Enhanced Fat Metabolism
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- čas přidán 29. 08. 2024
- Fats and sugars are the main fuels that the mitochondria uses as the main fuel in each cell. Usually sugar is the main and easiest fuel of choice.
When nutrients are scarce, in time of starvation or extreme exertion, cells will switch to breaking down fats instead.
www.ncbi.nlm.n...
www.ncbi.nlm.n...
This approach is a little different, what is done here is the enzyme prolyl hydroxylase 3 (PHD3) is inhibited, PHD3 acts as a brake that inhibits unnecessary fat metabolism. This brake is released when fuel is low and more energy is needed, such as during exercise. By inhibiting PHD3 production, we allow for more fat metabolism.
AMPK production is also induced to compound this effect along with some enhanced nutrient absorbtion directly to muscles which altogether works toward super charging muscle recovery and increasing the usage to fat for energy which can lead to the loss or rather 'usage' of fat stores.
Here is a summary from an article on neuro science news
"Rapid alterations in cellular metabolism allow tissues to maintain homeostasis during changes in energy availability. The central metabolic regulator acetyl-CoA carboxylase 2 (ACC2) is robustly phosphorylated during cellular energy stress by AMP-activated protein kinase (AMPK) to relieve its suppression of fat oxidation. While ACC2 can also be hydroxylated by prolyl hydroxylase 3 (PHD3), the physiological consequence thereof is poorly understood. We find that ACC2 phosphorylation and hydroxylation occur in an inverse fashion. ACC2 hydroxylation occurs in conditions of high energy and represses fatty acid oxidation. PHD3-null mice demonstrate loss of ACC2 hydroxylation in heart and skeletal muscle and display elevated fatty acid oxidation. Whole body or skeletal muscle-specific PHD3 loss enhances exercise capacity during an endurance exercise challenge. In sum, these data identify an unexpected link between AMPK and PHD3, and a role for PHD3 in acute exercise endurance capacity and skeletal muscle metabolism."
(2-3 times is pretty effective )
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For those who have questions, this track takes away your hunger and will help you loose weight. This is perfect to help you with intermittent fasting. Thank you sapien we are all so grateful for your blood and sweat ❤
@Mironova.14 sure, but keep it simple with 1 or 2 tracks. This track and Sapien's stomach shrinking track will work best to keep you in shape even whilst eating your favourite foods
@Mironova.14 that's because subconsciously you don't understand let alone believe that Sapiens tracks actually work. Plus you can't expect sudden changes overnight. The society we live in has transformed us overtime to become highly impatient humans. Its not your fault, just trust that if it works for others then it will work for you. Be patient, trust in the process and importantly be consistent in believing and listening to tracks. You will see results overtime. Person to person is different how results reacts. Belief in his work and not getting too stressed out makes results come faster.
If you pay for meds from pharmacy you'd take them until dosage is complete right? This is free so take them just like that. You got nothing to loose.
Hope it helps ;)
@Mironova.14 yeah this video alone will help you. Listen to it as much as you want but like I said you won't loose a lot visibly as you expect. It takes time but it does work. I'm using it to good affect so it will work for you. Try listening to this with a good diet and intermittent fasting. That will speed it up. Try reduce eating carbs.
BTW know that you are beautiful so don't be stressed about your physical aspect. some of us like curvy ladies.
@Mironova.14I recommend you to listen subconscious limits removal with another vedios ..it will boost up your results ..sapien just released 3.0 version
@@kjillukkumbura9248 Hello, please tell me which videos will help me lose weight, I have a lot of fat on my thighs and buttocks and a little on my stomach, but I want to be very, very thin
Honestly the only weight loss audio that actually works
The people for whom this vedio doesn't seem to work ..i recommend you all that you may increase your listening time in start ..for example it is recommend 2-3 times you can listen 5-6 times ..and over time you will feel the changes ..and then you can decrease the listening time to normal 2-3 ....for me personally if i listen to it for 2-3 times a day ..i don't crave anything or feel hungry for almost 2 days (i just eat one meal a day ...and one glass of milk in evening these days) so i don't feel much hungry ..so in short this vedio definitely works! Just believe in it guys!
