Pernicious Anaemia : Definition, Pathophysiology, Clinical Features, Diagnosis, Treatment (HD)

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  • čas přidán 3. 07. 2024
  • Topics Include:
    - What is Pernicious Anaemia
    - Pathophysiology of Pernicious Anaemia
    - Genetic Factors
    - Auto Immune Factors
    - Antibodies Against Parietal Cells
    - Antibodies Against Intrinsic Factor
    - Blocking Antibody and Binding Antibody
    - Site of Gastric Atrophy
    - Clinical Features
    - Lab Diagnosis
    - Schilling Test
    - Blood Picture
    - Bone Marrow Findings
    - Treatment and Dosage of Deep Subcutaneous/ Intramuscular Vit B12 Injection
    Hope it is helpful . - Dr. Rabiul Haque

Komentáře • 97

  • @rishikagupta2110
    @rishikagupta2110 Před 3 lety +4

    u r the best teacher pls keep uploading videos ....in 2020 also ur lectures are helping me n many more medical students

    • @RabiulHaque
      @RabiulHaque  Před 3 lety +1

      Thank you for your feedback. Take care and stay safe.

  • @XRPVampire
    @XRPVampire Před 4 lety

    Bravo, well done!

  • @taooflovepassionandcomedy8722

    Thank you young man I shall have some very stern words with my doctor you have told me some thing no Doctor in Australia has ever mentioned.

    • @RabiulHaque
      @RabiulHaque  Před 5 lety

      Thank you for your feedback. Take care and stay blessed. :)

  • @esterherschkovich6499
    @esterherschkovich6499 Před 3 lety +1

    Oh gosh hate the getting old bit!I work as a Nurse+its hard going,need injections 2 monthly..fatigue!Thank you for your explanation.

    • @RabiulHaque
      @RabiulHaque  Před 3 lety

      Thank you madam for your feedback. Take care and stay safe. Best wishes from Bangladesh.

  • @elainec.s.1275
    @elainec.s.1275 Před 8 lety +3

    Thank you Doctor. Will listen to other video's. I have pernicious anemia and the B 12 def. I was in my early 30''s when it was found. When you mentioned the thyroid factor. It is in my family. I am trying to find out why I need to inject every 8 - 10 days. Again, than you so much.

  • @sumitasingh6225
    @sumitasingh6225 Před 8 lety +9

    Doing great job God bless you

    • @RabiulHaque
      @RabiulHaque  Před 8 lety

      +Sumita Singh Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)

  • @onlyoneboss
    @onlyoneboss Před 8 lety

    very helpfull vdeo..thnks sir..frm india

  • @sweetys3266
    @sweetys3266 Před 9 lety +3

    Thanks you Dr. Rabiul!

    • @RabiulHaque
      @RabiulHaque  Před 9 lety

      sweety sharma Thank you for liking my videos. Best wishes from Bangladesh.

  • @felixkamugisha4647
    @felixkamugisha4647 Před 7 lety

    Thanks Dr Rabiu for your nice teaching videos. God bless you abundantly! Fr. Dr. Felix

    • @RabiulHaque
      @RabiulHaque  Před 7 lety

      Thank you for liking my videos. Best wishes from Bangladesh. :)

  • @paraymuzafar1724
    @paraymuzafar1724 Před 3 lety

    very nyc
    May Allah Bless u

  • @esterherschkovich6499
    @esterherschkovich6499 Před 3 lety +1

    Why put thumbs down?,When it's an informative video!

  • @shahriar6180
    @shahriar6180 Před 8 lety +1

    this is just awesome!! thank you so much..

    • @RabiulHaque
      @RabiulHaque  Před 8 lety

      +shahriar Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)

  • @lindadahlen7407
    @lindadahlen7407 Před 4 lety +1

    Your explanation is very thorough. Thank you very much. It will help with my treatment plan of PA diagnosis and other autoimmune issue going on. I have senile osteoporosis also at age 59. Now I know the relation of osteoporosis, high calcium in my blood and hyperparathyroidism. I will talk with my doctor about this correlation. Thank you again!

