Hello, I am very glad, you exist and make those videos. I would like to see all of them, your videos are really helpful. You are really amazing teacher and very good speaker, I am czech and I understand you every word. Very good job. I wish you all of the best.
Ak you have been the best so far.. I actually used your video as a substitute for my text book when I had enzymology text.. and here I am using your video for a substitute for lipid metabolism text.. I appreciate your efforts in putting up those writing and skillful representations to avoid imagination.. thanks again
You're a saint for helping us get through these tough classes. You should set something up so that when students become doctors, you get free medical care for life :)
Thank you so much man! You're a lifesaver! I really appreciate your detailed drawings- it takes me a while to write them in my notebook, so I assume it takes you a long time drawing them. I really appreciate your efforts and am so thankful!
sir... i almost write you comment on every video i watch for you because i'm always fascinated by your great explanation and the way you get into deep details ... just exactly what i need for my medical biochem class..... i'm forever thankful and this channel is underrated it is actually perfect
Thank you so much for making these videos! I was having trouble understanding this process since lehninger biochemistry is rather advanced. Somehow you manage in 16 minutes so make everything crystal clear wheras the book and my lecturers failed to do so after many hours. A first year med school student thanks you dearly. Cheers from Sweden
I don’t know how to thank you 🙏! You’re the best ever man who have youtube channel .. you should get a huge award for this ! Even if they gave me Nobel award .. it would be not enough to give it u!
Aye man good luck to whomever has a biochemistry final exam coming up. Mine is in exactly 2 weeks and I'm just starting to study for it. This shit looks so tough man :(
I Always watch your lectures because you just make my learning 1000% more efficient and save me tons of time. I wish you were my lecturer. Thank you very much.
thank you so much for the effort im so glad that i found your channel ,, its really a BIG help ! i literally would fail without your videos please keep up the hard work
I love all my professors, but as a person who has little to no background on biochemistry and then taking the class in med school, they sometimes go too fast for me to understand. Thank you for all these lectures!!
I love love love all d videos of yours . those help me a lot to understand the things deeply and also in a easy way . thank you very much for making such amazing videos .
Thanks, sir it is very nice and easy to digest. Thanks for the efforts taken to simplify such a difficult portion in detail pls continue it for us, sir.
Would be awesome if you got subtitles for your videos :) the auto one is okay, but sometimes not correct and I find it better to learn when I can read and hear. Thanks for the great vids!
I'd like to see a video comparing and contrasting the human biochemistry with regards to eating a pure fat diet versus a pure carbohydrate diet over a day, week, month and until death. With considerations to a hypo-caloric, iso-caloric and over-caloric calories of these single macronutrient diets. Biochemistry of liver, muscle and fat cells. Hormonal communication btn the various organs including the brain, heart, kidney and the aforementioned.
Thank you very much indeed. However, what is the difference between acetyl CoA used in the first step in synthesis and the one used to produce malonyl CoA?
Thanks for ur efforts! u made it much easier. but frankly, this is the most difficult lecture i ever watched on ur channal😔😔 why our body is this complicated ?!! 😅😅
hey , just wanna put out some love out there , would have probably honestly failed without you. you put the video up just in time for my exam. i would suggest having other topics in biology explained by you or your colleagues . as currently the explanation videos of science and especially current biology is of very low quality. much love . peace
Is this a little incorrect? You need another "charged manonyl group" to get on there and act as a nucleophile upon CO2 leaving. Then it can attack an acetyl, CoA.......but you don't have the last step set up for that.....isn't the chain supposed to be on the Cys-S- side(flopping back and forth so to speak) as it grows in order to provide access for a nucleophilic attack?
Thanks for all those helpful lectures .. but I have a little question .. does the acetyl bind first with ACP !! I've read it in Harper I guess that the Acetyl bind with CYS-SH while the Malonel bind with ACP.. Can u please tell me which references do u use ??
From what I understand it's also O.K. to write it like you did below, the only thing being it's 14 H+ as you are using also 14 NADPH's. By using that stoichiometry you are taking into consideration also the ATP molecules you used in the 7 reactions of the Acetyl-CoA Carboxylase reaction.
Yeah. Biotin is a coenzyme, meaning that it is needed for ACC to function properly. The carbon from HCO3- binds to biotin before getting transferred to acetyl-CoA and if there is no biotin, this step can't proceed meaning we won't be able to commit acetyl-CoA to fatty acid formation
Mr. AK, its me again, first step is catalyzed by acyl transferase or acetyl transferase? or it doesnt matter which one? bcoz acyl n acetyl are different molecule. thanks for posting anyway
+CitraTheKrumZ It's Acetyl-Transferase, it transfers an Acetyl residue from Acetyl-CoA to the -SH group of Cys in the Conjugating ensyme which then conjugates this Acetyl residue with the Malonyl residue placed on the Phosphopanteteinil group and CO2 is then removed.
