Neurodegeneration and Neuronal Reprogramming

Andrew Yoo, Ph.D., provides insight into the ongoing research on neurodegeneration and neuronal reprogramming, highlighting the complexities and challenges in modeling and understanding these processes. [7/2024] [Show ID: 39454]
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[@monkstink1913]

This lecture is extaordinary! Using direct reprogramming to retain the age-associated epigenetic marks is such as smart strategy. The proposed mechanism for Huntington's is also really interesting, like how age-related RCAN1 upregulation hinders the activity of autophagy-relevant TFs such as STAT3. Given that the Huntington protein is involved in vesicular motor transport along the axon, perhaps you could measure if there are trafficking deficits which might contribute to the disease phenotypes. Perhaps when Huntinton accumulates, it no longer mediates dynein-mediated vesicular transport, which could result in autophagic factors being depleted in distal areas of the axon, thereby resulting in axon degeneration.

[@time_g_space]

can the Salk institute please bring back the Salk science and music series?

[@SyonNathanAaronAstinHewson]

I Diane Margaret Astin Hewson do not have neuron degenerative disorder I have brain damage an aneurysm containing cerebral fluid burst in my brain and I suffered from a suffusion which damaged the balance center in my brain I drag my right foot because I was injected with Depixol in the upper right quadrant and my sciatic nerve was damaged I have a shattered pelvis because my pelvis was broken when my husband rammed a metal fire poker very hard into my anus and up into my bowel his name was David Anthony Harper. I made a full statement to the police and had an examination by a female police officer doctor