Megaloblastic Anaemia: Vit B12 & Folate Deficiency Anaemia, Pernicious Anaemia (HD)
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- čas přidán 8. 11. 2013
- Topics Include:
-What is Megaloblastic Anaemia
-What is a Megaloblast
-Difference Between Megaloblast & Normoblast
-Types
-Vit B12 and Folate Deficiency Anaemia
-Vit B12 & Folate Metabolism
-Role of Vit B12 & Folate in DNA Synthesis
-Vit B12 Absorption
-Role of R Binder, Intrinsic Factor, Transcobalamin I & II
-Causes of Megaloblastic Anaemia
-Clinical Features of Megaloblastic Anaemia
-Pernicious Anaemia
-Lab Diagnosis
-Special Tests
-Schilling Test & Diagnosing Pernicious Anaemia
-Blood Picture
-Bone Marrow Findings
-Why Megaloblast cause Anaemia ?
-Criterias of Hypersegmented Neutrophil
-Treatment
-Dosage of Deep Subcutaneous or IM Vit B12 injection
Hope it is helpful . - Dr. Rabiul
I'm a struggling nursing student. Thank you so much for breaking this down. You explained it very well and thank you for not talking too fast. It really allowed me to absorb what you were saying.
Thank you for your feedback. Take care and stay safe. Best wishes from Bangladesh. :)
I’ve dealt with all these issues for 20 years and couldn’t get better until I added be riboflavin. I finally started methylating! Thank you!
thank you so much :D this was really helpful!
this helped me for my exams ... thank you dr..
Thanks for the video doc, and especially for answering the question of why exactly megaloblasts cause anemia.
Shrivesh Singh Thank you for liking my video. Glad to know it was helpful. Best wishes from Bangladesh. Here is link of my newest video on DIC : Disseminated Intravascular Coagulation : You can check it out too ! czcams.com/video/LJYAzH1R3_4/video.html
Thankyou so much I have understood so well. We all appreciate your efforts may God bless you ❤️
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Thank you for posting this, it was very helpful
Fjuks Thank you for linking my video. Take care & stay blessed. Best wishes from Bangladesh.
thank u so much...very informative..
So helpful.Thank u so much 💯
Truely well explained, Thanks Doc))))))
Thank you so much for this awesome video.
Yashar Mashayekhi Thank you for liking my video. Glad to know it was helpful. Best wishes from Bangladesh. :)
Amazing lecture..thanks for uploading..This is very helpful to me...plz sir upload more about Leukemia too
Very helpful and informative.Can learn faster through these videos. Thank you very much for sharing these videos.God bless you.
Betty Thomas Thank you for liking my videos. Best wishes from Bangladesh.
God bless you in case you saw my comment it helped me a lot
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Amazing lecture sir.
I wish to write something about the word Folate, the etymology of this word.
Folliage means leaves, folate is a vitamin derived from leafy vegetables like Spinach, the word follicle is used to mean "a little bag", in olden days little bags would be made out of leaves.
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thanx...........it really helped me understand
Very clear and helpful thx doc❤️
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Very much Helpful vidio.. thanks.
+Nargish Perveen Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
I thought that this subject was so well presented explaining every step of each process never assuming previous knowledge. Exceptional teacher, I only wish I had lecturers of this calibre.
Theodora Feliciotto Thank you very much for your kind comments. Glad to know it was helpful and easy to understand. My newer videos are shot with better camera. Here is a link of a video I have just uploaded on "Pathologic Calcification" . Pathologic Calcification : Definition, Types, Pathogenesis & Morphology (HD)
You can check it out too ! Take care & stay blessed. Best wishes from Bangladesh.
Thank you so much for your lectures doc. They have been a big big source of help in my medical examination. God bless youuuu
Thank you for your feedback, take care and stay blessed.
Very good!!!
Really very nice sir,my vit b12 levels are 107.7 and i am under neurologist,i have this problem since 4 years.
Kept everything very simple, very well structured, remarkably explained. Very well done to you. Definitely going to be some use in my exams!
Hello, Thank you for liking my videos. Glad to know they were helpful. My newer videos are recorded with better camera ( Canon 700 D ) . You can check them out too ! Here is a link of one of my latest uploads !
Tetralogy of Fallot HD
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thank u so much sir...for providing these video....
Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
very nice and useful video..keep it up doc!!!
+vaibhav charan Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
Thanks a lot sir... I read this topic in book but can't understand but after watching your video my consepts are clear.... Thanks again 🙏🙏🙏
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Thank you it's quite helpful
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Tnq sir
It has covered all my confusions
😍😍😍
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Superb lec
Thanks doctor
A wonderful class.. thank you sir 👍😊
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Thank you so much sir....
Your videos are really helpful.. 😇
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very nice vdeo..very help full..plz explain leukemia too...
Thank-you so very much
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Thank you very much sir upload new video for us
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Liked ur lecture sir and its very simplified and easily understood.Can u plz upload lecture on MDS ( myelodysplastic syndrome). Thanx.
