Hidden Secrets of Omalizumab mechanism of action & Pharmacology

Hidden Secrets of Omalizumab mechanism of action & Pharmacology #omalizumab #omalizumaburticaria
In this video it is described that
Omalizumab works by binding to immunoglobulin E (IgE), a key player in allergic responses. By binding to IgE, omalizumab prevents it from attaching to receptors on mast cells and basophils, thus reducing the allergic response. This action helps in reducing the symptoms associated with allergic asthma and CIU.
Precautions:
Hypersensitivity Reactions: Patients should be monitored for signs of hypersensitivity reactions during and after administration.
1. Malignancies: There have been reports of malignancies in patients treated with omalizumab. Caution is advised, especially in patients with a history of malignancy.
2. Acute Asthma Exacerbations: Omalizumab is not indicated for the treatment of acute asthma exacerbations or status asthmaticus. Patients should have appropriate rescue medications available.
3. Parasitic Infections: Omalizumab may increase the risk of parasitic infections. Patients should be evaluated for parasitic infections before starting treatment.
4. Pregnancy and Lactation: The safety of omalizumab during pregnancy and lactation has not been established. It should be used with caution in pregnant or nursing women.
Interactions: Omalizumab is not known to have significant interactions with other medications. However, caution should be exercised when administering omalizumab with other immunosuppressive agents due to the potential for increased immunosuppression.
Side Effects:
1. Injection Site Reactions: Pain, redness, itching, or swelling at the injection site are common side effects of omalizumab.
2. Headache: Headaches are a common side effect reported by patients receiving omalizumab.
3. Upper Respiratory Tract Infections: Nasopharyngitis and upper respiratory tract infections may occur.
4. Viral Infections: Increased susceptibility to viral infections, such as influenza, has been reported.
5. Anaphylaxis: Although rare, anaphylaxis can occur with omalizumab administration, particularly in patients with a history of severe allergic reactions.
Patients should be informed about these potential side effects and advised to seek medical attention if they experience any concerning symptoms. Overall, omalizumab is considered a safe and effective treatment for allergic asthma and CIU when used appropriately under medical supervision.