    • @RabiulHaque
      @RabiulHaque  Před 4 lety

      Thank you for your feedback. Take care and stay blessed. :)

  • @dr.mjwesley6691
    @dr.mjwesley6691 Před 7 lety +1

    Awesome job. I'm preparing for board wanted to go through haematology real quick. Your videos helped me a lot. Every point is very crisp and clear. Please keep uploading more. Thank you so much for making it, Thank you for making it free as well. God bless you!

    • @RabiulHaque
      @RabiulHaque  Před 7 lety

      Thank you for liking my videos, best wishes from Bangladesh. :)

  • @durgachalise5661
    @durgachalise5661 Před 4 lety

    Thank you sir....

  • @beenaasokan8569
    @beenaasokan8569 Před 7 lety

    thank you. it helped me a lot in immunology paper.

    • @RabiulHaque
      @RabiulHaque  Před 7 lety

      Thank you for liking my videos. Best wishes from Bangladesh. :)

  • @mwazanjibanda2315
    @mwazanjibanda2315 Před rokem

    your lessons are super helpful, I understand everything clearly when you tech...thank you very much

    • @RabiulHaque
      @RabiulHaque  Před rokem

      Thank you for your feedback, take care and stay blessed.

  • @laila5597
    @laila5597 Před 6 lety +1

    جزاك الله خيرا

    • @RabiulHaque
      @RabiulHaque  Před 6 lety

      Thank you for watching my videos and for your feedback. Take care & stay blessed. :)

  • @karmadoma9687
    @karmadoma9687 Před 5 lety +1

    This was very helpful 😊

    • @RabiulHaque
      @RabiulHaque  Před 5 lety

      Thank you for your feedback. Take care and stay blessed. :)

  • @dr.praveenkumar9392
    @dr.praveenkumar9392 Před 4 lety

    Thanks sir

  • @paraymuzafar1724
    @paraymuzafar1724 Před 3 lety

    nycc very Good❤️❤️

  • @nuzhatnowshin6957
    @nuzhatnowshin6957 Před 8 lety +1

    thank you sir ...it was really helpful :)

    • @RabiulHaque
      @RabiulHaque  Před 8 lety

      +Nuzhat Nowshin Thank you for liking my video. Glad to know it was helpful. Best wishes from Bangladesh. :)

  • @smitasimi1190
    @smitasimi1190 Před 9 lety +1

    Thank u Dr Rabiul

    • @RabiulHaque
      @RabiulHaque  Před 9 lety

      smita simi Thank you for liking my video. Best wishes from Bangladesh. :)

  • @10dubious
    @10dubious Před 8 lety +2

    Thank you so much for making these videos! I am currently taking a course on the pathologic basis of disease and your videos have helped so much. You are a great teacher and I sincerely appreciate your generosity in sharing these videos with all of us.

    • @RabiulHaque
      @RabiulHaque  Před 8 lety

      +Dubious Observer Thank you for liking my video. Glad to know it was helpful. Best wishes from Bangladesh. :)

  • @laila5597
    @laila5597 Před 6 lety +1

    your lectures are really helpful - greetings from UAE

    • @RabiulHaque
      @RabiulHaque  Před 6 lety

      Thank you for watching my videos and for your feedback. Take care & stay blessed. :)

  • @phurbutsering1128
    @phurbutsering1128 Před 9 lety +2

    Thank you for the great video. Helped me understand pernicious anemia for my exams

    • @RabiulHaque
      @RabiulHaque  Před 9 lety

      Phurbu Tsering Thank you for liking my video. Glad to know it was helpful. Best wishes from Bangladesh. :)

  • @drswetaruparel
    @drswetaruparel Před 5 lety

    Thanks a lot!!!

    • @RabiulHaque
      @RabiulHaque  Před 5 lety +1

      Thank you for your feedback. Take care and stay blessed. :)

  • @PoojaPatil-qz3tv
    @PoojaPatil-qz3tv Před 3 lety +1

    Thank you so much sir.... Your videos are really very helpful.. 😇

    • @RabiulHaque
      @RabiulHaque  Před 3 lety +1

      Thank you for your feedback. Take care and stay safe. Best wishes from Bangladesh. :)

  • @PrinceKumarsHere
    @PrinceKumarsHere Před 3 lety

    Thanksss a lot sirr.. from AGMC student

  • @docnature9289
    @docnature9289 Před 7 lety

    i would like to suggest u sir to go through all points mentioned in harsh mohan book of pathology... it will b very helpful for us then.. thanks for teaching us sir !