Just say it it just amazing I think u covered whole topic perfectly so nice
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thanks sir I'll do my best
Thanks sir
Thank you sir...I dont find your video on leukomia lymphoma
I am from Nepal and i've been watching ur videos and they have helped me in learning CVS pathology. Hope you will make videos on leukemias as well.
dude lebowski Thank you for liking my videos. As always, best wishes from Bangladesh. :)
Thank q so much sir.It really helps me a lot... plus m having presentation 2morow
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Thanks sir...... God bless uhh
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شكراً !
Thank You :)
god pless u is very good lecture
Pls continue making such mind blowing videos sir👌👌..if possible for all subjects 💕
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Hello Doctor Hague, my RBC low, hemoglobin low, Hematocrit low but my Vitamin B12 normal and iron normal. What kind of anemia I have?
:) Realy helpful ... (Y) Thank you for uploading this video..
Thanks for liking my videos . I have uploaded a new video yesterday . "Pernicious Anaemia" . That is my first video recorded with my new canon 700D camera ! Hope it is helpful . Take care & stay blessed ! More videos coming soon !
tnk u so much for video...it becomes useful for me😊
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Rabiul Haque 😊😊tnk u
Thank u so much Sir
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thank you so much for this great lecture but i have one comment and three questions:
first ;a comment you did not mentioned the iatrogenic causes of folic acid deficiency such as methotrexate and sulphamethoxyzole
second a question about the difference between folic acid and folate and why the size of RBC becomes bigger in megaloblastic anemia and what are the steps from the megaloblasts to macrcytes
greetings from Lebanon
Thank you
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Sir would you plz explain why there is multilobed neutrophil
gr8,can i have systemic pathology lecture pls..
THANK YOU SO MUCH SIR....SUCH A WONDERFUL TEACHING.....YOU ARE REALLY GOD GIFTED and i am fortunate to be one of your online student.. i always follow you and your lecture.
In service student ...Lovely Professional University Punjab India. Nationalities Bhutanese
+Tshewang Dorji Thank you for liking my video. Glad to know it was helpful. I had travelled to Bhutan many years ago - very peaceful and beautiful country ! Best wishes from Bangladesh :)
Thank you...hope you will visit Bhutan in future as well
Are the B12 shots more effective for recovery for chronic B12 deficiency from auto immune PA.
Awesome!!
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super explaining sir
Thank you for liking my videos. Take care and stay blessed. :)
What is considered low folate levels in ug/L?
شكرا جزيلا
Thank you for your feedback. Take care and stay blessed. Here is a link of my new immunology video on transplantation and graft rejection. czcams.com/video/o2vm2Sh1W84/video.html
thank u Dr but what causes neutrophils to be hypersegmented?
Thanks.....
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extremely helpful. thank you doc. love the popeye reference.
Alvin Prasad Thank you for liking my video. Glad to know you liked the popeye reference. Best wishes from Bangladesh. :)
thank you sir :) its very nice
+jasmine florence Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
Rabiul Haque thanks sir it is very nice
Please explain pathogenesis of magaloblastic anaemia also
May god bless you.
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thnx so mush sir
Thank you for liking my videos. Take care and stay blessed. :)
all ur videos r very very helpful... thanks :)
Thank you liking my videos. My newer videos are taken with a better camera ( Canon 700D ). You can check them out too! Take care and stay blessed. More videos coming soon! :)
great!! :) keep the good work up!!
Rabiul Haque nice education 😊😊😊
do u have biochem lectures
thanks
+mohamed haneen Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
thank you
but i`m not sure as it`s correctly to speak about analogy megaloblast - erythroblast (4) !
analogy is megaloblast - normoblast (5)
I am a medical student .
And your lectures really helps me a lot to understand the topic .
Thank you so much sir.
It is really helpful for me.
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nyc👍👍
can more than 1000 mcg b12 be toxic? ... good informative video ... thank you
I m not a medical student but sn engineer from Pakistan, I have vB12 deficiency, its very interesting to know about IF and slivery system
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very helpful..but imp topic like lab findings are not fully covered....
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sir if someone has malabsorbtion we will find more than 10 % of radioactive b12 in urine can u explain why it is good sign of absorbtion if we find more than 10 % not abad sign of malabsorbtion thnx very mush for ur video
Sir help me a person suffering from these diseases how many day for cure these disease..... Pls reply me as fast as possible
1000 daily for 1 week?? here in holland the doctors do 2 times for 5 weeks, when really necesarry. what would be better you think?? i thinks it s all about looking how the patient feels. and i feel 0.0 improvement after 8 injections now
We will be discussing the Folate trap and genetics which interrupt this whole cycle?
Yo man super helpful video love the no glasses bruh Lets hook up :D
+SexWax _ Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
Hello Sir, I was searching for congenital dyserythropoietic anemia diagnosis, and found your videos. My nephew is suffering from congenital dyserythropoietic anemia(CDA). He is 2 year old. Local Doctor say for blood transfusion every two week.
Would be very helpful if you highlight some suggestion or any help..
