Haemolytic Anaemia - classification (intravascular, extravascular), pathophysiology, investigations

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  • čas přidán 3. 02. 2019
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    "Haemolytic anaemia is defined as anaemia due to premature destruction of RBC. RBC also known as erythrocytes are produced in the bone marrow and then enter circulation to become mature. The mechanism of RBC haemolysis can be intravascular which means destruction of RBC within the vasculature or haemolysis can occur extravascularly. Which means haemolysis outside the vasculature typically in organs such as the spleen and liver where the reticuloendothelial system resides.
    Haemolysis stimulates the kidneys to produce EPO a hormone which stimulate erythropoesis the production of RBC. RBC are produced via the myeloid progenitor cell line to become erythrocytes in the bone marrow. Erythropoesis is also stimulated by other hormones including androgens and thyroid hormone."
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Komentáře • 129

  • @Allan.drummer
    @Allan.drummer Před 5 lety +124

    Amazing! Best G6PD deficiency explanation yet. Short and sweet. How have you not won a noble prize for these drawings and explanations!?!

    • @SHOIBG10
      @SHOIBG10 Před 2 lety +2

      He classed G6PD under intracapsular, extravascular. it is intracapsular but its a intravascular disease not extravascular!!!

  • @mpelimakama1641
    @mpelimakama1641 Před 2 lety +2

    Thank you so much Osmosis! 😄, it's been 5 years in Med School🇹🇿. Never Felt so excited and got Hands on Medical Content to Learn, Thank you for that

  • @pennylayne710
    @pennylayne710 Před 4 lety +12

    I would love to see the behind the scenes on this! Like how do you always have enough space!? Excellent videos. I've watched many in preparation for BOARDS. Thanks!

  • @user-mq9jg7pz2l
    @user-mq9jg7pz2l Před 18 dny

    Armando , may God continue to bless you. Great medical content.

  • @user-fx7pj3sk1r
    @user-fx7pj3sk1r Před 5 lety +33

    The best physiology youtube channel - for medical science, veterinary science

  • @avjitsingh1404
    @avjitsingh1404 Před 5 lety +14

    Its an honor to have got some knowledge through your pictorial presentation. You are a real big help to lot of different students from different fields. Thanks alot Sir, God Bless you always!

    • @DentalClinician
      @DentalClinician Před 5 lety +1

      czcams.com/play/PLT0nQuD9NwdlltAaSinDkdsTRUfBSob4l.html

  • @DocNaDer_2023
    @DocNaDer_2023 Před 4 lety +3

    best channel ever ! u saved my medical exams 😍

  • @abdullahalameer5557
    @abdullahalameer5557 Před rokem +1

    Amazing & astonishing… literally worths the 13 min!!! Thanks!👌

  • @xZenize
    @xZenize Před 5 lety +2

    Your videos are soooo helpfull, but im really having trouble with understanding the mechanisms of cytokines. I would be so thankfull if you could explain a little bit about cytokines! Thanks in advance you're the best!

  • @InsightfulScience
    @InsightfulScience Před 5 lety +8

    Armando, you are so close to one million! You'll be there in under a week! Big congratulations my man!

  • @leodash5835
    @leodash5835 Před 4 lety +1

    Its really magical how you explain this and it gets so easy man you are my hero

  • @CynBH
    @CynBH Před 5 lety +1

    I've had one dog and one cat killed by autoimmune hemolytic anemia. Until my shepherd mix got it, I had never heard of it. Ten years later when our cat was diagnosed, I was devastated. My dog's disease progressed slowly, so he actually died from the anemia. The cat's disease progressed so rapidly that she actually went into liver failure from the sharp increase in bilirubin.

  • @mohammedsalahadin1680

    I can’t stop thanking you, it was so helpful thanks dear❤❤❤

  • @vartikashukla8914
    @vartikashukla8914 Před 2 lety

    Wowwww...fabulously explained
    Thankyou so much🙏❤

  • @fasamah.kollie8767
    @fasamah.kollie8767 Před rokem

    Greats 🤝it’s worth my appreciation. The foundation is builded.

