What is Parkinson's disease? | Nervous system diseases | NCLEX-RN | Khan Academy
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- čas přidán 2. 06. 2024
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so many things that can go wrong with the human body. its amazing everyone just doesn't drop and die.
lol
i have ocd, tourette's , and multiple personality disorder ... i shouldn't exist right now honestly
+THE16THPHANTOM Everyone dies sooner or later...
+THE16THPHANTOM Living DOES have the highest death rate...
True that
i love the narrator's voice so much
Chinh Tran Ikr!?
+Chinh Tran the thirst is strong
"ear orgasms"
+Wildd Cardd lmao😂😂
All i could hear was Mouse Squeaking
Phiphiphiphiphiphi
My grandfather worked in Vietnam during the Viet nam war and our family has long thought that Agent Orange caused his Parkinson's. Its so enlightening to hear now that pesticides/chemicals can cause Parkinson's.
thank you so much for this video! it really gives good insight on Parkinson's disease. This helped me to understand my dad so much better.
My mom has it. 😪😢😳
Author Janae Marie same :,(
@@AuthorJanaeMarie Hi. Sorry to hear that. Does it have a stable treatment?
Don't you hate it when you find some illness and you have all of the symptoms and most of the causes...
Yup
Old post, but yeah. I read a lot on this sort of stuff, nearly all diseases have symptoms that the average person likely experiences.
Aric Ley The only one i didn't have was the metal part. After the video I learned that I have parkison's disease in my family tree too.
Conspiracyman Yeah my best friend has it (hence what brought me here, to learn about it) and she doesn't have the metal symptoms either but everything else. Darn that sucks, if you're in your 20s or over I think you should be fine (if you're worried you should talk with your doctor though to make sure). Just try to live a healthy life as best as you can man. This disease is no joke for sure. Technically it's worse than cancer in my opinion cause there is no cure.
exactly
That's it what it feels like walking in water the slow resistance walking against the water. I've had such difficulty in explaining what I feel like. i am a young onset patient and people tend to expect me to be as though I'm in my 40s when my life is really like an 80 year old. Parkinson's is total devastation like the person I used to be died and was replaced by this version that physical and cognitive limitations
Debbie June Jeffries My dad is 43 and has been diagnosed with Parkinsons whenever he was 37. Youre not alone.
I'm so sorry for you diagnosis, I can only imagine what it must be like everyday. My best advice, as cheesy as it sounds, is that you have to stay positive and look for the good in every situation. You are a fighter and will move many people's lives for that reason, we're given difficult situations not because we deserve them, but because we are strong enough to handle them and surpass them. I hope you are still living life to the fullest in the best way you can, you have a new life, but it doesn't mean it can't be beautiful, I wish you the best:)
I've been saying for years, I feel like a giant rubber band is holding me back.
You have a very good voice and speech. God bless.
I love how she narrated and how clear her diction is. thank you so much!
You're doing a great job khanacademymedicine. THUMBS UP FOR YOU!
Thank you very much! Super informative and beautifully-drawn. I enjoy your voice as well.
I bawled my eyes out listening to this video. My heart breaks for my fellow human beings suffering from this horrible disease. Even though I'm perfectly well.
I just want to say THANK YOU from the bottom of my heart for all your videos, I am in nursing school and it's sad to say, but true that your videos teach me much more and engage me much more than any of my professors. THANK YOU X a million!
I do have a book for you
Wow you really broke this down very nicely. I have a friend with PD so just wanted to become more familiar with it 😌
Quality and informative video! I enjoyed this.
Thanks a lot ! I want to become a surgeon so thanks for the medical info 🚑
Thank you for the video.my mother got diagnosed with Parkinson's yesterday.apart from the tremors and stuff I hadn't a clue about it.very informative.
Rest in peace ali the idol of generations
ideal
Anthimos Konstantinidis &&hs
Thank You, very Informative video.
Rip Muhammad
Muhammad who, Muhammad who??? Muhammad Ali!!! He's Cassius Clay my friend!!! Have a great day.
@@SkyhighStarlight ???
Have some shame
@@ornament_of_throne12346 It was a joke. Jesus Christ.