  • @SJonny-zo3qe
    @SJonny-zo3qe Před 8 lety +1

    thanks sir

    • @RabiulHaque
      @RabiulHaque  Před 8 lety

      +SK Iftakharul Alam Thank you for liking my video. Glad to know it was helpful. Best wishes from Bangladesh. :)

  • @saahilkhan1150
    @saahilkhan1150 Před 6 lety +1

    Sir u r great ,long live sir love from india ,plz upload more and more videos

    • @RabiulHaque
      @RabiulHaque  Před 6 lety

      Thank you for your feedback. Take care and stay blessed. :)

  • @srirambhardwaj2343
    @srirambhardwaj2343 Před 4 lety

    Thank.you.very.much.sir.

    • @RabiulHaque
      @RabiulHaque  Před 4 lety

      Thank you for your feedback. Take care and stay blessed. :)

  • @coolameloblast
    @coolameloblast Před 3 lety +1

    Thanks

    • @RabiulHaque
      @RabiulHaque  Před 3 lety +1

      Thank you for your feedback. Take care and stay safe.

  • @surenderjanagal7
    @surenderjanagal7 Před 3 lety

    Osm sir 👌👌

    • @RabiulHaque
      @RabiulHaque  Před 3 lety

      Thank you for your feedback. Take care and stay safe. Best wishes from Bangladesh. :)

  • @srirambhardwaj2343
    @srirambhardwaj2343 Před 4 lety

    Thanks.a.lots.

    • @RabiulHaque
      @RabiulHaque  Před 4 lety

      Thank you for your feedback. Take care and stay blessed. :)

  • @ninjanicnic
    @ninjanicnic Před 6 lety +3

    Pretty good but not all PA will present mesoblastic and glossitis or nerve damage /neuropathy.
    Also as in all autoimmune patients may not have antibodies at time of test but may develop later or not but still have PA .
    Gene mutation may be cause .
    Loading doses should be until no further symptoms.
    The monthly or 3 monthly is not enough for reversal of symptoms or healing nerve and tissue damage.
    The maintenance dose is just enough to keep the person alive but with no energy and still in chronic pain .
    Shillings test no longer done .
    Look at active B12 tests for all low B12 (non diet related)
    MMA homocysteine and to a degree MCV (but this may rise and fall with other factors and not always be high Evan with a diagnosed PA)
    Better than some information but still flawed .

  • @niamaali9534
    @niamaali9534 Před rokem

    Really helpful video... thank you sir🤎🤎🤎

    • @RabiulHaque
      @RabiulHaque  Před rokem

      Thank you for your feedback, take care and stay blessed.

  • @hmmmmankind2399
    @hmmmmankind2399 Před 7 lety

    thankyou sir

    • @RabiulHaque
      @RabiulHaque  Před 7 lety

      Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)

  • @paraymuzafar1724
    @paraymuzafar1724 Před 3 lety

    thnkuuuuy

  • @mahnazashrafi2530
    @mahnazashrafi2530 Před 9 lety +1

    thank you from italy

    • @RabiulHaque
      @RabiulHaque  Před 9 lety

      Mahnaz Ashrafi Thank you for liking my videos. As always, best wishes from Bangladesh. :)

  • @drnavneet6594
    @drnavneet6594 Před 7 lety +1

    nice class sir from india

    • @RabiulHaque
      @RabiulHaque  Před 7 lety +1

      Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)

  • @aliciamilam5636
    @aliciamilam5636 Před 2 lety

    Wonderful man u are . Can u cover herbs for these anemia.. rosemary helps with pain.. for ssd.

  • @gautamil20
    @gautamil20 Před 5 lety

    He didn't talk about one more C/F which is Dyspepsia as a result of achlorhydria .Achlorhydria occurs because of reduced HCL production as there is gastric atrophy of parietal cells and we know parietal cells secrete HCL hence achlorhydria and thus Dyspepsia. :)

  • @norxgirl1
    @norxgirl1 Před 10 lety +4

    good info....from what I am learning, folate/folic acid, which is in most processed foods these days, can mask a Vitamin B12 Deficiency. Please see Sally Pacholok's _Could It Be B12?_

    • @drsaikatchakraborty
      @drsaikatchakraborty Před 5 lety

      Folic acid is vitamin B 9 needs to pregnancy and without it abortion may take place

  • @charrison58a
    @charrison58a Před 8 lety

    thanks for the info. what have you known that a person has taken other than b12 injections.