  • @mitalipriyadarshani2526

    You are awesome and unique😍😍 you cleared my baseline concept👍Thank you so much

  • @anime2002LOL
    @anime2002LOL Před rokem

    رائع جدا
    شكراً لجهودك العظيمه 🥰🌟

  • @user-tb4vx5kp1q
    @user-tb4vx5kp1q Před 4 lety +13

    Thank you so much, great explanation as always. I would like to note that the enzyme is called G6PD and the "D" stands for dehydrogenase not deficiency, so the correct name is "G6PD deficiency". Thanks again!

  • @kay6914
    @kay6914 Před 5 lety

    Amazing!! You made it so simple ❤️

  • @moathbanimelhem1860
    @moathbanimelhem1860 Před 5 lety

    Keep going you are doing amazing work

  • @ecedenizturan784
    @ecedenizturan784 Před 2 měsíci

    Excellent excellent excellent explanation thank you

  • @aytakchichak7456
    @aytakchichak7456 Před 4 lety +1

    thanks alot.How can we get the pdf of your drawings plz?

  • @santiagoespiritualidad3857

    Hola amigos son geniales,un abrazó desde colombia

  • @GhulamMurtazaDahar
    @GhulamMurtazaDahar Před 5 lety

    which software do you use?

  • @shahzaibkhan-jo9fn
    @shahzaibkhan-jo9fn Před 5 lety +2

    Amaaaaaazing dear

  • @shoroqzaki285
    @shoroqzaki285 Před 5 lety +1

    That pdf make me thankful ♥️

  • @luichilml
    @luichilml Před 5 lety

    YOUR VIDEOS ARE GREAT!

  • @abdullahmohammed2553
    @abdullahmohammed2553 Před 5 lety +1

    very helpful. Thank you very much

  • @raycage7592
    @raycage7592 Před 4 lety

    I came here for the G6PD deficiency explanation and it did not disappoint.

  • @TheFirozRizvi
    @TheFirozRizvi Před 3 lety

    So helpful! Thank you!

  • @patriciadesouzapimenta5127

    Great video!! thank you!

  • @noornzar9305
    @noornzar9305 Před 10 měsíci

    Medical students need more videos like this

  • @naveenan8709
    @naveenan8709 Před 10 měsíci

    Hello sir ,can u tell how hemolytic anemia can affect the function of other essential organs ?

  • @saravera5784
    @saravera5784 Před 5 lety +1

    Wonderful video. It's Malaria & BABESIOSIS in extracorpuscular haemolysis. Bartonellosis includes Cat Scratch disease, Trench Fever & Bacillary Angiomatosis.

    • @snigdhashanti6839
      @snigdhashanti6839 Před 4 lety +1

      perfect!! wondering how no one corrected it. Also isnt it G6PD Deficiency?

  • @meloked7516
    @meloked7516 Před 3 lety

    is G6PD should intravasculer haemolysis, right? its make hemoglobynuria so it should be intravasculer hemoliysis

  • @santiagomaciasvillegas2186

    Son geniales amigos,un abrazo desde San Jerónimo Antioquia colombia

  • @praveenavr2747
    @praveenavr2747 Před 4 lety

    Its very usefull to dental students also

  • @sivilifestyles
    @sivilifestyles Před rokem

    fantastic explaination 😊

  • @jk1239
    @jk1239 Před rokem

    Sir please tell how to get your notes pdf plz 🙏

  • @rushikeshharne3194
    @rushikeshharne3194 Před 5 lety +2

    Loved it

  • @13haiamrit
    @13haiamrit Před 3 lety

    Haptoglobin is less because in Hemolytic Anemia, it is being used up a lot than usual??

