I Sent My Dog's DNA To 3 Different Companies...
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- čas přidán 14. 07. 2024
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I sent my dog's DNA to three different DNA testing companies and the results all came back differently! Let's talk about why: reference panels!
Another giant thank you to my Patreon supporters, including my amazing ribosomes:
Alexey Guzey
Dominick Mendoza
Marcel Ward
Russ Determan
Ben Krasnow
Thorsten Auth
Joshua Davis
Brad
Mathieu Moog
Diane & George Dainis
Don Burlone
Tim McNally
William Pilkington
TIMESTAMPS
00:00 Introduction/Sponsor
01:26 Meet Penny!
02:37 Dog DNA Basics
04:20 DNA Test Science
06:54 Penny's Results!
08:12 Reference Panels
09:10 Human Ancestry
10:21 Thank you!
Twitter: @AlexDainis
Instagram: Alex.Dainis
TikTok: @alexdainis
Patreon: / alexdainis
Sources
www.genomia.cz/en/test/length...
www.nature.com/articles/s4146...
embarkvet.com/resources/dog-h...
darwinsark.org/faqs/#section-...
-irp.nih.gov/blog/post/2019/08...
bigd.big.ac.cn/dogsdv2/
www.americanscientist.org/art....
www.sciencenewsforstudents.or...
www.upi.com/Science_News/2021...
This video was sponsored by DataCamp. - Věda a technologie
DataCamp: Invest in yourself! Use my link and check out the first chapter of any course for FREE! bit.ly/39hw8tp
Have you gotten an update yet!! My dogs wisdom panel just got updated they just got a whole bunch more reference samples
Thanks dear
Thank you so much for making this video! 😊 This was the BEST explanation of these tests I’ve found yet. I mulled over getting one of these tests done for my new rescue dog but interestingly I am starting to come to the conclusion that I can, with 99.9% certainty and no assistance, declare that she is, in fact, a dog. 🐶
American Staffordshire terrier and American Pitbull is often considered the same exact breed. So I would say those tests where rather consistent with one another.
I had no idea, but a few people have mentioned that now! So yeah, they’re even closer!
@@AlexDainisPhD I mean... what is a dog breed anyways? Also... with genetic engineering being a thing... how long until we see the most "husky of huskies"?
2 different breeds and are not considered the same. I believe the later of the breeds was just added to one of the register lists. In depth owners will call you out on this to and some get pretty defensive.
These two are separate breeds as I understand, but both are considered pit bulls.
Pitbull is the slang for fighting dogs....American Staffordshire Terriers were not bred for fighting.
"They pretty much all have brains"... [citation needed]
Hahaha fair point
Usually they have brains. I’ve met a few dogs that made me wonder a bit.
Is this where all my Patreon money is going? Is it? Seriously?
Because it's awesome and I want more!
Hahahaha I’m so glad you approve!!! Thank you!!!
Oh man, I can't imagine all those draining hours of painstakingly having to compile so many cute dog pictures. Science communication can be such a cruel and demanding task sometimes. You really took a bullet there for us!
Thank you for recognizing this truly difficult feat. Sometimes it felt as if I could not take just one more doggo and then there it was... another good pupper. Another snoot to boop. More toe beans. It was all just... too much.
@@AlexDainisPhD Truly you are the hero we need but don't deserve.
😂😂
Great video. I was looking for a comparison of the different canine DNA testing. This is the best for explaining how the tests are done and then the comparison of the 3 tests. Thanks, I am now a subscriber. 👍❤🐶
I’m so happy it was helpful!
2:48 - Y'know how they have the t-shirts with chemical structures for molecules like caffeine? I think you should try to find the part of the DNA sequence for a couple of these traits and make shirts with that sequence and the caption, "toe bean gene" or "boopable snoot gene". That would be some great merch!
Oh my gosh!!! This is an amazing idea and I can’t believe these companies aren’t already doing that for their merch!
