Transition State Analogues/Inhibitors - Medicinal Chemistry 1.13

A chemical reaction will go through a high-energy intermediate state called the transition state. One strategy that drug discovery scientists came up with is designing an inhibitor that resembles the structure of the transition state. Also, this inhibitor could potentially bind strongly to the active site, even much stronger than the substrate or the products. This type of inhibitors is called transition state analogues or inhibitors.
By definition, transition state analogs are compounds with chemical structures that resemble the transition state in the enzyme-catalyzed reaction. Even though the transition state analog or the inhibitor resembles the structure of the transition state, it is much more stable than the transition state itself. The two primary tools for characterizing transition states are kinetic isotope effect (KIE) and computational chemistry, or a combination of both.
Two examples of transition state analogues/inhibitors would be methylthioladenosine nucleosidase inhibitors and HIV protease inhibitors.
-About me-
I am a computational chemist in the pharmaceutical industry. I created the Mole Man Chem channel to explain some basic medicinal and biochemistry concepts because I believe the best way to relearn a concept is through teaching.
Feel free to email me with any questions at [e-mail]
-Video lists-
Medicinal chemistry playlist: • What Is a Drug, Therap...
Drug discovery explained playlist: • What is the controvers...

[@EdT.-xt6yv]

1:45 compound/inhibitor= TS-ANALOG