Histamine Receptors, Pharmacological actions of histamine

Histamine Receptors, Pharmacological actions of histamine
The histamine receptors are G protein-coupled receptors which bind histamine as their primary endogenous ligand.
There are four known histamine receptors:
H1 receptor
H2 receptor
H3 receptor
H4 receptor
H1R are expressed in many cells, including mast cells, and are involved in Type 1 hypersensitivity reactions. H2R are involved in Th1 lymphocyte cytokine production. H3R are mainly involved in blood-brain barrier function. H4R are highly expressed on mast cells where their stimulation exacerbates histamine and cytokine generation.
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