@@AlexDainisPhD Please tell me that means you'll do it! I mean, I'm sure there isn't literally a single gene responsible for each of those particular traits, but maybe you could find something vaguely close enough to work for a cute shirt. (Or I guess you could just make up something plausible.)
I can imagine a shirt with three or four panels/sections (four or nine would work if it was a grid layout), with a traditional double helix drawing in each (to make it more visually attractive than just a bunch of letters), with the ATCG labels along each. Then each diagram could have one of those labels ("boopable snoot gene") -- either right below that diagram, or with an arrow pointing to one nucleotide (or section). Heck, maybe the nucleotide(s) being pointed out could be little paw prints.
Other good ones could be "puppy dog eyes gene", "floopy ears gene", "squirrel chasing gene", "tail wagging gene", or "fuzzy noggin gene" -- or some cuter way of saying each.
But I think the last one should be something like "best friend gene".
I've been thinking about doing DNA testing on my newly adopted dog, Baxter, and I stumbled across your video doing research. Thank you for posting this was very informative and it reminded me how fascinating DNA is.
This articulates what I thought about these tests. Mine was a gift and I enjoyed the process but the whole idea just started my brain in curious mode
Always good to see a video from you. Thank you for posting.
Thanks for watching! There should be many more coming soon (for real this time!)
Great job on your explanation of everything! Thank you
From making Song parody videos to being a researcher, Alex has changed a lot! Keep it up.
Very helpful video-for learning about dog testing AND genetic testing in general!
I just used Embark because they were the only one that had Carolina Dog in their breed panel. I can't wait to get the results!
Oh cool!! Yeah it was really fun getting them back!
I used wisdom panel it's the most accurate DNA test, I got my results in 2.5weeks I have her family tree and relatives closest relative is a brother from a previous litter!!
This is an amazingly well done video, thank you
This is fantastic! A great explanation (and so many dogs :) )
Thank you!!! I am always happy for an excuse to add good good dogs to a video :)
Thank you for this video!
I thought you were going to send your dog's DNA to a human DNA tester to see if they would reject it as not human. That might be an interesting question as well. I'm sure they get a tiny fraction of those.
So some people have done that, and they act like it's a big "gotcha" when the company sends back results saying "You're canadian!" when they're actually a chihuahua. But many of these companies just use a chip that's looking for tiny pieces of DNA to bind, and there is a lot of DNA overlap between humans and dogs (we're mammals with similar organs etc etc). So yeah, some of the dog DNA could bind to the chip and give some calls. It won't mean anything (because reference panel selection is important!) but it's like getting back puzzle pieces with the right shapes, but from the wrong puzzle. You could fit them into the missing spots on your "human" puzzle and they wouldn't make the right picture but you could still squish them in and return a result.
@@AlexDainisPhD I would say that's a pretty big gotcha.
There seriously wasn't enough skepticism back in the day when ancestry and 23andme were sponsoring everything in youtube.
@@iseriver3982 it's a big gotcha to those who don't know how those things work... to a geneticist, it's more like a big "duh".
@@AlexDainisPhD Why do I find the Canadian part so funny
@@AlexDainisPhD great explanation. It makes sense that the reference panel is the key of any result. And the puzzle example is brilliant. Thank you very much.
First time seeing your channel. Love it, great job, and tag line “Go forth and do science” is awesome! Thanks for posting.
Aw yay!!! So glad you liked it :) Welcome!!
Thank you so much, this is by far the clearest and best explained video about Canine DNA Tests. Thank you so much!
I love the shot of you and Wolfe at the end.
Cute puppy - i just ordered a dna kit to test a new adoptee I got. This was really informative.
Glad you're back Alex! hope you are doing well
I am! And thank you!! This is hopefully the first of much more consistent uploads coming soon...
Wow I had no idea I was getting a lesson on animal genetics today! Thank you very much, you explained it well
Very useful information!
You are back Alex ❤️🥰
I am back!!
