Rejuvenation With Exosomes & Stem Cell Secretome | Modern Healthspan Clips
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- čas přidán 13. 06. 2024
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Here are some clips from four of our guests on exosomes and the secretome from young cells being used in rejuvenation of the immune system and more generally. The guests are Drs Harold Katcher, Hans Keirstead, Paul Robbins and Ducan Ross. I have linked to each of the original interviews in the video. Please watch the whole interview for the complete story.
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#exosomes #e5 #stemcells - Věda a technologie
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So when will Do Not Age start selling this mysterious porcine extract?
Hi Paul thanks for the question! There is a couple of issues here, which were not covered in this video, though we do dive into in the original. The first is approval, the solution is not GRAS not approved so not available for humans. The second is delivery and dosage, as it requires a lot of E5 and needs to be injected (or be done as a transfusion). So even when E5 is complete it will not be available as a pill. Though topical E5 might be possible.
@@ModernHealthspan I've already been stuck with more needles than I can count. Inject me with that stuff, I'll be the first volunteer.
Paul Robbins comments on stem cells made me recall (hopefully correctly) that short bouts of fasting appears to replace old cells with younger cells and in the process transiently increase stem cells in circulation, in which case the pool of exosomes would also be enhanced. Clearly an area to watch. Thanks!
I absolutely love this format! it's broken up into short chunks that can be paused and mentally digested, and it's all related so I don't have to google that much terminology. Thank you so much.
Thanks to you and your guests Richard.
The flow of the video is seamless.
Hi thanks for your comment. I suspect you are not being entirely serious. It is true, the video takes the input from four doctors and puts them together. In the original interviews there was no intent to build material that would be used in a cohesive way. But thanks for the thought. Perhaps what I should do is create a video with commentary and pull in clips from the channel to back up what I am saying.
So interesting Richard. I’ve noticed this pattern too, that many aging researchers seem to be honing in on exosomes/secretome from youthful stem cells, as the primary ingredient for rejuvenation.
So, exosomes are more powerful than stem cells?
@@DeusExMachina50 it seems that the secretome (including exosomes) from the stem cells is more effective than the stem cells themselves.
@@bw4611 Wow, that's exciting!
This is very interesting, Richard!
I have an unrelated question for you. Have you produced any videos mentioning Trigonelline? Renue by Science just started promoting this. If not, you might want to invite someone to talk about it.
Hi thanks for sharing. I have seen more references to using these secretome or exosomes and it also seems to be the closest to the clinic. With respect to the discussion on stem cells: The issue with these is that they trigger the immune system. Dr Keirstead mentioned it in this video, the secretome has no-self where stem cells do. In the original interview with Dr Ross he also talked about it. Foreign stem cells tend to get destroyed by the immune system.
I love this Katcher guy. He looks like he's about 110 years old. A walking ad for his anti-aging program 😅
He's researching, not participating. But I see what you mean. I mean, He didn't show us his hand...
@@bmack500 I doubt whether his hand looks any better than his face 😂
You could have just said thanks
@@timskolnik3819 But instead I actually expressed an opinion. You might want to try it sometime.
@@jontpt I am not sure what you mean by that. Which hand are you referring to?
Hi Richard. I find Dr. Harold's work is the most important.
Is this interview new?
Hi Anthony, thanks for the question. The interview was from Sept 2023 so it is not new. Dr Katcher is no longer with Yuvan Research (the company set up to productize E5) though the company is still moving forward. I believe Dr Katcher is looking for other ways to move forward with E5. I am also following Yuvan but have nothing to report as yet. I certainly hope that E5 can be brought to the clinic by some route, however I see Dr Keirstead's approach as being closer at the moment. Especially given his experience in working with the FDA and that his solution is based on human secretome. I just see getting approval for cross-species interventions will be tougher.
This is certainly a most frustrating situation.
Its my belief that Dr. Katchers was Yuvan, so without his involvement, we are looking at Tesla without Elon or Apple without Steve. I just hope Dr. Katcher is continuing his work.
physician here devoted to clinical applications of science- also consider literature assessing intelligence of pigs being equivalent to a three year old human. We just speak so easily about “porcine” sources
So how many young pigs to produce the human treatment?
Is the lotion available for purchase in India? Link please
Thank you for this video and your effort, you are on the right track. I really appreciate your work. Richard, please I have a question: Harold Katcher said that exosomes that he extracted from the blood come from all cells from all organs because they have different cargo and targets. Does this mean that if we used placental based exosomes or Mesenchymal stem cells exosomes then they would have much less effect as the first option. Is this correct? assuming exactly the same dose.
Anyone knows where can I buy secretomes over the counter?
Why isn't therapeutic cloning talked about anymore if it had such great results in mice trials before 2010? Seems like we could be rejuvenating and replacing organs already.
Cure ocular surface disease please! ❤️
Hi thanks for your comment.
@@ModernHealthspan great videos. I hope this becomes a real solution.
Cure 20 years of chronic back and knee pain too lol. Stupid early 20s job. You're invulnerable at that age. What could possibly go wrong? :D
@@squamish4244 yep! We all make mistakes in our 20s. Some get out lucky though.
@@SkipYearSix Some do. I sincerely hope this works for ocular surface disease. The cure for most diseases is simple: don't get old :P
Link to new paper?
The Geroscience paper by Keirstead is "Reversal of deficits in aged skeletal muscle during disuse and recovery in response to treatment with a secrotome product derived from partially differentiated human pluripotent stem cells". Correct me if I'm wrong, Richard @ModernHealthspan . YT is already mad at me for the first link and won't let me add a 2nd, but a Google search will get the link to the paper.
Paul Robbins - "Regulation of chronic inflammatory and immune processes by extracellular vesicles" - again, CZcams doesn't want people posting links, but Google.
I *think* the paper Ross is referring to is "The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets"
@@scottmiller2591 much appreciated!
Hi Brett, thanks for the question. For which interviewee? The original videos normally have the links to the relevant papers. I will include them in the clip as well next time.
Is this old? Katcher not part of Yuvan research any longer, or?
He is not. Apparently he was frustrated with the glacial pace of Yuvan. He's still working on exosomes though.
Biological packet communication ;).
Hi Scott. Seems to work like UDP!
Dr ketchup