Immune Checkpoint Inhibitor-Associated Nephritis ft. Jamie S. Lin, MD, FASN

Northwestern University hosted Jamie S. Lin, MD, FASN Assistant Professor of Medicine (Nephrology) atthe University of Texas MD Anderson Cancer Center, as part of the Renal Grand Rounds.
Jamie presented the talk "ImmuneCheckpointt inhibitor-associated Nephritis: Epidemiology, Management, and Surveillancee" with key takeaways:
1. The spectrum of injury in immune checkpoint inhibitor (ICI)-nephrotoxicity is broad and can include: acute interstitial nephritis (AIN), acute tubular injury, glomerulonephritis/vasculitis, and electrolyte disturbances
2. Infliximab, a monoclonal antibody targeting TNF alpha, can be used as second-line therapy for difficult-to-manage AIN cases.
3. Less than 25% of patients with a diagnosis of ICI-associated AIN will redevelop AIN following ICI therapy re-challenge.
About Dr.Lin:
Jamie is an Assistant Professor of Medicine at the University of Texas MD Anderson Cancer Center. She obtained her undergraduate degree from the University of Pennsylvania and her MD from the University of Nebraska College of Medicine. Subsequently, she completed her internal medicine residency at Baylor College of Medicine. During her nephrology fellowship at the Hospital of the University of Pennsylvania, Jamie distinguished herself as a research scholar on the Division's NIH T32 grant and was honored with the NIDDK F32 award.
Her outstanding research has been recognized through various prestigious accolades, including first place at the National Young Investigator's Forum at NKF and Best Oral Presentation at the Basic Research Forum for Emerging Kidney Scientists at ASN and APS. Jamie's research findings have been published in reputable journals such as the Journal for ImmunoTherapy of Cancer, OncoImmunology, JCI Insight, and Frontiers in Immunology. Her research interests revolve around the investigation of small GTPase proteins and immunotherapy-associated nephrotoxicity.
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