Pharmacokinetic (ADME) | Excretion of Drug From Body | Drug Excretion | Kinetics of Elimination

Route of Drug Elimination- • Pharmacokinetics | ADM...
Download "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Test and other GPAT Materials - play.google.com/store/apps/de...
Pharmacokinetics is currently defined as the study of the
time course of drug absorption, distribution, metabolism, and excretion.
Pharmacokinetics of a drug depends on patient-related factors as well as on the drug’s chemical properties. Some patient-related factors (eg, renal function, genetic makeup, sex, age) can be used to predict the pharmacokinetic parameters in populations. For example, the half-life of some drugs, especially those that require both metabolism and excretion, may be remarkably long in the elderly
In pharmacology (and more specifically pharmacokinetics), absorption is the movement of a drug from the site of administration to the bloodstream.
Before drugs can be clinically effective, they must be absorbed. Absorption is the process of a drug moving from its site of delivery into the bloodstream. The chemical composition of a drug, as well as the environment into which a drug is placed, work together to determine the rate and extent of drug absorption. Absorption involves several phases. First, the drug needs to be introduced via some route of administration (oral, topical-dermal, etc.) and in a specific dosage form such as a tablet, capsule, solution and so on. Drug absorption is determined by the drug’s physicochemical properties, formulation, and route of administration. Dosage forms (eg, tablets, capsules, solutions), consisting of the drug plus other ingredients, are formulated to be given by various routes (eg, oral, buccal, sublingual, rectal, parenteral, topical, inhalational). Regardless of the route of administration, drugs must be in solution to be absorbed. Thus, solid forms (eg, tablets) must be able to disintegrate and deaggregate.
Pharmacokinetic- “What does BODY 1 do to the DRUG 2” we have simple interchanged the BODY and DRUG to make a definition. And as per the definition, our body responds to any drug by giving ADME effects.
1. A Stands for - Absorption
2. D stands for - Distribution
3. M stands for - Metabolism
4. E stands for- Elimination
Drug excretion is the process of eliminating a drug from the body. A drug, which is either biologically active itself or a prodrug, may be excreted in its original chemical state. Alternatively, all or a portion of a drug may undergo chemical modification and be eliminated as biologically active, or inactive, metabolites (see the record on Drug Biotransformation) renal excretion plays an important role in eliminating unchanged drugs or their metabolites into the urine. A major characteristic of compounds excreted in urine is that they are polarized (i.e., charged) and water-soluble. Drugs that are lipid-soluble are not readily removed by the kidneys and require hepatic metabolism (e.g., phase I and phase II biotransformation reactions) to increase their water solubility for possible urinary excretion.
Get in touch with the solution by just clicking following links-
Facebook Page- / pharmavideo
Facebook Group- / solutionpharamcy
Instagram- / solutionpharmacy
Mail Us for Free Pharmacology Materials- [e-mail]
LinkedIn- / pushpendrakpatel

[@vaishnavishinde2199]

Really u n Ur teaching is amazing sir ....tysm....becaz of teachers like uh....we students can learn ....tysm🙏...

[@solutionpharmacy]

Thank you so much for your vauable feedback

[@marwahkemanegi3391]

Sir I am a MBBS student, and I want to you cover all tooics of medical pharma bcz your teaching standard is so easy and understanding
Thank you✨

[@solutionpharmacy]

Finished all topics

[@marwahkemanegi3391]

@@solutionpharmacy sir I didn't find your lecture on "kinetics of elimination "

[@solutionpharmacy]

@@marwahkemanegi3391 its not available. Sorry

[@doctorwrongside6763]

Thanks sir for helping us ...plz plz plz cover all topics of kd Tripathi for helping MBBS students also plz sir

[@solutionpharmacy]

Manish Chikna Thanks alot. Sure i will cover all topics.

[@stub_born]

Yes sir for mbbs prefer KDT

[@AnjaliKumari-ox9bi]

Yes sir kdt.. Please explain this book

[@nimmijain1599]

Thank you sir ji acha laga 🌹

[@saumyajitadhya4964]

Sir you r so awesome and very very helpful....we are so greatful to have teacher like you.

[@solutionpharmacy]

Thank you so much

[@AakashKumar-zl3ns]

Sir plzz cover topic for mbbs students also..
Please make lecture on first pass metabolism and Kinetics of elimination.

[@_travelling_lover2355]

Great method to understand ❤️ I love it.. thank you so much sir ....