@@SkyhighStarlight where you live. drop location
@@insect6003 Im in Russia. An hour trip from Moscow.
Very helpful,great video♥️
Excellent explanation thank you
This is the first time since my diagnosis that I understand what Parkinson’s is. Thank you so much, medical professionals don’t seem to know what to say or how to say it.
VERY HELPFUL :) THANK U SO MUCH !
Great video! You have a very soothing beautiful voice and really good information! Thanks!
Brilliant video, thanks
Thank u so much I wanted the quick revision..U explained it really well
Anne Hathaway played a character with early onset of Parkinson's in the movie Love and Other Drugs
thank you. my dad was diagnosed with Parkensons earlier this year, and your videos are helping me understand it better. for some reason i dont get so scared or upset when it explained in a medical/scientific way. xo
I do have a book for you
@jacie
This symptoms are seen in my mom
Can u told me it cure by medicine or possible to do surgery.
@@Surya_Rao
There is no cure...im so sorry.
Science is making great strides in research into parkinsons and surgery is avalible to lessen symptoms, however this is no cure.
One of the most recommended drugs in the parkinsons community is marijuana or CBD oils to help symptoms.
I'm so sorry to hear about your mum, I will pray for her tonight.
Great video. But I miss one important thing. The differences in Parkinson forms (Tremor-dominant and Akinetic-regidity). So is Tremor-dominant less agressive with more physical problems than cognitive problems. Akinetic-rigidity is very agressive with a lot of cognitive problems.
I was on risperidone for two weeks and I was starting to develop this slowly until I quit
i love Khan Academy :*
thanks for the video help my family understand what I have 😁
I'm currently doing a research placement and the scientists there are looking at whether vitamins can prevent the death of those dopamine neurons. So far they are showing brilliant results with vitamins B3 and D3, mainly D3. So if you're a panicker then these vitamins may be a good place to start.
D3 and B3 will help?
Great video
There you go, always someone, willing to contribute with a good "dose" of criticism, "squeaky" sound!
Thank you!
thank you so much
RIP TO THE GREATEST OF ALL TIME MUHAMMAD ALI MAY GOD ACCEPT YOU IN HEAVEN
You have beautiful hand writing too.
Thank u !!
Thanks sir g🙏
My dad has this and it's so sad to see him like this.. He sleeps a lot and when he's home he looks around like he don't know where he's at
Stevie from Good Mythical Morning, is that your voice?
You explained it really well. Thank youu☻
Thank you so much, this really helped me in my physiology class
I have at least half of these symptoms including tremors
I love my new INBRIJA inhaler. Anytime I feel an off period I just use my inhaler and I’m back on within minutes of using it.
My pops had Parkinson’s he passed away some time and he was in the later stages and it killed me when I saw him on his death bed
My friend was diagnosed with PD(Parkinson’s Disease) in the summer of 2012 and I was diagnosed 5 years ago. Her initial symptoms were quite noticeable so was mine. She first experienced weakness in her right arm and her speech and swallowing abilities were profoundly affected. She did so much to seek help for this disease, as she had been her brother's caregiver a few years earlier for the same disease. Early this year she started on organic/natural PD treatment from Best Dr Madida on CZcams which she introduced to me too. The treatment worked very effectively and all her symptoms and mine simply disappeared completely after 7 weeks of usage.
I'm here from Kjaerbye.
Hi there, I have a question regarding the treatment part. Does physiotherapy have a role in the treatment plan of the disease or even can affect it in any way ?! and why ?!
R.I.P Ali
very nice video.. my grandfather have this condition .. i really dont know what to do until i tried ayurvedic products by planet ayurveda.. they showed a lot of improvement in case of my grandfather
what is the software that is used to make these videos?
Good
Oh lord....I have like 80% of these symptoms
I bet the narrator is Canadian lol
+Sassy Cat I don't know lol, maybe accent
thank you for saying that
You can hear it because of the way she says "about".
well, i bet she speaks English
I'm a 16 year old male and I may have Parkinson's disease
What about alpha-synuclein aggregation as a cause of PD?