@Mironova.14 yess ofc it will .. listen to automated workout vedios ..with this ..that works wonder
@@glowingup3536Dear friend, please help me I really want to lose weight, did I understand correctly I'm listening to this metabolism field, leg training field, buttocks training field and upper body training field?
@@glowingup3536
What are ur results ?
It could be also that problem lies somewhere else, for example health issue such as diabetes etc.
@@Olivqa22idk where it is now but he had a blood sugar one that was incredible. Im definitely in agreement people need to use multiple based on their situation.
Listened to this 3x in the AM and barely felt hungry all day… THANK YOU FOR REUPLOADING!
I love the rotating orange circle thing.
.....now loading
I notice that when I stopped listening for a few weeks now I eat more because I was hungry far more than usual, then I realised I stopped using this and now restarting again
Dear Sapien Medicine.. Accept my sincere gratitude ❤
And me 😊
I use this to feel less hungry in the mornings
I know.... SUCH a helpful little thing. Why is it when you get started losing extra weight one gets HUNGRIER?
I recall only listening to this three times on a row on a random weekday. The following weekend i ate way more carbs than i should have and gained a bit of weight weighed about 97 kg, i looked gross. The next Friday (today) i weighed myself AFTER eating just right before bedtime and scored exactly 94.00 kg Im a skinny fat person so minimal weight gain is super noticeable, but i looked at myself in the mirror today and looked skinnier, ive noticed im starting to get cheek lines on my face too. I havent exercised nor starved myself at all. I still ate carbs in moderation since then. I eat twice daily at most tho.
I get botox for my glabella lines and usually I get 3-4 months. This time, I only got 2 months.
I was trying to find out why, and I found that the length of time it lasts depends on your metabolism.
So this is confirmation this is working :D
Consistent every day use is recommended ❤️
Sapien, I hope you live your best life for many years to come. Wishing you the best from our hearts!
This is a godsend with late night cravings 😅
Lolz 😂 High five for combatting gluttony with fat killing frequency!
@Mironova.14start your healthy lifestyle please and listen these audios twice a day. Everything will work consistency is the key.
@Mironova.14Intermittent fasting is helpful. I tend to only eat within a 6 hour window. Cutting sugar is also a game changer.
@Mironova.14 try going on a calorie deficit and everyday eat 500 calories less than what u burn. u should be able to lose 10kg in around 5 months of doing this, or u can eat less calories and lose weight quicker
it is not gluttony but leptin resistance in overweight people causing overeating at night@@pickmeupstix
I have trouble with stubborn fat around my hips and butt, this alongside Testosterone and DHT audios seems to work very well for me. Thank you! I am in calorie surplus too so...
@Anna-Leigh77 NOT for women.
Thank you Sapien and team. I love this one.❤😊
Podrìas por favor decirme de qué trata éste video , mi celu no tiene para traducir al español , de antemano te lo agradezco 🙏🙏🙏
Love the dramatic music
Thanks a million Sapien - you're the BEST!!!!!
I've been on a keto for 2 years and it works similarly, I'll try to use it to speed up the process. Sometimes on keto, everything slows down.
Thank you for everything you do! I love your audios!! God bless you today and always.
Day 1: 68 kilos
Updated; 66 kilos
After how many days
also dieting and calorie deficient
day 1: 151.3 pounds
day 2: 150.7
Just 2 days worth of updates? Lol
Im 47 and recently gained 4 kg and I see myself at 64 kg again
I’m receiving with love
I’m shedding off this weight
I’m stopping binge eating
I’m stopping thinking with my stomach
I’m looking sexy
I’m loosing this weight
I’m feeling confident
I’m my own skinny self again
Lots of love Sapien
Putting this on all the subs im listening to in my playlist:
Day 1: ✅
Dah 2: ✅
Just started listening to this one too. Did you get any results? Also I recommend adding the stomach shrinking one, it adds lines to your stomach and makes it so flat
@@randomeperson1400 no results at the moment except I don't get hungry as often
Please reupload the beauty ones too. Thank you indeed.