Biotin is a carrier molecule of CO2. It's what holds onto the CO2 for the carboxylase to add it to the acetyl CoA. Biotin is attached to the acetyl CoA carboxylase enzyme
Wow that must have been so much effort to write and draw all that! my biochem exam is next week! Thankyou so much!
Hello, I am very glad, you exist and make those videos. I would like to see all of them, your videos are really helpful. You are really amazing teacher and very good speaker, I am czech and I understand you every word. Very good job. I wish you all of the best.
Ak you have been the best so far.. I actually used your video as a substitute for my text book when I had enzymology text.. and here I am using your video for a substitute for lipid metabolism text..
I appreciate your efforts in putting up those writing and skillful representations to avoid imagination..
thanks again
You're a saint for helping us get through these tough classes. You should set something up so that when students become doctors, you get free medical care for life :)
Thank you so much man! You're a lifesaver! I really appreciate your detailed drawings- it takes me a while to write them in my notebook, so I assume it takes you a long time drawing them. I really appreciate your efforts and am so thankful!
Thanks for saving my life. You are my hero. Best teacher in the world. Thank you.
sir... i almost write you comment on every video i watch for you because i'm always fascinated by your great explanation and the way you get into deep details ... just exactly what i need for my medical biochem class..... i'm forever thankful and this channel is underrated it is actually perfect
Thank you so much for making these videos! I was having trouble understanding this process since lehninger biochemistry is rather advanced. Somehow you manage in 16 minutes so make everything crystal clear wheras the book and my lecturers failed to do so after many hours. A first year med school student thanks you dearly. Cheers from Sweden
This is really a great video! The graphic you drew is the best I could find in the net and you explained it very well! Thank you very much!!!
Thanks for saving my biochemistry. You are a great teacher.
I don’t know how to thank you 🙏!
You’re the best ever man who have youtube channel .. you should get a huge award for this ! Even if they gave me Nobel award .. it would be not enough to give it u!
Aye man good luck to whomever has a biochemistry final exam coming up. Mine is in exactly 2 weeks and I'm just starting to study for it. This shit looks so tough man :(
I Always watch your lectures because you just make my learning 1000% more efficient and save me tons of time. I wish you were my lecturer. Thank you very much.
thank you so much for the effort
im so glad that i found your channel ,, its really a BIG help ! i literally would fail without your videos
please keep up the hard work
Thank you so much!! You help me a lot in understanding Biochemistry 🙏🏼
I love all my professors, but as a person who has little to no background on biochemistry and then taking the class in med school, they sometimes go too fast for me to understand. Thank you for all these lectures!!
Im in the same boat. How is it going for u now? Ur still surviving med school? Im in Block 2 dying with all this biochem 😥
@@lucilaalvarez5034 u still alive? lol
sir, thankyou so much you really helped my degree life. i wish you all the best in everything. regards from Malaysia!
I think the FAS enzyme activity of building Fatty Acids is way more complicated than the regulation of AC Carboxylase
you are amazing, your videos are brilliant and highly appreciated. thank you
I really need this , hope one day after I graduate to comeback and watch this again
Ur videos cleared all my doubt in this chapters. really a perfect explanation . Thank you 😄
You made me speechless
Thanks aloooot may god bless you
you are amazing! without you I will definitely fail in the biochemistry! plz keep uploading more videos!
Very to the point presentation. Good job! Pls keep uploading more.
I love love love all d videos of yours . those help me a lot to understand the things deeply and also in a easy way . thank you very much for making such amazing videos .
So much effort on the board with super cool diagrams👌.. Cellular metabolism is easier for me now💯👏
Thank You So Much! Your videos are very very helpful
Thanks, sir it is very nice and easy to digest. Thanks for the efforts taken to simplify such a difficult portion in detail pls continue it for us, sir.
I'll have to admit that this video is better than the one from ninja nerd . Thank you. Easier to understand and just to the point
wooow loud and clear
thank you so much
I appreciate you so much. thank you sincerely
Finally got it thank you so much
Thank you so much. This is great
very nice sir
God bless you
thank you so much sir.i really use your videos to revise for biochem exams.its amazing.thanks again.keep going plz.regards from kenya
thank you very very very much
So amazing lecturer,big up to u
OMG, i finally got it thanks to you!!! thank you so much for making it easier!! :)
best wishes for you,,,thanks a lot,,
thank you so much sir.it was really helpful.
Thank you!
You’re a legend, some heros are fr hidden
U r such amazing
Thank u so much🌺
Thanks.
