Heme Review
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The More Data You Have, The Further You Are From The Truth
Dr Pavlos Msaouel: faculty.mdanderson.org/profiles/pavlos_msaouel.html
Produced by @chubbyemu
Audio only version: spotifyanchor-web.app.link/e/C3WPkgNWZzb
0:00 Pretext and context MD Anderson Cancer Center
1:42 The Early Experiences That Shaped Dr Msaouel
3:39 The System of Cancer Research In the United States
5:25 FDA Drug Approvals and Special Designations For Oncology
11:09 A trade-off in our current system
12:35 Whoops 😞 I misspoke
14:35 Randomized trials are not supposed to be representative of a population
18:10 Inference for the treatment of Katie Coleman (metastatic oncocytoma)
25:12 It is much more valuable to refute hypotheses than to confirm them
28:05 All Models Are Wrong, But Some Are Useful
30:05 Recasting the Bias-Variance Trade-off as the Patient Relevance-Robustness Trade-off
33:38 High Relevance, Low Robustness: Subjective Bayes
34:46 High Robustness, Low Relevance: Pure Randomization
41:47 Signal To Noise Ratio
45:49 The Big Data Paradox
53:41 How the Big Data Paradox fits in with Katie Coleman's case
54:33 How the Big Data Paradox fits in with other branches of medicine
57:54 How do we rectify subjectivity in The Truth?
01:00:43 How do we address the problems introduced by the Big Data Paradox?
01:04:21 Duality in nature and a Twitter argument re: the Evidence-Based Deep Medicine Iceberg
01:07:03 Why the ideas coming from MD Anderson are coming from MD Anderson
01:09:39 Where you can find Dr Msaouel
Dr Msaouel: PavlosMsaouel
Heme Review: HemeReview
Production Assistant: Nick Brown
Secret channel: @BigEmus
Cancer Patient Speaks With Her Oncologist ► czcams.com/video/Nddft_nc3Yc/video.html
A Woman Had A Headache Lasting 3 Days (Katie's case) ► czcams.com/video/i9fLEvgZzRE/video.html
References:
Stephen Senn. Statistical Issues in Drug Development.
Why representativeness should be avoided. academic.oup.com/ije/article/42/4/1012/656034
Commentary: Representativeness is usually not necessary and often should be avoided. academic.oup.com/ije/article/42/4/1018/658638
Impervious to Randomness: Confounding and Selection Biases in Randomized Clinical Trials. www.tandfonline.com/doi/full/10.1080/07357907.2021.1974030
A Causal Framework for Making Individualized Treatment Decisions in Oncology. www.mdpi.com/2072-6694/14/16/3923
Causal Diagram Techniques for Urologic Oncology Research. www.sciencedirect.com/science/article/pii/S1558767320301932
Causal inference and the data-fusion problem.
www.pnas.org/doi/10.1073/pnas.1510507113
Causal Inference: What If. Miguel A Hernán and James M. Robins. www.hsph.harvard.edu/miguel-hernan/wp-content/uploads/sites/1268/2023/04/hernanrobins_WhatIf_31mar23.pdf
There is Individualized Treatment. Why Not Individualized Inference? arxiv.org/abs/1510.08539
Unrepresentative big surveys significantly overestimated US vaccine uptake. www.nature.com/articles/s41586-021-04198-4
Unrepresentative Big Surveys Significantly Overestimate US Uptake arxiv.org/pdf/2106.05818.pdf
Statistical Modeling: The Three Cultures. hdsr.mitpress.mit.edu/pub/uo4hjcx6/release/1
How “centaur AI” will radically reshape the future of healthcare. bigthink.com/health/how-centaur-ai-will-radically-reshape-the-future-of-healthcare/
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Komentáře

  • @StopWhining491
    @StopWhining491 Před 23 hodinami

    Great demo!

  • @eleanorlao8393
    @eleanorlao8393 Před dnem

    Sounds alarming. If you taking capsule with 8 oz of water would it dissolve? Thanks!

  • @nielsniels5008
    @nielsniels5008 Před dnem

    Why is there a shot of a car with license plate ligma

  • @davonnaweleczki6213

    How did you end up clearing that psyllium blockage?

