024 - Can French maritime pine bark help pain and fatigue?
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- čas přidán 7. 07. 2024
- Here are the results from a small pilot study I conducted on French maritime pine bark (Pycnogenol) for Gulf War Illness, with a particular focus on chronic pain/fatigue. You can find the full-text of the paper here: pubmed.ncbi.nlm.nih.gov/33802... - Jarred Younger
- Věda a technologie
Thank you. It's great to know we haven't been forgotten by everyone. Keep bringing the light! One day the sun will shine again. Thank you.
Thank you for all your amazing sharings and points of view. As a MCAS patient, trigeminal post traumatic neuropathy, and being a DO and trained in aromatherapy in France for 2 decades, I would totally agree on the balancing effect of the immune system, instead of boosting. Especially if using a real essential oil. The entourage of all the compounds found in one specific essential oil. To extrapolate, oregano essential oil is well known as an antibiotic (antibacterial)however it will balance the un wanted microbiote bacterias without killing all the other well balanced bacterias. It is also to be said that one synthesized substance doesn’t have the levo or dextrogire balance of all the entourage, making it less potent. Again thank you so much for your amaaaazing expertise shared. I watched your video regarding the imagery of the T cells potentially passing the blood brain barrier…these studies will help considerably so much patients. 🙏 🙏 🙏
I see the French avatar. I have a meeting with the radiology group next week to schedule our ME/CFS participant for the leukocyte imaging study, and finalized the healthy control manuscript last week. Lots going on! - Jarred Younger
For me a family financial personal difficult situation has led me to having pain and stiffness in my whole body and insomnia. Poverty is the key to illnesses in my opinion. Thanks 🙏
The stress of poverty for sure. 🥺
I believe that all major stressors in a person's life can lead to illness. This can include poverty, the illness of a family member, the loss of a loved one, the loss of a beloved pet if you had a strong bond with it, or your partner leaving you, and so on. It all depends on how much one of these triggers affects your mind, as we are not all the same. But I definitely agree with you.
@@simonep3443 thank you for your understanding.
My husband left me on 3 January 2020 after 30 years of marriage and I don’t have any future security or sufficient income and surviving on government’s minimum pension. My health is declining and I can’t work nor earn. This is why I am very sick.
💔
@@shad6519 I'm so sorry you are experiencing such difficulty. I hope you can find resources to help!
Educational, fascinating, and quite helpful. Thank you, Dr. Younger! 🙂
My 38 year-old son has everything you’re talking about and he now has autoimmune encephalitis. He’s had severe head pressure and pain for years, and it escalated after having Covid while he was battling mold toxicity and Lyme disease 3 years ago. I was his caretaker because I am retired and I had had mold toxicity in a different place, and I realized he had mold toxicity when he was at my house and talking. He wasn’t making sense. I gave him the visual test for mold, and he failed miserably. His house with his father had severe mold.
He has tried to take his life several times, and we are desperately trying to get to the root of the problem now, but you are describing him now.
He’s on disability, but it’s not enough to live on, and his father and I are trying to get him situated before we pass.
He’s has had brain damage since he had severe neurological damage and meningoencephalitis at age 7, and we noticed a change in his personality. however, we can’t prove he’s had these problems before he was 18. I don’t know why, because he has been in therapy, rehabs, had several severe TBIs with subarachnoid hemorrhaging, since he was 8 years old, and we have files and files of his therapy and journals.
The system has just labeled him as bipolar, an addict, drug seeker, depressed, anxiety-ridden and put him in jail several times (where he had 5 seizures within 3 months), and he developed mild again.
I believe he will take his life when we die, if he doesn’t do it before.
His pain levels are a 9 every day, and no one will give him pain meds because of his past reputation.
Sorry for your situation 🙏
This makes me so sad. I had a similar experience with my daughter. Not as severe but similar.
May God bless your son, husband and you...and give you strength, guidance and most of all, a healing solution.
@@tbridge36918 I’m so sorry! If it’s half as bad as our son, I feel bad for you and I’ll pray for you. 🙏
I don't know why the current diagnoses he is given are psychiatric. Just a single brain hemorrhage could cause all the issues you mentioned, not even considering the added effect of the other brain events. With those brain events, some or most of the problem is almost certainly neurologic, with damage to neurons. However, it is worth exploring issues like reactive gliosis, where microglia constantly cause brain inflammation after a serious injury. Sometimes addressing the secondary brain inflammation can bring symptom severity down to a more manageable level, even if it won't fix the neurological damage. Ultimately, I think the brain modulation tools being developed and tested now will be the way to address neurological problems. They are being used for depression, movement disorders, Alzheimer's Disease, chronic pain, and addiction. I expect there to be a significant increase in research using these tools soon. Thank you for sharing this. - Jarred Younger
Thank you so much for studying supplements and off-label medication usage. Not to mention making these videos explaining your research for us. ❤️
I've been taking pycnogenol, Kaire brand, since the 90's. I'm 66. Zero high blood pressure, arthritis, and my skin is remarkable for my age. I have great workouts including running and lifting weights. I take it in the mornings and I feel focused.