Thanks
Narayan Jalan Hello, congenital dyserythropoietic anaemia is a rare disorder where there is ineffective production of Red Blood Cells ( RBC) and less than normal quantity of hemoglobin in the blood. As suggested by your nephew's physician - such disease do need frequent blood transfusion in frequent interval ( e.g. 2 to 4 weeks interval ) because the patient does not produce sufficient RBC by himself to meet his body's demand. At the same time chelation therapy is also given to remove excess iron as a result of frequent blood transfusion. Sometimes Bone Marrow transplant is considered but it has it's risk to consider as well. That is as far as I know, since I am not a haematologist - I will recommend you to follow your physician's advice and follow their treatment guideline strictly and ask for their advice and opinion. Wish you all the best and apologies for late reply ( I live in Rajshahi 6 days as a non resident post graduate trainee of MD Pathology Course and net connection is not good here always, I stay in Dhaka (the capital) for one day and that is when I get high speed net for youtube uploads)
*****
Thanks a lot for your reply. Really appreciate your suggestions.
Hii sir. I want to know why hypersegmented neutrophils are formed
Thank you for your question. The short answer is "nuclear-to-cytoplasmic asynchrony". It means in megaloblastic anaemia the nuclear maturation is delayed while cytoplasmic maturation and haemoglobin accumulation proceed at a normal pace. This leads to hypersegmented neutrophils, even megakaryocytes may have bizarre multilobate nuclei due to same reason.
Take care and stay safe. If you like these lectures do subscribe and share them with your friends. Best wishes from Bangladesh. :)
MY MOTHER HAS MEGALOBLASTC ANEMIA DECADES MDS RA DEASESS WHAT IS THE MAJOR SOLUTION SIR
Thank you for your feedback. Treatment depends on underlying cause. If it is due to vitamin B12 or folate deficiency, life long vitamin B12 or folic acid supplement is required according to the cause. Please visit your physician for more information. If there is some underlying condition that is hampering vitamin B12 or folate absorption that may also require correction. Take care and stay blessed.
Sir reference book
Tnkuuu soo much.. sir reallyy helped me. A lot....
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Bone marrow picture?
sir i have doubt.... is megaloblastic anemia and macrocytic anaemia same means when asked to write in exam any one of them we can write same???
Thank you for your question. In macrocytic anaemia, red blood cells are abnormally large. MCV > 98fL. It can be divided into megaloblastic and non-megaloblastic. So macrocytic anaemia is a broader term. It can be either megaloblastic or non-megaloblastic based on appearance of eryhtroblasts. Take care and stay safe.
@@RabiulHaque thanks sir for answer 😇😇 ....your vedio very helpful for us during covid time thanx sir 😊
Why hypersegmented neutrophils are seen in megaloblastic anemia sir?
Issues with the DNA synthesis results in Uradine insertion rather than Thyamine, resulting in hypersegmentation of the nucleus. This is because Vit B12 is required as a co-enzyme to convert homocysteine to methionine necessary for the conversion of folate to thyamine. Without either of these, DNA synthesis does not properly occur.
thank u . v nice and helpful.but, i think Haptocorin (R binder) is secreted from parietal cells of stomach not from saliva.
Fixed acids are produce due to metabolism. They need to be kept in constant check to enable the body to keep a constant environment. These acids are regulated by bicarbonate via a reaction that produces carbon dioxide and water, they are regulated indirectly as once the fixed acids enter the blood stream they dissociate into their respective hydrogen ions, it's these hydrogen ions that combine with the bicarbonate to produce carbonic acid that will disassociate to form carbon dioxide and water thecarbon dioxide gets excreted via the lungs, this reaction uses up the bicarbonate and returns the levels to the normal levels. Iftheirs is an exces left the kidneys will excrete the hydrogen ions.
oh yes you speak next about it
+Eva Gold Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
+Rabiul Hague Thank you ! Best wishes from Ukraine :)
Eva Gold do you have such problem... of meghaloblastic
🖤🖤🖤
Thank you for your feedback. Wish you all the best.
Sir are u from Bangladesh
Yes. Thank you for your feed back. Take care and stay safe.
curtains
Plz explain in hindi
Roshni Patel 😂
MY MOTHER HAS MEGALOBLASTC ANEMIA WHAT IS THE MAJOR SOLUTION SIR
Thank you for your feedback. Treatment depends on underlying cause. If it is due to vitamin B12 or folate deficiency, life long vitamin B12 or folic acid supplement is required according to the cause. Please visit your physician for more information. If there is some underlying condition that is hampering vitamin B12 or folate absorption that may also require correction. Take care and stay blessed.
i have it
Thank you for your feed back. Please take your prescribed vitamins in proper dosage regularly and visit your physician regularly for follow ups. Take care. Best wishes from Bangladesh.
i get injections it is autoimuum with me vitamins don't help me i have it for 16 years it damage my nerves and brain
with me it is gentic.and can be caused by a unkwown disease the don't know what
You should use long board 😂
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Poppay the seller man........spelling coorect??????🤔🤔
We used to watch "Popeye The Sailor Man" cartoon on TV in our child hood. The close captions in my videos are auto generated by google and some time they spell incorrectly. Take care and stay blessed. :)
@@RabiulHaque i also used to watch that cartoon.....nd i didnt complain about auto generated spelling......i asked it bcoz i didnt knw the right spelling😅😅😅😅
Lol