Histamine Synthesis and Metabolism Pathway

Lesson on Histamine Synthesis and Metabolism from the amino acid Histidine. Histamine is a biogenic amine that acts as a local signaling molecule and a neurotransmitter in the central nervous system. Histamine is produced from the essential amino acid histidine in mast cells, basophils, ECL cells and histaminergic neurons. Histamine is important in several processes including anaphylactic (allergic) responses, regulation of gastric secretion, and also acts as a potent vasodilator. Histamine is eventually metabolized by key enzymes including diamine oxidase (histaminase) and histamine N-methyltransferase, and histamine metabolites are eventually secreted in the urine.
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JJ
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
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JJ

[@mrmeach1967]

Thanks for making a video about histamine that doesn't start right off discussing histamine intolerance.
I get it - we all get it - that too much of this stuff is problematic, but practically every video out there fails to discuss this molecule without viewing it as an evil substance. In a similar fashion, cholesterol gets no love either, even though it too is metabolically essential.

[@Ruktiet]

You forget how doctors actively deny the existence of this condition, leaving people scratching their heads when they can’t get any help for their mystery symptoms, which naturopaths prey on.

[@MohammedAli-bj9jk]

can you provide some valuable sources like books, articles, ets?
many thanks for the calm, rich, to the point info.

[@wallibaba8659]

I'm histamine patient it's help me alot

[@hawleybrown5162]

What's the point of adding the ribosyl? Is it a vehicle for getting rid of the ribosyl? Also, why does the pathway with the histamine N-methyltransferase happen, requiring SAM, if you can get the end product of the acetaldehyde directly from the diamine oxidase? Does N-methyl histamine have any purpose in the body?

[@warrenl4196]

Thank you so much! I think this is prolly the answer I'm looking for to dealing with my chronic hives, swelling, and rhinitis. Way more useful than all other videos related to this topic I've watched combined.
There are tons of mysterious, sometimes even conflicting suggestions about treating symptoms based individual opinions or stupid observational studies on the internet. Without an objective molecular-level explanation, most observational studies are just academic trash that do not make any sense, nothing better than a psychic.

[@anastasiavarianichenko9026]

Hello. Have you reached to cope with your allergy?

[@pghuman100]

This was a great video! Thanks for taking the time to share your knowledge

[@samaraharjumand2419]

Thank you, sir! Thank you so much! This video just solved my problem. You can make understand difficult topics so easily!! Really glad that I found it in the very first go.

[@user-ou5yy2he5r]

thank you very much for the informative video. I have a question. Βy what criteria does the organism choose which metabolic pathway to follow for instamine metabolism?

[@megsarna7429]

Why histamine intolerance happens after Covid infection? Wats d cure?

[@germanshepherdmom1143]

I’m on a low histamine diet for 2 weeks now. I hate it. One more week of this torture and then I’m going back to my favorite foods.

[@szymonbaranowski8184]

I expected something with more factors creating or inhibiting histamine and info on what it does in organism and when it gets deregulated. B1, zinc, copper. it's degradation pathway

[@arpitapattnayak325]

Ur just best ❤️

[@vanmccall7770]

I been studying the way the body works for a few years.I usually see what the answer is,but not on this subject.

[@sweetynirwan6315]

Thanks ...very good explanation..

[@fahadalkarim1651]

Thanks

[@giffarriahsan6727]

knowledge is power!

[@User-to7nb]

perfect- thank you dude