Berberine Benefits: Which Are Real and Which Are Hype?
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- čas přidán 1. 06. 2024
- You might have heard the buzz around berberine, often referred to as “nature's Ozempic”.
Berberine is a powerhouse for many things, from reducing inflammation to regulating blood sugar levels.
Tune in to hear which benefits the science supports (and the surprising ones it doesn’t) and get a simple dosing guide.
And if you have any additional questions you would like answered in the future, let me know in the comments!
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Timestamps
00:00 Intro
01:00 What is berberine?
01:37 Weight loss
02:34 Cholesterol
05:52 Blood sugar
08:47 Gut health
11:15 SIBO
12:53 Berberine dosing guide
Featured Studies
Biological properties and clinical applications of berberine: pubmed.ncbi.nlm.nih.gov/32335...
Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders: pubmed.ncbi.nlm.nih.gov/30186...
The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of RCTs: pubmed.ncbi.nlm.nih.gov/31915...
The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of RCTs: pubmed.ncbi.nlm.nih.gov/32690...
The effect of berberine supplementation on lipid profile and obesity indices: An umbrella review of meta-analysis: www.sciencedirect.com/science...
Berberine decreases plasma triglyceride levels and upregulates hepatic TRIB1 in LDLR wild type mice and in LDLR deficient mice: pubmed.ncbi.nlm.nih.gov/31666...
Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption: pubmed.ncbi.nlm.nih.gov/25002...
Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of RCTs: pubmed.ncbi.nlm.nih.gov/36941...
Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of RCTs: pubmed.ncbi.nlm.nih.gov/31094...
The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of RCTs: pubmed.ncbi.nlm.nih.gov/34956...
Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: pubmed.ncbi.nlm.nih.gov/37598...
Effects of berberine and barberry on selected inflammatory biomarkers in adults: pubmed.ncbi.nlm.nih.gov/37675...
Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice: pubmed.ncbi.nlm.nih.gov/31306...
Berberine Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D Receptor Activity: pubmed.ncbi.nlm.nih.gov/37046...
Berberine influences multiple diseases by modifying gut microbiota: pubmed.ncbi.nlm.nih.gov/37599...
Berberine Improves Intestinal Motility and Visceral Pain in [...] Mouse Models: pubmed.ncbi.nlm.nih.gov/26700...
A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant IBS: pubmed.ncbi.nlm.nih.gov/26400...
Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis: pubmed.ncbi.nlm.nih.gov/34509...
Berberine and rifaximin effects on small intestinal bacterial overgrowth: pubmed.ncbi.nlm.nih.gov/36873...
Berberine and health outcomes: An umbrella review: pubmed.ncbi.nlm.nih.gov/36999...
Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats: pubmed.ncbi.nlm.nih.gov/21637...
Efficacy of berberine in patients with type 2 diabetes: pubmed.ncbi.nlm.nih.gov/18442...
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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
Music featured in this video: "Modern Technology" by Andrew G, audiojungle.net/user/andrew_g
*Full transcript available on CZcams by clicking the “Show transcript” button on the bottom right of the video. - Věda a technologie
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I’ve been using it over a year now, carnivore for 2 as of August 1st this year down 120lbs. I also have a mechanical heartvalve Aorta. I recently had an Echo done, my cardiologist was blown away with my progress , last time I had one done in 2021 after having 2 strokes and weighting 285lbs. My heart valves are clean as a whistle. He said “ next appointment in 5 years😊
You are fantastic!
Congratulations!
What brand
Congrats! How much berberine have you taken??
@@jd5787 I take 2 daily
It makes me so mad that I can get Metformin with zero copay with my Medicare but have to pay for Berberine. Same with doctors, zero copay but Medicare will not cover functional medicine doctors.
What a rip off.
😅😅😅😅😅😊😊😊888
Government is not your friend. To understand better follow the money. The bad players are Democrats and the RINO’s along with the hidden people behind the curtain.
That’s right. The drug companies are powerful and their reach is wide
At least it works and dont have to deal with the excruciating side effects.
Excellent presentation-my ears perked up when I heard a 30% reduction in colo-rectal adenocarcinoma polyps.
I’m taking Berberine for Thrush and Candidas Abdicans. It helped by reducing sugar craving, and thus helped me eliminate honey, maple syrup, and fruit intake. I did loose about 4 lbs, I’m not overweight. Very helpful.
Great to hear, thanks for sharing!
Great breakdown of the research. Thanks
You're welcome and thanks!
Berberine made me lose 6kg without dietary changes making me feel underweight.. i then stopped taking it, and now gaining weight slowly
It’s best to start out slowly
Are you a male or female, and how much milligrams daily?