  • @quentingivens4
    @quentingivens4 Před 2 dny

    Just dropped in to salute a fallen demigod. When I managed a cafe I peaked at 18 cups of coffee per day, and it warped reality in my chest cavity, so I can't imagine what getting a full 2 gallons in less than half that time must have felt like

  • @Teddytheviking
    @Teddytheviking Před 2 dny

    I've been regularly drinking coffee for breakfast for at least 10 years now, and there was a moment last year when I felt that I sleept pretty poorly, that I was going to try and skip coffee. I got a persistent but mild headache, so I didn't think too much about it. After a few days I started to feel pretty down, almost constant anxiety, depressed even. Nothing made sense, and I didn't see the point of anything, and I was tired. I just thought that this was a result of my poor sleep. After a bit more than a week I was in a bad mood and decided: "f*ck it, I'll just make some coffee for breakfast, and after 1-2 hours, ALL symtoms went away. That's when I realized: "yeah, maybe that was coffee withdrawl..."

  • @LouisCasas
    @LouisCasas Před 2 dny

    *" . . . and on the next edition of The Darwin Awards"* 🏆

  • @cookinthekitchen
    @cookinthekitchen Před 2 dny

    Im surprised you shouldnt eat 5 day old pasta but that is a good reminder

  • @Celluarexpress
    @Celluarexpress Před 3 dny

    They eat dogs how are bats worse?

  • @Celluarexpress
    @Celluarexpress Před 3 dny

    I used to burn Plastic as a kid around 8 ..I would attempt a replicate a toxic waste dump as i was always obsessed with dumps, 😂. I would burn these chemicals and did my best not to inhale but luckily no cancer. Im 28. I'm not sure if the feds really were paying attention because I don't think they would have burned if they knew they'd get burned like this. That's just my opinion not fact.

    • @Celluarexpress
      @Celluarexpress Před 3 dny

      And I'm not known to trust them to begin with.😮

  • @Djprudex
    @Djprudex Před 4 dny

    The brain is a kind of processing unit that also needs high amounts of coolant...lol it's funny we use all our energy to try to keep machines cool while neglecting ourselves 😅

  • @Mo-rd1ow
    @Mo-rd1ow Před 4 dny

    why would u talk about all these other issues before getting on topic pff we dont care about what supplements and protein powder u used to mix. why is it so hard for many youtubers to just stick to what the title says

  • @fanofcodd
    @fanofcodd Před 4 dny

    I only use coffee when I need it. No addiction so far

  • @mariekatherine5238
    @mariekatherine5238 Před 5 dny

    Who operates on his own cancer?

  • @redleaderracing
    @redleaderracing Před 6 dny

    The idea is not to do it abruptly

  • @redleaderracing
    @redleaderracing Před 6 dny

    The idea is not to go off it completely. It's to lower it to zero, have half a coffee, next day quarter, next day a sip to keep the headache away. I did it like 5 years ago. Worked perfectly

  • @Danimal-76
    @Danimal-76 Před 6 dny

    Same funny haircut 😂

  • @StopWhining491
    @StopWhining491 Před 6 dny

    Totally off topic: You 2 guys must have the same barber. But this was a great interview. Thanks.

  • @sursomsatan1225
    @sursomsatan1225 Před 6 dny

    I drink coffee after a workout because it helps me calm down and go into rest mode mentally. It has that effect with my letter combination.

  • @creaturelost4354
    @creaturelost4354 Před 7 dny

    No coffee no talkie. More espresso less depresso.

  • @eSKAone-
    @eSKAone- Před 7 dny

    I had extreme vertigo

  • @clean04si
    @clean04si Před 7 dny

    Why are you taking any supplements at all??? Most people just dont push themselves enough to achieve results. Once people start breathing heavy or sweating they stop their workout and rest and drink. Right when they are getting into the zone, they give up, thinking the journey to that point was the workout, meanwhile its a warmup.

  • @parker73724
    @parker73724 Před 7 dny

    I definitely dont think this is the same for everyone. I drink at least one to two cups a day of coffee but when I go on vacation and dont have a coffee maker I can go for a week without really noticing any symptoms at all (besides being slower to wake up in the morning). I personally think if I had symptoms like these it would be best just to cut out caffeine entirely after weening off it.

  • @BiljnaIshrana
    @BiljnaIshrana Před 8 dny

    Thank you for sharing this very important information. I know people who sell their recipe books full of the exact "paste" you are showing in the video. In these recipes, this paste is spread out on a sheet and dehydrated, so to become a wrap. Basically, the wrap consists of veggies, dates and psyllium. I tried it few times and SUFFERED the most terrible constipation and stomach ache. 🥹

  • @Opa_Joke
    @Opa_Joke Před 8 dny

    Aaaaaah 😤 coffee. Now i gotta stop alcohol

  • @marcnangelu
    @marcnangelu Před 8 dny

    Great vid thanks for the info ℹ️ 😮

  • @Heyok-vx7yf
    @Heyok-vx7yf Před 8 dny

    Most headache pills contain caffeine precisely because, unbeknownst to majority of sufferers, most headaches are the result of caffeine withdrawal.

