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BRAIN Journals
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Registrace 15. 05. 2015
Welcome to the CZcams channel for BRAIN: A JOURNAL OF NEUROLOGY and it's sister journal, BRAIN COMMUNICATIONS
The video abstracts posted on this channel are created by authors to promote their manuscripts.
Brain has published landmark papers in clinical neurology and translational neuroscience since 1878. The Editorial Board reflects the journal's broad coverage and international readership.
The Brain Communications team is committed to fair, transparent, and author-friendly publication of rigorous research studies related to neurological and psychiatric disease or maintaining brain health. We aim to be a force for good in the translational neuroscience field by facilitating a high standard of rigour and transparency and promoting career development of neuroscientists. Brain Communications is an open-access, international, editorially independent, peer-reviewed journal that welcomes both direct submissions and manuscripts transferred from our sister journal Brain.
The video abstracts posted on this channel are created by authors to promote their manuscripts.
Brain has published landmark papers in clinical neurology and translational neuroscience since 1878. The Editorial Board reflects the journal's broad coverage and international readership.
The Brain Communications team is committed to fair, transparent, and author-friendly publication of rigorous research studies related to neurological and psychiatric disease or maintaining brain health. We aim to be a force for good in the translational neuroscience field by facilitating a high standard of rigour and transparency and promoting career development of neuroscientists. Brain Communications is an open-access, international, editorially independent, peer-reviewed journal that welcomes both direct submissions and manuscripts transferred from our sister journal Brain.
Head motion in the UK Biobank imaging subsample
Read the full paper in BRAIN COMMUNICATIONS here: academic.oup.com/braincomms/article/6/4/fcae220/7703144
Head motion in the UK Biobank imaging subsample: longitudinal stability, associations with psychological and physical health, and risk of incomplete data
Joey Ward, Simon R Cox, Terry Quinn, Laura M Lyall, Rona J Strawbridge, Emma Russell, Jill P Pell, William Stewart, Breda Cullen, Heather Whalley, Donald M Lyall, Head motion in the UK Biobank imaging subsample: longitudinal stability, associations with psychological and physical health, and risk of incomplete data, Brain Communications, Volume 6, Issue 4, 2024, fcae220, doi.org/10.1093/braincomms/fcae220
Participant motion in brain magnetic resonance imaging is associated with processing problems including potentially non-useable/incomplete data. This has implications for representativeness in research. Few large studies have investigated predictors of increased motion in the first instance. We exploratively tested for association between multiple psychological and physical health traits with concurrent motion during T1 structural, diffusion, average resting-state and task functional magnetic resonance imaging in N = 52 951 UK Biobank imaging subsample participants. These traits included history of cardiometabolic, inflammatory, neurological and psychiatric conditions, as well as concurrent cognitive test scores and anthropometric traits. We tested for stability in motion in participants with longitudinal imaging data. All functional and T1 structural motion variables were significantly intercorrelated. Diffusion motion variables showed weaker correlations around r = 0.1. Most physical and psychological phenotypes showed significant association with at least one measure of increased motion including specifically in participants with complete useable data. Poorer values in most health traits predicted lower odds of complete imaging data, with the largest association for history of traumatic brain injury Worse psychological and physical health are consistent predictors of increased average functional and structural motion during brain imaging and associated with lower odds of complete data. Average motion levels were largely consistent across modalities and longitudinally in participants with repeat data. Together, these findings have implications for representativeness and bias in imaging studies of generally healthy population samples.
Head motion in the UK Biobank imaging subsample: longitudinal stability, associations with psychological and physical health, and risk of incomplete data
Joey Ward, Simon R Cox, Terry Quinn, Laura M Lyall, Rona J Strawbridge, Emma Russell, Jill P Pell, William Stewart, Breda Cullen, Heather Whalley, Donald M Lyall, Head motion in the UK Biobank imaging subsample: longitudinal stability, associations with psychological and physical health, and risk of incomplete data, Brain Communications, Volume 6, Issue 4, 2024, fcae220, doi.org/10.1093/braincomms/fcae220
Participant motion in brain magnetic resonance imaging is associated with processing problems including potentially non-useable/incomplete data. This has implications for representativeness in research. Few large studies have investigated predictors of increased motion in the first instance. We exploratively tested for association between multiple psychological and physical health traits with concurrent motion during T1 structural, diffusion, average resting-state and task functional magnetic resonance imaging in N = 52 951 UK Biobank imaging subsample participants. These traits included history of cardiometabolic, inflammatory, neurological and psychiatric conditions, as well as concurrent cognitive test scores and anthropometric traits. We tested for stability in motion in participants with longitudinal imaging data. All functional and T1 structural motion variables were significantly intercorrelated. Diffusion motion variables showed weaker correlations around r = 0.1. Most physical and psychological phenotypes showed significant association with at least one measure of increased motion including specifically in participants with complete useable data. Poorer values in most health traits predicted lower odds of complete imaging data, with the largest association for history of traumatic brain injury Worse psychological and physical health are consistent predictors of increased average functional and structural motion during brain imaging and associated with lower odds of complete data. Average motion levels were largely consistent across modalities and longitudinally in participants with repeat data. Together, these findings have implications for representativeness and bias in imaging studies of generally healthy population samples.
