CRISPR Wins the Nobel Prize!! Science News 3.1
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- čas přidán 22. 07. 2024
- It's been a rough year full of rough news but today there was some news that made me smile! Early this morning it was announced that this year's Nobel Prize in Chemistry was awarded to Jennifer Doudna and Emmanuelle Charpentier for their work related to CRISPR.
Part Two Here: • CRISPR Nobel Livestrea...
I was so excited. Literally dancing around my apartment excited. So I dropped everything and spent the day making a video about it so that I can talk about it with you. Like the previous Science News videos, this is part one, talking about the news. Next Monday at 12pm PT/19:00 GMT I'll hold a livestream part two to answer all of your questions and talk to you about it.
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Big L for Virginijus Šikšnys. His publication wasn't even considered as he's from small unknown country. Quote from wiki:
"Publication of CRISPR-Cas
Since 2007 V. Šikšnys focused on mechanistic studies of CRISPR-Cas, the newly discovered bacterial antiviral systems, and was among the first to demonstrate programmable DNA cleavage by the Cas9 protein.[4][5][6][7] According to V.Šikšnys, his article was not even considered as serious by the editor board of the academic journal and was not sent to the reviewers, therefore the time needed to be recognized as first was lost.[8] Martin Schlak reported that Šikšnys submitted his article describing DNA cleavage by Cas9 to Cell Reports on April 18, 2012. After its rejection without peer review, he sent it to PNAS one month later, and it took several months for review and publication. In the meantime, Jennifer Doudna and Emmanuelle Charpentier had published their findings in Science where their findings were reviewed and accepted within two weeks.[9]"
en.wikipedia.org/wiki/Virginijus_%C5%A0ik%C5%A1nys#Publication_of_CRISPR-Cas
Yeah, this is one of the (many) really messed up parts of how science publishing currently works. He did share the Kavli prize with them though I believe.
Wow! Less than 10 years from the groundbreaking work to a Nobel prize.
Right?! It's so fast and so well deserved!!
Well explained! Love the windshield wiper analogy. We need a video on what is in your freezer :)
That video is coming soon!! ;)
I hope this tool be used for new discoveries and solve problems. I dont do anything work-related with biology or science but this gets me excited, too. I enjoy reading and learning more about it through science communicators like you. Thank you =)
This all makes me so happy, thank YOU!
Great video. I’m looking forward to part two. Also, your enthusiasm is wonderful.
Thanks for watching! I think part two will be really fun!
So proud of them! Soooo excited when i saw this pop out from your channel. Thanks @alexdainis 😊
I know! I don't know them personally, haha, but am so so proud!!
Sent this video to my mom, very well explained!
Aw, thank you!! I'm always so flattered when people find it helpful enough to share!
Namaste Alex!!! thanks for valuable inputs very helpful...
I inspired from your video. So thank you.
It means so much to see ourselves in our role models. To see an approachable role model in our goal life is so wonderful. You are and will be one of those role models as an approachable science communicator. 100% agree.
Nice video I really need it for my Genetic engineering presentation.😊🙌🏻👏🏻👏🏻👍🏻
My chemistry prof always said that the Nobel Prize in chemistry is a second physics Nobel Prize because it's frequently won by physicists. Glad they mixed it up with some biology now :D haha
Hahaha I was a little surprised it was in Chemistry, but I'll take it!
When I first heard about the award I thought “hey, I now what CHRiSPR is, I saw a video that Alex did.” Thanks for the heads up.
This made me so happy to hear!!
many thanks
0:57 Of course they do. Let's be honest.
Well, maybe not a unicorn, but a pegasus at least then.
I'm pretty sure a unicorn would be much easier to produce than a Pegasus, unless you are trying to make sure that they can only be tamed by virgins.
A new video!!! I’m so excited!!! WERE ALL EXCITED :):):):)
Can confirm. Am excited!
@@SinisterPuppy EXCITED
Me toooooooooo
Alex Dainis :):) your excitement surrounding CRISPR and the recognition of the awesome achievements of others is infectious and I love it :):) can’t wait for the next video/stream/anything else :)
New news of science yes. 😮
I was so excited when I found out, I called my friends and family to let them know as if I personally know the scientists!! Such role models 😌
Same! I immediately texted my lab best friend, who I worked with CRISPR with, as if we had one it ourselves, hahaha!
Ive been watching CRISPR for awhile, its amazing what can be done. I think most scientists have the communities best interest at heart. We have a chance to change humans forever and stop diseases and disabilities why would anyone stand in the way of true human progress.
awesome!
Thanks!
This is exciting!!!!!! Very exciting.