  • @amulyakandukuri504
    @amulyakandukuri504 Před 8 lety

    Hi sir coukd u explain disorders of leucocytes and lymphoreticular tissues

  • @purposewithoutlimitstv3522

    Thank you. How long does it take for B12 supplementation to see healing in the nerves and motor and sensory function? Year?

  • @ohgreat3363
    @ohgreat3363 Před 6 lety

    is there microbiology and pharmacology videos like this
    PLEASE HELP

  • @subhajitbiswas7630
    @subhajitbiswas7630 Před 10 měsíci

    Autoimmune gastritis blood test sujjest ana test sa pata chal sakta hain kay

  • @drsaikatchakraborty
    @drsaikatchakraborty Před 5 lety

    Sounds are not so loud. Some ward's missing. Pls write more bigger some words are too small to read.
    Thanks for your videos.

    • @RabiulHaque
      @RabiulHaque  Před 5 lety

      Thank you for your feedback. Take care and stay blessed. :)

  • @spinach5204
    @spinach5204 Před 5 lety

    Very nice video! I just want to know what sources you used for this video?

    • @RabiulHaque
      @RabiulHaque  Před 5 lety

      Thank you for your feedback. I took help from Robbins & Cortan Pathologic Basis of Disease 8th edition, Harsh Mohan Text Book of Pathology 6th Edition, De Gruchy's Clinical Haematology in Medical Practice 5th edition etc. to make this video. Take care and stay blessed. :)

    • @RabiulHaque
      @RabiulHaque  Před 5 lety

      Thank you for your feedback. I took help from Robbins & Cortan Pathologic Basis of Disease 8th edition, Harsh Mohan Text Book of Pathology 6th Edition, De Gruchy's Clinical Haematology in Medical Practice 5th edition etc. to make this video. Take care and stay blessed. :)

  • @khalidashouk5573
    @khalidashouk5573 Před 10 lety

    Well done Dr. you are doing great Job, but try to use power point and animations available , or make your own animations. best regards from another Dr

    • @RabiulHaque
      @RabiulHaque  Před 10 lety +1

      Thank you Dr. Ashouk for liking my videos & for your suggestions. I do have plans for making some small duration videos where I will use powerpoint. But for my long duration videos I will continue using white boards as my students feel like they are actually in my class by doing so ( I started uploading to youtube when my students could not come to medical college for political crisis). Take care & stay blessed. Best wishes from Bangladesh :)

    • @everydaydissociation
      @everydaydissociation Před 9 lety +1

      ***** Yes sir I too prefer the white board and marker

    • @taloolalady0not
      @taloolalady0not Před 7 lety

      Yup, keep that white board- its more engaging than a plain old picture.

  • @drhamdaankhan3691
    @drhamdaankhan3691 Před 5 lety

    Sir, plz kindly change your white board...good lecture.

    • @RabiulHaque
      @RabiulHaque  Před 5 lety +1

      Thank you for your feedback. I have addressed the white board issue in my newer videos. Take care and stay blessed. :)

  • @totanshit9341
    @totanshit9341 Před 3 lety

    Sir please make hindi.

  • @vyomsingh1179
    @vyomsingh1179 Před 7 lety

    sir i come to know about B12 deficiency or meghaloblastic anemia in 2011 but i suffered before this a lot .... bcoz of this diagnosed later.... i am taking ayurvedic medicine for that including panchkarama.. my highesht hb is 11.7 mg/dl.... when i take proper diet .... but i am suffering from gastric problems .... i used to take b12 tablets quarter a year... 10 tablets... i want to know what more i can do to live healthy.... how can my hb reach normal... my age is 30yrs....

  • @sukantachakraborty9950

    Why Pernicious Anaemia is rare before the age of 30?

  • @Yogaasambandam
    @Yogaasambandam Před 5 lety

    Thank you sir

    • @RabiulHaque
      @RabiulHaque  Před 5 lety

      Thank you for your feedback. Take care and stay blessed. :)