  • @daniadm1223
    @daniadm1223 Před 2 lety

    Very helpful thanks 😊

  • @ClaraLL
    @ClaraLL Před 5 lety

    Good Stuff :)

  • @mohammedabd6696
    @mohammedabd6696 Před 3 lety +1

    You are fabulous

  • @queenbeequeenb9
    @queenbeequeenb9 Před 2 měsíci

    Thank you ❤

  • @DrAdnan
    @DrAdnan Před 5 lety +6

    Watching these along with sketchy is gold 👏

    • @itsfootballnotsoccer6140
      @itsfootballnotsoccer6140 Před 11 měsíci

      woah thanks for the recommendation mate ..i know I'm 4 years late but you've helped a fellow student here

  • @joy4336
    @joy4336 Před 5 lety +4

    Nice video...need more

    • @DentalClinician
      @DentalClinician Před 5 lety +1

      czcams.com/play/PLT0nQuD9NwdlltAaSinDkdsTRUfBSob4l.html

  • @dinaalbushra5364
    @dinaalbushra5364 Před rokem

    Amazing thank u

  • @muhammadkamran4798
    @muhammadkamran4798 Před 4 lety

    Mind blowing

  • @kasunsanjeeva8787
    @kasunsanjeeva8787 Před 4 lety

    supper explanation

  • @rohitpadme1478
    @rohitpadme1478 Před 5 lety +3

    3 am .in india...osm..👍

  • @farzanasharminnipa7812
    @farzanasharminnipa7812 Před 9 měsíci

    Thank you

  • @shimadavari4501
    @shimadavari4501 Před 5 lety

    best out of best

  • @AlohaUlises
    @AlohaUlises Před 5 lety +3

    Kundos on you getting a sponsor!!! Great!!!! :D :D

  • @Reem-ki4fj
    @Reem-ki4fj Před 2 lety

    perfectly perfect

  • @JR-gv4ew
    @JR-gv4ew Před 3 lety

    Thank u Sir

  • @maro9999999991
    @maro9999999991 Před 4 lety

    Genius !!

  • @EssexEx
    @EssexEx Před 2 lety

    Wouldn’t haptoglobin levels increase if there’s more haeme in circulation? Or are they not produced more in proportion to the haeme increasing in the body?

    • @user-hy2tc3qz2p
      @user-hy2tc3qz2p Před 10 měsíci

      Hemoglobin actually binds with heptoglobin and this complex is eaten up by macrophages that's why heptoglobin level decreases

  • @srirambhardwaj2343
    @srirambhardwaj2343 Před 4 lety

    Thank.you.very.much.sir.

  • @knightstormbringer
    @knightstormbringer Před 5 lety +1

    Just to clarify, G6PD is intravascular, right?

    • @armandohasudungan
      @armandohasudungan  Před 5 lety +2

      Hey, its one of those which are both intravascular and extravascular most likely. But because it is abnormal will definitely be cleared up by the spleen/liver.

  • @harinipreethi5932
    @harinipreethi5932 Před 3 lety

    Why neutrophilia and thrombocytosis in hemolytic anemia

  • @suryaa109
    @suryaa109 Před rokem

    What's the permanent solution for hemolytic anemia?

  • @hammhann3818
    @hammhann3818 Před 4 lety

    Thaaaaaaanx 🌹❤️🌹🎉

  • @anuragtiwari917
    @anuragtiwari917 Před 3 lety

    In warm autoimmune hemolytic disease, body temperature is at 37 degrees only.

  • @joycezhang3966
    @joycezhang3966 Před rokem

    Thanks!

  • @GeorgeAscue
    @GeorgeAscue Před 5 lety

    Thanks

  • @user-fi5mn8gv4z
    @user-fi5mn8gv4z Před 2 lety

    thanks

  • @bilalturkan8004
    @bilalturkan8004 Před 9 měsíci

    G6PD deficiency causes intravascular hemolysis hence patients present with haemoglobinuria which is dark or red urine often mistaken as haematuria.

  • @medicosthings...8132
    @medicosthings...8132 Před 5 lety +10

    Please use English subtitles in your videos because of difference pronunciation if different country

  • @TheX7mood
    @TheX7mood Před 4 lety

    Well explained!!