Thank you Alex for a wonderful explanation.
SO exciting!! I'm glad you found it helpful!
This brilliant ladies absolutely deserved the Nobel Prize! Also a question: can targeted DNA methylation be used instead to turn off specific genes and get clues about their possible functions?
I'm very excited for a series about CRISPR.
Hope to see you Monday :)
@@AlexDainisPhD If I can make it, I absolutely will!
I had a dream about you last night. Pretty weird out of nowhere since I haven't seen a video of you in months, then suddenly this vid is in my feed.
The dream algorithm knows.
Last night I had a dream about inheriting a really creepy box full of stamps and skeletons from a dead relative so... I hope that wasn't also a part of yours.
Despite everything bad happening around, things like these make me really excited about the future. I want gene editing to be my retirement hobby in a few years. I want it to improve the quality and longevity of people's lives. And of course I want flying unicorn squirrels.
Also, we need to combat cancer on a whole new level if we want to travel to other worlds. So I'm very curious about the ways we can use CRISPR to treat it.
Hey, i have a question! So we know that when a phage enters the bacteria, the defence mechanism is sending Crispr\cas9 system to cut and denaturate that virus DNA and I read that own bacterian dna is methylated so that system doesn't cut its own dna , is that true? and how did bacteria acquired that methylation mechanism, I cant find many info about that specific topic..
Can it be used to regenerate damages?
Hey Alex, I am an undergrad majoring in Computer Science(no experience in biology) in my last year. I would love to go to a grad school wherein they apply AI/Deep learning in Crispr technology, do you have any recommendations for universities or particular professors?
Alex, I have one question about CRISPR: There's a novel called "Change Agent" by the amazing SciFi author Daniel Suarez. It is about how someone had gotten infected with a viral agent that changed his DNA "in vivo" so that he took on the appearance of a totally different person. My question is: How likely is something like that to occur and take place in the future? How big is the danger of this technology being developed?
I haven't read the novel, but I will absolutely discuss why something like this isn't really possible in the discussion on Monday!
I am really excited too!!! ( I am a biotechnology undergrad)
Yeah! It's such an awesome time to be in biotech!!
Aww job alex
Why did they decide to go down this path as having potential?
Important not to create unicorns or giant flying squirrels?? Those are some oddly specific examples, but ok then... (Please make sure the flying squirrels are big enough to saddle and ride).
The Crispr discovery was such a brilliant, game changing discovery I am honestly surprised it took this long for them to win the award, though I had no idea it took so long from discovery to Nobel award.
Our legislation is still trying to catch up with the changes from the digital revolution that is now ~30 years old, there is no freaking way they will be ready to handle the implication from the medical/genetic revolution that is about to start coming on just as fast as the digital age did. It's going to be interesting century.
See you on monday then!
Yay!! See you then!
My best friend uses CRSRP to knock out genes in order to determine what each protein in a mitochondria does. She is presenting her final defense and receiving her PhD from Emory on October 29th.
Yay!!! Congratulations to her for defending (and to you for having such a cool friend)!!
@@AlexDainisPhD She had her private PhD defense on Thursday, so the rest is really just a formality.
Unfortunately for me she will be moving to California in a few months to start a Post Doc position at Stanford University, while I have to say here in Georgia to care for elderly parents with a lot of health issues.
This prize is certainly well deserved. I do agree that this debate on ethical use of gene editing needs to happen though.
As a well functioning autistic person, I find it truly scary how often people call for the complete eradication of autism through the use of this technology. Don't get me wrong, if we can use this to help alleviate the distress some of us face through this kind of therapy, I'm all for it, but for a lot of us, our autism is just part of our character. It allows us to see the world in a completely novel way, and do things that neurotypicals just don't understand.
I understand that our understanding of the genetic roots of autism are not well enough understood to eliminate it through gene therapy, but even so we need this debate now. A lot of people want to do some truly scary stuff with this technology and we need to have a debate on that.