[@solutionpharmacy]

Thank you

[@shivaniverma8282]

Thanku so much sir for all vedios ...these vedios is very helpful for me...In this time for my exam ...

[@solutionpharmacy]

My pleasure

[@nisthapal8580]

Thank you so much sir 🙌

[@THESHIV2.O]

Best explanation sir 🙏 thank u

[@hadikhan5821]

This help us a lot sir
Thank you so much for such a adorable lecture ❤️❤️🙏🙏

[@solutionpharmacy]

My pleasure. Thank you for your kind feedback and love

[@anjalimehra8149]

Thank you sir🎉🎉🎉❤

[@bhavanishetty2418]

Thankk u so much sir...I listened all ADME viedos which was smply awesome

[@solutionpharmacy]

Thank you so much

[@famouseffects6415]

Very excellent teacher 💯♥️

[@shubhamparmar4294]

This help us alot sir
Thanku so much sir for such a adorable lecture ❤️

[@solutionpharmacy]

Thank you so much

[@RxDharmendra22]

Thanks Sir
You are great sir

[@muskanrai9567]

Thank u so much sir for clearing my concepts

[@solutionpharmacy]

Muskan Rai my pleasure

[@saugatbk2289]

thank you very much sir
love from nepal

[@user-zm8qj9jf4n]

Superb explanation

[@palakkumari504]

The beat teacher sir

[@rxajaykumar7557]

Ty

[@babitababita6067]

Thankyou sir for flow chart

[@kuneshchoudhary1784]

I'm so excited
Thank u so much sir
Meri class me 60 student hai un sbko mene solution pharmacy Chanel k bare m btaya

[@solutionpharmacy]

Thanks alot. Really you have done a great support for us.

[@anime__gate]

You are a amazing sir!!

[@solutionpharmacy]

Roronoa Zoro thank you

[@dentallifee8631]

From Pakistan... Thank u so much Dear Sir

[@sannadhamrah7265]

Thanks allot sir...

[@swatibatra2158]

Sir please upload the video on Biopharmaceutics and pharmacokinectics concepts

[@advaitchautmal6279]

Thank you sir. Sir please do video on kinetics of elimination

[@50sabrasiddique67]

Thank you sir...allah aapko sehat mane rakhe..

[@solutionpharmacy]

Bahut bahut shukriya. Aap bhi salamat rahe

[@shubhambhosale9799]

Thanks you sir😊

[@SidraLively]

really helping me alot.. thumbs up from Pakistan

[@solutionpharmacy]

Sid Raa Thank you

[@koftasam]

Gajab sir Pura mast video hai sir ji .aap jiyo hazaro saal

[@solutionpharmacy]

Bahut bahut dhanyawaad. Aap bhi khush rahein.

[@rajendrameena5884]

sir ji aap aise hi hard work karte raho aapko humari tarhph se bahut bahut dhanyavad 💕🙏🙏

[@solutionpharmacy]

Thank you so much

[@krishnamedico1055]

Awesome sir shaandaar lecture

[@solutionpharmacy]

Thank you

[@sanskritiaghao5648]

Thanku for helping it means alot

[@solutionpharmacy]

My pleasure

[@vinitasolanki3627]

Thanks a lot sir.👍

[@solutionpharmacy]

My pleasure

[@drahmerpatoli9197]

Thank uh sir,, u r outstanding ☺ bcz of uh im easy to improve my pharma,, sir could you plz make videos about mechanism of antibiitic,antifungl,antipyretuc,antiviral,corticosteroid uses,,

[@solutionpharmacy]

ahmer patoli Thank you. I have already uploaded antibiotic and other are in sequence and soon available

[@tarunkumargoyal7532]

Sir, the description of the process in description box is wonderful

[@solutionpharmacy]

Thank you

[@beautyofpakistanbeautyofpa1688]

Thank you sir every time

[@solutionpharmacy]

Most welcome

[@hardikdahima2499]

You are great...

[@solutionpharmacy]

Thank you

[@VivekSharma-zd2gx]

Thank you. So much sir very nice video watching sir . welcome to salutation of pharmacology lI Thanks

[@solutionpharmacy]

Thank you so much

[@kirangaonkar7596]

Thank u sir...🙏🙏

[@solutionpharmacy]

My pleasure

[@drxsamar1409]

Thank you so much sir 🙏

[@solutionpharmacy]

My pleasure thank you

[@AshishKumar-lf4ln]

Super sir

[@73mrunaleesaktel12]

Thanku sir...great 👍 work😊

[@solutionpharmacy]

Thank you

[@rajeshwankhade1349]

U r great sir 4 us...

