Amino Acid Stereochemistry R and S vs D and L Configuration
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- čas přidán 8. 03. 2016
- leah4sci.com/aminoacids presents: Amino Acid Stereochemistry finding R and S or D and L on Fischer Projections and linear molecules.
📺Watch Next: Amino Acid Stereochemistry R&S vs D&L • Amino Acid Stereochemi...
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This is video 4 in the MCAT amino acids tutorial video series. How to determine if amino acids are R/S or D/L from linear and Fischer forms and how to quickly convert between them.
Referenced in this video:
Chirality tutorial series: leah4sci.com/chirality
Catch this entire video series along with my amino acid cheat sheet, tutorials and practice quiz on my website:
leah4sci.com/aminoacids
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This video should be obligatory viewing in any organic chemistry/biochemistry class that teaches L vs D orientation. Amazing
Haha glad it helped
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Four years later and this video is still helping students! Thank you for helping me with Fischer projections of amino acids, something I was really struggling with!
You're very welcome, glad it helped!
I like the detail you went into they usually don’t teach this into depth, they just scratch the surface and move on. Thanks for the vid it helps even 5 years later 👍
Glad it was helpful!
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Compliment*
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6:32-7:43
Literally, in less than a minute and a half you taught me such an easy way to tell apart an L and D Fischer projection. I thought it would take forever for me to learn how to tell them apart! Thanks again!
Oh wow! So glad I helped you understand it so quickly!
This is perfect, thank you! This is the only resource I've found that explains how to determine L and D
Happy to help!
Of all science teaching videos I've ever seen, you make the best. Infinite thanks to you!
You're very welcome!
Paused my biochem reading for lecture to learn a bit more about L & D since I never saw this in O-chem. Appreciate the thorough lesson!
So glad I could help!
My prof never went into this either, glad the video helped
I love you so much. You are so unbelievably helpful. Not only do you explain things super well, and make everything really clear, but you also maintain an animated voice which makes all the difference. The inflections and "enthusiasm" in your speech (whether feigned or genuine) really helps to pay attention and pick up the information. You are a godsend.
Thank you very much! My goal is to always make it as fun as possible :)
Thank you so much! I was panicking over having to learn this, but you made it really easy :)
You're welcome, hopefully no more panicking!
This was AMAZING!!! I finally get it! Thank you!!! I always thought this was difficult to understand but you made it SUPER simple! Thank you!
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This was so good! It really helped explaining what my professors or book could't, right before my exam. I quite enjoy the amount of examples.
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Thank you very much. Glad you enjoyed it
Leah I love you 💕 got an A on my orgo 1 and B on orgo 2 with the help of your videos and advice. You should be on the top recommended for the MCAT exam study sources.
oh wow! good to know that! Congratulations! Thank you for the nice feedback. Always glad to help :).
Oh wow congrats on acing orgo! Hope you aced your MCAT as well
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I am from india and i really loved and actually just grasped everything u said in minutes rather then spending hours with books and then the books made sense thanks ma'am it was really very helpful
Glad to help! :)
Awesome video, excellent and simple explanation, just what I needed. Thanks a lot. :)
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Aww, thanks for that! I'm glad my resources help you to understand!
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awesome!!!! i just lost my stress on covering this part of aminoacids. thankuuu soo muchhh!!!
Yay! I'm so happy to hear that, and you are very welcome!
so glad this video helped reduce your stress
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You're very welcome and thank you for your kind words. A lot of work goes into this, but I love doing it!
wow the configuration part! thanks for sharing! i totally get it now!
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Thank you so much for making this video! You have helped me understand this topic more than 3 years of university could🥴
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literally never took organic chem and this video helped me understand the concept almost entirely omg i love u :((
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This is the greatest trick in organic chemistry THANK YOU
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i'm from Argentina and i couldn't find this exactly explication in spanish, i'm so glad to have found your video thank you very much
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Glad you were able to understand in english
Not only great but is actually the best thank you for the explanation 🙏🙏🙏
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This was so helpful, thank you so much for sharing your knowledge.
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I wish i found u years ago , thank you for this video, it really clarifies this confusing concept
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THANK YOU SO MUCH!!! I was so lost looking absolutely everywhere and you had the easiest to understand lesson about this. I'm still a little confused but better than I was, initially when my teacher was showing it, it all flew over my head and I was so overwhelmed. Thank you!! I sent your link to my classmates as well!!
You are very much welcome! Glad to have helped and thanks for sharing the video :)
You're very welcome! Hope watching it a second time helped it all click
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Very clear explanation..thank you!
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for the S-Aspartate question at 21:15 if we used the guess and check method, even if we place the +NH3 on the right side for D configuration it would still be an S, so no matter the L or D conformation it will both be S, so how can you use this method if you're trying to compare the S configuration of the line and wedge to both the L and D conformation if both are S?
