Bonnie Bassler (Princeton) Part 1: Bacterial Communication via Quorum Sensing
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- čas přidán 26. 03. 2010
- www.ibiology.org/microbiology...
Bacteria, primitive single-celled organisms, communicate with chemical languages that allow them to synchronize their behavior and thereby act as enormous multi-cellular organisms. This process is called quorum sensing and it enables bacteria to successfully infect and cause disease in plants, animals, and humans. Investigations of the molecular mechanisms underlying quorum sensing are leading to the development of novel strategies to interfere with quorum sensing. These strategies form the basis of new therapies to be used as antibiotics. See more at www.ibioseminars.org - Věda a technologie
![[Conférence] K. XAVIER - Bacterial interspecies quorum sensing in the mammalian gut microbiota](http://i.ytimg.com/vi/gaze7s5cb1k/mqdefault.jpg)
You are so interesting to listen to. Your emotions transfer directly into the information you are passing on. I can stay engaged listening to you even though I really may only get a small portion of it. Your ability to wrap up the large picture within the specifics is masterful and I'm thankful for you. Hugs :)
Just look at how passionate Dr Bassler is about her work. If only we could all be like that about what we do. Dr Bassler, I am in awe of your obvious love and excitement for and about your field of study. You are as beautiful as you are brilliant, and also, your sense of humour peeked through your presentation. Wow what a complete woman! Kudos to you.
You are a wonderful rarity, Bonnie Bassler. So often the fascinating world of microbiology (or just about any other field of science) is made dull or inaccessible by people who don't themselves know how to communicate. I loved this video. I look forward to watching more lectures by you. This presentation was wildly engaging and easy to follow while providing enduring interest in the subject. Thanks!!!
This was one of the best and most engrossing talk on a subject in microbiology that I have ever had. Thank u Dr. Bonie bassler:) I wish I have an opportunity to work under you someday.
And I dearly wish they taught us microbiology like that in our medical school..
bhai etna bhi centy mat ho
I think she should be addressed as Dr. Bonnie Bassler, not Mrs. Bonnie Bassler.
@@sonakshisrivastava6958 thanks for bringing that up. I made the correction!
I am a physics major starting to work my ways towards applications in biology, and I must say that the excitement displayed in this video with regards to the process of discovery and to the various dimensions of interconnectedness being uncovered in (micro)biology is incredibly inspiring. Thank you for this wonderful video and for showing how passion can override the occasionally tedious and intimidating nature of exploring topics like these in great detail. 😁👍
This is one of the best academic videos i have seen for now. Thank you and pleaswe stay healthy and strong so that you can give me more of this and to others.
You are awesome
I first saw a presentation by Dr. Bassler more than 10 years ago and have been fascinated by what I regard as her breakthrough work ever since. My field is not biology, but I cannot stop thinking about the implications. What I wonder most about is whether quorum sensing/signaling can be put to work in cancer therapy. Clearly, there is a new line of research in infectious bacterial disease and possibly viral disease, and it seems reasonable to me that anti-cancer research is closely related. Has the mainstream of research once again neglected a new line of research?
@smartereveryday, please consider interviewing Dr. Bassler.
One of our most brilliant scientists.
It was dopeeeee 🔥 never had such interest in a micro topic in a very long time
Thank you for this information. I got goosebumps hearing about the squid's beneficial microbes. I study microbial nutrition - particularly natto - this encourages me in my efforts. Thank you again for your knowledge and passion.
I’ll apply to Princeton for my postgrad if you’re teaching! 😂 You made what I thought was boring and unrelatable so interesting I’ve watched it twice now - and watched your tedtalk.😂
Bonnie Bassler is wonderful! I recently watched a lecture series by Yale's Stephen C. Stearns, but he is such an extremely unpleasant person, I could not finish the series. Bonnie Bassler, however, is a joy to watch and listen to, so I am sure I will do that a lot. Am already a fan. Princeton wins.