[@solutionpharmacy]

Thank you

[@purbaroy433]

Thank you sir

[@solutionpharmacy]

Welcome

[@vijaypatel9698]

Hello sir super video thankyou sooooomuch

[@solutionpharmacy]

vijay patel Most welcome sir

[@sobiaabbas2242]

Nice ....

[@shubhamnaiknaware1746]

You are amazing sir👍🙏

[@solutionpharmacy]

Thank you

[@muskansharma3697]

Kudos to your efforts Sir🙌🙌....(that I am not PharmacoPhobic now)

[@solutionpharmacy]

Thank you

[@doctordj4007]

Sir belive me your teaching technic is brilliant

[@solutionpharmacy]

Thank you so much for your feedback

[@mariamuskan6974]

Thank you sooooo much sir 🤩

[@solutionpharmacy]

My pleasure

[@Pharmainform]

good

[@maheepalkumar3725]

Your explanation is so good. Thanks a lot

[@kipayari7531]

Sir I'm a veterinary student and it's very very helpful for me. Thnk u so much sir.......

[@solutionpharmacy]

My pleasure. Thank you for your feedback

[@neerajpatel2083]

Thank u sir

[@solutionpharmacy]

Welcome

[@ankursharma6905]

Very well sir ,keep it up

[@solutionpharmacy]

Thank you so much

[@kavitayadav-kz2um]

Thank you so much sir ji ❤

[@solutionpharmacy]

Most welcome

[@varshab8847]

Really good videos sir 👌 Hatts off to your efforts.

[@solutionpharmacy]

Varsha B Thank you so much

[@nazishkhan72]

Thanks sir ,respect from Pakistan

[@solutionpharmacy]

Thank you. Return love from the INDIA

[@stub_born]

Lots of support from europe

[@solutionpharmacy]

Thank you

[@aprajitaprajapati3475]

Sir plz upload a video on topic-" drug disposition "

[@touseefkhan1621]

thanks lottttt sir...

[@solutionpharmacy]

My pleasure

[@abhishekyadav6865]

Nice lecture

[@solutionpharmacy]

Thank you

[@drxgarimasahu3072]

A lot off thanks sir

[@solutionpharmacy]

My pleasure

[@arjunrana6465]

awesome

[@solutionpharmacy]

Thank you

[@manjuprajapati9637]

Sir water sewer and pillar kya hota h

[@mahimaverma4374]

Sir is there video on kinetics of elimination ???

[@drfarokhmaster10]

once again excellent lecture, please tell simple book with diagrams

[@solutionpharmacy]

Jagdish prasad

[@aasimiqbal5260]

love from Ambikapur (Chhattisgarh)
#stay at home

[@solutionpharmacy]

Great. I know ambikapur. I am also from Chhattisgah. Stay safe

[@anshujjeniya8230]

Sir aap ne kinetic of elimination p video nai bnaya kya

[@RajuSingh-gm7mz]

Sir kinetics of elimination?

[@rajivdas8185]

Good

[@solutionpharmacy]

Thank you

[@eventswithdeeksha7802]

Sir kya ADME ke question me final exam me kvl chart bna skty h kya (d pharm 2 year)

[@user-pu1lj4fb3j]

Pl answer my question, what is excretion and what are the verious processes used in the excretion of crude drugs??

[@faizanrasoolshah7683]

Good sir

[@solutionpharmacy]

Thank you

[@asrafatima1462]

Thank you so much sir. thanks and love from pharmdians. Sir aap kinetics of elimination pe video nhi banaye

[@solutionpharmacy]

Thank you

[@achyootkoirala5220]

awesome love from nepal

[@solutionpharmacy]

Thank you

[@munabhandari4366]

Sir please clear my confusion about distribution of dopamine from levoda inactive prodrug ? ...
Please sir
From Nepal

[@solutionpharmacy]

We have many animation video on levodopa. Please watch.

[@HassanRaza-tt2ig]

Assalamoalikum Sir,
Koi drug humari body mai Kitna ersa rehtti hai?

[@Heartless030]

Sir!! Which book u refer for pharmacology??
I m using KATZuNG and Trevor's
But i am not satisfied..