I know a person when they pick up something they shake so much and I'm very concerned should I be worried is this Parkinson's disease?
Can you get Parkinson’s from too much stress , depression, or anxiety? Cause i have all 3 and my hands tremble sometimes but not all the time , or can i have tremors because of something else?
did you fucking draw all that with a mouse??!!
No, she might be using a tablet and a touch-pen/stylus. A mouse wouldn't create such precision
Idk I've seen some pretty good mous drawings so it's the same to me
Pen and tablet, Like a WAcon
Can't you just give them cocaine, that's a dopamine reuptake inhibitor....(yes I know a lot of other bad things happen with cocaine)
you're right..
Well, then dopamine would accumulate in the synapse so it'd lead to an amplified signal to the receiving neurons. It'd be bad for the brain because dopamine can interact with other chemicals to become a free radical. There's a looot of articles online that state Parkinson Disease could be attributed to cocaine abuse as well.
R.I.P Ali :'(
Can you get Parkinson's disease from getting struck by lightning? Or from too much stress?
Here goes,
Posting this here because I know some of you do research and think I may have stumbled upon a very important insight concerning the etiologies of various neurodegenerative disorders and maybe degenerative disorders in general.
I’ll cut to the chase and ask the question and then explain how I got to the hypothesis. It is: Is it possible that distinct neurodegenerative and musculoskeletal degenerative disorders are in fact be specific symptom complexes that correspond to dysfunction of specific substructures of the cervical ganglia which subsequently alter certain functionalities of the choroid plexus and have downstream effects on the basal ganglia and spine?
A recent medical situation in my life prompted me to conduct some personal research to better understand my condition. As a result, I became familiarized with the dynamics of a specific system of structures in the body that, if better understood and regarded as a unified whole, could potentially shed a brighter light in the etiologies of degenerative disorders.
Essentially, my research led to make connections between three structures in the neck and head: the cervical ganglia, the choroid plexus, and the basal ganglia.
A few observations became key in developing this idea about cervical ganglia involvement in degenerative disease. The first had to do with the basal ganglia. Basal ganglia dysfunction can cause a dearth of dopamine in the brain and subsequent cluster headaches and Parkinsonism/movement disorder symptomatology. This structure controls voluntary movement in the body and so in the case of movement disorders, it is usually the culprit. The question then becomes what is the fundamental cause of this dysfunction?
jamanetwork.com/journals/jamaneurology/fullarticle/784785
Thinking about a specific syndrome called Eagle’s Syndrome which often presents with symptomatology similar if not identical to that of neurodegenerative/movement disorder. Eagle’s Syndrome is an abnormal ossification and elongation of the styloid process at the base of the skull that interferes with the cervical ganglia and carotid arteries in the neck and creates symptoms.
actascientific.com/ASDS/pdf/ASDS-02-0202.pdf
I wondered if superior cervical ganglia dysfunction could have downstream effects on the basal ganglia and cause disorder. So I began to attempt to understand the dynamic relationship between the cervical and basal ganglia.
I began to look more closely at the cervical ganglia, in particular the superior cervical ganglia. This structure innervates the eye, parts of the face, the throat and sinuses, stimulates mucous production, has a part in regulating heartbeat (an aside: the disruption of the cervical ganglia when an Eagle’s Syndrome sufferer turns their head can result in panic symptoms: palpitations, dry mouth, gagging, so this could be a tool when thinking about mental heath physiopathologies as well), and also found that it is the only peripheral structure that sympathetically innervates areas of the head and brain. In particular, it innervates a structure in the brain called the choroid plexus. This was the next bridge on my way to the basal ganglia.
en.wikipedia.org/wiki/Superior_cervical_ganglion
The choroid plexus and found that it has a few very important functions: 1. To release transferrin that promotes iron homeostasis in the brain 2. Send agents to bind with antibodies to be flushed out of the system when infections are resolved and 3. Stimulate production of cerebrospinal fluid. That all struck me as fairly promising.
en.wikipedia.org/wiki/Choroid_plexus
I started with antibodies and found articles about post-infection movement disorders (specifically PANDAS, about which there is now literature about non-pediatric cases) where it is shown that sufferers have anti basal ganglia antibodies.
