis. C.Pneumoniae is known for altering fat metabolism in its hosts (as part of its survival mechanism), so potentially an obesity drug could suppress the infection. Would love to see a more robust study!
I think more modern evidence such as the famous study in the US military argues against any association of MS with any pathogen other than EBV.
Is it true that some have tested positive for MS, but not Epstein Barr?
@@timothycarter9208 It is rare in adults with MS to test negative for EBV antibodies. In the study on the US military, there was only a single instance of this. Explained here: czcams.com/video/3bkEXWg3kTw/video.html
@@DrBrandonBeaber the US military study was virus-centred [looked at EBV-infection status, as well as at cytomegalo virus (CMV)]. The theory is that EBV “opens the door” to another pathogen such as the bacteria c.pneumoniae. Wonderful thing about C.pneumoniae is that it can be eradicated with antibiotics.
Dunno why you deleted my comment. I was just sharing information about a clinical trial I saw. I have had MS for 21 years.
I did not delete any comments on this video.
@@DrBrandonBeaber Maybe it deleted automatically because I shared a link. Anyway, was just sharing a trial from Australia I saw for progressive MS. It involves metformin and alpha lipoic acid.
@@rogerwilkerson2Can you share the link again. Thanks.
@@traceywhiting7093 It deleted again. Just Google PLATYPUS trial multiple sclerosis Australia. It should come up. It waa news medical article. 😀
@@traceywhiting7093I replied, but my comments keep disappearing. Google PLATYPUS trial for MS.
well then you will never hear of this again.
I suspect there will be more on this in the future.
Hahaha too bad I got diagnosed with MS while using tirzepetide.
I know someone who was diagnosed with MS a few months after using liraglutide (saxenda), another GLP-1 drug.
And I presume no one reported this to FAERS?
Did not. Do you think I should?