Always informative..every possible mediation for chronic disease is helpful🙏💞
I second that! Thank you, Dr Younger, your videos are excellent and give me hope for effective treatment(s).
Thank you! - Jarred Younger
Thank you so much for your videos!
Thank you Jarred for a well researched, informative video.
Thanks! - Jarred Younger
I am a Gulf War Veteran and I have been taking pine bark supplement for several years.
I also take curcumin. Can not take bosweilla because it irritated my colon.
Pine bark and curcumin both seem to be helpful for GWI. We didn't find a strong enough benefit with Boswellia, and you're right that it can be too strong for people. - Jarred Younger
Thank you so much for your scientific approach and clear and concise information. For mecfs, Dr John Chia has me on DHQ and equilibrant. DHQ is I believe from Siberian pine bark. I have definitely found DHQ helpful at improving my immune system and I just feel better. These two medicines however do not relieve my PEM or enable increased activity that I am aware of.
Thanks! Oh, your doc is forwarding thinking. I have not seen any head-to-head comparisons of quercetin and dihydroquercetin for chronic inflammation, but DHQ has several properties that are interesting to me. I love Siberian Pine nut oil for food. - Jarred Younger
Pycnogenol moved the needle for me. Will be trying higher doses of 100mg+ 🙏🏽
Good luck!! - Jarred Younger
Adding to the anecdotes, pycnogenol worked for me somewhat with ME/CFS (post-COVID) with Nattokinase, but not 100%. dropped like…30-50% brain fog + fatigue symptoms.
There is some theory that in ME/CFS the body does not use oxygen efficiently. I have issues with “air hunger”, feeling like I cannot get enough air, but can still take deep breaths and my oxygen levels are fine. Being super well hydrated helps and I use ChlorOxygen. If the body is indeed not using oxygen efficiently, will the increased blood flow to the brain help much?
I am one of those with low blood pressure, taking midodrine (along with Wellbutrin for anxiety which also increases pressure), so I will definitely check in with my doctor before trying this.
Get tested for Babesia. That's it's characteristic symptom. It's hard to test for. I had air hunger and didn't test positive for Babesia for years. Good luck.
@@ClaireCaoimheRaeMoonshadow I have that and low blood pressure too. I need to catch up with what this scientist is saying. I just found him today!
Good luck! My son and I could both use oxygen, but at least I don’t smoke!
@@SuperScaryInteresting you say that, because I’m recovering from a live form or Babesia Mycroti that my doctor had never seen alive before! I went through all the malaria symptoms as it was being killed off! I still have problems and it will probably plague me forever, because a bunch of latent viruses resurfaced, and I have autoimmune issues from breast implants and then mold toxicity almost killed me. That’s when the Lyme hit me. I’ve had air hunger for years on and off and now my ex has it in his mold remediated house. He’s in denial that he needs to keep it mold free by using air purifiers and taking precautions that it doesn’t return, because it will.
@@Tinyteacher1111 I think someone needs to start a “Dr. Younger Fan Club”! 😆
If pulse oxygen looks normal, one thing to rule out is an oxygen perfusion issue, where adequate oxygen does not reach the entire brain. That is a pretty standard MRI or PET scan for hypoxia. I don't know how often someone has good perfusion but poor oxygen utilization. There isn't a clinical scan to detect that, but standard fMRI is sensitive to oxygenated to deoxygenated blood, so it could show abnormal usage. - Jarred Younger
Are there any metabolites that labs can test for that might modulate pain and fatigue? With these complex chronic conditions, it seems like we need better diagnostics.
We are working on that as well. I have not been satisfied with blood tests, so I have been working mostly on brain scans. But if we can find an accurate blood-based proxy for the more complicated brain tests, we would definitely get that out to clinicians to use. - Jarred Younger
Thanks
Thank you
I read "Can French manicure help pain and fatigue"? 🤣🤣🤣
😄
Probably, looking good does help the mood as does gentle pampering.
Well, now I have my video topic for next week. - Jarred Younger
I am taking Pycnogenol for endolymphatic hydrops. Haven’t noticed an effect yet, but keeping my fingers crossed.
I used to take Pycnogenil in the early 1990's which was from the maritime bark. Not sure why I discontinued using it other than cycling through a ton of supplements "du jour".
Ever lookee into Airnergy for that?