www.ncbi.nlm.nih.gov/books/NBK333433/
It struck me that if a substructure of the cervical ganglia that innervates parts of the choroid plexus that promote production of antibody binding agents is dysfunctional, an infection could very well trigger an indefinite autoimmune response, attacking the basal ganglia and other systems. Some neurodegenerative and degenerative disorders like MS are thought to be autoimmune, and disruption of the cervical ganglia and subsequent introduction of infection could precipitate an indefinite autoimmune response. Symptom progression might depend on the nature of the ganglia dysfunction (if it is ongoing, say, due to injury and resulting occlusion, or intermittent, say, due to Eagle’s Syndrome, in which turning the head causes ganglia disruption), theoretically accounting for the different subtypes of MS.
www.nationalmssociety.org/What-is-MS/Definition-of-MS/Immune-mediated-disease
I also had the thought that if iron deregulation in the brain could be caused by dysfunction of a specific substructure of the cervical ganglia and subsequently the choroid plexus, maybe iron irregularities in the basal ganglia would be observed in sufferers of movement disorders, and sure enough, it’s observed in most, if not all of them. At this point I felt like I was really onto something.
www.ncbi.nlm.nih.gov/m/pubmed/22266337/
And then a thought occurred to me: what if the first domino to fall in the etiologic chain of ALL of these degenerative disorders begins in the cervical ganglia? This could be why there are peripheral nervous system symptoms that manifest early in diseases like MS (the cervical ganglia innervates the eye and throat and heart, so vision dysfunction, dysphasia, heart rhythm problems etc would be some of the first symptoms you’d expect to see in this etiologic formulation). I’d seen papers talk about a corticothalamic basal ganglia circuit, but not much of anything about the cervical ganglia or choroid plexus, and I thought, “maybe the cervical ganglia is part of that circuit, affecting it indirectly but very profoundly.”
Not everyone who suffers from degenerative diseases would have Eagle’s Syndrome of course, but maybe there would be occlusion/tortuosity of the ECA or cervical ganglia, or maybe a trauma shifted their positions leaving the cervical ganglia susceptible to injury, or maybe genetic degenerative disorders’ gene expressions simply omit instructions for certain substructures of the cervical ganglia to form and subsequently instruct the choroid plexus.
So the idea is, if there are three main tasks of the choroid plexus, then there are seven combinations of those tasks (1; 2; 3; 1+2; 2+3; 1+3; and 1+2+3), and there are two ways for each of those tasks to dysfunction (over-firing or under-firing, although I’m not exactly sure about this detail), then each combination of simultaneous or sole dysfunction of cervical ganglia substructures which correspond to areas of the choroid plexus that are involved with completion of one of these three tasks would represent a distinct symptomatology-i.e., a distinct degenerative disorder.
Important to note is that for antibody binding dysfunction due to lack of transferrin to become part of a neurodegenerative symptom complex, it may require an initial infection of a certain type to kick-start an autoimmune response strong enough to manifest in this way. In my reading about PANDAS I came across mention of “molecular mimicry,” and I thought maybe it was possible in the case of infections that feature such molecules, and in patients that have cervical ganglia dysfunction, that since the infection that the immune system (now totally unchecked by transferrin-aided antibody binding) is targeting resembles healthy structures in the body that all of these factors compounded could lead to ongoing destruction of healthy body tissue.
It may be the case that I’m off base, or there are ways to easily prove false all that I’ve said, but I don’t know that. That’s why I’m posting, because in the unlikely event that this is not totally crazy, and might actually be plausible, it will be in the hands of people who can do something with it. A theory is judged by its explanatory power, and to me, this one seems to explain a lot. Could it be the skeleton key that unlocks understanding of these diseases and leads to new treatments and potentially cures? Is it simply that the cervical ganglia needs to be attended to more intensively when these disorders manifest?
