Longitudinal progression of grey matter atrophy in non-amnestic Alzheimer’s disease

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Non-amnestic Alzheimer’s disease is associated with hippocampal sparing; however, the progression of this condition is understudied. Phillips and Da Re et al. show that the focus and rate of atrophy differ across non-amnestic phenotypes, and that longitudinal atrophy is associated with both domain-specific cognitive decline and degree of structural connectivity.