zhlédnutí: 31
Video
The Brain Conference 24 - Advanced Therapies
zhlédnutí 172Před měsícem
The Brain Conference took place at the Royal Geographical Society, London on the 15th March 2024. For our session on advanced therapies, we welcomed: Chair: Dr Rita Horvath Co-Chair: Dr Meher Lad Prof Gabriele Lignani: Gene Therapy for Epilepsy Prof Matthis Synofzik: Brain precision medicine 2.0: individual patient-customized antisense oligonucleotides for severe neurodegenerative brain disease...
The phase coherence of the neurovascular unit is reduced in Huntington's disease
zhlédnutí 60Před 2 měsíci
Read the full paper in Brain Communications: academic.oup.com/braincomms/article/6/3/fcae166/7689585?searchresult=1 Huntington's disease (HD) is a neurodegenerative disorder in which neuronal death leads to chorea and cognitive decline. Individuals with ≥ 40 CAG repeats on the IT15 gene develop HD due to a mutated huntingtin protein. While the associated structural and molecular changes are wel...
Leriglitazone halts disease progression in adult patients with early cerebral adrenoleukodystrophy
zhlédnutí 567Před 3 měsíci
Read the full paper in BRAIN: academic-oup-com.libproxy.ucl.ac.uk/brain/advance-article/doi/10.1093/brain/awae169/7687562?searchresult=1 Cerebral adrenoleukodystrophy (CALD) is an X-linked rapidly progressive demyelinating disease leading to death usually within a few years. The standard of care is hematopoietic stem cell transplantation (HSCT), but many men are not eligible due to age, absence...
The BRAIN Conference 2024 - Welcome and Plenary
zhlédnutí 255Před 3 měsíci
The BRAIN Conference 2024 took place on the 15th March, at the Royal Geographical Society, London. We were delighted to welcome so many attendees for our first ever in-person conference, which covered a broad range of neuroscience topics. We were extremely pleased to host our Plenary Speaker, Professor Colin Espie, Professor of Sleep Medicine at the University of Oxford. Here we present the int...
Plasma pTau181 and pTau217 predict asymptomaticamyloid accumulation equally well as amyloid PET
zhlédnutí 92Před 3 měsíci
Read the full paper in Brain Communications: academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcae162/7680229 The dynamic phase of preclinical Alzheimer’s disease, as characterised by accumulating cortical amyloid-β (Aβ), is a window of opportunity for Aβ lowering therapies to have greater efficacy. Biomarkers that accurately predict Aβ accumulation may be of critical importan...
COVID-19 associated cerebral microbleeds in the general population
zhlédnutí 109Před 4 měsíci
Read the full paper in Brain Communications: academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcae127/7645966 Cerebral microbleeds (CMB) are frequent incidental findings on brain magnetic resonance imaging (MRI) and have previously been shown to occur in COVID-19 cohorts of critically ill patients. We aimed to determine the risk of having microbleeds on medically indicated bra...
A novel technique for in-depth analysis of brain white matter fibre tracts - Brain Communications
zhlédnutí 177Před 4 měsíci
Integration of diffusion tensor imaging parameters with mesh morphing for in-depth analysis of brain white matter fibre tracts Data reduction methods such as averaging are commonly used in high-dimensional MRI analysis, but this results in information loss. However, individual variability makes group-wise comparisons difficult without averaging. Tayebi et al. introduces a novel method that comb...
Cerebral Tau Pathology in Cerebral Amyloid Angiopathy
zhlédnutí 447Před 5 měsíci
In this study performed by Tsai et al, cerebral tau burden measured on PET is higher in cerebral amyloid angiopathy than hypertensive small vessel disease. Cerebral amyloid angiopathy-related vascular pathologies, especially cortical superficial siderosis, are potential markers of cerebral tau pathology suggestive of concomitant Alzheimer’s disease. Read the full paper here: academic.oup.com/br...
