Friedel-Crafts acylation | Aromatic Compounds | Organic chemistry | Khan Academy
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- čas přidán 18. 10. 2010
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Friedel-Crafts acylation reaction. Created by Sal Khan.
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Organic Chemistry on Khan Academy: Carbon can form covalent bonds with itself and other elements to create a mind-boggling array of structures. In organic chemistry, we will learn about the reactions chemists use to synthesize crazy carbon based structures, as well as the analytical methods to characterize them. We will also think about how those reactions are occurring on a molecular level with reaction mechanisms. Simply put, organic chemistry is like building with molecular Legos. Let's make some beautiful organic molecules!
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i like the plot twist at the end ; we think that Friedel was president but BOOM ! it's actually crafts :P what a revelation !
thank-you sir . . i have my midterm coming up, i have been struggling, but i feel more confident now :D !! thank you !
Khan Academy,
I just finished watching your segment on CBC news. In your interview you explained that you initially intended the videos for the "13 year old version of yourself; kids with an interest in learning." However, as a 3rd year biochemisty major, I wanted to extend my sincere gratitude as your videos have helped me out of countless organic chemistry, physics, and biology jams when the professor and textbook were unclear.
Thank you and keep up the amazing work! :)
"My Penmanship is deteriorating" Lmao... I actually laughed at that.
It doesnt matter, we know what they mean. Usually, the Kekule structure is used in mechanisms to make it easier to see whats going on. It helps us visualise the locations of the electrons. I personally use both so its fine, and its good to get into the habit of using both. Hope this helps.
Sal I just want to correct a small mistake you made:
the aluminum chloride IS a catalyst with respect to alkylation reactions but the aluminum chloride in acylation reactions is NOT a catalyst because (after the reaction has been completed) the free electrons on the oxygen of the ketone will react with the lewis acid alcl3 to form a salt; and this salt must be broken with water which breaks the alcl3.
for acylation you need a 1:1 stoichometric ratio to achieve final product.
this man can learn you anythangs...
you teach me more than my teacher. I will call you my teacher. Thanks a lot!
You forgot the HCl that is also formed in the end.
But the H is just a proton and it doesn't have an electron to share with chlorine?
10:10 the H and the Cl from AlCl4- will become HCl and the AlCl4- will become AlCl3. It does have an electron, the electron, 2 electrons come from chlorine.
We stan a person studying chemistry and having a guns n roses icon
sorry to interrupt, actually it was James Mason Crafts who was the president of MIT, not Friedel.
First of all, I love all your videos! One question, is it possible to do this Friedel Crafts acylation adding an aldehyde to the benzene? Instead of adding the ketone to the benzene ring. Thank you!
sir second hybrid structure reacts not the first one . In second one c has a Delta +ve charge and not full +ve charge due to which no hydride shift happens
thankyou, at the time i wrote that comment i was fairly new to organic chemistry and yes i understand what you mean
You are an excellent teacher, thank you!
this is sooo difficult!! but thanks for the simple explanation!
Why are all the last video's of this playlist privated?
I LOVE U SOO MUCH u earned yourself a subscriber
how is chlorine donating an e- to hydrogen and the benzene ring with out interacting, if that happens, shouldn't it be bonding with hydrogen forming HCl? or couldnt Cl- attack the positive charge on the benzene ring? im alittle lost at about 9:15
nice sir I have understand it very easily
why we put positive charge in the benzen ring inspite out
Thank you so much
does akylation work the same way? And how do you do the carbocation rearrangement with this type of rxn. My prof has a question on it but he never went over it in class
FCA is really useful on any test that involves synthesizing anything with benzene in it.
Got benzene? Just add the rest of the molecule with a chlorine in it!
I know that's an oversimplification, but I love this reaction. It's the reason I'm getting a C instead of a D!
"My penmanship is deteriorating" Lmao
Oxegen: NOOO THEY BE STEALING MAH ELECTRONS!!
but al has config 2,8,5 so 3 valence electrons which is satisfied by 3 cl electrons so it stable right so why cl will attack alcl3 as its stable?
second resonance structure more stable due to octet
Well explained❤
Alkylation often over alkylates where acylation doesn't.
Why are you using Kekule's notation of the Benzene ring? Shouldn't you use a ring to represent the aromaticity and not alternating double bonds? Because Benzene is a perfect hexagon?
didn't understand where did the yellow Cl from AlCl4 went to, does someone know?
James Crafts was a former president of MIT, not Charles Friedel.
Thats Good :)
We also have another product: H-Cl
How to remember the catalysts easily
would HCl be created as a byproduct of this reaction?
Yes
Acetophenone is the common name. 1-phenylethanone (not phenylmethanone, that's be benzaldehyde or phenylmethanal, not even a ketone) is the IUPAC name.
despite what people think h-cl bond at 432kj/mol to disassociate is more stable than
c-cl 330kj/mol or c-h 410kj/mol bonds so in the right conditions hcl can be a leaving group
this reaction can also proceed with na+-oh as a consumable catalyst which will yield sodium chloride and water as byproducts
tony rosati So is this the reason why the chlorine attacked the hydrogen, not the carbokation?
thats good for remembering what?
I dont understand, i thought FC reactions failed if the halides were attached to SP2 or SP carbons? someone help! lol
does somebody know why a solvent with a nitro group is needed?, for all friedel crafts acylation procedures I've seen nitromethane or nitrobenzene is always used, however, they are not included in the mechanism
your awesome
Why doesnt the chlorine attack the carbokation instead of the hydrogen?
Aleksi Nuutila i think the acyl substituent pulls the electron towards its side (through resonance), so it protects the ring from further substitution.
But what happens to the chlorine at the end
Abhishek Bisen had become Hcl
you forgot the formation of HCl, hydrochloric acid, the Cl from the Aluminum tetrachloride and the H from the benzene
Great otherwise
Anisol ... p2p??? Fiedelcraft
Aluminium.
@ojay12341234 what did he say?
why cant we write like normal people lol and yes hcl will be the leaving group of this reaction
+tony rosati The hydrogen is the leaving group. The base could be water to form hydronium ion, it could be the Cl- to form HCl, it could also be the AlCl4- to form AlCl3 and HCl.
تعالى هناا يفلاح 😂
جخّه (Y)
:D
wtf