I am impressed by the description ! Hope results will be even more impressive ! Thank you !
Me alegro por tí , yo no sé inglés y mi celu no traduce 😢 así que me informo con los comentarios 😊
Actualiza la app y te aparece la opción de traducción
@@lourdese6007 gracias lourdes 💖
@@elianahenriquez9753 hay una app que traduce fotos yandex translate puede tambien servir para las capturas de pantalla.
Tradução da descrição dos benefícios do vídeo: Gorduras e açúcares são os principais combustíveis que as mitocôndrias usam como combustível principal em cada célula. Normalmente, o açúcar é o principal e mais fácil combustível de escolha.
Quando os nutrientes são escassos, em tempos de fome ou esforço extremo, as células mudam para a quebra de gorduras.
Esta abordagem é um pouco diferente, o que é feito aqui é que a enzima prolil hidroxilase 3 (PHD3) é inibida, a PHD3 atua como um freio que inibe o metabolismo desnecessário da gordura. Este freio é liberado quando o combustível está baixo e mais energia é necessária, como durante o exercício. Ao inibir a produção de PHD3, permitimos mais metabolismo da gordura.
A produção de AMPK também é induzida para compor esse efeito junto com alguma absorção aprimorada de nutrientes diretamente para os músculos, o que funciona em conjunto para supercarregar a recuperação muscular e aumentar o uso de gordura para energia, o que pode levar à perda ou melhor, ao "uso" de estoques de gordura.
Aqui está um resumo de um artigo sobre notícias de neurociência
"Alterações rápidas no metabolismo celular permitem que os tecidos mantenham a homeostase durante mudanças na disponibilidade de energia. O regulador metabólico central acetil-CoA carboxilase 2 (ACC2) é fortemente fosforilado durante o estresse energético celular pela proteína quinase ativada por AMP (AMPK) para aliviar sua supressão da oxidação de gordura. Embora o ACC2 também possa ser hidroxilado pela prolil hidroxilase 3 (PHD3), a consequência fisiológica disso é mal compreendida. Descobrimos que a fosforilação e a hidroxilação do ACC2 ocorrem de forma inversa. A hidroxilação do ACC2 ocorre em condições de alta energia e reprime a oxidação de ácidos graxos. Camundongos PHD3-nulos demonstram perda de hidroxilação do ACC2 no coração e no músculo esquelético e apresentam oxidação elevada de ácidos graxos. A perda de PHD3 específica do corpo inteiro ou do músculo esquelético aumenta a capacidade de exercício durante um desafio de exercício de resistência. Em suma, esses dados identificam uma ligação inesperada entre AMPK e PHD3 e um papel para PHD3 na capacidade de resistência ao exercício agudo e metabolismo do músculo esquelético."
(2-3 vezes é bem eficaz)
Excellent idea! Ketosis enhanced!
Thank you.
Thermogenesis Extreme fat burn , Please upload this back😢❤
Yes but that app is shit, this CZcams is so convenient
@@Fammalicious-Recipe Please tell me is he better than the others? More powerful?
I've always wondered when would be the perfect time to listen to this?
Please reupload dark circle removal and height booster please we are eagerly waiting 🙏🙏🙏🙏🙏
There is a vedio already for height boost
Teşekkürler ederim...❤❤❤❤❤iyiki varsınız
Ise yariyormu?
The cut is gonna be insane!
Thank u for this one too Sapien
thank you so much Sapienmed team 🙏🙏🙏🙏🙏🙏
What a huge effort ❤
Crossing my fingers on this one!! My hunger is out of control lately!
Grazie caro Sapiens🙏
You are the angel, dear Sapien, we were missing for quite some time, however so happy to find the track again. But why can't we download this precious one, without purchasing CZcams premium. R they putting pressure to us or you have some clause with them?🤔🤔🤫
CZcams don't let you download any video unless you have prime.
