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Thanks Matt for bringing many Weird science 🧪 stuff that many follow to some senses 👍🏻

I'd like to hear a comparison between rapamycin and anti-IL-11.

Please someone enlighten me. As i learned rapamycin is pro inflammatory. It creates inflammation. How is this inflammation cause increased lifespan? Paper: www.nature.com/articles/nri2457

Love that rapamycin idol sitting behind Matt’s chair 😂

Has anyone looked on the patent websites there are so many anti-aging patents. So why can’t the public get access to it.

I wish there were places where you could tell a biochemist what you need, and they could develop a therapy, gene edit, or molecule to fix it or replace what's lacking. Maybe AI will be the answer. Nothing is ever going to happen if relying on the FDA the process way to long and expensive.

Need to be responsible here by emphasizing on the side effects to calculate a benefit/risk ratio, useful for making informed decision.

To elaborate on the "cancer killswitch" point: If you've got cancer, that means that a bunch of other genes in the cancer cells have gotten mutated/switched on (oncogenes), while a bunch of others have gotten switched off (tumor suppressor genes). Moreover, the cancer cells that are driving the tumor growth have to have had repeatedly mutated in such a way as to successfully evade the immune system's innate anticancer defenses, in a malign version of natural selection. Thus, like Matt says, at that point the plasmid gene that initiated the cancer cascade likely wouldn't be playing any role whatsoever, so switching it off would be a useless endeavor.

Love these!

Could we build a computer model of the human body? That way every cell and tissue type could be monitored for best results before human trials.

Are cuts healing slowly

If Follistatin increases muscle, how many older people would not die from falling if they had more muscle? Didn't Dr Attia did a podcast on the percentage of people that die from falling due to lack of muscle approximately one year later?

There are drugs where untold people have died just waiting for the FDA approval! A DISGRACE! With offshore protocols, who knows when they would get approved for anti aging because FDA didn't even consider aging a disease that we ALL die from. THE FDA EITHER NEEDS NEW LEADERSHIP OR DISBANDED! The FDA has made raw milk illegal!

Bryan Johnson is playing an extreme game and he's definitely passed on the risk. However, I like guys like that in the sense that they can teach us a lot with their results. For people like me who want to tread a safer path, I'll keep an eye on developments. Assuming the people involved are honest on CZcams then what is happening is pretty cool!

Same here. Wasn't convinced until I took it for myself. Same effect. Didn't exptected!

Great video. Bryan has been putting out better and better content. Super HD quality and good editing + memes.

I did some digging on population levels and found the average follistatin level from various cohorts was 11-13.5 ng/ml. We don't know what assay they used, but on face value Bryan's pre-value seems low, and its perhaps no surprise they found beneficial effects in someone who was low to start with.

Great format, thanks from Italy!

Indian yogis laughing in the corner When you talk about longevity

I believe that Liz Parrish has received follistatin gene therapy (amongst other therapies) back in 2015.

Excellent science based explanation. Thanks Matt for your open mind!

I am sure there are some people over at rapanews that would do this gene therapy, along with their carnivore diet, blck market peptides, and supra physiological dosages of testosterone and be delusional enough to think they will live to 120.

If you don’t like sauna, all good. But I need to flag something her: there are human studies

Brian Johnson is young. When will he see any meaningful benefits, 70s? He doesn't look skin fresh 20s. Not even close to 40s.

Brian Johnson diet terrible. No variety, no organic. Don't remember but it was mediocre. Does he do high muscle mass bodybuilding? No steroids of course.

Brian Johnson a scam His bed is plastic petro foam toxic fumes. Avocado organic cotton why not w his $$$$. BJ sunplements are cheapo garden variety. I do better. He doesn't look a day older than 65.

I took the test where you upload a picture of your face. That internet site was mentioned once by Nick. Turns out my eyes look more than 20 yrs younger than my chronological age.

In terms of risk reward, there’s 100% chance you’re going to die if you do nothing!

Thank goodness for the wisdom of MK! I actually have friends who are considering this gene therapy. Now I am armed with necessary information to forewarn my dear friends and potentially save their lives. After all, if someone wants more muscles, they can get a personal trainer and hit the gym and do the necessary work. Food, exercise, sleep!

I have myself studied, kill switches. When these are introduced into cells, they give one the ability to cause the cell to commit apoptosis. There are a number of animal studies, as well as in prokaryotes. I understand that Liz Parrish also had a genetic therapy. I believe it was used to extend the length of her telomeres. Your podcast are excellent. Love to hear your thoughts on the Liz Parrish therapy attempt as well as others.

I'd like this format on a now-and-then basis, but don't turn it into a "reactions" channel. Follistatin gene therapies have been tried in various clinical trial settings in the USA. The delivery systems were different, but surely there is more info out there about the safety and efficacies measured so far.

I'd really like to know (maybe it's worth its own video?) what you think about Greg Fahy's thymus regeneration experiments/clinical trials.

Someone's gotta do it!

I appreciate you diving into the science, but it looks like you agree that people shouldn't have bananas in general 😂

I was surprised about the negative sentiment towards blood transferase. What about the way Alhahest does it? Or the Conboy lab with blood dilution?

Are you guys aware of the recent news article about the therapeutic that reduces interleukin 11 which slowed ageing in mice. You guys care to comment at some point. Its safe to use in humans as well.

I've heard you mention that a low-carb diet can be healthy, but a whole food plant-based diet can also be very beneficial. The latter often includes 60 to 70% of its carbs coming from healthy sources like beans, chickpeas, lentils, rice, and quinoa.

REQUEST for the co-host to stop saying Rapamyacin when it's Rapamycin!!!

I have no experience with mice, but it seems self evident to me that putting mice on a complete and sufficient exercise program is simply impossible. And thus any testing in mice related to an intervention that increases muscle size and strength is at best relevant to only sedentary humans.

Love this format as there's a lot of noise out there much of which many of us lack the ability to comprehend much less assess. I always appreciate your balanced and fair analysis with out too many smirks at the charlatans that have swarmed to the longevity space, using the search for the fountain of youth to find the pot of gold at the end of the rainbow .

This new Nature study is bonkers, I'd love to see a video discussing it: " Inhibition of IL-11 signalling extends mammalian healthspan and lifespan." The study used knockouts and IL-11 suppression in late middle age. Very interesting results: The first genetically engineered mice so they were unable to produce interleukin-11 The second waited until mice were 75 weeks old (roughly equivalent to a 55-year-old person) and then regularly gave them a drug to purge interleukin-11 from their bodies The results, published in the journal Nature, showed lifespans were increased by 20-25% depending on the experiment and sex of the mice.

Alcoholic !

Thanks for doing this review and hope to see many more in the future.

I've been a follower, but pretending you know little about Johnson's practices is downright disengenous. Asking if he's 60 (when you know he's 46), is sadly juvenile. I'm sensing a degree of 'sour grapes...?'

Matt Kabaerlein's podcasts are insanely underrated.

Wonderful Podcast... brainstorming in action..

Dr Brad youtuber is literally starting a human Rapamycin trial today.

czcams.com/video/OGHod-MqCmA/video.htmlsi=zbRoPbOrY4SoRtZV

You should probably talk to the NZ doctor youtuber starting a Rapamycin trial..