Thanks for this. I've been taking berberine for a while now for a candida overgrowth and it is one of the things that helps. I just take it as needed - one capsule usually once or twice a day depending on if I'm eating legumes or carbs. I've heard mixed reviews on berberine for a number of perceived benefits so it great to hear more data/outcomes.
Thank you so much for sharing!
What is your opinion on Dihydroberberine please? Great video😊
It's made in your gut when you take berberine. No need to buy that.
Good video Ty
Thank you, I have been researching berberine, because of the excellent improvements in my overall health, my question, was whether it would benefit me to take probiotics, thank you for answering my question before I could ask it.
You discussed gut health. I discovered recently that a teaspoon of food grade Diametrious Earth improved my gut dramatically. So much so it unfroze my shoulder. My shoulder was frozen due to broken bone repair surgery. The unfreezing occurred starting in 2 days after Diametrious Earth and completed within 4 days. My theory is my immune system was repaired allowing inflammation repair in shoulder. Operation 4-2023 frozen by may 2023 remained frozen till 10-2023 even with daily physical therapy. Also my blood pressure is now 120 after years of around 145 to 155.
Hi Dr Rusico thank you for all your valuable information. Do you know of any studies that show improvement of biofilm infection and particular fruits that can help break it down. This would be much appreciated! Thank you in advance 💯
I'm not convinced that direct biofilm treatments are effective, we have a study under peer-review on this topic as we speak, stay tuned :)
@@DrRuscioDCmuch appreciated, look forward to the findings and anything that can help 💯
I've seen doctors online promoting a different form called "dihydroberberin" as to have less side effects on the stomach. What is your take on that?
One form seems to work better for sonn my e. You may want to try them both and see
It all breaks down into Berberine .Don’t be fooled by marketing.Also the body can only absorb very little .Hope this helps you.
Excellent presentation. How much, minimum or maximum, Berberine is recommended to intake to benefit from its effectiveness????
Everyone is different. Try taking one a day for a week and see how you feel. I've taken it on and off for years and don't feel or see any results. I started taking one two times a day and I see a big difference in my sugar. I'm 120 lbs so don't take it for weight loss but my energy is much better and my sense of well being
Everyone’s tolerance is different. Start out slow and see how you react
Hi Dr Ruscio, have you also looked into gymnema silvetre? Its supposed to also help with bloodsugar and gut symptoms.
I know of it, haven't fact checked in a while tho.
Beer Erin’s is amazing for ibs symptoms !! I have used it several times in the past and recently restarted it when I was having severe constipation from unknown but suspected Gi bug. I had completely lost my appetite after being sick in October and it was still continuing in January along with recent onset constipation. Within a week or two, taking 2 capsules daily, my appetite is back however the normalization of bms came sooner.
I would not dismiss this amazing herb for GI issues as I have previously used it when I was having ibs-d and it worked just as well to resolve it. There are still plenty of foods I need to avoid, so it’s not magic but it is one of the few go to herbs I use for ongoing gut issues.
I’m already pretty thin- it has not caused me any weight loss.
Gkk oh ad to hear
GlD you have had good results
What is beer erin
I forgot to add- I use barberry as my berberine herb. I don’t tolerate other herbs it’s made from. I buy it bulk in 1pound bag and encapsulate them myself.
Where do you order barberry? Thank you
This was super interesting. What are your thoughts on people using berberine to minimize their risk of insulin resistance, prediabetes, and type 2 diabetes?
In the video I do discuss berberine and blood sugar. There is some nuance with how one would use berberine for the conditions you mentioned. Due to legality, I cannot provide medical advice here. If you would like a personalized approach, please consider working with us!
drruscio.com/virtual-clinic/
Can someone explain/ respond to why Berberine caused my neutrophil count to go down drastically (very harmful)? Stopped and two months later, back to healthy count!!
I thought HbA1c was a measure of glycation, not oxidation.
It's most accurate to say glycation, agreed. Similar processes but with some nuanced differences.
Does it blunt muscle growth? Like metformin due to inhibition of MTOR?
Hello Dr. I am 41, training 6 times a week and walking a lot. I am a vegan and I eat pretty clean. I still cannot shade some body fat on my lower body. Do you think I should try Berberine? Anybody can try this supplement I suppose even fit people? Thanks
I take 300mg after both my meals. I never get additional gastric upset. Before food does irritate my stomach a bit.
Took berberine 2 weeks now. Lost 3lbs. Im going to lose weight but it may take me a while. I'm ordering milk thistle too.
