Overview of DNA Damage

NA damage is an alteration in the chemical structure of DNA, such as a break in a strand of DNA, a base missing from the backbone of DNA, or a chemically changed base as 8-OHdG. Damage to DNA that occurs naturally can result from metabolic or hydrolytic processes. Metabolism releases compounds that damage DNA including reactive oxygen species, reactive nitrogen species, reactive carbonyl species, lipid peroxidation products and alkylating agents, among others, while hydrolysis cleaves chemical bonds in DNA.[1] Naturally occurring oxidative DNA damages arise at least 10,000 times per cell per day in humans and 50,000 times or more per cell per day in rats,[2] as documented below.
DNA damage is distinctly different from mutation, although both are types of error in DNA. DNA damage is an abnormal chemical structure in DNA, while a mutation is a change in the sequence of standard base pairs.

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[@hussainbiology]

thanks for appreciation..Glad it helps ✌️❤️❤️

[@sahithipindiprolu4723]

Thanks a lot Sir. The video was really helpful. May I please know what are your reference books?

[@mohdjunaidkhan95]

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[@hussainbiology]

Thanks Junaid bhai....

[@TomAustinIII]

Single strand breaks and oxidative damage are the most common

[@mvvlogsshorts9930]

The video is very helpful and informative.

[@hussainbiology]

Thanks Mansi for appreciation....

[@yazanabandah1677]

Ap Endonuclease cleaves the 5’ end .. and Lyase cleaves the 3’ end .. then DNA polymerase and DNA lygase play role.
You forgot to mention the Lyase part!
“Base-specific Glycosylase removes altered base and creates AP site (apurinic/apyrimidinic). One or more nucleotides are removed by AP-Endonuclease, which cleaves the 5′ end. Lyase cleaves the 3′ end. DNA Polymerase-β fills the gap and DNA Ligase seals it. Occurs throughout cell cycle.” GEL PLease! (The steps gylcosylase, endonuclease, lyase, polymerase, ligase)
The quote is from FA USMLE step 1, biochemistry section (2 section), page 40.

[@NitrogenVM]

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[@hussainbiology]

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Teaching wow biggest fan sir

[@zahidhassan1250]

Sir Can we say Dna slippage is a Dna Damage process/ it's a mutation please answer?

[@TupeDavid]

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[@bharatidas2108]

Thank you sir for detail Explaination

[@hussainbiology]

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[@vuan8393]

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[@di_0b]

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[@hussainbiology]

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what abt prokaryotic Repair mechnaism ????

[@hussainbiology]

SOS Repair | Coming soon

[@Alextherock9]

If you have a dna problem or damage that causes psychological problems, does it come from the father of the mother? All the children psychological problems.