Thanks so much the video was so helpful
thanks very much for your efforts 😍good future for you ❤👌
👏👏👏wow, very helpful. Thank you so much
Would be awesome if you got subtitles for your videos :) the auto one is okay, but sometimes not correct and I find it better to learn when I can read and hear. Thanks for the great vids!
handsom,thanks so so so much💌💙
I'd like to see a video comparing and contrasting the human biochemistry
with regards to eating a pure fat diet versus a pure carbohydrate diet
over a day, week, month and until death. With considerations to a
hypo-caloric, iso-caloric and over-caloric calories of these single
macronutrient diets. Biochemistry of liver, muscle and fat cells.
Hormonal communication btn the various organs including the brain,
heart, kidney and the aforementioned.
Is the acyl-malonyl ACP condensing enzyme a domain of the FAS or is it a separate enzyme?:)
Thank you very much indeed.
However, what is the difference between acetyl CoA used in the first step in synthesis and the one used to produce malonyl CoA?
Thanks for ur efforts! u made it much easier. but frankly, this is the most difficult lecture i ever watched on ur channal😔😔 why our body is this complicated ?!! 😅😅
Hossam Hossam 😂😂
انت طب بشري تانيه؟؟
عراسي 😙 وانت موفق.. بس عنجد يا هيك الشرح يا بلا.. فخامه يا زلمي 👌
طب بشري تالتة
hey , just wanna put out some love out there , would have probably honestly failed without you. you put the video up just in time for my exam.
i would suggest having other topics in biology explained by you or your colleagues . as currently the explanation videos of science and especially current biology is of very low quality.
much love . peace
Noe. Biochem is lyf. Just kidding...
круто объясняешь
Hey Genius, can you please so a video on pulmonary function tests??👍🏽🙏🏽🙏🏽🙏🏽
Is this a little incorrect?
You need another "charged manonyl group" to get on there and act as a nucleophile upon CO2 leaving. Then it can attack an acetyl, CoA.......but you don't have the last step set up for that.....isn't the chain supposed to be on the Cys-S- side(flopping back and forth so to speak) as it grows in order to provide access for a nucleophilic attack?
Thanks for all those helpful lectures .. but I have a little question .. does the acetyl bind first with ACP !! I've read it in Harper I
guess that the Acetyl bind with CYS-SH while the Malonel bind with ACP..
Can u please tell me which references do u use ??
Thank you. ..but is really the carboxylation irreversible? I've read that's reversible
Good explanation lecture
This video explains How you could ingest something killed you to understand in just 16 minutes
that is one involved whiteboard
(4 carbon) the last sentence
I owe you my grades!!
The video is sliiightly cut short in the end; not enough time to finish saying 4 Carbon Molecules (only gets to "4 c...")
amino acid S is serine not cysteine , amazing video though thank you!
Help needed:
The stochiometric equation of fas:
1Acetyl coA + 7 malonyl CoA+ 14 NADPH + 14Hplus-------------> 1Palmitate + 14NADPplus + 7CO2 + 6H2O + 8CoA
Could this be also written as??
{8Acetyl coA+ 14 NADPH + 7 Hplus + 7ATP--------> 1 palmitate + 14 NADPplus + 8 coA + 6H2O + 7ADP + 7Pi } ??
please help!
From what I understand it's also O.K. to write it like you did below, the only thing being it's 14 H+ as you are using also 14 NADPH's. By using that stoichiometry you are taking into consideration also the ATP molecules you used in the 7 reactions of the Acetyl-CoA Carboxylase reaction.
What if we don’t have enough biotin? Would that suppress fatty acid formation?
Yeah. Biotin is a coenzyme, meaning that it is needed for ACC to function properly. The carbon from HCO3- binds to biotin before getting transferred to acetyl-CoA and if there is no biotin, this step can't proceed meaning we won't be able to commit acetyl-CoA to fatty acid formation
I LOVE YOU
can i get that note behind u
Mr. AK, its me again, first step is catalyzed by acyl transferase or acetyl transferase? or it doesnt matter which one? bcoz acyl n acetyl are different molecule. thanks for posting anyway
+CitraTheKrumZ It's Acetyl-Transferase, it transfers an Acetyl residue from Acetyl-CoA to the -SH group of Cys in the Conjugating ensyme which then conjugates this Acetyl residue with the Malonyl residue placed on the Phosphopanteteinil group and CO2 is then removed.
+Adnad Omerovic yep thanks, I was misheard between acetyl and acyl
I love you
Doesn't the fatty acid synthase complex have *6* domains and an ACP domain? You said 7 🤔
Great video. Btw what ethnicity are you?
An alien... duh caucasian.
Sir what is use of boitin in first step.....pls do reply
Biotin is a carrier molecule of CO2. It's what holds onto the CO2 for the carboxylase to add it to the acetyl CoA. Biotin is attached to the acetyl CoA carboxylase enzyme
13:27 for screenshot
its too hard :(
where is your beard ?
Bhoo here 😁😂🤦♂️