Nonspecific interstitial pneumonia (NSIP): multiple examples with typical imaging patterns

I review multiple cases of NSIP on imaging and share clinical and diagnostic pearls for the radiologist and anyone else interested in thoracic imaging. NSIP is usually secondary rather than idiopathic and the most common underlying condition is connective tissue disease. This will be exemplified in this video. Some literature that is helpful in diagnosis will also be covered. Diffuse pulmonary ossification's significance in the setting of interstitial lung disease will also be discussed.
Papers:
1. Differentiating Usual Interstitial Pneumonia From Nonspecific Interstitial Pneumonia Using High-resolution Computed Tomography: The "Straight-edge Sign" (pubmed.ncbi.nlm.nih.gov/29683...)
2.CT Features of the Usual Interstitial Pneumonia Pattern: Differentiating Connective Tissue Disease-Associated Interstitial Lung Disease From Idiopathic Pulmonary Fibrosis (pubmed.ncbi.nlm.nih.gov/29140...)
3. Diffuse Pulmonary Ossification in Fibrosing Interstitial Lung Diseases: Prevalence and Associations (pubmed.ncbi.nlm.nih.gov/28182...)
4. Diffuse Pulmonary Ossification on High-Resolution Computed Tomography in Idiopathic Pulmonary Fibrosis, Systemic Sclerosis-Related Interstitial Lung Disease, and Chronic Hypersensitivity Pneumonitis: A Comparative Study (pubmed.ncbi.nlm.nih.gov/32842...)

[@tameembhat415]

Can we call post COVID Changes as NSIP pattern if it is like NSIP

[@lalali1177]

Thanks Dr!

[@santhoshkumar-tt4sb]

Excellent

[@Dougie-]

I'm having increasingly trouble breathing. I'm put on a 12 weeks cortisone cycle while waiting for a new CT and a doctor appointment in mid January. Nice going through December not knowing much 😔
What does all this say (badly Google translated)? IPF? NSIP?
«Spirometry: FVC 2,1 L (43 %), FEV1 1,75 L (45 %), 83 % av FVC. PEF 5,7 (65 %)
Gas diffusion: DLCO 3,5 (37 b%), KCO 1,23 (81 %)
Pletysmography: TLC 3,19 (46 %), RV 1,68 (80 %), 52 % av TLC.
Total lung capacity is barely 46%.
Fine reticular thickenings with bronchiectasis with basal predominance in both lower lobes. Subpleural clearing and relatively sharp demarcation against what is perceived as normal lung tissue.
Hearing bilateral inspiratory crackles»

[@radiologydarkroom7709]

fibulous