I wonder what the interactions are on the curcumin , boswella and French maritime pine bark, I know that you mentioned some of the ant inflammatory properties but I was wondering how it would be possible or if it is possible to find out on your paper that was released. Thank you very much. I specifically have CF/ Fibromyalgia, PSA and have a very difficult time healing without scaring which is painful and then makes my surgeries more painful and I don’t heal properly. I do feel that using natural anti inflammatories could be helpful I just wanted to see if there was access to the effects on a cellular level or interactions good or bad. Thank you. 😊
Worst case scenario it will give you beautiful skin.
:-) I heard it does. - Jarred Younger
Thank you for this video! Do you ever test to find if anything helps Post Exertional Malaise in your studies?
We ask about PEM, but I don't run specific tests for it. We do monitor daily or weekly activity (and other variables), so PEM can be detected that way. - Jarred Younger
@@youngerlab thank you for your reply! I have sever LC and PEM keeps my bedbound. Just looking for anything new that may help there.
I’m already taking the Nature’s Way Nettle Leaf extract (870mg 2x daily) after a previous video. I think I’ll try this too as my cognition is so poor these days.
Hey Shelley, I also added Natures Way Nettle Leaf to my regimen. Going to plant nettle in a shady place at the edge of my garden as well (behind a fence panel for safety of people). Also ordered some leaf (organic, of course) and have been using it in place of parsley and spinach for garnish in cooking. I like the taste.
I hope the tests come up with something valuable! - Jarred Younger
dear Dr. Younger: have you ever looked into the impact of antibiotics like Ciprofloxacin into the development of autoimmune/inflammatory conditions, and how it could possibly ammended?
You probably know that several antibiotics carry a small risk of causing autoimmune disease. And the fluoroquinolones like Cipro can make existing autoimmune disorders worse. It seems to be a combination of distinct properties of the drugs together with the unusual environment of the body during severe infection. I don't think the mechanism has been definitively described. I haven't heard of a solution specific to autoimmune conditions that are caused by antibiotics. I haven't done any experimentation in this area. - Jarred Younger
Is there a benefit to getting the Pure Encapsulations brand? It is costs 4 times more than the Life Extensions brand. Both list Pycnogenol 100mg as the active ingredient.
There should not be a difference between the two. All products using the trademarked name Pycnogenol must use the same substance manufactured by Horphag. In the case of these two you mentioned, the differences are limited to the different gelcapsule material, and filler material. Both use vegetarian options that work well for people even with sensitive stomachs. I would just scan the ingredient list to see if one has something that you are sensitive or allergic to. - Jarred Younger
I very much appreciate this quick answer - thank you!
Thanks Doctor.
What do you know about TURPENTINE ( PINE)???
Not much, except it has strong anti-bacterial properties used on surfaces. It was used in some medical applications quite a while ago, but I can't think of any reason to use it now. There are some potential uses for the pine seed oil. - Jarred Younger
I hope one day you get a chance to report on migraine. Lots of people struggle with it and not have good treatments available.
Ty. How or where can I get this to try for my chronic spinal cord pain?
I don't know how well it may work for chronic spinal cord pain specifically, but Pure Encapsulations pycnogenol is pretty easy to get online. - Jarred Younger
I’m thinking of Korean red pine oil.. but the oil is from the pine needles. Supposed to be anti bacterial among other things. Maybe check that out too?
Yes that is a popular treatment - the top would be anti-bacterial. I don't know if the needles have the procyanidins needed for the anti-inflammatory and pain benefits. - Jarred Younger
How can one tell what is working if taking a large quantity of supplements? Studies generally use only one supplement in isolation to determine efficacy. Do the benefits change when combined with other supplements, particularly the multi-formula ones?
That is a big consideration when taking something new. I test only a single therapeutic agent at a time. This is part of the "reductionist" scientific approach. It is ok for us to see if a compound treatment has synergistic effects, but we always have to test each treatment individually as well. The more treatments that are added, the greater the risk of side-effects, so we want to make sure it isn't one or the other treatment that is driving all the beneficial effects, making the polytherapy unnecessary. So, barring other instructions from a clinician, if I am testing something for myself personally, I would change only one thing at a time and monitor changes over three months before trying something else. - Jarred Younger
@@youngerlab Thank you for your response. It is very helpful. As someone researching and treating myself (40 years) I am finding that many of us with chronic viral sequelae continue to add to our arsenal of supplements which may actually result in the "law of diminishing returns".
What about suramin ? A pine bark med now showing benefits for autism-how to get?
Have you looked at lions mane? Seeing several neuro scientist «promoting» it.
What’s the difference between French pine bark and a native species to the United States? Have they tested other species of pine bark?