Sapien plz humble request for full body detox advance detox and intestine healing and regeneration plzz plzz plzz
Thank you Dearest Sapien ❣️
I dont have fat to lose, but I am borderline diabetic, so I listen to this.
P.S....I would need my dictionary and thesaurus🤔 to decipher the neuro science news article😁😁😁 but thanks for adding it on💗🕉️
Listen his diabetes one.
@@Fammalicious-Recipe where is the diabetes one. Please let me know. I have been searching and requesting for 3 months
@@yutikakaslay9062 It was available, but when his channel got hacker all videos were deleted, he is reaploading all of them ofcourse it will take time.
@@yutikakaslay9062when you go to the forum there’s a search bar at the top, type diabetes and threads will show up which discuss it
Thank you 🙏 please upload the Vitamin D one
Dear Sapien please make one pheromone😊
Thank you sooo much for this ive been listening to this for years❤
Has it helped you to lose weight through the years? If so, how much?
❤🙏Thank you for al your loving energy!.....this music is probably a requiem for fat cells though😂
@@petrar.2372 o dear... there is a video for that too😜
Super funny !
Muchísimas gracias, Sapiens, pon algún video para sanar el vph, te lo agradeceríamos muchas.
HPV is a virus is it not?, so wouldn't the virus disrupter work?
😊can you make on hair regrowth please
Thanks for everything. Such a blessing in my life
20 may-72.5,(IF(12-8pm))
21 may-72.15
Love you Sapien Medicine...yoyr a Rock in this Community 💥🌴🌊☺️
I've been listening to this video off and on over a week. Sometimes I would play it back to back 4X each day. Unfortunately for me I had to go to the ICU for reasons but while I was in there I asked for nic patch once and didn't keep on that long eh maybe 30mins or so. Now I got released I haven't had a craving not once. Sig smoke makes my head hurt to the point I have to leave the area where side sig smoke is. Seems to work.
Thank for being less loquacious in the description😊
Gratitude.💖
Sapien please make a frequency sound for weight gain
Please when you Get time , can you please reupload liver fat reducer. 😊tk you
India landed on moon tonight
8 months late to your comment. Jai Hind 🇮🇳
Sapien will you upload hearing loss recovery video???
Will this help me to loose weight?
Yeah in the info it says helps the loss of fats
Please Upload Extreme Fat Burn Thermogenesis 😢
@user-wl2fq2fn4o
Yess I am waiting for it reupload again,
I feel like His Thermogenesis works more good,
Well I combining them now adays, I listen one video thrice per day like
Monday Thermogenesis
Tuesday Fat Burn
Wednesday Liver Fat reduce thursday Enhance Fat metabolism
Friday super fast metabolism
Saturday Cardio
I need to lose a little fat too although a bit of fat is sexy.
Did u get some results ?
@@Fammalicious-Recipe
Thank you ❤
Didn't get the description. Csn anyone explain in easy way? Also, may I use this for weight loss?
@Mironova.14 ???
Alguien sabe si existe alguna música para eliminar los grasa ( rollitos ) en espalda alta Por favor si pudieran ayudarme se los agradeceré muchísimo 😊
@p.c3554 Did you find it yet ? If yes then please recommend me
@@sakshi6744desgraciadamente aún no ! Al parecer no hay frecuencias para esta condición , si tú llegas a saber de algo por favor me lo dices …
If you get hunger pangs from dieting.... recommend using this. I mean spacing out when you eat counts i guess but helpful is helpful
Thank you, please reupload the bone lengthening audio
Thank you so much sapien ❤
How come this makes me feel less hungry but burns fat, yet the old metabolism booster one also is supposed to burn fat quciker but makes me starving hungry?
This one makes me hungry and the other one not.
@@Sveta069 😲
Bc raising/boosting metabolism means your resting metabolic rate is higher which means you burn more calories in your resting state. So you have to resupply calories still bc your body needs energy.
Slow metabolism can be a cause of weight gain though and can actually happen from eating too little - you don’t supply enough food and calories so you start burning less which can become a vicious cycle.