According to the literature, somewhere between 80-95% of Eagle’s Syndrome patients who undergo styloidectomies have complete cessation of symptoms. If I am right about the cervical ganglia’s role in degenerative disorders, and some of these patients’ styloid process was in contact with their ECAs and cervical ganglia, the neurological symptomatologies that presented may well have progressed into full-blown neurodegenerative disorder if left unaddressed. It could very well be the case that these successful surgeries represent instances of the curing of previously thought to be incurable neurodegenerative conditions. But again, Eagle’s syndrome merely represents one mechanism of action that could cause cervical ganglia dysfunction.
I’d appreciate any response, even if it’s to tell me why I’m off base. I hope you’ve read with an open mind, and were willing to ask yourself “what if?” So, the question is: is it possible that superior ganglia dysfunction is the primary etiological feature of a host of neurodegenerative disorders? That this could be a unifying theory?
THANK YOU SO MUCCCHHHH U JUST SAVED MY LIFE
I can't with the mouth sounds, hahahaha suddenly I felt the urge to chug a 1 gallon of water
Anneka Dungca OMG YES
Did she say a dope meme neuron?!?!?
yes.
Farvids Dopamine producing neuron they die from parkinson's. Dopamine is a chemical needed to move. i know too well i have it
Debbie June Jeffries I'm aware
Farvids No you she said dopamine
Farvids Dopamine
Great video. I have a question, does Parkinson's present more on certain race?
Of course not, it just depends on your health I guess. We are all the same, so yea.
+Gerardo Soriano
www.ncbi.nlm.nih.gov/pmc/articles/PMC2865395/
+Tory Gaming
Yeah, all races look the same, so yeah.
Charybdys :D
👍👍👍👍
RIP Muhammed Ali
culprit - Übeltäter
I got parkinson now ill be 65 april.1 my syptons are getting harder to deal with quickly i have 3 children and devorced question what do you know about turning glieal cells of the brain into neurons human trials i was into cbs in my 4yr honorably dis charged duty at a young age 17 yrs please help me
My grandma has it
i heard that weed helps with the shaking .
is a coughing fit a sign of parkinsons?
if so hillary has it
Look up Parkinsins in the on line encyclopedia. I don't believe coughing is but there is a swallowing disorder that should make you cough. Fluid goes down into the lungs and causes parkinsons pneumonia I believe that would cause someone to cough..
because my hand shakes more than others would that mean I have it?
Why don't you talk about physical therapy for treatment? It is an alternative for surgery
where can I find sources? I'd like to learn more
can't we me make dopamine artificially?
Not bad
My mom has just been diagnosed with this recently. I'm so scared.
Author Janae Marie same
Happy Potter How are you two handling it?
My mom has had it for a few years. It gets worse but it’s all about keeping a positive attitude and to always laugh At yourself. It makes it easier to deal with if you just learn to look at the positive side and not sweat the smaller things and just try and be happy
Enjoy every day with her!!!
We will be okay 👌
6:23 I don't know why but my dad is in his 50's and have parkinson's disease
So a lot of old people have parkinsonism?
A great video, but I can't get through it all, you really need to drink water, all the smacking and swallow 😷
I am worried because it feels like my bed is shaking when it’s not. It’s been happening all year. I moved and it still happens, so it’s me. And I can be holding my phone out right in front of me, and the phone is moving. So I guess I’m having tremors. But if I hold my arms straight out in front of me, everything is fine and I’m not shaking. Maybe it’s subtle and it’s going to get worse. Sometimes I can wake up and my heart feels like it’s in a panic
Watchs this once
Me: i have Parkinson's
Muhammad Ali brought me here
Hopefuly they'll come out with a good drug that would help. If it is hereditary it will happen. 2025 will be a global research for that. Do they start losing their memory too?
marlene ramos ayurveda system of Medicine already has treatment for it
Hillary???
my lecturer spent an hour for the same amount of info
everybody has it some time 's
the wheezing in the "s"es
that bugs me too
when she said 'dopamine' I thought she said dope meme XD
My grandma has it...💔
I came here from
Oniosion's video lmao
Tylerisdunwityou me too lol
now i know
Daisy award nominations
non-genetic risk factors:
exposure to pesticides, cleaning chemicals
history of concussions
regularly breathe in copper
more likely for men
My moms been diagnosed with this. 😭