@@AlexDainisPhD i am watching your vedios for a year now , im 11 years old. But i want to be a genetic scientist like you when i grow up , and i am starting a youtube channel because i inspire you soo much , thank you soo much for sharing alex .
This makes me so so happy! I’m so excited to see the science that you do!
Really? You'd love your dog the same if it was half loch ness monster? I feel like any animal would be made much cooler by being half loch ness monster, I'd be so excited if my pet turned out to be an elusive cryptid.
Hahaha, okay this is a very good point! I would still love her so much, but probably differently. And we'd really need to move somewhere that has a pool...
With Embark it’s more than just breed identification they have over 140 known genetic diseases. Many of which if you know you can adjust and have your dog live a longer healthier life. Also just cool knowing the history of your dog if it’s a mix breed.
This is one of the best random suggested videos ever..but why does the dog look completely over the entire conversation ?🤣🤣🤣
Hahaha she was such a reluctant costar.
Get vid Alex, love your work 👍
I get my dog's results back from Embark in two weeks! I am very excited to see what he may be a mix of. He is very interesting looking.
It’s worth going back and checking later on after more data is added.
My dog’s DNA results changed pretty fairly drastically on the wisdom panel. Going from 6 or so breeds up to 10.
Awesome photos and videos of dogs! =)
Thank you!! They were all due to the lovely lovely people of twitter who responded to my call fo dog pictures with so much enthusiasm. I've truly never had a better time opening my notifications list than when it's full of pups!
I came from your hamburger video :) and I am in love with your content!!!
I love this! It would be very interesting to send a "purebred" off to see how it compares to the reference population.
Yeah! That would be super interesting to compare.
Subscribed!!
I started to realize this when I tested my puppies. Both my girls are litter mates. Interesting thing was, one of my girls came back with one extra last percentage being golden retriever. While the other stayed at 5 with the last being lab.
I also found there brother’s results as-well through relatives. And he was generally the same EXCEPT he had the last small percentage of super mutt. Estimated being Akita inu and cocker spaniel. Which I didn’t see on neither of my girls results.
I tested with embark. It was interesting.
BEST EXPLANATION EVER on both dog dna and human dna
Love, love, LOVED this video! Although, any excuse to look as dogs while learning science is fantastic.
I'd love my dogs the same if they were part loch Ness monster, because I feel like maybe they can be worked with. Now Cthulhu, I'm not sure. Does not seem eminently trainable... :). In all seriousness I am so chuffed that I found this video. My husband and I were early adopters of 23andMe, so I'm very happy to hear a scientist's explanation of these tests/services! ♥️
Thank You!!! So much this is exactly what I was looking for.
So basically the most popular dog DNA test should be the most accurate in theory. Right?
Google apparently says american pitbull and american staffordshire terrier are basically the same.
Oh interesting!! You can probably tell from my hesitancy in pronouncing it that I was not familiar with it before now, haha.
Yup! They are basically the same, though a lot of people will argue about it with you.
I think I'm gonna have to watch the video again... I got distracted by all the cute doggos!
I absolutely got distracted while editing!
I would trust Embark over all the others. They have the most reference dogs.
Fantastic,make videos like this.
Great video! It’s nice to hear from a dog owner who has deep knowledge of genetic testing. I get why they ask your breed but we submitted to Embark without giving them anything more than “mixed breed” and our dog’s age. In reality our dog is a “designer breed” with two AKC registered purebred parents. I kind of expect Embark to mess it up for the reasons you mentioned.
hello! im curious. did you get the results? 😊😊would love to know!
This is an amazing video! I might try the test myself and find out if I'm part Loch Ness Monster. ))))
Madame, you are a highly intellectual young lady
Nice video very educational. I just sent my dog’s dna sample. Just a little worried cause i could not take the sample for more than 5 secs each time. Lol. Hopefully i got enough cells.