Inflammatory Myopathies - The Brain Conference 2023
zhlédnutí 309Před 7 měsíci
Inflammatory Myopathies - The Brain Conference 2023
CNS diseases in low and middle income countries - The Brain Conference 2023
zhlédnutí 104Před 7 měsíci
CNS DISEASES IN LOW- AND MIDDLE-INCOME COUNTRIES Chair: Alfred Njamnshi - Co-Chair: Gagandeep Singh Welcome & Intro: Alfred Njamnshi Overview of burden and challenges (WHO IGAP on epilepsy & other neurological diseases) Basic Science Research Talk: Paul F. Seke Etet Experimental models of epilepsy in LMIC Data Blitz: Kireshnee Naidu The genetic profile of a South African inherited myopathies co...
Brain endothelium class I molecules regulate neuropathology in experimental cerebral malaria
zhlédnutí 185Před 7 měsíci
Malaria infection has high mortality due to a deadly brain complication called cerebral malaria. Fain et al. show that specific immune molecules found on the blood vessels supplying the brain are the initiators of this pathology, with different molecules capable of instructing immune cells to initiate disease in distinct ways. Read the paper here: academic.oup.com/brain/advance-article-abstract...
CNS disease and the microbiome - The Brain Conference 2023
zhlédnutí 609Před 9 měsíci
CNS DISEASE AND THE MICROBIOME Chair: Sarkis Mazmanim Data Blitz: Kerri Kinghorn Clinical/Translational Research Talk: Paul Wilmes Data Blitz: Elisa Menozzi Teaching Talk: Emeran Mayer
Depicting the anatomy of the gyral white matter
zhlédnutí 198Před 10 měsíci
Read the article here: academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcad265/7307581 A cerebral gyrus is made up of an external layer of folded cortex and an inner core of white matter. The architecture of the core has specific features that make it distinct from the white matter of the deep brain regions. Limited externally by the gray matter that covers the top of the gyr...
Early-infantile developmental and epileptic encephalopathy
zhlédnutí 272Před 10 měsíci
Read the paper here: academic.oup.com/braincomms/article/5/5/fcad243/7266792 Agarwala et al report that in babies with early-onset epileptic encephalopathy, after comprehensive metabolic, neuroradiological and genetic evaluation, the most common cause is an underlying genetic defect. Children with vitamin responsive epilepsies had the best probability of seizure control and good long term neuro...
Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy
zhlédnutí 1KPřed 10 měsíci
Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy
Fast ripples reflect increased excitability that primes epileptiform spikes
zhlédnutí 248Před 11 měsíci
Fast ripples reflect increased excitability that primes epileptiform spikes
RCT evaluating the specificity of alpha/delta ratio neurofeedback in reducing tinnitus symptoms
zhlédnutí 127Před 11 měsíci
RCT evaluating the specificity of alpha/delta ratio neurofeedback in reducing tinnitus symptoms
The comparable tumour microenvironment in sporadic and NF2-schwannomatosis vestibular schwannoma
zhlédnutí 202Před rokem
The comparable tumour microenvironment in sporadic and NF2-schwannomatosis vestibular schwannoma
Improving tremor response to focused ultrasound thalamotomy
zhlédnutí 946Před rokem
Improving tremor response to focused ultrasound thalamotomy
Less is more in language production: An analysis of agrammatism in primary progressive aphasia
zhlédnutí 410Před rokem
Less is more in language production: An analysis of agrammatism in primary progressive aphasia
Latent disconnectome prediction of long-term cognitive-behavioural symptoms in stroke.
zhlédnutí 514Před rokem
Latent disconnectome prediction of long-term cognitive-behavioural symptoms in stroke.
A vertigo network derived from human brain lesions and brain stimulation
zhlédnutí 349Před rokem
A vertigo network derived from human brain lesions and brain stimulation
Uman type neurofilament light antibodies are effective reagents for the imaging of neurodegeneration
zhlédnutí 190Před rokem
Uman type neurofilament light antibodies are effective reagents for the imaging of neurodegeneration
Predicting amyloid PET and tau PET stages with plasma biomarkers
zhlédnutí 177Před rokem
Predicting amyloid PET and tau PET stages with plasma biomarkers
Directional and general impairments in initiating motor responses after stroke
zhlédnutí 95Před rokem
Directional and general impairments in initiating motor responses after stroke
Haemorrhage of human foetal cortex associated with SARS-CoV-2 infection
zhlédnutí 338Před rokem
Haemorrhage of human foetal cortex associated with SARS-CoV-2 infection
Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies
zhlédnutí 138Před rokem
Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies
Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study
zhlédnutí 439Před rokem
Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study
Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease
zhlédnutí 622Před rokem
Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease
thanks
Thanks a lot for this information sir.
Really interesting.
Hello and thanks for the video for someone who struggles with my depression and Insmonia could citalpram provide any benefits??
I enjoy this presentation very much. It is interesting
Great talk! Congratulations!
What a phenomenal talk, loved learning about the role of REM and sleep spindles, thank you Dr. Poe!
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Very similar to corticobasal degeneration and progressive supranuclear palsy
cool