[@solutionpharmacy]

I have uploaded a vidoe on books. Please have a look

[@PriyankaKumari-jt5ks]

Sir indian pharmacopeia legal issues topics ka video nhi sirji

[@saurabh_sahani]

Nice explanation. 🙏❤❤

[@solutionpharmacy]

Thanks alot

[@saurabh_sahani]

@@solutionpharmacy sir.. K. D. T. Me kinetics of elimination भी दे रखा h..
1sr & o order kinetic..
With plateau principal....

[@solutionpharmacy]

Ha usko bhi banaunga. Par usme thoda time hai

[@KrishKumar-to8tg]

Iam u're new viwer bt I'm ruglar before 2 days 😊

[@solutionpharmacy]

Thank you

[@deekshanama9255]

Sir konsi btai ti aapne book

[@solutionpharmacy]

Pharmacology Books- Tips and Tricks (Part-05)=Build Your Own Library With Book Suggestion (HINDI)
czcams.com/video/4qjLQqfwGog/video.html

[@TheKINGDA2]

Sir aapne isme cleareance Miss krdiya plz btade usky bare me thora aura plasma half life bhi nahi btaya ?

[@solutionpharmacy]

Ok sir aage kisi video me aapke suggestion ko follow karne ki kosis karunga. Thoda time lagega par jarur kar lunga. Thank you for suggestion

[@mahfooz136]

Sir, please jo bhi book ya topic apne youtube me dala hai uska link provide kar dijye description me.

[@solutionpharmacy]

Pura video channel pe hai to 1500 link kaise dal sakte hain ? Aap channel aur playlist me dekhiye

[@lakshtube123]

Nono pharmacokinetic ka video mujhe chahiye sir

[@poojameena9801]

in the zero order kinetics, either given constant or variable dose of drug but in both conditions rate of drug elimination is constant
this statement is true or false ??
plss answer sir

[@solutionpharmacy]

Yes correct. 0 order is free from cons

[@abhishekvishwakarma3446]

Very good video sir
Plz cover all topic
And also make all video which help MBBS students

[@solutionpharmacy]

akask jain Thank you sir. Sure i will

[@abhishekvishwakarma3446]

@@solutionpharmacy I'm not sir
I'm 2 year MBBS student

[@solutionpharmacy]

akask jain Every single person is respected for us. 👍

[@FatimaAli-hk2xs]

Which book you're following?

[@solutionpharmacy]

KDT

[@gaganrathore5455]

Thank you sir for explaining pharmacokinetics study of drug elimination ...🙏

[@solutionpharmacy]

Welcome dear

[@DextroGaming]

sir i have a small doubt .. after absorption of drug, distribution is maximum in the part of brain , kidney and liver as the blood is higher in these compartments .sir I want to know to cross the brain barrier drugs need to be lipid soluble in nature . but liver try to make it water soluble so after metabolism how drug will act on brain . i am really confused in this section sir please help me .

[@solutionpharmacy]

Yes you are right but lipid soluble drugs are given by parenteral so they distributed to brain then go for metabolism

[@stub_born]

Getting interest in Pharma due to u

[@solutionpharmacy]

Thank you

[@drmubasharhomeopathytips1601]

Sir can you tell me name of book and author from which you get this all material ??

[@solutionpharmacy]

Many books including KDT, Lippincott, P Jagdish prasad, padmaja udaykumar etc

[@abdullahofficial2795]

Sir those drug which not metabolic occure and eliminate from body this drug show effect or not 🤔🤔

[@solutionpharmacy]

No they will not show effect

[@neemishaprasad]

sir thank you for the videos please upload pharnaceutics video.

[@solutionpharmacy]

Thank you so much. Actually belong to pharmacology and i dont have depth knowledge of ceutics. Although in future i will try to do so.

[@neemishaprasad]

Sir can u upload videos on antihypertensive drug chapter of k.d tripati... I almost watch ur every videos its very useful thank u .

[@solutionpharmacy]

Neemisha Prasad Thank you. Sure i will upload that topic too but as per its sequence. Please keep supporting.

[@shrutishreya845]

In tubular reabsorption, lipid soluble drugs are reabsorbed but how after even going through metabolism, drugs still lipid soluble

[@solutionpharmacy]

In phase of merabolism they try to convert it into polar

[@sourajyotifitness8345]

Renal And Hepatic Clearance Difference ? Please tell Sir

[@solutionpharmacy]

Sourajyoti Fitness organ only