As soon as you said you were told that she was part corgi, I went 'nope'. Now don't get me wrong, I don't know a lot about dog breeds, but there is one thing I know for sure about corgis. Corgis have two copies of either a dominant or co-dominant (can't remember which) dwarfism gene, which is why their legs are stubby. So all corgi crosses look like a corgi that's cosplaying as another breed, because even when they inherit just a single copy of this dwarfism gene it will still be expressed.
It also would be very interesting to see a video about your or just a random person DNA results. I did mine and it was very interesting. I have 2% of gypsy!!😁
I have one from like five years ago but I should do an update!
This was a great video. Our dog’s DNA came back as 100% beagle from Wisdom Panel. However he certainly appears to be a mix. Should I question their 100% certainty?
I'll be curious to see what your thoughts are on the genetic testing companies that are more focused on health and disease.
@1:38 - No idea why, but your image in the mirror made me laugh out loud.
"You and me are 99.9% identical" You don't know me! I am actually a meat popsicle.
Multipass!
What fascinates me is the tremendous variation between dogs that is seemingly unmatched by any other pet bred in similar circumstances.
I did look in to it once but found a few explanations ranging from: It being predominantly down to the length of time weve been breeding them. To: There being more fundamental genetic reasons for the changes (At least one paper calling it a 'slippery' genome).
Ive learnt from similar questions that the answer has a tendency to be somewhere in between, or perhaps the former led to the latter, its still quite opaque to me.
They do have an absolutely remarkable amount of variation. Looking at a dachshund and a german shepherd and remembering that they're the same species is kind of mind blowing!
@@AlexDainisPhD Is it possible that Phenotypic Plasticity is a trait that can be selected for? Possibly a by-product of selecting for other traits?
I’ve always found this fascinating too. So cool!!
A question I've never gotten answered: Everbody always says DNA are the instructions to build cells/body, but what mechanism carries out those instructions ? Instructions by themselves don't do anything. what mechanism takes raw materials and puts them together to build a cell and eventually a body ?
GOD! LOL!
7:45 "Mexican street dog" 💀
I wonder how that gene pattern formed and how it's different to just any regular mutt?
I'll be looking if you did a video comparing different dna companies for humans.
This was super informative! Thank you!
Is it beneficial to call one of the companies to see if they have reference samples for the Catahoula Leopard Dog breed? My dog is mixed & supposedly his mother was Catahoula.
I used Wisdom Panel, because I suspected my dog was part Catahoula Leopard, one of her eyes is multicolored, half blue. Found out she’s 75%Am Staff, 12.5% Boxer, and 12.5% Australian Cattle Dog. Now I completely understand her habits, mannerisms, and behaviors and can see each breed’s influence. Pretty cool, I knew her mama was a Red Nosed Pittie, but wasn’t sure about Daddy, he looked like a Pit mixed with maybe Weimereiner. I’ve had other dogs tested, where they came back with 15 or more breeds, which isn’t very helpful and likely not very accurate. I’m not sure if Catahoula is one of the breeds they test for, but I would think it was. Now I’m curious.
@@twatts1523- one of the forums I read said “the results could be skewed because the sample population of catahoula in the wisdom panel genetic bank is probably very small compared to other breeds.”
wait 3-5 years and once they've got far more references, you'll get more accurate results
Pretty consistent! Mainly Chihuahua, Cocker Spaniel, & Pitbull (which I felt in my bones she was! She has the squared/strong cheek and jaw arch of them, that's how I knew mine was part Pit before her DNA test confirmed it!). Looks like 1/3-ish Chihuahua, 1/4 Cocker Spaniel, & 1/8 Pit (which is often a mix of Staffy or AmPit).
Truly! I see her face so much in other chihuahuas and pit bulls now.
What was the other test u used besides embark n wisdom? Do they do genetic health n color traits as well?
Have you tried the apps on your phone that tries to identify your dog's breed just from a single photo? And see if they match with the DNA results you got?
Oh, I didn't know those were a thing! I'll have to try!
@@AlexDainisPhD My dog is a purebred miniature pinscher, which is not very common and the app was able to identify her as 100% min pin. I also tried it on my mum's dog who is a mixed breed and it seemed to pick the right mix.
