TMS Alcohol Protecting Group Using Silyl Ether
VloĆŸit
- Äas pĆidĂĄn 14. 02. 2022
- Leah4sci.com/alcohol presents: TMS Protecting Group for Alcohol using a Silyl Ether - Reaction and Mechanism
đșWatch Next: Introduction to Alcohol Properties and Reactions âą Introduction to Alcoho...
Need help with Orgo? Download my free guide â10 Secrets to Acing Organic Chemistryâ HERE: leah4sci.com/orgo-ebook/
In this video, youâll learn how to protect the acidic proton of an alcohol from strongly basic reagents like alkynide ions and Grignard reagents by forming the trimethyl silyl ether using TMS-Cl. Youâll see a detailed breakdown of the reaction and mechanism of the alcohol protecting group - TMSO and learn how to deprotect the alcohol with the use of tetrabutyl ammonium fluoride - TBAF.
âȘ Links & Resources Mentioned In This Video â©
âžAlcohol Reactions Series + Cheat Sheet Leah4sci.com/Alcohol
âžAcetals and Ketals in Organic Chemistry Leah4sci.com/Acetal
âžGrignard Reaction and Mechanism Leah4sci.com/Grignard
âžPolar and Nonpolar Covalent Bonding âą Ionic, Polar Covalent ...
- - - - - - - - - - - - - - - - - - - - - - - -
â± In this video:
[0:29] Why Protecting Groups are Used
[1:43] Ethers as Protecting Groups
[2:46] Structure of TMS
[3:06] Structure of TBAF
[3:32] Protecting Group Full Reaction and Mechanism
[5:37] Simplified Reaction and Mechanism
[7:30] Another Practice Example
- - - - - - - - - - - - - - - - - - - - - - - -
Follow along with your semester by using my Orgo Syllabus Companion: leah4sci.com/syllabus
For more in-depth review including practice problems and explanations, come join my online membership site, the Organic Chemistry Study Hall: leah4sci.com/join
âQuestions? Ask me here: Leah4sci.com/contact
đ©âđ« For private online tutoring visit my website: leah4sci.com/organic-chemistry
Letâs connect:âžInstagram: / leah4sci
âžFacebook: / leah4sci
âžTwitter: / leah4sci
âžPinterest: / leah4sci
đ Subscribe to my channel so you donât miss out on any new videos đ
leah4sci.com/youtube
đ©șđ My MCAT CZcams Channel: leah4sci.com/MCATyoutube đđ©ș
Leah your lesson is wnderfull you make chemistry much easier
Yay! Happy to help!
Wow this was very good. Ty!
Glad you enjoyed it!
Brilliant
Love this stuff
Thank you so much
You're so welcome! Happy to help.
@@Leah4sci â€ïž
Thanks ma'amđ..you r on fiređ„
You're so welcome!
Hello Lea! Thank you for this amazing video. May I ask what apps do you use to create these short lectures?
You're very welcome! Let's keep the questions relevant to orgo please
this makes me miss ochem! ty for the video~
You're very welcome and yay for missing ochem. It's my secret mission to make students love the subject
do we need to pay for the ebook or is it free i signed up for it through my email but i have not received it
It's free. Please email me at leah4sci.com/contact and my assistant will help you.
Hi madam....neat handwriting and good explanation.. I'm working in R&D Dept. I' regularly follow s your videos.. please make a video on ammine protection and deprotec...
Thanks for the recommendation. I post free videos as I have time and am always looking for suggestions. For more help with this topic in the meantime, contact me through my website: leah4sci.com/contact
Hello, ma'am! I just wanna ask, when is the release of the alcohol reaction cheat sheet, as well as the practice quiz?
I'm sorry, but neither are in the works currently. I post free material as I have time. For more help with this topic in the meantime, contact me through my website at Leah4sci.com/contact or join my Organic Chemistry Study Hall at Leah4sci.com/join
@@Leah4sci I see. Thank you so much, ma'am Leah!
Ma'am can you make a video on the reaction mechanisms of Grignard reactions?
I do have a video on the Grignard reagent, plus an article and cheat sheet found at Leah4sci.com/Grignard
Can we deprotect TMS using H3O+???
I believe that a strong acid in a THF/water solution would also work. But TBAF is the more commonly used method.
Super đđđ đźđłđźđłđźđł
Thank you
Hlo Leah đ.....iam student of b.pharmacy in india I have exam on basicity of aromatic amines nd effect of that basicity on substituents of amines topic soo please I kindly requested you too doo an video on thizzz plzzz....đđ
By the by I love u nd the way u teach â€ïžđ
I'm sorry, but I don't offer tutoring over social media. For help with questions like this and more, I recommend joining the organic chemistry study hall. Details: leah4sci.com/joinï»ż or contact me through my website leah4sci.com/contact/
Are you going to upload videos regularly?
I can't make any promises with a newborn
@@Leah4sci Fine