Pines in the U.S. have not (to my knowledge) been compared to maritime pine for biomedical purposes. It is likely that the polyphenols could be extracted from several pine tree species. There are a small number of pine extract products that don't use maritime pine, but they haven't been rigorously tested for medical efficacy. - Jarred Younger
There's a pharmaceutical grade pynagenol from Norway..that's what I use. Bionord I think the brand is off the top of my head..was an incredible addition at first.
The best hitters for me .
Natural black seed oil( but too much orha six for use all the time , but it stopped my POTS and anxiety straight away...but the THYMOQUINONE makes it hard on the kidneys I believe)
Quercetin and broccoli seed extract...helped with dysautonomia and anxiety.
Nicotine took me out of depression but I don't want to develop heart disease!
Zoloft stopped the pressure in my neck as did aspirin and made that vascular tightness much less difficult.
Diaezepam at first was such a beautiful release from the PTSD hypersensitivity.
It still helps but I have to use very sparingly.
Cacoa powder ( definitely not the ceremonial grade tho) helps with circulation.
Beta blockers...not sure I'd be alive without them stopped the adrenaline rushes
Hope that is some useful feedback
Interesting list. I have not researched black seed oil or broccoli. I'll have to look up what the proposed active ingredient and mechanism of action is for those. Thanks -- Jarred Younger
@@youngerlabBlack seed In Islam is used for almost all ailments
@@youngerlab broccoli seed extract jarred...it's very very potent. The sulphoraphane protects DNA and is a strong antioxidant
Black seed oil is said to cure everything but death..lol..as the old saying goes.
But is has THYMOQUINONE in it and by God, that stuff is good.
Thank you for listening and responding
@@youngerlab broccoli seed extract is like a field of broccoli in a capsule....really worth checking out as is black seed..quercetin and all, you seem to know about.
Cacoa powder is a great one for endothelial dysfunction.
But got easy on it.abd don't get ceremonial cacoa...it's like a drug!
Cacao definitely helps the most with the heart I noticed! Less aching next day too and improves mood. Heart rate variability improves significantly
Lost my mum.to seevre ms in your observations on s it safe woth fybromyalgia ms in family
I am sorry to hear about your mom. I cannot think of any reason pycnogenol would be contraindicated in ms. But, I don't think a study has ever been done, so using it in ms is definitely experimental. - Jarred Younger
@@youngerlab thankyou mines fybromyalgia or migraine in the body what ime taking it for seams autism causes all these things with the hypomobility have you got any research on heds autism link with OCD I've tryed pine bark tea but not this
I'll tell you what helped with my dysautonomia and anxiety.
Black seed oil.
Pynagenol
Quercetin.
Aspirin
Cacoa powder
Chlorella and spirulina
Broccoli seed extract
Things that are bad for me but also work and use sparingly where possible
Zoloft.
Propanol
Nicotine gum
Diaezepam.therecthe " dark" meds
@@oliverbird6914seams those are in mcas do you have fybromyalgia or chronic migraine autism? I have them all so all inflammation
@@oliverbird6914going to try nicotine patch
The fatigue and pain are nothing compared to the PEM
Yes we have to knock out PEM to make any real progress. - Jarred Younger
Yes, PEM is key. But I found that once I reached a certain level of fatigue and pain, I was no longer able to engage in activity that triggers PEM. 😥
Russ Barkley did a brief overview of the literature to date about pine bark re ADHD: czcams.com/video/F0dz8vMSeXA/video.htmlfeature=shared&t=262 His assessment and the conclusion of the meta-analysis of the to-date research on this compound is that research is very poorly conducted and results from the research aren't reliable. He went so far to state that there are 'many other reasons' why the findings concluded that their were benefits.
Thanks. I didn't mention ADHD because I don't know a clear mechanism for antioxidants to help that condition. But I don't keep up with the ADHD literature, so I can't make a strong argument either way. I watched that section of the video you mentioned and I didn't hear the exact criticism of the underlying studies. I'm guessing the sample sizes were low, or they weren't placebo-controlled. The abstract of the paper he discussed didn't describe the methodologically limitations either, so I would have to dig deeper to see what the concerns were. But I'm not really qualified to assess ADHD treatments anyway! - Jarred Younger
James M. Greenblatt uses pine bark extract for ADHD. For best effect He recommends to combine it with other OPCs. His ADHD book has a whole chapter about pine bark extract and other OPCs.
As a sufferer I can tell you this stuff works...at first at least...you acclimatize but it still helps.
That's my lives experience.
When I first took it I felt amazing for a few hours each time
@@youngerlab Very fair points! And, in no way am I criticising you or your work.
My only reason for highlighting this is because of how often it's pushed for cognitive impairments, ADHD and after seeing Russ Barkley's video I took a step back.
Keep up your great work!
@@oliverbird6914 Hmm, that's interesting. Unfortunate too. I've read others say the same, that it's fine for a couple of days but it quickly stops working. I wonder why this is the case.