Interesting but I’ve seen results from these companies that say a dog is 100% purebred when it very obviously isn’t .
At the beginning of the discussion about Penny, I saw her running down the hall, and I immediately thought of my sweet Heidi, who I lost on 1/19/2021. And then I thought, why do I see Heidi in Penny. Heidi's little front legs were no longer than 2 inches long. She had long reddish hair along with a floofy tail. But that sweet little face on Penny just shouted out dachshund. I thought I was crazy. But then I saw that one of the tests said she had dachshund. Also, judging by the way she behaved on the video, she seemed so much like my baby. Then when you said she liked chicken, I thought that's it , they are distant relatives.
BTW, that's her little pic on my comment.
Has any of those companies tested siblings and came back with the same result, even on different litter?
Thank you so much for breaking this down. ❤️
I was so upset with the results we got for some of our dogs.
One was that our dog results came back as 100% American Bully and they gave us a list of relatives. However at least one of those relatives had 0% American Bully. So how can they be related?
It's important to note that they only look at the DNA for a limited sample (those submitted).
I did 23 and Me three years ago and it gets updated from time to time. I want to test my two dogs.
Is there a way to find out which companies have the biggest pool?
Penny is absolutely adorable.
Thank you! We think so too :)
So no corgi after all... interesting. Penny looks just like my little Ranger that passed in July. I wish I had done a kit on him.
Would have been nice to compare the results of inherited condition markers...I just sent my mixed breed puppy's in to make sure she's not particularly prone to DCM, since I head she has some dobie in her. We'll see what Embark says.
What three companies did you use? I only heard of one but didn’t notice the other two. I’m curious if the others because I have a dog that isn’t quite est terrier (her coat is too soft to be a real rat terrier) but she is definitely rat in appearance and temperament, but she’s so old that when she passes I would like to find one like her to keep me company . Thanks for the help
Did that one say there was a bit of Great Pyrenees? ... Interesting
The interesting thing is that whether you become a dog owner or not might also be determined by genes. At least that's what recent study says. See "Evidence of large genetic influences on dog ownership in the Swedish Twin Registry has implications for understanding domestication and health associations".
Ohhhhhh this is fascinating I will absolutely look into this.
That would be intersting research to explore.
Question: Were these DNA tests double blind? I ask because many of these companies give the option to include photos, videos, and descriptions of the dog. As a fellow scientist, i think that's super sus...
Given how these DNA companies (both human and dog) work, I doubt it. They literally just put the processed sample into a chip, feed the output from the chip into the current version of their statistical model, and send you the results. There's not really any room for fudging, since they will also give you the raw data from the chip at your request, which would allow anyone to refute any nonsensical data, destroying their reputation.
I wanted to find out what other breed is in my dog other than Pomeranian. Her hair is not double coated which most Poms are. I bought a kit called DNA my dog. I unwrapped the plastic and when I opened it I only found a box inside. Nothing else was in there. I have never done this before but I know there was at least supposed to be swabs. I contacted the company "Petsmart" and told them I found things were missing from the kit, so I have to take it back and get another one. I will this time get them to open the kit so we can make sure what was supposed to be in there. Kind of disappointing.
same here.....my little [30lbs] rescue has crazy DNA.....at least i know why she pushes my Rhodesian and pitt /malinois around.....she's a big dog in a little body.....big bravery.....they are cool with it & are good to her !..........she's pitt, rottie, GSD, ACD, & other breeds in trace amts....
Penny is not a mutt. In the canine worshiper's lexicon she is a GBD (Generic Brown Dog).
I agree with you in spirit but I refuse to call anything about this lovable little weirdo generic!
Embark really said Mexican Street dog OMGGG
I’m just in a. Few minutes and I totally see the Corgie. She’s so cute!
Just curious, Are you sponsored by any of the companies?
Nope! I didn't even tell any of them I was making this video, just bought tests like a normal consumer.