I'm confused by your question. If we swapped the NH3 group with the Hydrogen and had the NH3 on the right side of the Fischer, we would have an R configuration to the stereocenter. Making a swap like this changes the configuration of the chiral center.
For help with questions like this and more, I recommend joining the MCAT Study Hall. For more details, visit join.mcatstudyhall.com/ or contact me through my website leah4sci.com/contact/
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Love this video! I love how you encourage understanding, not just memorization. I struggled with this topic a lot but you made it understandable! Thank you!
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Thank you! and absolutely YES to understanding before you attempt to memorize. If you memorize you forget, and then what?
If you understand you can reason your way through it because of what you truly GET
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Good video for quick exam prep but not very much for learning chemistry tbh. The principle and logic behind this chemistry are not explained (which is not required if you just want to pass exams especially for premeds). But I appreciated the effort. Thanks.
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this is so helpful, wish I had found the video earlier
Glad it was helpful!
You're very welcome! Better late than never, right?
I am stunned
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Can somebody explain why she does the second swap (during 10:32) ? I know she said to "maintain the chirality," but can somebody explain that please! Thank you:)
At this point in the video, we are trying to transform the Fischer projection of R-alanine into proper form where all carbons would be along the vertical backbone of the molecule. That means we need to swap our carboxyl group to the top-most position, so that it falls along the vertical.
When we make that swap, we also need to swap two other groups in order to maintain an R configuration at the chiral center. If we didn't make a second swap, we would then have the S configuration of alanine. Which is a different stereoisomer of our original molecule.
I came looking for non coded Amino Acids. But I don’t think this is about that. But u could help me. So the line is - amino acids having D-Configuration or which aren’t alpha amino acids are Non coded. What does this D configuration mean ?
To be non-coded simply means that the amino acid was not coded for by the DNA sequence. It must have been synthesized by some other process, outside of the body. All of the amino acids derived from natural (human-made) proteins are of the L configuration. D-amino acids are found in nature.
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Can you reiterate how exactly you know when to change the direction of our loop when connecting 1,2&3? Is It only when the hydrogen is coming out of the paper?
Go back to this series: leah4sci.com/chirality/
I cover this extensively here: leah4sci.com/chirality
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Thank you for your videos. You are a best teacher ever.I have followed your materials to improve my knowledge.
I have a question in Stereochemistry. There are some few videos in youtube that they mention III ry amine have a chiral center. There is a problem because when I do the ACS questions they not accepting it as a correct answer. please give me an answer If you have a free time to attend with this matter. Thank you
I'm sorry, but I don't offer tutoring through CZcams comments. For help with questions like this and more, I recommend joining the MCAT Study Hall. For more details visit join.mcatstudyhall.com/ or contact me through my website leah4sci.com/contact/
This is a tricky question, Tertiary amines are technically chiral due to their shape, but the 4th group is a lone pair which is constantly inverting and so you won't ever have just R or S. Quaternary amines on the other hand can have 4 unique subs for a proper chiral center
Thank you soo much
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Thanks, you are a life saver!
Now I have to move on and deal with E/Z, though. -.-
Glad I could help!
Is this what you are referring to?
leah4sci.com/cis-trans-and-e-z-geometric-isomers/
Ah, yeah, exactly! Thank you :D
You're very welcome! I cover that in detail as well
but we should draw perfect fischer by placing most oxidised carbon on top and maximum carbon vertically right ?
Yes, correct. For more detailed help on drawing Fischer projections, make sure to see my series at Leah4sci.com/Fischer
You are the best ... thank you so much
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Why did you skip the two hydrogens of the CH2-SH group? Wouldn't the Carboxyl group have higher priority due to the amount of bonds to oxygen?
Both Sulfur and Oxygen are directly bonded to a carbon on the chiral center. If Sulfur outranks Oxygen with its atomic number, the number of bonds to Oxygen are irrelevant. Sulfur is the winner and would be higher priority.
this was awesome.. thank you :)
+Yanique Cooke you're welcome
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Very very helpful!
thank you!
Thank you
Maam my question is, in last ex.of aspartate you have shown that hydrogen atom in front to the observer but as the (Fisher projection formula) but a/c to Fisher projection rule it should be at left side of horizontal bond as it is back side of the plane, how it is possible
I'm sorry, but I don't offer tutoring through CZcams comments. For help with this and more I recommend joining the MCAT study hall. Full details: join.mcatstudyhall.com
Leah4sciMCAT i wonder who would pay hundreds of dollars just for that question to be answered when they can simply go on a forum to ask for free
awesome video, thank you so much
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best voice EVER
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Thanks ❤
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I'm wondering how you know if the H group is forward or not in the simple diagram rather than with the wedges and dashes?
I believe you're asking how to tell the configuration when presented with a Fischer projection. For more on these drawings, visit Leah4sci.com/Fischer
Do you mean in Fischer? see Mr Organic Chemistry in this video or here: leah4sci.com/fischer