Paracetamol (Tylenol; acetaminophen): How can the potency be increased?

Paracetamol (aka Tylenol; acetaminophen) is a weak analgesic and people often wonder if the potency can be increased. This video discusses that, and the safety issues around the drug.

[@Suitswonderland]

Is it not they are just metabolised different, since they are both COX 1 inhibitors the stomach issues which come when combined or even used alone.

[@PharmacoPhoto]

Hi, the research is still saying that "the precise mechanism is still uncertain" and that the primary mechanism may be central (brain) rather than peripheral (COX enzyme(s)). Here is the abstract from one of the most recent reviews: Paracetamol (acetaminophen) is the most commonly used over-the-counter (OTC) drug in the world. Despite its popularity and use for many years, the safety of its application and its mechanism of action are still unclear. Currently, it is believed that paracetamol is a multidirectional drug and at least several metabolic pathways are involved in its analgesic and antipyretic action. The mechanism of paracetamol action consists in inhibition of cyclooxygenases (COX-1, COX-2, and COX-3) and involvement in the endocannabinoid system and serotonergic pathways. Additionally, paracetamol influences transient receptor potential (TRP) channels and voltage-gated Kv7 potassium channels and inhibits T-type Cav3.2 calcium channels. It also exerts an impact on L-arginine in the nitric oxide (NO) synthesis pathway. However, not all of these effects have been clearly confirmed. Therefore, the aim of our paper was to summarize the current state of knowledge of the mechanism of paracetamol action with special attention to its safety concerns.