  • @Spidaface666
    @Spidaface666 Před 9 dny

    *I do 6 to 800mg of caffeine a day mixed with MCT oil and an aspirin*

  • @pinksugaar
    @pinksugaar Před 10 dny

    I took it instantly blew up insane gas blocked didn’t poop for a day itchy skin all over body

  • @iShredStreets
    @iShredStreets Před 12 dny

    In my work field, I visit many customers daily. Most of them offer me coffee. I tell them “I love coffee but I don’t drink it”. I really love the smell. I drink it maybe twice a year.

  • @jonnawyatt
    @jonnawyatt Před 12 dny

    13:42 Ruby Franke type Mum?😬

  • @bobwade2534
    @bobwade2534 Před 12 dny

    Must be a blissful ending

    • @yellowఔ
      @yellowఔ Před 13 hodinami

      its a deliriant, so similar effects to datura, anything but fun

  • @TheLegenDacster
    @TheLegenDacster Před 14 dny

    Everything in moderation Peeps. Thanks Dr B. Best wishes to everyone.

  • @LiamDuchesne-fm4bz
    @LiamDuchesne-fm4bz Před 16 dny

    You should do a video on mad honey

  • @andreaarias2085
    @andreaarias2085 Před 17 dny

    Thank you for this information!

  • @JohnToland-jh5if
    @JohnToland-jh5if Před 19 dny

    ok you have sufficiently sccared the crap outta me, no mutamucil for me

  • @Botstopperog-rv4pn
    @Botstopperog-rv4pn Před 21 dnem

    Im eating mac and cheese form 2013, and i see THIS (It was those microwave meals kinda)

  • @leoleony1
    @leoleony1 Před 21 dnem

    I’ve been using it since 2012 and well, here I am 😅. Self experimentation, permissible by the Geneva convention, but of course, this isn’t an endorsement.

  • @joshpegg4523
    @joshpegg4523 Před 22 dny

    All I learned from this video is that I need a CZcams channel so I can buy a tax deductible coffee machine 🧠

  • @CS-os5pt
    @CS-os5pt Před 23 dny

    What about Metamucil cookie with psyllium?

  • @agems56
    @agems56 Před 23 dny

    So after wasting minutes of my life watching this... what actually happened?

  • @supremecash6814
    @supremecash6814 Před 24 dny

    well i been taking one dose of benadryl which is 25mg everday for a year now but every 2 months i usually take a week break so i dont build my tolerence high enough and i haven't really had any issues with my memory so far i do this because i have bad insomnia and any other supplement won't work trust me i tried most, i also don't have health insurance so i can't just go to the doctor and ask for some medicine and refills for a good cheap price.

  • @Shep01
    @Shep01 Před 25 dny

    I was a daily three or four cups of coffee drinker. I dropped caffeine this year decaf isnt horrid. Four day headache later. But now when i used caffeine like once or twice a week its crazy how much harder it hits when your body isnt caffeine adjusted.

  • @dsanchezc3
    @dsanchezc3 Před 26 dny

    One spoon full of this in a 24oz glass with water before bed does wonders in the morning.

  • @WinS392
    @WinS392 Před 26 dny

    I stopped cold turkey a couple of weeks ago, going from probably ~300mg caffeine daily to zero. I had mild headaches for a few days and my throat felt weirdly dry, but that was it.

  • @kerrynicholls6683
    @kerrynicholls6683 Před 26 dny

    Why are you doing this, pick a name and stay with it. I have to say I preferred the Chubbyemu. Hopefully 🤞 you won’t continue with this double featured versioning. Why do you need to do this twice?

  • @averyalexander2528
    @averyalexander2528 Před 27 dny

    i had a "gut feeling" (lol) that i needed to come back to this video as i have started taking psyllium husk again recently. i took a number of psyllium pills i know i can handle but enough water? should i take another pill? now i have my answer, not today, no. i may take more psyllium in the future but be more careful about when i take it and with how much water. ive generally been consuming things very irregularly the past week

  • @llcooljay66
    @llcooljay66 Před 27 dny

    I just found these and I’m addicted

  • @llcooljay66
    @llcooljay66 Před 27 dny

    I’m sad this channel has passed way it seems

  • @grovegroupadmin480
    @grovegroupadmin480 Před 27 dny

    I LOVE STRONG COFFEE DRINKS, BUT MY BODY DOES NOT. Drink lots of water and green tea in the morning or a coco (good for brain) drink with fresh cream, no milk. Feel so much better.