So so amazing, excellent. Clear great tone, nice illustrations. Good presentation
Very Informative and impresssive video. Thank You Dr Bonnie Baseler
English is so hard,but teacher is so interesting and excellent(my brain is booming)
I am very fascinated by your talk and I wish you a lot of new results in molecular biochemistry. I will follow your research !
Thank you for such an inspirational talk!
Excellent presentation! Great delivery! Quorum Sensing is very promising.
Great vídeo! Very interesting to learn about communication of bactéria. Esta mulher é uma cientista admirável, muito bom este vídeo!!!
My professor linked this to a PowerPoint book and at first I was like NOOOOO but you make it so interesting I ended up watching the whole thing and was left curiosity!!! Thank you!!
Excellent talk...my concentration hardly shifted!
This is mindblowing.
Wonderful, amazing!! Bonnie Brasser you are the Christopher Colombus of a new world of biological communiction - i wonder... what would you discover if you got into motor molecules - how they communicate - another great mystery...
bravo....beautiful discovery!
This is fascinating!
Unfortunately, the vid stopped part way through, so forgive me if you already answered this, but could the manipulation of the peptides in these quorum sensing systems be an answer to the problem of evolved resistance to antibiotics?
Absolutely amazing!
So clear and articulate
Great videos and explanations, thank you :)
Excellent presentation.....
thank you very much this is very impressive
in terms of time, how long did it take you to perform all of these experiments and reach those conclusions? i'm assuming you had many misleads, or am i wrong?
p.s. great video, thanks!
Thank you very much.
great talk
its really interesting topic, brief explanation, I am doing seminar on it and it help me a lot
thank you mam, its very informative talk
Te quiero mucho Bonnie Bassler 🥰😘
Is it possible that bacteria ( viruses etc) could manipulate the system they colonize in order to make it behave in a way they are interested in?
So they communicate like plants. They use a dispersal method since they are limited in sensing their surrounding environment.
Someone please tell me what they feed on!!!
I saw an article on the effectiveness of using certain naturally occurring clays as antibiotics; especially red . Makes me think that perhaps it is the clays that may be binding with the various inter and intra species communication molecules. www.nature.com/articles/srep19043
It's quite astounding. But what is the interest of bacteria in colonizing big systems if these systems die ? Do they have an interest in their death as lions that kill their prey in order to eat them ? Would the bacteria survive the decomposition process ?
Your perception of what bacteria want is wrong. A bacterium simply reacts to a biochemical stimulus. If it is beneficial it will thrive. If not it will die.
If it results in the death of the host too quickly it is not beneficial, it did not have time to infect other hosts. Example is the pest virus in the middle ages, after an initial succes to many people died and thus it could not sustain itself, it went to the fringes.
An other more successful virus is the influenza virus, it does not kill the host but makes it sneeze and infect others before the immune system can suppress it.
It is not a strategy as we perceive it but it simply is how biochemistry works.
And do not forget that a dead host will most probably be eaten by other animals who can get infected and that would complete the circle.
"All the things we'd like to do," eh, Bonnie? I like that.
P.aeruginosa sounds like the original gangster bacteria. Out of curiosity can these bacterium be tricked into not forming Biofilm in a lung through introducing some other less harmful bacterium? Probably a stupid question but I'm curious if this could be done.
exactly my thought. not stupid at all. it may actually work. exciting! isnt it?
Great information but I suspect that commercial interests will misdirect this line of research. The next logical question would be, how does our immune system interact with quorum sensing to protect itself from pathogens. And how can we enhance that.
But the pressure will be directed toward, a patentable drug. Then natural solutions will be marginalised or outright banned. Marijuana and THC and Cannabidiol for example.
The whole universe is quantum mechanical in nature, as long as we do not understand how quantum computation does many operations simultaneously and how superimposed states represents the various dimensions we live in, we shall know nothing.
I see.
is B. Bassler Dutch from origin?
No, why?
I saw this woman on ted
Enjoyed this talk about communication by bacteria side product. Funny thought: It seems the bacterial variant to piss, by which it can smell others. Just like dogs ;)
Idea: Maybe we can confuse salmonella with boron?