I’m experimenting rn which work better. You can lose weight eating a lot if you have a fast metabolism and burn off calories quick and things like exercise obv help that. You have to eat enough in order to benefit from exercising or else it’ll just burn you out.
I don’t really like having to eat a lot I sometimes feel it’s a nuisance but undereating has only made me feel worse.
One is fat burning and one is metabolisation of fat, so your body is using fat as fuel hence the appetite suppression, kind of like keto
Si me pueden recomendar un audio para infección gracias 🙏🏻
Man I love the music in this. Hopefully this can help with not breaking a fast and losing my mind. 😉
I have a question. Please reply. How do you find these frequencies and their effects ?
He has answered those in his forum. Basically said research and science
thank you sapien, you're the best
Lo acabo de encontrar... Yo hace unos días me he puesto a dieta. He decido bajar de peso. Y deseo empezar a comer menos. Deseo poder empezar a comer una vez a día.
You can work up to eating once a day! You can start with 8 hour eating window for a few weeks, then try 6, and so one until you reduce your window to 1 or 2 hours
Brain gets better food when fat is metabolised… it helps with homeostasis
Where is the gyno one? Can’t Find it anywhere
I wonder if it will work if I listen while sleeping?
😊yes
No. He said it himself. You need to be awake. Quadibles work while sleeping tho
U are the best detective in this case. I k ow i always say it but its damn true.
First! Thank you Sapien 🌞
Hello 👋 please let me know if it is safe to use while pregnant?
Hi..
I wouldnt listen while pregnant to this..
Been in your situation during my latest pregnancy and this one I did skip over..
It feels like it will target the fat cells of the featerus/baby.. but idk❤
Better not to listen during pregnancy. Tc God bless you 💓
@@Malina4477 thank you very much
@@monadarlo2479 thank you 🙏🙏❤️
Hey! i saw this comment, 11 months later. Congratulations mama!
Gracias Sapien por todo tu trabajo , pero ... cuando subirás , stomach tightening ? ... y el otro , creo que contrae el estómago ( algo así cómo un corsé ) esperaré ésos con emociòn ... gracias 😊
Thank youuuuuuuu😘😘😘
can I download this as a wav file?
Do we have to understand all the scientific terms in order for it to work?
😊no
No bru
Lots of love you too much blessing
What happened to this channel? Where did everything go?
Apparently they got hacked and most of their videos got deleted, that's why they are all slowly being uploaded again
THANKS AGAIN sapien medicine peace and prosperity
Can I listen to it in combination with metabolism booster
Sure but I’d imagine boosting metabolism might actually increase hunger … since you’re burning more calories …
but try it and see there’s a lot of good feedback in the comments saying they eat normally and still use fat
Love para sapien !!!! Algo para estreñimiento porfavor 😅
El de metabolismo rápido te sirve para eso 👍🏻😉
@@ximealejandra1102 gracias bella
How is your thyroid?
Are headphonea necessary?
No
uno de androstenol amigo
Does it help digest fat?
yes
Is there any thing to digest protein as well?
Can I listen to this with the genetic advance weight loss one?
Yes
@@mayful444🎉😊
Yess
❤❤❤❤❤
I didnt understand well … i have to be in ketosis inorder to listen to this audio ??
Nope, this is designed to put you into fat-burning mode 😊
@@ladymoniquevonmolendorff5304 thanks 🙏
❤Sapien Medicine Superhuman Genius please
Yo también quiero ese , por favor mis amores .MSapien .❤
He uploaded it!
Genial 💜💜💜
thx❤
❤❤❤
Iam first to like
Mais elle existait déjà celle là !!
Yes, the channel got hacked and most of the videos got deleted, so they're re-uploading everything
Nice song
🥳🥳🥳💥💥💥💥❤️❤️❤️❤️❤️
0:33
Haha stoners saviour!! Munchies begone!!❤
This subliminal is for WHAT
Not a subliminal.
It's a morphic field to put you into fat-burning mode
@@ladymoniquevonmolendorff5304do we need headphones
@@followurheart1112 no.... speakers are fine too....