Extracellular matrix Regulation for Tissue Engineering and Regenerative medicine | Prof.Greeshma

This talk features Prof.Greeshma Thrivikraman, a new member of the IIT Madras faculty, whose research focuses on the key aspects of regenerative biomaterials and tissue engineering.
Abstract:
Living cells in our body constantly sense a diverse array of spatial, chemical and physical signals presented by their surrounding local microenvironment, comprising an intricate meshwork of macromolecules known as the extracellular matrix (ECM). The complex cell-ECM interactions occurring on a micro-nano length scale are perceived to regulate tissue development/homeostasis in healthy tissues, while any aberrant changes in these interactions can lead to disease progression and loss of tissue function. Hence, manipulating cell-ECM interactions synthetically using various biomaterial-based strategies has been very promising in regenerative medicine to drive specific therapeutic outcomes. In this backdrop, the talk will summarize my research work in understanding the role of distinct physical factors such as stiffness, topography, dimensionality, geometry and conductivity in guiding desired cellular responses, namely cell proliferation and stem cell differentiation and how it can be incorporated in the scaffold design to create functional tissue constructs. Altogether, these findings will possibly create new avenues for development of novel therapeutic approaches and improved human disease models for drug discovery and screening.

[@sayakroychowdhury1954]

Thanku ma'am. The video was really interesting and informative 🙂