I’ve been taking berberine and milk thistle for about 2.5 weeks now, can’t say it’s doing better than a proper diet and exercise at this stage, I’m pre diabetic, I need some help to knock me in the normal range. I will complete one months supply, at 1 (500mg) capsules of each 2x a day with meals. I want to try inositol next, as I think there are more long term studies people taking that over the years.
Why milk thistle
@@ketokarbs3671 look up the benefits of milk thistle
To protect the liver.
Is berberine good or bad for lymphoma?? And what is its dose?
Great question! Every person is going to have different needs. To make sure you know what's right for you, ask your doctor or reach out to us at the clinic! drruscio.com/virtual-clinic/
From what I have read, lymphoma loves high cholesterol. Ancient therapies for lymph often included ginger which is possibly great at lowering cholesterol. So I would think something that lowers cholesterol would be antagonistic to lymphoma. But I am not a doctor and have drawn that conclusion. What do you think?
Dr Ken Berry just did a podcast this week with a lady that specializes on this very topic! A lifestyle change to carnivore helps to eradicate it.
I’ve found that 300mg with my 2 meals per day doesn’t give me any side effects. However, at that dose I only get a reduction in blood sugar of about 10%.
I have heard that since it’s anti microbial and fungal that it may kill some good probiotics. Is this true?
I heard that too.
It’s possible but only at very high doses
I heard it was great because it didn’t kill good bacteria
I’d be interested in a video of the research on Acarbose since it seems to be a positive microbiome regulator
Are you spelling it right
Which is a trustable brand for berberine?
British supplements 👍
You did not mention Dihydroberberine which is 5 times more powerful than just Berberine. A1c 6.0 in Jan 2024 just completed A1c April 2024 it was 5.6. I started Dihydroberberine 1-5-2024.
Hi can you recommend a brand / source? Thanks.
@@gordonauchincloss9161 I have posted here 5 times to answer but it keeps getting deleted. A mazon Doub le Tr ee.
My cholesterol improved, my a1c improved, my triglyceride improved. But!!! I did lose muscle
Bummer about the side effects. Maybe it’s safe to add after doing probiotics for at least 3 months and the gut heals?
Sounds reasonable :)
Look into dihydroberberine. I just got mine today actually.
By chance are you familiar with supplementing thiamine? I heard this could help with symptoms of leaky gut
I haven't seen any credible evidence on this, although I may have missed it.
I’ve been taking berberine and milk thistle for about 2.5 weeks now, can’t say it’s doing better than a proper diet and exercise at this stage, I’m pre diabetic, I need some help to knock me in the normal range. I will complete one months supply, at 1 (500mg) capsules of each 2x a day with meals. I want to try inositol next, as I think there are more long term studies people taking that over the years.
Moringa is excellent for blood sugar and energy
Confusing...😵💫😱
You are a rare doctor that cares about side effects. The pharmaceuticals that are pushed by doctors that have tons of side effects makes me cringe. It interests me greatly to know why doctors readily prescribe drugs that can cause organ damage and death but don't warn or caution you like they do some herbs that have been studied.
Berberine is a seriously miracle drug.
500mg a day no side effects if I take with a slice of toast. Thank you for the info.
Happy to help 😊
I took 250 mg of brine for the first time and had some weird side effects with it. I immediately had to go to the bathroom, I was feeling very very nauseous and I didn’t but I did feel like I needed to vomit. I just felt very sick for about three hours after I took it and then I started to feel a little better thankfully it didn’t get as bad as it felt like it was going to. Is this normal? I do have leaky gut. I also developed really bad Sebo and I just cleared a sea diff infection in my colon. I definitely have a lot of digestive issues going on and still getting to the bottom of this. I suspect I have low stomach acid and poor bio flow And previous to going on the carnivore diet in the past nine months I was having diabetic symptoms and hypoglycemic episodes. I am not diagnosed diabetic. I am actually very petite so clinically Doctor look at me and say you’re fine. Which is bullshit because they’re not listening to what I’m telling them is happening to my body. And while I’ve been on the carnivore diet, I’ve tried to add a few different things in and it seems like my body literally cannot break down carbs, starches, sugars, etc. right now.
Have u seen a gastro expert? There are some who have holistic approach. Chicago Illinois
It’s best to start out slow and take with meals
Berberine is also antibacterial. it will negatively impact the gut microbiota. why do we want to reduce the all-important diversity of gut microbiota?
I was assured by another Dr that it won't be an issue.
This effect is dose specific and if it occurs taking a good probiotic would help
I watched your video. I would point out when you told people to discuss with your doctor,Berberine. I would argue to tell your doctor not be weak. Doctors today are weak and prone to falling for medical propaganda and not science.
Thats a fact
If berberine causes GI issues at only 300mg how can it be considered a good choice for any of the problems discussed?