Non-Canonical NF-kB Signaling Pathway | Mechanism and Function

Lesson on the Non-Canonical NF-kB Signaling pathway.
The Noncanonical NFkB signaling pathway is primarily involved in B cell maturation, lymphoid organogenesis and immune system functioning. This signaling pathway differs from the canonical pathway in terms of cell receptors and cytosolic adaptor proteins. In a constitutional, inactivated state, cell levels of NIK are kept low due to proteasomal degradation. However, when this pathway becomes activated, NIK levels rise, leading to activation of IKKalpha and subsequent formation of an active protein dimer. This active protein dimer translocates into the nucleus and leads to the induction of non-canonical NF-kB signaling genes, which increase B cell survival. Unsurprisingly, mutations in this pathway can lead to the onset of specific immune cancers including Hodgkin’s lymphoma and diffuse large B cell lymphoma.
**Re-uploaded to support 1080p video quality.**
Hey everyone. Here is an introductory lesson on the Noncanonical NF-kB signaling pathway, its purpose, mechanism, function, which genes it induces and its involvement in certain immuno-pathologies. This video also marks the beginning of videos in 1080p high definition.
I hope you find this video helpful. If you did, please like and subscribe for more videos :)
JJ
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[@thesuperiorbench6307]

Absolute legend, Vids like this make it so much easier to read through dense papers online. Thanks

[@rajiv89hyd]

Excellent explanation! Thank you very much.

[@797brm]

This is gold!

[@xrcc202]

All my doubts are solved. Just great❤️
You saved my life😀

[@aajbakeraajbaker8444]

this is amazing!

[@tahmidfaisal9147]

great explanation!

[@apurbamukherjee794]

Thank you sir for this nice video 👍

[@benslyly557]

great video thanks a lot ! please can u share with us the one of canonical NFKB pathway ! as soon as possible !

[@akshaykumar-wj4sv]

thank u

[@saduenas]

Great video!! thank you!.... is there a video of the Canonical pathway??

[@anleyteferra7846]

Thank you so much!

[@ldjt6184]

Very interesting. So why would a drug like Aubagio, with NF-kB inhibiting properties, cause lymphoma?

[@pranavsopory]

doc, what about the canonical pathway? i can't find the link... SOS (great vids btw!)

[@mariammoumi9622]

It's not available, so sad because his explanation is great! His drawings are too, i use them in my class and all studentes get it the first time.

[@ramyarompicherla6637]

Can you add canonical pathway

[@asaadtrabolsi2350]

great video! can you please link the Canonical activation video? I can not find that on the channel

[@benslyly557]

neither do i and i really need it can u please let me know if you've found it somewhere else ?