Pharmacology of Anti-Arrhythmic Drugs | Dr. Shikha Parmar

Heart arrhythmia, also known as irregular heartbeat or cardiac dysrhythmia, is a group of conditions where the heartbeat is irregular, too slow, or too fast. Arrhythmias are broken down into Slow heartbeat: bradycardia. Fast heartbeat: tachycardia. Irregular heartbeat: flutter or fibrillation.
Symptoms of arrhythmias include
(1) Fast or slow heartbeat
(2) Skipping beats
(3) Lightheadedness or dizziness
(4) Chest pain
(5) Shortness of breath
(6) Sweating

[@tanmaysharma3103]

Thanks Dr. Shikha, Your videos are always helpful and i just wanted to thank you for putting the effort to create them :D

[@footballWorldsss]

Am Watching And Getting Everything 👌

[@24kokilae51]

Very easy undersanding, Excellent job mam❤️ please make more videos

[@alishachauhan1361]

Thank you ma'am ☺️

[@dr.rajeshsingh9690]

Mam as you have put Sotalol in class II but it has potassium blocker properties also? Do sotalol is safe to be used on opd basis for an elderly fit and fine persion having assymtomatic aFib. Do there is no risk of torsade from Sotalol use? Kindly brief about it. Thanks.

[@sanjayjoseph950]

Straight home run from the bat.. This is best VDO u need to pass ur cardiology topic. This VDO is of the highest quality in content and presentation. Thanks a lot

[@DrShikhaParmarClasses]

Thanks a lot for your rewarding and inspiring words to do better

[@onyaguchinyere806]

Thank you ma i always watch your video before reading any topic in pharmacology. Keep up with the good work.
You teach with my school curriculum

[@DrShikhaParmarClasses]

Great! Nice to know that you are finding these videos helpful 🙂

[@pavasowbi6852]

Very nc session

[@user-ph2me2ed4c]

Wow ❤❤❤❤
Greeeeeeeeaaaaaaat💞💞

[@kesavanR007]

❤

[@med_abhinav]

Really very nice explanation 😊
Thank you ma’am .

[@DrShikhaParmarClasses]

Thanks for liking 🙂

[@tahiransari5270]

Good

[@24kokilae51]

Torsade de point is twisting of peaks but when do Q-T interval prolong mam

[@DrShikhaParmarClasses]

Certain medications, electrolyte abnormalities like low blood potassium, low blood calcium and disease states like intracranial hemorrhage, heart failure can prolong the QT interval. Prolonged QT genetic syndromes also exist.

[@riteshchaurasia8016]

Is it necessary that if there is decrease in effective refractory period then there isrolongation of action potential duration

[@DrShikhaParmarClasses]

during a cardiac cycle, once an action potential is initiated, cardiac cell contacts and relaxes.
Now cell enters ERP, where new action potential cannot be initiated. So, if ERP is prolonged, it means there is prolongation of action potential duration as the cell can respond to stimuli again only when this ERP is over.

[@obiwan922]

34:57 Why does the repolarization curve for Class 1C match with the repolarization curve before antiarrhythmic drug given (i.e. normal heart action potential curve)? We know the Y-axis represents time. And the starting point of depolarization curves for Class 1A, 1B, 1C are all same. In the graph; in case of class 1C the depolarization curve reaches peak most lately (in comparison to other depolarization curves). In addition, if plateau phase starts from that point, shouldn’t the repolarization curve for class 1C finish later? So how does that make no change in action potential duration?
P.S. Y-axis should read X-axis.

[@DrShikhaParmarClasses]

Please refer to the Action Potential curve (8.09 min) once again. It is not Y axis but X-axis that represents time.
Yes, in the graph, in case of class Ic the depolarization curve reaches peak most lately because these drugs are very potent blockers of Sodium channels thus they show marked reduction in conduction velocity and fall is slope of Phase 0.
Very important to understand that prolongation of Action Potential duration is due to Potassium Channel blockade. Refer to graph of Action Potential if potassium channels are blocked repolarization of cell will take longer time. Class Ia drugs increase APD because they also block potassium channels while class Ic drugs do not block potassium channels so they do not change action potential duration. Hope this clears your doubt.

[@riteshchaurasia8016]

Is it necessary if there prolongation of ERP then there isrolongation of action potential duration

[@DrShikhaParmarClasses]

during a cardiac cycle, once an action potential is initiated, cardiac cell contacts and relaxes.
Now cell enters ERP, where new action potential cannot be initiated. So, if ERP is prolonged, it means there is prolongation of action potential duration as the cell can respond to stimuli again only when this ERP is over.

[@pralayasahoo1825]

Mam plz can you tell me the name of the book 📖???

[@DrShikhaParmarClasses]

You can refer Essentials of Medical Pharmacology by K.D. Tripathi

[@001-vikasagrawal7]

Mam overall session is excellent in terms of understanding the basics of arrhythmias right from there pathology and using graphs in each class of drugs but mam there is less content in aspect of drugs like it's adverse effects,indications, interactions etc.

[@DrShikhaParmarClasses]

Basic understanding of the concept is the most important aspect of antiarrhythmics. Now you are not required to cram. You can easily memorize. Helpful not only for university but also competitive exams. Glad you have understood that.
Now For drugs please refer to a good book of pharmacology like Essentials of Pharmacology by KD Tripathi

[@001-vikasagrawal7]

@@DrShikhaParmarClasses ok mam🙏