Our Instruction Manual for Existing: DNA Structure & Replication: Crash Course Biology #33

Your DNA contains all the instructions your body needs to function. In this episode of Crash Course Biology, we’ll figure out what this giant instruction manual looks like and how this three-billion-letter code gets copied into your trillions of cells through DNA replication.
Introduction: DNA & The Human Genome 00:00
The Structure of DNA 1:36
Chromosomes 3:51
DNA Replication 4:16
How DNA Replication Works 6:06
Mutations 7:51
The Okazakis 10:04
Review & Credits 11:23
This series was produced in collaboration with HHMI BioInteractive, committed to empowering educators and inspiring students with engaging, accessible, and quality classroom resources. Visit BioInteractive.org/CrashCourse for more information.
Check out our Biology playlist here: • Biology
Watch this series in Spanish on our Crash Course en Español channel here: • Crash Course Biología
Sources: docs.google.com/document/d/1G...

[@maximummax29]

I have been watching Dr. Sammy religiously lately to remind my self of basic concepts I need for my exams. Your a life saver man

[@LoganHolbrook-pp3hv]

I have a cellular bio test tomorrow and was still confused on DNA replication, but you guys came in clutch!!!!

[@KelsieJG__they-them]

Every time I have to remember which pairs go together, I just remember the round letters go together (C and G) and the pointy letters go together (A and T).

[@docjoe86]

I often say DNA is like an expensive cookbook in the reference section of a library (the nucleus) and mRNA is like a photocopy you make of the pages you need.
This analogy would have been much more relevant 20-30 years ago!

[@WCOBDisorder]

I literally just finished making an EdPuzzle for the older Crash Course on this topic!

[@MrMetro-mt5qv]

So now we see why Wolverine developed bone claws and a healing factor.

[@isabelleminienpoule4094]

So well explained. Thanks Sammy and the whole team

[@kmcsciguy]

Extremely well done and concise!

[@nuggetsofinfos]

That’s a lot to digest but I love it!

[@kayliegrace2002]

I just graduated from high school a few months ago and I still watch this sometimes and the funny thing is science was one of my least favorite subjects 😄

[@elius_robinc]

Lol just im learning English and now I step by step understanding that I need to learn a lot and a lot by your videos

[@TrynaDoMyBestHehe]

All the best buddy!

[@tamikovacs3887]

Such an interesting report, thank you

[@jonahsimmons5686]

Wow a lot of this I haven't read about in over a decade! This is only the second video I've watched so far but awesome videos!

[@theblackdeath4450]

Its always feels amazing to be the first in a Chanel that you really like 😂❤

[@luigiKnight222]

Another piece of knowledge installed 🎉🎉🎉

[@Davlavi]

Another great video.

[@AQDhandlelol]

Great vid

[@VichCel]

Awesome 👍

[@user-ej4ur3eu2e]

Thank you

[@rebekahcreates]

Oh I love this topic!

[@TrynaDoMyBestHehe]

I think at 3:30 we can also make another mnemonic like remember it as G3 Cat2 (or just G Cat), G has 3 bonds with C and A has 2 bonds with T. Hope it helps.

[@user-xb4md6je6v]

Do you have videos on good stress vs. bad stress, resilience, and all forms of mental health promotion and prevention?

[@ayeshawaheed2240]

Wonderful

[@ramnextgen]

The music of Crash Course - is the same as the ringtone Seedling in iPhones, right? Are these based on any important western musical compositions? Thanks!

[@gailaltschwager7377]

Thank you!

[@qmano9836]

6:15 yes dr. Sammy, you are!!!

[@VortexBricks]

Hank: you wanna make one?

[@avokardoes7]

Do you guys purposely use angel numbers to time your youtube video timings like 13:31, 13:13, 12:36, 12:34 and 11:11. Coincidence, marketing tactic or purposefully done for motivation? Love the videos!!

[@andreaslambis8784]

human genome was decoded in '01

[@DracarmenWinterspring]

The human genome project was declared complete in 2001 but it only contained 92% of the genome (at high accuracy). It took until 2022 to fully complete it, IIUC mostly because a lot of the gaps had a bunch of near-identical repetitions of sequences, which made it hard to confirm exactly what was there with the fastest techniques we had for reading DNA.

[@chinobambino5252]

A large portion of it was, arguably the most relevant parts to medicine (protein coding genes etc) but the full end-to-end sequence of each chromosome was completed in ‘22. Mostly. I’m sure there are still bits that are missing, for a variety of reasons.

[@maryam0378]

Wonderful 😊 I hope that there is an Arabic translation ❤

[@pinktights747]

❤

[@sebali-ferguson6303]

BIOCHEMISTRY CRASH COURSE WHEN?

[@Beryllahawk]

It IS incredible that life can work with a four letter alphabet, from two different angles - one being "only four." The other being "FOUR?!"
Because us humans created the entire Internet out of ones and zeroes. Binary can certainly function for lots of complex stuff! So having twice as many pairs to work with? It's double binary!
(I recognize that I am no doubt vastly oversimplifying here.)

[@TheDanEdwards]

*Teleological language for science is a bad choice.* To declare (as in the video title) "Our Instruction Manual for Existing" raises the question: _Who is the Instructor?_ And then there are the ancillary questions such as what if one does not want to follow the instructions?

[@cynthiaanderson3742]

ANCESTORS DNA OF AFRICA 😎 😎 😎 😎 ❤❤❤❤❤🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉AMEN AMEN AMEN 🙏 🙌 ❤️ 👏 💖 😊 🙏 🙌 ❤️ 👏 💖 😊 🙏

[@McB33fy]

Guys, here me out!
Dinosaurs 🦕

[@yamilemagubeni9834]

So all of this is by excidant

[@OsirisMalkovich]

"Most useful?" Wouldn't the "most useful" instruction manual be something that most humans could _actually use?_ In all of human history only a handful of humans have been able to do that so far.

[@kaiezesi6630]

1st

[@Mirandas_learning_land]

First