Yes to all of this, and thank you for sharing! This is exactly why I think everyone needs a voice in this conversation. I like to think that people approaching these conversations have only the best of intentions, but we need all kinds of perspectives to make sure that we're moving forward in a way that takes everyone into consideration.
wait, i have never heard of this story about human embryos being genetically modified by crispr.
what was the fate of those embryos?
if they ended up just fine, then despite the the ethical issues, this could be a huge breakthrough!
everybody is afraid of "those with wealth and power creating a race of super-human children" as the worst possible result of this. and beyond this being completely far-fetched, it doesn't sound as bad as these opponents of genetically engineering humans seem to think.
what is most likely, is that we would use gene editing to create humans, that simply lack any genetic defects.
we can't make humans that see in the dark, but we can make humans that aren't colorblind!
why is that a bad thing? IF, and it's a huge "if", we are able to edit genes with such precision that we can for example, modify a sperm cell which has color blindness coded into it's genes to have normal vision by editing the genes responsible for color blindness (assuming we know exactly what we're doing).
we could code into embryos, the ability to tolerate lactose.
we could code into embryos which have "sickle cell anemia", to have normal blood cells instead.
and the list goes on ad-infinitum.
will this create "super-humans"? no! it will simple weed out harmful genetic mutations that have accumulated in the human gene pool.
and even assuming it will only be the absolute richest people who can afford this, which sounds very unlikely....the genes of their "improved" kids, will still be passed on to the rest of humanity like every other gene.
I can definitely talk about this story in more detail Monday, but the two twins were born alive and /seemingly/ healthy. But there were a lot of problems with how the scientist did the work, both ethically (from forging documents to not properly consenting the parents) to scientifically--he wasn't able to show that CRISPR worked the way he wanted it to, he wasn't able to convincingly show that there weren't off-target effects from CRISPR cutting elsewhere in the genome, and what he did show was that one of the children was likely a chimera with edits made in some cells but not others. It's a big story, but I think it shows that we're are not at the point where we can say that this is near safe enough to do. And due to patient privacy, at least publicly we have no further information about these children beyond the fact that they were born--there are still a lot of unknowns.
At some point we'll need to throw ethics out the window to see if we can correct leading causes of birth defects and hereditary issues. What are the biggest hurdles to overcome before the scientific community feels comfortable enough to start human trials?
So there are guidelines laid out by a number of different organizations for when we think proceeding with something like this could be okay (a lot have to do with safety, and we have not met all of the criteria yet) so I'll make sure to compile where the leading organizations stand right now to talk about that Monday!
🌹🌹🌹♥🙏
you're Canadian?
I'm not, but I get asked that about once a week :)
Yes, but can it help me raise an army of the undead gaint space hamsters? For science, you know. 🐹
I mean your big issue there is gonna be the *undead* part, you're gonna need the hamsters to be alive to make any changes...
Undead is not set in stone. They can be a little alive I guess.
The issue is making them giant. And then making them space. Not exactly sure what that is yet but I'll jump off that bridge when I come to it. 😁
I'm an engineer and analyst. It's my job to look for solutions so I'm not worried.
I want a unicorn. 🦄
I mean, fair. Me too.
Sooooo.... Cat-Girls will soon be a normal? ;p
Debbie Downer says: For those who would put their trust and faith in scientists, you should perhaps examine a chronicle of U.S. experimentation from the 19th to the 20th centuries involving human subjects: “Unethical Human Experimentation in the United States”. Find out for yourself where the names for the SALK institute, MKUltra program, CIA and Army research, and other entities originated or the activities they engaged in. Then tell me how much faith we should have in those who pervert science to rationalize their own bizarre and sick agenda’s. You will be shocked to know how many well-known names were involved. If you want even worse listings, check those military histories of Germany, Japan, the USSR, etc. Find out about every-day violations of ethical standards by scientists from the Office of Research Integrity. Scientists are fooled by other scientists all the time...often for decades at a time. Scientists are guilty of some of the worst atrocities on humans ever known. It is not “science” that is evil, but those who pretend (or don’t pretend) to abuse its potential for good or evil. Spare me your uninformed nonsense on how wonderful and knowledgeable scientists are, even as a group. They are guilty of corruption and horrors as much as any other group of people. That anyone should think scientists are especially altruistic apart from the rest of the population should have their head examined. The garbage that mainstream media puts out as “science” each day is full of human error and misrepresentation. Ulterior motives of a self-deluded half-truth is what drives their agenda...often full of outright lies. However...the evil don’t care if it is not true...as long as you support their coveted agenda. Be careful what you are asking for with eugenics...you might get it...then regret it.
Breaking a gene to figure out what it does reminds a lot of reverse engineering programs. You break a piece of code and hope it has a visible effect when it runs if it runs.
Yes!!!! It's the same thing-our DNA *is* code!
Wait I can do CRISPR from home?
You can! I'm so excited for the miniPCR lab to be released.
@@AlexDainisPhD I don't know the first thing about editing genes but I'm interested in learning. I'm also a little worried about gene editing kits being available to anyone.
Can I crisper the gender of my daughter? I much rather want a son. I also have a fridge, so I'm set, yes?
I have a feeling that if your hands are tied you may not be able to speak