@@AlexDainisPhD Thank you for the neutral review. I am always curios about my DNA of my adopted dog.
So it appears these Pet/HUMAN DNA companies are not too accurate. I also tested with 3 companies and they all gave me genes from totally different countries.
Your paternal great grandparents were pretty much 100% Lithuanian so that 25% is pretty much spot on! (Don't be weirded out, I'm your second cousin..) Cute dog! We have what we believe to be a Jack Russell Chihuahua (rescue dog) and she looks very much like your Penny just a little smaller and black instead of brown. We should probably have her tested to find out for sure, but her aggressive and very hyper behavior tell me we probably have it nailed.
Haha, which second cousin?! None of you were born in 1993... ;) I'm gonna guess based on our Lithuanian connection, you're one of Richard's kids??
@@AlexDainisPhD that is exactly correct. Your Grandmother (my Aunt Jean) is actually my Godmother. I live the next town over from your parents in N. Attleboro.
Any chance you can do the same for a cat (if you have any friends with cats)? 🤔
This reminds me of those memes where the "black box of Artificial Intelligence" is being opened, and out comes nothing but statistics ;-)
I’m not gonna lie, I was kinda hoping you’d send it to the ones that test _human_ DNA. See what they come back with.
I mentioned this in another comment, but some people have done that and it's kinda unfair. From my other comment: "many of these companies just use a chip that's looking for tiny pieces of DNA to bind, and there is a lot of DNA overlap between humans and dogs (we're mammals with similar organs etc etc). So yeah, some of the dog DNA could bind to the chip and give some calls. It won't mean anything (because reference panel selection is important!) but it's like getting back puzzle pieces with the right shapes, but from the wrong puzzle. You could fit them into the missing spots on your "human" puzzle and they wouldn't make the right picture but you could still squish them in and return a result."
They should *probably* throw out the sample for being low quality, but if you get enough calls... I can see why sometimes they might return results.
I clicked here because I just got the results back from Embark and I am pretty sure they are not correct. My dog looks (and behaves) like a certain giant breed (ancient) and does not look (or behave) like the DNA results I got at all. I am now curious about trying two other companies just to see.
EDIT: I think you explained why the results are so off.
half Loch Ness Monster😂😂😂😂
American Staffordshire terrier is a pit bull, but bread for show. It wasn't bred for fighting instincts.
Looks to me like the folks at the shelter were most accurate.
2AM in korea... worth it
finally back!!!!
Now all this info made me wonder what type of dog I'd come out as if I took the test instead of my dog... 🤔🤭
Especially because my husband thinks I'm a Tazmanian Devil...
After seeing Penny, I'm going to guess before I watch the rest of the video. I would guess Chihuahua and Beagle. Maybe a little Jack Russell. (edit: I wouldn't have guessed THAT!)
These were *my* guesses before getting the results too!!! I really expected some beagle....
@@AlexDainisPhD Certain breeds seem to mask the traits of others in mixed parentage dogs. Chihuahua is usually dominant in a cross, and we've all seen dogs where you know one parent was a Black Lab, but who knows what the other one was.
I'm surprised she has no beagle, too, but I can see the pitbull/Am staff in her.
Interesting,,,,
Soooooooo cute! The dog's cute, too!
Huh, for some reason I've always wondered if you might be part Asian.
Do you still have access to lab equipment for genetics work? That'd be cool to see!
I do have some access to lab equipment! Might be a few videos investigating the DNA in your food coming soon... ;)
I don't see the Great Pyreneese :-). I would have said jack russell x cavalier or beagle but chihuahua x cocker seems quite accurate.
I just got my dog dna from Wisdom panel and it was so Off. the results were poodle and Chihuahua. Which she is not either. Her mother is Maltese and some other mix. She is large like long with long hair and looks like a border collie.
Puppppiiieeeesssss!!!! Puppies and genetics :):):):):)
I had so much fun editing this because puppies!!!!
@@AlexDainisPhD that’s because puppies are best :):)
And kitties too :):):)