  • @prikwilson
    @prikwilson Před 5 lety +1

    Kindly add a video on emergency drugs if possible..

  • @nal9345
    @nal9345 Před 5 lety +5

    it would be nice if you upload what you draw as a pdf, so i can print and study it. please consider this:(

  • @harvestmoon3098
    @harvestmoon3098 Před 3 lety

    It is actually G6P”D” deficiency, “D” is stand for Dehydrogenase

  • @goncalosanhudodeportocarre9591

    Great video, like always, but isn't the sound cut off at the end?

    • @armandohasudungan
      @armandohasudungan  Před 5 lety +1

      Haha you are right. It was meant to say extracorpuscular and intracorpuscular causes of haemolysis. Cheers!

  • @hazalsarird1219
    @hazalsarird1219 Před 3 lety

    video ends unexpectedly :D

  • @lunamoondrop
    @lunamoondrop Před rokem

  • @TheSaneInternational-SNI
    @TheSaneInternational-SNI Před 5 lety +1

    its 3 am!!
    love from India 😊😊

  • @shaimaa1611
    @shaimaa1611 Před rokem

    Wow

  • @berserkberry9284
    @berserkberry9284 Před 4 lety +1

    Armando, you've got an attractive voice.

  • @imperiusss
    @imperiusss Před 4 lety +4

    But with G6PD deficiency, you have also intravascular hemolysis, not only extravascular!

  • @rehabhh5834
    @rehabhh5834 Před 10 měsíci

    But g6pd deficiency is intravasculer hemolysis

  • @Jen6374
    @Jen6374 Před 4 lety +2

    I have this No fun I was 2 pints short of blood almost killed me I had transfussion

    • @patriciawilder66
      @patriciawilder66 Před 4 lety

      How do you find out if you are short of blood, I've been sick with this anemia for some time, getting much worse, constantly needing to sleep, and dizzy all the time 😪

  • @mroosie7488
    @mroosie7488 Před 4 lety +12

    I'm here 1 day before my finals..

  • @sayyedsayam8158
    @sayyedsayam8158 Před 3 lety

    2 nd half month to go for Exams

  • @ozzyoz6206
    @ozzyoz6206 Před 5 lety +2

    Your legacy will be bigger than Netter

  • @anasalhumaidi6775
    @anasalhumaidi6775 Před 10 měsíci

    ياريت يترجم كلامه للعربي

  • @samsungm4124
    @samsungm4124 Před 9 měsíci

    WTH?!
    G6pd is intravascular not extravascualr hemolysis

  • @fikrikiky8445
    @fikrikiky8445 Před 5 lety

    Like

  • @user-xn8dp5zy8t
    @user-xn8dp5zy8t Před 5 lety +1

    Allow the ads bro

  • @stelonkangabam4567
    @stelonkangabam4567 Před 5 lety +2

    I wanna marry this guy😂

  • @Arbazkhan-qe1mu
    @Arbazkhan-qe1mu Před 5 lety

    Not bad

  • @pracheesolanki
    @pracheesolanki Před 5 lety

    ew your accent

  • @Arbazkhan-qe1mu
    @Arbazkhan-qe1mu Před 5 lety +1

    Somewhat boring

    • @CynBH
      @CynBH Před 5 lety +14

      Yours is a somewhat unnecessary comment. It's a medical lecture, not an action movie. It's meant to be informative (which this video is), not entertaining. Those of us who are trying to learn are actually interested.

    • @kamaltahir6440
      @kamaltahir6440 Před 5 lety +1

      It's interesting actually

    • @stelonkangabam4567
      @stelonkangabam4567 Před 5 lety

      It's interesting actually and helpful as well.

    • @reefraz6963
      @reefraz6963 Před 5 lety +1

      Ur in wrong channel. Plz go away n delete ur comment as well

    • @DentalClinician
      @DentalClinician Před 5 lety +1

      @@reefraz6963 czcams.com/play/PLT0nQuD9NwdlltAaSinDkdsTRUfBSob4l.html